Forschungsthemen

  • chronisch-entzündliche Darmerkrankungen
  • Ernährung
  • Inflammation
  • mehrfach ungesättigte Fettsäuren
  • Oxylipine
  • ketogene Diät
  • Alterung

Ausgewählte Publikationen

Schebb, N. H., Kühn, H., Kahnt, A. S., Rund, K. M., O''Donnell, V. B., Flamand, N., Peters-Golden, M., Jakobsson, P. J., Weylandt, K. H., Rohwer, N., Murphy, R. C., Geisslinger, G., FitzGerald, G. A., Hanson, J., Dahlgren, C., Alnouri, M. W., Offermanns, S., Steinhilber, D.: Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far? Front. Pharmacol. 13, 838782 (2022). [Open Access]

Marbach-Breitrück, E., Rohwer, N., Infante-Duarte, C., Romero-Suarez, S., Labuz, D., Machelska, H., Kutzner, L., Schebb, N. H., Rothe, M., Reddanna, P., Weylandt, K. H., Wieler, L. H., Heydeck, D., Kuhn, H.: Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5(-/-) Mice. Metabolites 11(10):698 (2021). [Open Access]

Rohwer, N., Chiu, C. Y., Huang, D., Smyl, C., Rothe, M., Rund, K. M., Helge Schebb, N., Kühn, H., Weylandt, K. H.: Omega-3 fatty acids protect from colitis via an Alox15-derived eicosanoid. Faseb J. 35(4):e21491 (2021). [Open Access]

Rohwer, N., Kuhl, A. A., Ostermann, A. I., Hartung, N. M., Schebb, N. H., Zopf, D., McDonald, F. M., Weylandt, K. H.: Effects of chronic low-dose aspirin treatment on tumor prevention in three mouse models of intestinal tumorigenesis. Can. Med. 9(7), 2535-2550 (2020). [Open Access]

Rohwer, N., Jumpertz, S., Erdem, M., Egners, A., Warzecha, K.T., Fragoulis, A., Kühl, A.A., Kramann, R., Neuss, S., Rudolph, I., Endermann, T., Zasada, C., Apostolova, I., Gerling, M., Kempa, S., Hughe,s R., Lewis, C.E., Brenner, W., Malinowski, M.B., Stockmann, M., Schomburg, L., Faller, W., Sansom, O.J., Tacke, F., Morkel, M., Cramer, T.: Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis. Oncogene 38(28):5670-5685 (2019). [Open Access]

Kroschwald, S., Chiu, C.Y., Heydeck, D., Rohwer, N., Gehring, T., Seifert, U., Lux, A., Rothe, M., Weyland,t K.H., Kuhn, H.: Female mice carrying a defective Alox15 gene are protected from experimental colitis via sustained maintenance of the intestinal epithelial barrier function. Biochim. Biophys. Acta Mol. Cell Biol. Lipids. 1863(8):866-880 (2018).

Ostermann, A.I., Waindok, P., Schmidt, M.J., Chiu, C.Y., Smyl, C., Rohwer, N., Weylandt, K.H., Schebb, N.H.: Modulation of the endogenous omega-3 fatty acid and oxylipin profile in vivo-A comparison of the fat-1 transgenic mouse with C57BL/6 wildtype mice on an omega-3 fatty acid enriched diet. PLoS One 12(9): e0184470 (2017). [Open Access]

Rohwer, N., Bindel, F., Grimm, C., Lin, S.J., Wappler, J., Klinger, B., Blüthgen, N., Du Bois, I., Schmeck, B., Lehrach, H., de Graauw, M., Goncalves, E., Saez-Rodriguez, J., Tan, P., Grabsch, H.I., Prigione, A., Kempa, S., Cramer, T.: Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A. Oncotarget 7(6):6693-710 (2016). [Open Access]

Rohwer, N., Cramer, T.: Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist Updat. 14(3):191-201. (2011).

Rohwer, N., Dame, C., Haugstetter, A., Wiedenmann, B., Detjen, K., Schmitt, C.A., Cramer, T.: Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB. PLoS One 5(8):e12038 (2010).