Forschungsthemen

  • Metabolische Erkrankungen: Adipositas und Diabetes
  • Alternsforschung und Stammzellbiologie
  • Degenerative Erkrankungen des Muskuloskelettalen Systems
  • Ernährung und Metabolische Flexibilität

Ausgewählte Publikationen

Gohlke, S., Zagoriy, V., Cuadros Inostroza, A., Méret, M., Mancini, C., Japtok, L., Schumacher, F., Kuhlow, D., Graja, A., Stephanowitz, H., Jähnert, M., Krause, E., Wernitz, A., Petzke, K.-J., Schürmann, A., Kleuser, B., Schulz, T. J.: Identification of functional lipid metabolism biomarkers of brown adipose tissue aging. Mol. Metab. 24, 1-17 (2019). 

Graja, A., Garcia-Carrizo, F., Jank, A.-M., Gohlke, S., Ambrosi, T. H., Jonas, W., Ussar, S., Kern, M., Schürmann, A., Aleksandrova, K., Blüher, M., Schulz, T. J.: Loss of periostin occurs in aging adipose tissue of mice and its genetic ablation impairs adipose tissue lipid metabolism. Aging Cell 17: e12810 (2018).

Ambrosi, T. H., Scialdone, A., Graja, A., Gohlke, S., Jank, A.-M., Bocian, C., Woelk, L., Fan, H., Logan, D. W., Schürmann, A., Saraiva, L. R., Schulz, T. J.: Adipocyte accumulation in the bone marrow during obesity and aging impairs stem cell-based hematopoietic and bone regeneration. Cell Stem Cell 20, 771-784 (2017). 

Schulz, T. J., Graja, A., Huang, T. L., Xue, R., An, D., Poehle-Kronawitter, S., Lynes, M. D., Tolkachov, A., O’Sullivan, L. E., Hirshman, M. F., Schupp, M., Goodyear, L. J., Mishina, Y., Tseng, Y. H.: Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance. Diabetologia 59, 1769-1777 (2016). [Open Access]

Xue, R., Lynes, M. D., Dreyfuss, J. M., Shamsi, F., Schulz, T. J., Zhang, H., Huang, T. L., Townsend, K. L., Li, Y., Takahashi, H., Weiner, L. S., White, A. P., Lynes, M. S., Rubin, L. L., Goodyear, L. J., Cypress, A. M., Tseng, Y. H.: Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med 21(7), 760-768 (2015). [Open Access]

Schulz, T. J., Huang, P., Huang, T. L., Xue, R., McDougall, L. E., Townsend, K. L., Cypress, A. M., Mishina, Y., Gussoni, E., Tseng, Y. H.: Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature 495(7441), 379-383 (2013). [Open Access]

Schulz, T. J., Huang, T. L., Tran, T. T., Zhang, H., Townsend, K. L., Shadrach, J. L., Cerletti, M., McDougall, L. E., Giorgadze, N., Tchkonia, T., Schrier, D., Falb, D., Kirkland, J. L., Wagers, A. J., Tseng, Y. H.: Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc. Natl. Acad. Sci. USA 108(1), 143-148 (2011).

Schulz, T. J., Westermann, D., Isken, F., Voigt, A., Laube, B., Thierbach, R., Kuhlow, D., Zarse, K., Schomburg, L., Pfeiffer, A. F. , Tschöpe, C., Ristow, M.: Activation of mitochondrial energy metabolism protects against cardiac failure. Aging (Albany NY) 2(11), 843-853 (2010).

Tseng, Y. H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., Ahrens, M. J., Dudley, A. T., Norris, A. W., Kulkarni, R. N., Kahn, C. R.: New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454(7207), 1000-1004 (2008). [Open Access]

Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., Ristow, M.: Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 6(4), 280-293 (2007). [Open Access]

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