Forschungsthemen

• Alterung
• Oxidativer Stress
• Ernährung
• zelluläre Seneszenz
• Langerhans-Inseln
• Beta-Zelle
• Proteinaggregate

Ausgewählte Publikationen

Kehm, R., Jähnert, M., Deubel, S., Flore, T., König, J., Jung, T., Stadion, M., Jonas, W., Schürmann, A., Grune, T., Höhn, A.: Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: role of Thioredoxin-interacting protein (TXNIP). Red. Bio. 37:101748 (2020). [Open Access]

Höhn, A., Tramutola, A., Cascella, R.: Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress. Oxid Med and Cell Lon 2020: 5497046 (2020). [Open Access]

Kehm, R., Rückriemen, J., Weber, D., Deubel, S., Grune, T., Höhn, A.: Endogenous advanced glycation end products in pancreatic islets after short-term carbohydrate intervention in obese, diabetes-prone mice. Nutr. Diabetes 9(1):9 (2019). [Open Access]

Press, M., Jung, T., König, J., Grune, T., Höhn, A.: Protein aggregates and proteostasis in aging: Amylin and β-cell function. Mech. Ageing Dev. 177, 46-54 (2019). [Open Access]

Kehm, R., König, J., Nowotny, K., Jung, T., Deubel, S., Gohlke, S., Schulz, T. J., Höhn, A.: Age-related oxidative changes in pancreatic islets are predominantly located in the vascular system. Redox Biol. 15, 387-393 (2018). [Open Access]

Höhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J.Grune, T., Castro, J. P.: Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol. 11, 482-501 (2017). [Open Access]

König, J., Ott, C., Hugo, M., Jung, T., Bulteau, A.-L., Grune, T., Höhn, A.: Mitochondrial contribution to lipofuscin formation. Redox Biol. 11, 673-681 (2017). [Open Access]

König, J., Besoke, F., Stuetz, W., Malarski, A., Jahreis, G., Grune, T., Höhn, A.: Quantification of age-related changes of α-tocopherol in lysosomal membranes in murine tissues and human fibroblasts. BioFactors 42, 307-315 (2016). [Open Access]

Nowotny, K., Jung, T., Grune, T., Höhn, A.: Accumulation of modified proteins and aggregate formation in aging. Exp. Geron. 59, 3-12 (2014).

Höhn, A., Sittig, A., Jung, T., Grimm, S., Grune, T.: Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts. F. Rad. Bio. Med. 53(9), 1760-1769 (2012).