Ansprechperson: Dr. Daniela Weber

Das Verbundprojekt food4future – Nahrung der Zukunft (f4f), gefördert vom Bundesministerium für Bildung und Forschung im Rahmen des Programms Agrarsysteme der Zukunft, untersucht radikale Innovationen für eine nachhaltige und gesunde Lebensmittelversorgung.

Das Projekt wird vom Leibniz-Institut für Gemüse- und Zierpflanzenbau (IGZ) koordiniert. Das Gesamtziel von F4F ist die zukünftige, nachhaltige Sicherung ausreichender und gesunder Ernährung. Das DIfE bearbeitet das Forschungsfeld „Smart Nutrition und tragbare Sensoren“ zusammen mit dem Fachgebiet Telematik der Technischen Hochschule Wildau. In einer Humanstudie werden über einen Zeitraum von 8 Wochen neuartige Hautsensoren für die Bestimmung des Carotinoid-Status, eine eigens programmierte Carotinoid-Ernährungs-App sowie standardisierte Methoden (Blutanalysen, Fragebögen) eingesetzt und verglichen. Neuartige, in F4F entwickelte Produkte (z.B. Algen-Smoothie) sollen über Ernährungsempfehlungen durch die App in einer Folgestudie mit einbezogen werden.

Ansprechperson: Dr. Annika Höhn

Das Deutsche Zentrum für Diabetesforschung e.V. (DZD) verfolgt das Ziel, durch interdisziplinäre und translationale Forschung die Ursachen des Diabetes zu klären und neue Präventions- und Therapiekonzepte zu entwickeln.

Die Prävalenz des Typ-2-Diabetes nimmt mit dem Alter deutlich zu, der Einfluss des Alterungsprozesses bei Typ-2-Diabetes Pathogenese ist jedoch noch unzureichend verstanden. Unsere Abteilung untersucht in Kooperation mit DZD-Partnern altersassoziierte Prozesse und deren Einfluss auf die Funktion insulinproduzierender Betazellen. Mithilfe von Einzelzell-Genexpressionsanalysen (scRNA-seq) soll die Diversität alternder β-Zellen in verschiedenen Altersstufen im Zusammenhang mit der Ernährung untersucht werden. Ein weiteres Interesse besteht in der Untersuchung sogenannter Senolytika, Wirkstoffe die gezielt gealterte Zellen eliminieren können. Wir untersuchen, ob diese Wirkstoffe spezifisch gealterte β-Zellen entfernen können und die funktionellen Konsequenzen dieser „Senolyse“. Diese Daten ermöglichen einen tiefen Einblick in das Spektrum alternder β-Zellen, deren funktionelle Rolle und pathophysiologische Bedeutung für die Entwicklung eines Typ-2-Diabetes.

Ansprechperson: Dr. Christiane Ott

Das Deutsche Zentrum für Herz-Kreislauf-Forschung e.V. (DZHK) verfolgt das Ziel neue Therapien und Diagnoseverfahren zu entwickeln, um die Lebensqualität der Menschen mit Herz-Kreislauf-Erkrankungen zu verbessern und die Sterblichkeitsrate zu verringern. Die Ursachen von Herz-Kreislauf-Erkrankungen, zu denen alle Erkrankungen des Gefäßsystems und Herzens zählen, sind äußerst vielschichtig. Neben einer genetischen Veranlagung zählen besonders Bluthochdruck, hohes Cholesterin, Diabetes, Rauchen körperliche Inaktivität sowie eine ungesunde Ernährung zu den Risikofaktoren. In Deutschland sind Herz-Kreislauf-Erkrankungen die häufigste Todesursache, wobei die Inzidenz mit dem Alter ansteigt. Da Herz-Kreislauf-Erkrankungen häufig chronisch verlaufen und so über einen langen Zeitraum in die Lebensqualität der Menschen eingreifen, ist das DZHK bestrebt neue Erkenntnisse aus der Grundlagenforschung zügig und zielgerichtet in der Klinik zur Anwendung zu bringen.

Unsere Abteilung beschäftigt sich damit, den Einfluss einer hochkalorienreichen Ernährung auf die Herzfunktion und den Herzmetabolismus zu untersuchen. Mithilfe verschiedener Altersstufen und Diäten soll untersucht werden inwieweit die Ernährung die alternden Herzmuskelzellen beeinflussen und die Kontraktion beeinträchtigen kann. Ein weiteres Interesse besteht in der Analyse von Proteinaggregaten, die sich im Alter vor allem auch vermehrt in den Herzmuskelzellen anreichern, und deren direkten Effekt auf die Funktion der Zellen. Um zu untersuchen inwieweit Ernährung zu einer verbesserten Herzmuskelzellfunktion beitragen kann, erfolgen zudem Analysen zum Einfluss verschiedener Nährstoffe auf die Kontraktion der Herzmuskelzellen.

Ansprechperson: Dr. Christiane Ott

Wie Spurenelemente im Körper verstoffwechselt werden ist schon gut verstanden, jedoch weitgehend unbekannt ist, wie sich Spurenelemente unter physiologischen und pathophysiologischen Bedingungen gegenseitig beeinflussen. Da das Gleichgewicht der Spurenelemente zudem vom Geschlecht, Alter und der Nahrungsaufnahme abhängig ist, untersucht die DFG-Forschungsgruppe FOR 2558 „TraceAge“ den Status und die Interaktionen der essentiellen Spurenelemente Eisen, Mangan, Kupfer, Iod, Selen und Zink im Blut mit verschiedenen Biomarkern des Alterns. Ziel ist es alters- und geschlechtsspezifische Spurenelement-Fingerabdrücke zu erhalten, die helfen genetische sowie umweltbedingte Veränderungen zu identifizieren und eine Grundlage für eine verbesserte Vorsorge hinsichtlich gesunden Alterns und zukünftige Interventionsstudien zu schaffen.

Im Fokus unserer Abteilung steht die Untersuchung des Spurenelementes Eisen, dessen Status, Aufnahme und Metabolismus im alternden Herzen sowie der Einfluss von Eisen auf die Kontraktion der Herzmuskelzellen. Besonders in den Mitochondrien, den Energielieferanten für die Zelle, spielt Eisen eine wichtige Rolle.  Auch die Analyse wichtiger Proteine des Eisenstoffwechsel, wie das Eisenspeicherprotein Ferritin oder der Transferrin-Rezeptor für die Eisenaufnahme, spielen eine wichtige Rolle, um Veränderungen im Eisenstatus zu charakterisieren. Innerhalb von „TraceAge“ untersucht die Abteilung, wie und ob sich der Eisengehalt von jungen zu den alternden Herzmuskelzellen verändert und welche Rolle proteolytische Systeme, wie das Ubiquitin-Proteasomale oder das Autophagie-Lysosomale Abbausystem bei dem Abbau der Proteine des Eisenstoffwechsels spielen. Neben der Analyse von Eisen soll zudem die Interaktion mit Kupfer und Zink, unter Betrachtung der Herzmuskelzellfunktion, Proteolyse und Markern des Alterns, untersucht werden.

Grune, T., Schnell, V., Jung, T.: High glucose leads to redistribution of the proteasomal system. Biofactors 49(3), 636-645 (2023). [Open Access]

Henning, T., Kochlik, B., Ara, I., González-Gross, M., Fiorillo, E., Marongiu, M., Cucca, F., Rodriguez-Artalejo, F., Carnicero Carreño, J. A., Rodriguez-Mañas, L., Grune, T., Weber, D.: Patterns of Dietary Blood Markers Are Related to Frailty Status in the FRAILOMIC Validation Phase. Nutrients 15(5):1142 (2023). [Open Access]

Henning, T., Wagner, P., Gedat, E., Kochlik, B., Kusch, P., Sowoidnich, K., Vastag, M., Gleim, J., Braune, M., Maiwald, M., Sumpf, B., Grune, T., Weber, D.: Evaluation of Modern Approaches for the Assessment of Dietary Carotenoids as Markers for Fruit and Vegetable Consumption. Nutrients 15(7):1665 (2023). [Open Access]

Kochlik, B., Franz, K., Henning, T., Weber, D., Wernitz, A., Herpich, C., Jannasch, F., Aykaç, V., Müller-Werdan, U., Schulze, M. B., Grune, T., Norman, K.: Frailty is characterized by biomarker patterns reflecting inflammation or muscle catabolism in multi-morbid patients. J. Cachexia Sarcopenia Muscle 14(1), 157-166 (2023). [Open Access]

Ott, C., Jung, T.: The MyoPulser field stimulator, a do it yourself programmable electronic pacemaker for contracting cells and tissues. Sci. Rep. 13(1):2461 (2023). [Open Access]

Rohwer, N., Jelleschitz, J., Höhn, A., Weber, D., Kühl, A. A., Wang, C., Ohno, R., Kampschulte, N., Pietzner, A., Schebb, N. H., Weylandt, K.- H., Grune, T.: Prevention of colitis-induced liver oxidative stress and inflammation in a transgenic mouse model with increased omega-3 polyunsaturated fatty acids. Redox Biol. 64:102803 (2023). [Open Access]

Walter, S., Jung, T., Herpich, C., Norman, K., Pivovarova-Ramich, O., Ott, C.: Determination of the autophagic flux in murine and human peripheral blood mononuclear cells. Front. Cell Develop. Biol. 11:1122998 (2023). [Open Access]

Bishop, C. A., Machate, T., Henning, T., Henkel, J., Püschel, G., Weber, D., Grune, T., Klaus, S., Weitkunat, K.: Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle. Nutr. Diabetes 12(1):20 (2022). [Open Access]

Haß, U., Herpich, C., Kochlik, B., Weber, D., Grune, T., Norman, K.: Dietary Inflammatory Index and Cross-Sectional Associations with Inflammation, Muscle Mass and Function in Healthy Old Adults. J. Nutr. Health Aging 26, 346–351 (2022). [Open Access]

Henning, T., Kochlik, B., Kusch, P., Strauss, M., Jurić, V., Pignitter, M., Marusch, F., Grune, T., Weber, D.: Pre-Operative Assessment of Micronutrients, Amino Acids, Phospholipids and Oxidative Stress in Bariatric Surgery Candidates. Antioxidants 11(4):774 (2022). [Open Access]

Herpich, C., Kochlik, B., Weber, D., Ott, C., Grune, T., Norman, K., Raupbach, J.: Fasting concentrations and postprandial response of 1,2-dicarbonyl compounds 3-deoxyglucosone, glyoxal and methylglyoxal are not increased in healthy older adults. J. Gerontol. Ser. A-Biol. Sci. Med. Sci. 77(5), 934–940 (2022). [Open Access]

Schiborn, C., Weber, D., Grune, T., Biemann, R., Jäger, S., Neu, N., Müller von Blumencron, M., Fritsche, A., Weikert, C., Schulze, M. B., Wittenbecher, C.: Retinol and Retinol Binding Protein 4 Levels and Cardiometabolic Disease Risk. Circ. Res. 131(7), 637–649 (2022). [Open Access]

Stokes, C. S., Weber, D., Wagenpfeil, S., Stuetz, W., Moreno-Villanueva, M., Dollé, M. E. T., Jansen, E., Gonos, E. S., Bernhardt, J., Grubeck-Loebenstein, B., Fiegl, S., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Capri, M., Hervonen, A., Slagboom, P. E., Breusing, N., Frank, J., Bürkle, A., Franceschi, C., Grune, T.: Association between fat-soluble vitamins and self-reported health status: a cross-sectional analysis of the MARK-AGE cohort. Br. J. Nutr. 128(3), 433-443 (2022). [Open Access]

Zhang, Y., Jelleschitz, J., Grune, T., Chen, W., Zhao, Y., Jia, M., Wang, Y., Liu, Z., Höhn, A.: Methionine restriction - Association with redox homeostasis and implications on aging and diseases. Redox Biol. 57:102464 (2022). [Open Access]

Hauffe, R., Rath, M., Schell, M., Ritter, K., Kappert, K., Deubel, S., Ott, C., Jähnert, M., Jonas, W., Schürmann, A., Kleinridders, A.: HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue. Mol. Metab. 53:101276 (2021). [Open Access]

Henning, T., Weber, D.: Redox biomarkers in dietary interventions and nutritional observation studies - From new insights to old problems. Redox Biol. 41:101922 (2021). [Open Access]

Herpich, C., Kochlik, B., Haß, U., Weber, D., Grune, T., Norman, K.: Altered Adiponectin Response in Older Women Following Dextrose and High-Fat Dietary Challenges. Mol. Nutr. Food Res. 65(17):2100487 (2021). [Open Access]

Korovila, I., Höhn, A., Jung, T., Grune, T., Ott, C.: Reduced Liver Autophagy in High-Fat Diet Induced Liver Steatosis in New Zealand Obese Mice. Antioxidants 10(4):501 (2021). [Open Access]

Ott, C., Jung, T., Brix, S., John, C., Betz, I. R., Foryst-Ludwig, A., Deubel, S., Kuebler, W. M., Grune, T., Kintscher, U., Grune, J.: Hypertrophy-Reduced Autophagy Causes Cardiac Dysfunction by Directly Impacting Cardiomyocyte Contractility. Cells 10(4):805 (2021). [Open Access]

Ott, C., Pappritz, K., Hegemann, N., John, C., Jeuthe, S., McAlpine, C. S., Iwamoto, Y., Lauryn, J. H., Klages, J., Klopfleisch, R., Van Linthout, S., Swirski, F., Nahrendorf, M., Kintscher, U., Grune, T., Kuebler, W. M., Grune, J.: Spontaneous Degenerative Aortic Valve Disease in New Zealand Obese Mice. J. Am. Heart Assoc. 10(23):e023131 (2021). [Open Access]

Ott, C., Tomasina, F., Campolo, N., Bartesaghi, S., Mastrogiovanni, M., Leyva, A., Batthyany, C., Meinl, W., Grune, T., Radi, R.: Decreased proteasomal cleavage at nitrotyrosine sites in proteins and peptides. Redox Biol. 46:102106 (2021). [Open Access]

Pivovarova-Ramich, O., Loske, J., Hornemann, S., Markova, M., Seebeck, N., Rosenthal, A., Klauschen, F., Castro, J. P., Buschow, R., Grune, T., Lange, V., Rudovich, N., Ouwens, D. M.: Hepatic Wnt1 Inducible Signaling Pathway Protein 1 (WISP-1/CCN4) Associates with Markers of Liver Fibrosis in Severe Obesity. Cells 10(5):1048 (2021). [Open Access]

Wardelmann, K., Rath, M., Castro, J. P., Blümel, S., Schell, M., Hauffe, R., Schumacher, F., Flore, T., Ritter, K., Wernitz, A., Hosoi, T., Ozawa, K., Kleuser, B., Weiß, J., Schürmann, A., Kleinridders, A.: Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus. Antioxidants 10(5):711 (2021). [Open Access]

Fernando, R., Castro, J. P., Flore, T., Deubel, S., Grune, T., Ott, C.: Age-Related Maintenance of the Autophagy-Lysosomal System Is Dependent on Skeletal Muscle Type. Oxi. Med. Cell. Longev. 2020: 4908162 (2020). [Open Access]

Fernando, R., Wardelmann, K., Deubel, S., Kehm, R., Jung, T., Mariotti, M., Vasilaki, A., Gladyshev, V. N., Kleinridders, A., Grune, T., Castro, J. P.: Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration. Red. Bio. 32:101507 (2020). [Open Access]

Häseli, S., Deubel, S., Jung, T., Grune, T., Ott, C.: Cardiomyocyte Contractility and Autophagy in a Premature Senescence Model of Cardiac Aging. Oxi. Med. Cell. Longev. 2020:8141307 (2020). [Open Access]

Hauffe, R., Stein, V., Chudoba, C., Flore, T., Rath, M., Ritter, K., Schell, M., Wardelmann, K., Deubel, S., Kopp, J. F., Schwarz, M., Kappert, K., Blüher, M., Schwerdtle, T., Kipp, A. P., Kleinridders, A.: GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity. JCI Insight 5(11):e136283 (2020). [Open Access]

Kehm, R., Jähnert, M., Deubel, S., Flore, T., König, J., Jung, T., Stadion, M., Jonas, W., Schürmann, A., Grune, T., Höhn, A.: Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: role of Thioredoxin-interacting protein (TXNIP). Red. Bio. 37:101748 (2020). [Open Access]

Kessler, K., Gerl, M. J., Hornemann, S., Damm, M., Klose, C., Petzke, K. J., Kemper, M., Weber, D., Rudovich, N., Grune, T., Simons, K., Kramer, A., Pfeiffer, A. F. H. , Pivovarova-Ramich, O.: Shotgun lipidomics discovered diurnal regulation of lipid metabolism linked to insulin sensitivity in non-diabetic men. J. Clin. Endocrinol. Metab. 105(3), 1–14 (2020). [Open Access]

Kessler, K., Hornemann, S., Rudovich, N., Weber, D., Grune, T., Kramer, A., Pfeiffer, A. F. H., Pivovarova-Ramich, O.: Saliva Samples as A Tool to Study the Effect of Meal Timing on Metabolic And Inflammatory Biomarkers. Nutrients 12(2):340 (2020). [Open Access]

Koelman, L., Grune, T., Pfeiffer, A. F. H., Rudovich, N., di Giuseppe, R., Aleksandrova, K.: In pursuit of novel biomarkers reflecting intestinal inflammation: temporal variability and phenotypic characterisation of serum calprotectin and lactoferrin. J. Lab. Prec. Med. 5:11 (2020). [Open Access]

Korovila, I., Jung, T., Deubel, S., Grune, T., Ott, C.: Punicalagin Attenuates Palmitate-Induced Lipid Droplet Content by Simultaneously Improving Autophagy in Hepatocytes. Mol. Nutr. Food Res. 64(20):2000816 (2020). [Open Access]

Pivovarova-Ramich, O., Markova, M., Weber, D., Sucher, S., Hornemann, S., Rudovich, N., Raila, J., Sunaga-Franze, D., Sauer, S., Rohn, S., Pfeiffer, A. F. H., Grune, T.: Effects of diets high in animal or plant protein on oxidative stress in individuals with type 2 diabetes: A randomized clinical trial. Red. Bio. 29:101397 (2020). [Open Access]

Raupbach, J., Ott, C., Koenig, J., Grune, T.: Proteasomal degradation of glycated proteins depends on substrate unfolding: Preferred degradation of moderately modified myoglobin. Free Radic. Biol. Med. 152, 516-524 (2020). [Open Access]

Reeg, S., Castro, J. P., Hugo, M., Grune, T.: Accumulation of polyubiquitinated proteins: a consequence of early inactivation of the 26S proteasome. Free Radic. Biol. Med. 160, 293-302 (2020). [Open Access]

Weber, D., Kochlik, B., Demuth, I., Steinhagen-Thiessen, E., Grune, T., Norman, K.: Plasma carotenoids, tocopherols and retinol - Association with age in the Berlin Aging Study II. Red. Bio. 32:101461 (2020). [Open Access]

Weber, D., Kochlik, B., Stuetz, W., Dollé, M. E. T., Jansen, E. H. J. M., Grubeck-Loebenstein, B., Debacq-Chainiaux, F., Bernhardt, J., Gonos, E. S., Capri, M., Franceschi, C., Sikora, E., Moreno-Villanueva, M., Bürkle, A., Grune, T.: Medication Intake Is Associated with Lower Plasma Carotenoids and Higher Fat-Soluble Vitamins in the Cross-Sectional MARK-AGE Study in Older Individuals. J. Clin. Med. 9(7), 2072 (2020). [Open Access]

Weindl, I., Ost, M., Wiedmer, P., Schreiner, M., Neugart, S., Klopsch, R., Kühnhold, H., Kloas, W., Henkel, I. M., Schlüter, O., Bußler, S., Bellingrath-Kimura, S. D., Ma, H., Grune, T., Rolinski, S., Klaus, S.: Sustainable food protein supply reconciling human and ecosystem health: A Leibniz Position. Global Food Security 25:100367 (2020). [Open Access]

Xu, C., Markova, M., Seebeck, N., Loft, A., Hornemann, S., Gantert, T., Kabisch, S., Herz, K., Loske, J., Ost, M., Coleman, V., Klauschen, F., Rosenthal, A., Lange, V., Machann, J., Klaus, S., Grune, T., Herzig, S., Pivovarova-Ramich, O., Pfeiffer, A. F. H.: High-protein diet more effectively reduces hepatic fat than low-protein diet despite lower autophagy and FGF21 levels. Liver Inter. 40(12), 2982-2997 (2020). [Open Access]

Castaño-Martinez, T., Schumacher, F., Schumacher, S., Kochlik, B., Weber, D., Grune, T., Biemann, R., McCann, A., Abraham, K., Weikert, C., Kleuser, B., Schürmann, A., Laeger, T.: Methionine restriction prevents onset of type 2 diabetes in NZO mice. FASEB J. 33, 7092–7102 (2019). [Open Access]

Castro, J. P., Fernando, R., Reeg, S., Meinl, W., Almeida, H., Grune, T.: Non-enzymatic cleavage of Hsp90 by oxidative stress leads to actin aggregate formation: A novel gain-of-function mechanism. Redox Biol. 21:101108 (2019). [Open Access]

Fernando, R., Drescher, C., Deubel, S., Jung, T., Ost, M., Klaus, S., Grune, T., Castro, J. P.: Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage. Exp. Gerontol. 117, 45-52 (2019).

Grune, T., Ott, C., Häseli, S., Höhn, A., Jung, T.: The “MYOCYTER” – Convert cellular and cardiac contractions into numbers with ImageJ. Sci. Rep. 9: 15112 (2019). [Open Access]

Kehm, R., Rückriemen, J., Weber, D., Deubel, S., Grune, T., Höhn, A.: Endogenous advanced glycation end products in pancreatic islets after short-term carbohydrate intervention in obese, diabetes-prone mice. Nutr. Diabetes 9(1):9 (2019). [Open Access]

Kochlik, B., Stuetz, W., Pérès, K., Féart, C., Tegner, J., Rodriguez-Mañas, L., Grune, T., Weber, D.: Associations of plasma 3-methylhistidine with frailty status in French cohorts of the FRAILOMIC initiative. J. Clin. Med. 8(7):1010 (2019). [Open Access]

Kochlik, B., Stuetz, W., Pérès, K., Pilleron, S., Féart, C., García García, F. J., Bandinelli, S., Gomez-Cabrero, D., Rodriguez-Mañas, L., Grune, T., Weber, D.: Associations of fat-soluble micronutrients and redox biomarkers with frailty status in the FRAILOMIC initiative. J. Cachexia Sarcopenia Muscle 10(6), 1339-1346 (2019). [Open Access]

Koelman, L., Pivovarova-Ramich, O., Pfeiffer, A. F. H., Grune, T., Aleksandrova, K.: Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation. Immun. Ageing 16:11 (2019). [Open Access]

Nitezki, T., Kleuser, B., Krämer, S.: Fatal gastric distension in a gold thioglucose mouse model of obesity. Lab. Anim. 53, 89-94 (2019).

Pinchuk, I., Weber, D., Kochlik, B., Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Dollé, M. E. T., Jansen, E. H. J. M., Gonos, E. S., Sikora, E., Breusing, N., Gradinaru, D., Sindlinger, T., Moreno-Villanueva, M., Bürkle, A., Grune, T., Lichtenberg, D.: Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study. Redox Biol. 24:101204 (2019). [Open Access]

Press, M., Jung, T., König, J., Grune, T., Höhn, A.: Protein aggregates and proteostasis in aging: Amylin and β-cell function. Mech. Ageing Dev. 177, 46-54 (2019). [Open Access]

Schröter, D., Neugart, S., Schreiner, M., Grune, T., Rohn, S., Ott, C.: Amaranth’s 2-Caffeoylisocitric Acid—An Anti-Inflammatory Caffeic Acid Derivative That Impairs NF-κB Signaling in LPS-Challenged RAW 264.7 Macrophages. Nutrients 11(3): 571 (2019). [Open Access]

Coleman, V., Sa-Nguanmoo, P., Koenig, J., Schulz, T. J., Grune, T., Klaus, S., Kipp, A. P., Ost, M.: Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling. Sci. Rep. 8:2446 (2018). [Open Access]

Georgiou, C. D., Zisimopoulos, D., Argyropoulou, V., Kalaitzopoulou, E., Ioannou, P. V., Salachas, G., Grune, T.: Protein carbonyl determination by a rhodamine B hydrazide-based fluorometric assay. Redox Biol. 17, 236-245 (2018). [Open Access]

Georgiou, C. D., Zisimopoulos, D., Argyropoulou, V., Kalaitzopoulou, E., Salachas, G., Grune T.: Protein and cell wall polysaccharide carbonyl determination by a neutral pH 2,4-dinitrophenylhydrazine-based photometric assay. Redox Biol. 17, 128-142 (2018). [Open Access]

Grune, T., Kehm, R., Höhn, A., Jung, T.: "Cyt/Nuc", a customizable and documenting ImageJ macro for evaluation of protein distributions between cytosol and nucleus. Biotechnol. J. 13:1700652 (2018). [Open Access]

Hugo, M., Korovila, I., Köhler, M., García-García, C., Cabrera-García, D., Marina, A., Martínez-Ruiz, A., Grune, T.: Early cysteine-dependent inactivation of 26S proteasomes does not involve particle disassembly. Redox Biol. 16, 123-128 (2018). [Open Access]

John, C., Grune, J., Ott, C., Nowotny, K., Deubel, S., Kühne, A., Schubert, C., Kintscher, U., Regitz-Zagrosek, V., Grune, T.: Sex differences in cardiac mitochondria in the New Zealand Obese Mouse. Front. Endocrinol.-Diabet. 9: 732 (2018). [Open Access]

Karademir, B., Sari, G., Jannuzzi, A. T., Musunuri, S., Wicher, G., Grune, T., Mi, J., Hacioglu-Bay, H., Forsberg-Nilsson, K., Bergquist, J., Jung, T.: Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib. Sci. Rep. 8(1): 16318 (2018). [Open Access]

Kehm, R., König, J., Nowotny, K., Jung, T., Deubel, S., Gohlke, S., Schulz, T. J., Höhn, A.: Age-related oxidative changes in pancreatic islets are predominantly located in the vascular system. Redox Biol. 15, 387-393 (2018). [Open Access]

Kessler, K., Hornemann, S., Petzke, K. J., Kemper, M., Markova, M., Rudovich, N., Grune, T., Kramer, A., Pfeiffer, A. F. H., Pivovarova-Ramich, O.: Diurnal distribution of carbohydrates and fat affects substrate oxidation and adipokine secretion in humans. Am. J. Clin. Nutr. 108, 1209-1219 (2018).

Kochlik, B., Gerbracht, C., Grune, T., Weber, D.: The influence of dietary habits and meat consumption on plasma 3-methylhistidine - A potential marker for muscle protein turnover. Mol. Nutr. Food Res. 62(9): 1701062 (2018). [Open Access]

Nowotny, K., Castro, J. P., Hugo, M., Braune, S., Weber, D., Pignitter, M., Somoza, V., Bornhorst, J., Schwerdtle, T., Grune, T.: Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts. Free Radic. Biol. Med. 120, 102-113 (2018). [Open Access]

Ott, C., Jung, T., Grune, T., Höhn, A.: SIPS as a model to study age-related changes in proteolysis and aggregate formation. Mech. Ageing Dev. 170, 72-81 (2018). [Open Access]

Hugo, M., Martínez, A., Trujillo, M., Estrada, D., Mastrogiovanni, M., Linares, E., Augusto, O., Issoglio, F., Zeida, A., Estrín, D. A., Heijnen, H. F. G., Piacenza, L., Radi, R.: Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP). Proc. Natl. Acad. Sci. 114, E1326-E1335 (2017). [Open Access]

König, J., Ott, C., Hugo, M., Jung, T., Bulteau, A.-L., Grune, T., Höhn, A.: Mitochondrial contribution to lipofuscin formation. Redox Biol. 11, 673-681 (2017). [Open Access]

Speckmann, B., Schulz, S., Hiller, F., Hesse, D., Schumacher, F., Kleuser, B., Geisel, J., Obeid, R., Grune, T., Kipp, A. P.: Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice. J. Nutr. Biochem. 48, 112-119 (2017). [Open Access]

Weber, D. Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Dollé, M. E. T., Jansen, E., Gonos, E. S., Franceschi, C., Sikora, E., Hervonen, A., Breusing, N., Sindlinger, T., Moreno-Villanueva, M., Bürkle, A., Grune, T.: Associations between specific redox biomarkers and age in a large European cohort: The MARK-AGE Project. Oxid. Med. Cell. Longev. 2017: 1401452 (2017). [Open Access]

König, J., Besoke, F., Stuetz, W., Malarski, A., Jahreis, G., Grune, T., Höhn, A.: Quantification of age-related changes of α-tocopherol in lysosomal membranes in murine tissues and human fibroblasts. BioFactors 42, 307-315 (2016). [Open Access]

Ott, C., König, J., Höhn, A., Jung, T., Grune, T.: Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts. Redox Biol. 10, 266-273 (2016). [Open Access]

Ott, C., König, J., Höhn, A., Jung, T., Grune, T.: Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts. Free Radic. Biol. Med. 101, 325-333 (2016). [Open Access]

Reeg, S., Jung, T., Castro, J. P., Davies, K. J., Henze, A., Grune, T.: The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome. Free Radic. Biol. Med. 99, 153-166 (2016). [Open Access]

Stuetz, W., Weber, D., Dollé, M. E. T., Jansen, E., Grubeck-Loebenstein, B., Fiegl, S., Toussaint, O., Bernhardt, J., Gonos, E. S., Franceschi, C., Sikora, E., Moreno-Villanueva, M., Breusing, N., Grune, T., Bürkle, A.: Plasma carotenoids, tocopherols, and retinol in the age-stratified (35–74 Years) general population: A cross-sectional study in six European countries. Nutrients 8:614 (Open Access) (2016). [Open Access]

Weitkunat, K., Schumann, S., Nickel, D., Kappo, K. A., Petzke, K. J., Kipp, A. P., Blaut, M., Klaus, S.: Importance of propionate for the repression of hepatic lipogenesis and improvement of insulin sensitivity in high-fat diet-induced obesity. Mol. Nutr. Food Res. 60, 2611-2621 (Open Access) (2016). [Open Access]

Hiller, F., Besselt, K., Deubel, S., Brigelius-Flohé, R., Kipp, A. P.: GPx2 induction is mediated through STAT transcription factors during acute colitis. Inflamm. Bowel Dis. 21, 2078-2089 (2015).

Hiller, F., Oldorff, L., Besselt, K., Kipp, A. P.: Differential acute effects of selenomethionine and sodium selenite on the severity of colitis. Nutrients 7, 2687-2706 (Open Access) (2015). [Open Access]

Höhn, A., Hartmann, P., Gebhart, V., Sonntag, J., Grune, T., Jung, T.: Actual Isothermal Effects of Water-Filtered Infrared A-Irradiation. Photochem. Photobiol. 91, 887-894 (2015).

Dietrich, S., Elorinne, A.-L., Bergau, N., Abraham, K., Grune, T., Laakso, J., Weber, D., Weikert, C., Monien, B. H.: Comparison of Five Oxidative Stress Biomarkers in Vegans and Omnivores from Germany and Finland. Nutrients 14(14):2918 (2022). [Open Access]

Draganidis, D., Jamurtas, A. Z., Chondrogianni, N., Mastorakos, G., Jung, T., Grune, T., Papadopoulos, C., Papanikolaou, K., Papassotiriou, I., Papaevgeniou, N., Poulios, A., Batrakoulis, A., Deli, C. K., Georgakouli, K., Chatzinikolaou, A., Karagounis, L. G., Fatouros, I. G.: Low-Grade Systemic Inflammation Interferes with Anabolic and Catabolic Characteristics of the Aged Human Skeletal Muscle. Oxidative Med. Cell. Longev. 2021:8376915 (2022). [Open Access]

Grune, J., Lewis, A. J. M., Yamazoe, M., Hulsmans, M., Rohde, D., Xiao, L., Zhang, S., Ott, C., Calcagno, D. M., Zhou, Y., Timm, K., Shanmuganathan, M., Pulous, F. E., Schloss, M. J., Foy, B. H., Capen, D., Vinegoni, C., Wojtkiewicz, G. R., Iwamoto, Y., Grune, T., Brown, D., Higgins, J., Ferreira, V. M., Herring, N., Channon, K. M., Neubauer, S., Sosnovik, D. E., Milan, D. J., Swirski, F. K., King, K. R., Aguirre, A. D., Ellinor, P. T., Nahrendorf, M.: Neutrophils incite and macrophages avert electrical storm after myocardial infarction. Nat. Cardiovasc. Res. 1(7), 649-664 (2022). [Open Access]

Hengstler, J. G., Baum, M., Cartus, A. T., Diel, P., Eisenbrand, G., Engel, K. H., Engeli, B., Epe, B., Grune, T., Guth, S., Haller, D., Heinz, V., Hellwig, M., Henle, T., Humpf, H. U., Jager, H., Joost, H. G., Kulling, S. E., Lachenmeier, D. W., Lampen, A., Leist, M., Mally, A., Marko, D., Nothlings, U., Rohrdanz, E., Roth, A., Spranger, J., Stadler, R., Steinberg, P., Vieths, S., Watjen, W.: Opinion on acetaldehyde as a flavouring substance: considerations for risk assessment. J. Consum. Prot. Food Saf. 17, 285-293 (2022). [Open Access]

Hoffmann, H., Ott, C., Raupbach, J., Andernach, L., Renz, M., Grune, T., Hanschen, F. S.: Assessing Bioavailability and Bioactivity of 4-Hydroxythiazolidine-2-Thiones, Newly Discovered Glucosinolate Degradation Products Formed During Domestic Boiling of Cabbage. Front. Nutr. 9:941286 (2022). [Open Access]

Morsiani, C., Bacalini, M. G., Collura, S., Moreno-Villanueva, M., Breusing, N., Bürkle, A., Grune, T., Franceschi, C., De Eguileor, M., Capri, M.: Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down Syndrome. Mech. Ageing Dev. 206:111691 (2022).

Schweizer, U., Wirth, E. K., Klopstock, T., Hölter, S. M., Becker, L., Moskovitz, J., Grune, T., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., Köhrle, J., Schomburg, L.: Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice. Redox Biol. 57:102490 (2022). [Open Access]

Zhang, X., Hasan, A. A., Wu, H., Gaballa, M. M. S., Zeng, S., Liu, L., Xie, L., Jung, T., Grune, T., Krämer, B. K., Kleuser, B., Li, J., Hocher, B.: High-fat, sucrose and salt-rich diet during rat spermatogenesis lead to the development of chronic kidney disease in the female offspring of the F2 generation. Faseb J. 36(4):e22259 (2022).

Zheng, Z., Xu, Y., Krügel, U., Schaefer, M., Grune, T., Nürnberg, B., Köhler, M. B., Gollasch, M., Tsvetkov, D., Markó, L.: In Vivo Inhibition of TRPC6 by SH045 Attenuates Renal Fibrosis in a New Zealand Obese (NZO) Mouse Model of Metabolic Syndrome. Int. J. Mol. Sci. 23(12):6870 (2022). [Open Access]

Aktypi, F., Papaevgeniou, N., Voutetakis, K., Chatziioannou, A., Grune, T., Chondrogianni, N.: Network analysis in aged C. elegans reveals candidate regulatory genes of ageing. Biogerontology 22, 345–367 (2021).

Bacalini, M. G., Reale, A., Malavolta, M., Ciccarone, F., Moreno-Villanueva, M., Dollé, M. E. T., Jansen, E., Grune, T., Gonos, E. S., Schön, C., Bernhardt, J., Grubeck-Loebenstein, B., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Capri, M., Hervonen, A., Hurme, M., Slagboom, P. E., Breusing, N., Aversano, V., Tagliatesta, S., Franceschi, C., Blasco, M. A., Bürkle, A., Caiafa, P., Zampieri, M.: Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study. GeroScience 43, 1283–1302 (2021). [Open Access]

Bartolomaeus, T. U. P., Birkner, T., Bartolomaeus, H., Lober, U., Avery, E. G., Mahler, A., Weber, D., Kochlik, B., Balogh, A., Wilck, N., Boschmann, M., Muller, D. N., Marko, L., Forslund, S. K.: Quantifying Technical Confounders in Microbiome Studies. Cardiovasc. Res. 117(3), 863–875 (2021). [Open Access]

Baumann, A., Hernández-Arriaga, A., Brandt, A., Sánchez, V., Nier, A., Jung, F., Kehm, R., Höhn, A., Grune, T., Frahm, C., Witte, O. W., Camarinha-Silva, A., Bergheim, I.: Microbiota profiling in aging-associated inflammation and liver degeneration. Int. J. Med. Microbiol. 311(4):151500 (2021). [Open Access]

Berndt, N., Eckstein, J., Wallach, I., Nordmeyer, S., Kelm, M., Kirchner, M., Goubergrits, L., Schafstedde, M., Hennemuth, A., Kraus, M., Grune, T., Mertins, P., Kuehne, T., Holzhütter, H. G.: CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases. Circulation 144(24), 1926–1939 (2021). [Open Access]

D’Aquila, P., Giacconi, R., Malavolta, M., Piacenza, F., Bürkle, A., Villanueva, M. M., Dollé, M. E. T., Jansen, E., Grune, T., Gonos, E. S., Franceschi, C., Capri, M., Grubeck-Loebenstein, B., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Hervonen, A., Hurme, M., Slagboom, P. E., Schön, C., Bernhardt, J., Breusing, N., Passarino, G., Provinciali, M., Bellizzi, D.: Microbiome in Blood Samples From the General Population Recruited in the MARK-AGE Project: A Pilot Study. Front. Microbiol. 12:707515 (2021). [Open Access]

Gomez-Cabrero, D., Walter, S., Abugessaisa, I., Miñambres-Herraiz, R., Palomares, L. B., Butcher, L., Erusalimsky, J. D., Garcia-Garcia, F. J., Carnicero, J., Hardman, T. C., Mischak, H., Zürbig, P., Hackl, M., Grillari, J., Fiorillo, E., Cucca, F., Cesari, M., Carrie, I., Colpo, M., Bandinelli, S., Feart, C., Peres, K., Dartigues, J.-F., Helmer, C., Viña, J., Olaso, G., García-Palmero, I., Martínez, J. G., Jansen-Dürr, P., Grune, T., Weber, D., Lippi, G., Bonaguri, C., Sinclair, A. J., Tegner, J., Rodriguez-Mañas, L., on behalf of the Frailomic initiative: A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts. GeroScience 43, 1317–1329 (2021).

Kananen, L., Enroth, L., Raitanen, J., Jylhävä, J., Bürkle, A., Moreno-Villanueva, M., Bernhardt, J., Toussaint, O., Grubeck-Loebenstein, B., Malavolta, M., Basso, A., Piacenza, F., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Jansen, E. H. J. M., Dollé, M. E. T., Salmon, M., Stuetz, W., Weber, D., Grune, T., Breusing, N., Simm, A., Capri, M., Franceschi, C., Slagboom, P. E., Talbot, D. C. S., Libert, C., Koskinen, S., Bruunsgaard, H., Hansen, Å., Lund, R., Hurme, M., Jylhä, M.: Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains. Sci. Rep. 11:6139 (2021). [Open Access]

Marbach-Breitrück, E., Rohwer, N., Infante-Duarte, C., Romero-Suarez, S., Labuz, D., Machelska, H., Kutzner, L., Schebb, N. H., Rothe, M., Reddanna, P., Weylandt, K. H., Wieler, L. H., Heydeck, D., Kuhn, H.: Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5(-/-) Mice. Metabolites 11(10):698 (2021). [Open Access]

Piacenza, F., Giacconi, R., Costarelli, L., Basso, A., Bürkle, A., Moreno-Villanueva, M., Dollé, M. E. T., Jansen, E., Grune, T., Weber, D., Stuetz, W., Gonos, E. S., Schön, C., Bernhardt, J., Grubeck-Loebenstein, B., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Franceschi, C., Capri, M., Hervonen, A., Hurme, M., Slagboom, E., Breusing, N., Mocchegiani, E., Malavolta, M.: Age, sex and BMI influence on copper, zinc and their major serum carrier proteins in a large European population including Nonagenarian Offspring from MARK-AGE study. J. Gerontol. A Biol. Sci. Med. Sci. 76(12), 2097–2106 (2021). [Open Access]

Pinchuk, I., Kohen, R., Stuetz, W., Weber, D., Franceschi, C., Capri, M., Hurme, M., Grubeck-Loebenstein, B., Schön, C., Bernhardt, J., Debacq-Chainiaux, F., Dollé, M. E. T., Jansen, E. H. J. M., Gonos, E. S., Sikora, E., Breusing, N., Gradinaru, D., Moreno-Villanueva, M., Bürkle, A., Grune, T., Lichtenberg, D.: Do low molecular weight antioxidants contribute to the Protection against oxidative damage? The interrelation between oxidative stress and low molecular weight antioxidants based on data from the MARK-AGE study. Arch. Biochem. Biophys. 713:109061 (2021).

Rohwer, N., Chiu, C. Y., Huang, D., Smyl, C., Rothe, M., Rund, K. M., Helge Schebb, N., Kühn, H., Weylandt, K. H.: Omega-3 fatty acids protect from colitis via an Alox15-derived eicosanoid. Faseb J. 35(4):e21491 (2021). [Open Access]

Sunjic, S. B., Gasparovic, A. C., Jaganjac, M., Rechberger, G., Meinitzer, A., Grune, T., Kohlwein, S. D., Mihaljevic, B., Zarkovic, N.: Sensitivity of Osteosarcoma Cells to Concentration-Dependent Bioactivities of Lipid Peroxidation Product 4-Hydroxynonenal Depend on Their Level of Differentiation. Cells 10(2):269 (2021). [Open Access]

Wächter, K., Navarrete Santos, A., Großkopf, A., Baldensperger, T., Glomb, M. A., Szabó, G., Simm, A.: AGE-Rich Bread Crust Extract Boosts Oxidative Stress Interception via Stimulation of the NRF2 Pathway. Nutrients 13(11):3874 (2021). [Open Access]

Fournier, Q., Höhn, A., Deubel, S., Milne, E., Bavcar, S., Morrison, L.: Characterization of Black Pigmenturia in a Cat with Apocrine Gland Cystadenocarcinoma. J. Comp. Pathol. 176, 145-150 (2020).

Giacconi, R., Maggi, F., Macera, L., Spezia, P. G., Pistello, M., Provinciali, M., Piacenza, F., Basso, A., Bürkle, A., Moreno-Villanueva, M., Dollé, M. E. T., Jansen, E., Grune, T., Stuetz, W., Gonos, E. S., Schön, C., Bernhardt, J., Grubeck-Loebenstein, B., Sikora, E., Dudkowska, M., Janiszewska, D., Toussaint, O., Debacq-Chainiaux, F., Franceschi, C., Capri, M., Hervonen, A., Hurme, M., Slagboom, E., Breusing, N., Mocchegiani, E., Malavolta, M.: Prevalence and Loads of Torquetenovirus in the European MARK-AGE Study Population. J. Gerontol. A Biol. Sci. Med. Sci. 75(10), 1838-1845 (2020).

Grassmann, S., Pivovarova-Ramich, O., Henze, A., Raila, J., Ampem Amoako, Y., King Nyamekye, R., Bedu-Addo, G., Mockenhaupt, F. P., Schulze, M. B., Danquah, I.: SNP rs6564851 in the BCO1 Gene Is Associated with Varying Provitamin a Plasma Concentrations but Not with Retinol Concentrations among Adolescents from Rural Ghana. Nutrients 12(6):1786 (2020). [Open Access]

Jin, C. J., Baumann, A., Brandt, A., Engstler, A. J., Nier, A., Hege, M., Schmeer, C., Kehm, R., Höhn, A., Grune, T., Witte, O. W., Bergheim, I.: Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels. Am. J. Physiol. Gastrointest. Liver Physiol. 318(4), G736-G747 (2020).

Lee, S. M. C., Ribeiro, L. C., Martin, D. S., Zwart, S. R., Feiveson, A. H., Laurie, S. S., Macias, B. R., Crucian, B. E., Krieger, S., Weber, D., Grune, T., Platts, S. H., Smith, S. M., Stenger, M. B.: Arterial Structure and Function during and after Long-Duration Spaceflight. J. Appl. Physiol. (1985) 129(1), 108-123 (2020).

Lossow, K., Kopp, J. F., Schwarz, M., Finke, H., Winkelbeiner, N., Renko, K., Meçi, X., Ott, C., Alker, W., Hackler, J., Grune, T., Schomburg, L., Haase, H., Schwerdtle, T., Kipp, A. P.: Aging affects sex- and organ-specific trace element profiles in mice. Aging-US 12(13), 13762—13790 (2020). [Open Access]

Peng, P., Goris, T., Lu, Y., Nijsse, B., Burrichter, A., Schleheck, D., Koehorst, J. J., Liu, J., Sipkema, D., Sinninghe Damste, J. S., Stams, A. J. M., Haggblom, M. M., Smidt, H., Atashgahi, S.: Organohalide-respiring Desulfoluna species isolated from marine environments. ISME J. 14(3), 815–827 (2020). [Open Access]

Rohwer, N., Kuhl, A. A., Ostermann, A. I., Hartung, N. M., Schebb, N. H., Zopf, D., McDonald, F. M., Weylandt, K. H.: Effects of chronic low-dose aspirin treatment on tumor prevention in three mouse models of intestinal tumorigenesis. Cancer Med. 9(7), 2535-2550 (2020). [Open Access]

Sharma, A., Weber, D., Raupbach, J., Dakal, T. C., Fließbach, K., Ramirez, A., Grune, T., Wüllner, U.: Advanced glycation end products and protein carbonyl levels in plasma reveal sex-specific differences in Parkinson’s and Alzheimer’s disease. Red. Bio. 34:101546 (2020). [Open Access]

Wernicke, C., Apostolopoulou, K., Hornemann, S., Efthymiou, A., Machann, J., Schmidt, S., Primessnig, U., Bergmann, M. M., Grune, T., Gerbracht, C., Herber, K., Pohrt, A., Pfeiffer, A. F. H., Spranger, J., Mai, K.: Long-term effects of a food pattern on cardiovascular risk factors and age-related changes of muscular and cognitive function. Medicine (Baltimore) 99(39):e22381 (2020). [Open Access]

Zenker, H. E., Raupbach, J., Boeren, S., Wichers, H. J., Hettinga, K. A.: The effect of low vs. high temperature dry heating on solubility and digestibility of cow’s milk protein. Food Hydroc. 109:106098 (2020). [Open Access]

Brandt, A., Hernández-Arriaga, A., Kehm, R., Sánchez, V., Jin, C. J., Nier, A., Baumann, A., Camarinha-Silva, A., Bergheim, I.: Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine. Sci. Rep. 9(1):6668 (2019). [Open Access]

De Francesco, D., Wit, F. W., Bürkle, A., Oehlke, S., Kootstra, N. A., Winston, A., Franceschi, C., Garagnani, P., Pirazzini, C., Libert, C., Grune, T., Weber, D., Jansen, E. H. J. M., Sabin, C. A., Reiss, P.; The Co-morBidity in Relation to AIDS (COBRA) Collaboration: Do people living with HIV experience greater age advancement than their HIV-negative counterparts?. AIDS 33, 259-268 (2019).

Erdem, M., Moeckel, D., Jumpertz, S., John, C., Fragoulis, A., Rudolph, I., Wulfmeier, J., Springer, J., Horn, H., Koch, M., Lurje, G., Lammers, T., Damink, S. O., van der Kroft, G., Gremse, F., Cramer, T.: Macrophages protect against loss of adipose tissue during cancer cachexia. Journal of Cachexia Sarcopenia and Muscle 10(5), 1128-1142 (2019). [Open Access]

Giacconi, R., Malavolta, M., Burkle, A., Moreno-Villanueva, M., Franceschi, C., Capri, M., Slagboom, P. E., Jansen, E., Dolle, M. E. T., Grune, T., Weber, D., Hervonen, A., Stuetz, W., Breusing, N., Ciccarone, F., Zampieri, M., Aversano, V., Caiafa, P., Formentini, L., Piacenza, F., Pierpaoli, E., Basso, A., Provinciali, M., Cardelli, M.: Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians. Nutrients 11(12): 2986 (2019). [Open Access]

Grune, J., Ritter, D., Kräker, K., Pappritz, K., Beyhoff, N., Schütte, T., Ott, C., John, C., van Linthout, S., Tschöpe, C., Dechend, R., Muller, D. N., Haase, N., Grune, T., Kintscher, U., Kuebler, W. M.: Accurate assessment of LV function using the first automated 2D-border detection algorithm for small animals - evaluation and application to models of LV dysfunction. Cardiovasc. Ultrasound. 17(1):7 (2019). [Open Access]

Henkel, J., Buchheim-Dieckow, K., Castro, J. P., Laeger, T., Wardelmann, K., Kleinridders, A., Johrens, K., Puschel, G. P.: Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH. Nutrients 11(11): 15 (2019). [Open Access]

Kong, W., Haschler, T. N., Nürnberg, B., Krämer, S., Gollasch, M., Markó, L.: Renal fibrosis, immune cell infiltration and changes of TRPC channel expression after unilateral ureteral obstruction in Trpc6-/- mice. Cell. Physiol. Biochem. 52, 1484-1502 (2019). [Open Access]

Leclaire, M. D., Nettels-Hackert, G., König, J., Höhn, A., Grune, T., Uhlig, C. E., Hansen, U., Eter, N., Heiduschka, P.: Lipofuscin-dependent stimulation of microglial cells. Graefes Arch. Clin. Exp. Ophthalmol. 257, 931-952 (2019).

Papaevgeniou, N., Hoehn, A., Tur, J. A., Klotz, L. O., Grune, T., Chondrogianni, N.: Sugar-derived AGEs accelerate pharyngeal pumping rate and increase the lifespan of Caenorhabditis elegans. Free Radic. Res. 53(S1), 1056-1067 (2019). [Open Access]

Pilleron, S., Weber, D., Pérès, K., Colpo, M., Gomez-Cabrero, D., Stuetz, W., Dartigues, J.-F., Ferrucci, L., Bandinelli, S., Garcia-Garcia, F. J., Grune, T., Féart, C., On behalf of the FRAILOMIC initiative: Patterns of circulating fat-soluble vitamins and carotenoids and risk of frailty in four European cohorts of older adults. Eur. J. Nutr. 58, 379–389 (2019).

Rietman, M. L., Spijkerman, A. M.W., Wong, A., van Steeg, H., Bürkle, A., Moreno-Villanueva, M., Sindlinger, T., Franceschi, C., Grubeck-Loebenstein, B., Bernhardt, J., Slagboom, P. E., Toussaint, O., Debacq-Chainiaux, F., Sikora, E., Gonos, E. S., Breusing, N., Stuetz, W., Weber, D., Grune, T., Basso, A., Piacenza, F., Malavolta, M., Collino, S., Jansen, E. H. J. M., Verschuren, W. M. M., Dollé, M. E. T.: Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study. Mech. Ageing Dev. 177, 135-143 (2019).

Ajana, S., Weber, D., Helmer, C., Merle, B. M., Stuetz, W., Dartigues, J. F., Rougier, M. B., Korobelnik, J. F., Grune, T., Delcourt, C., Féart, C.: Plasma concentrations of lutein and zeaxanthin, macular pigment optical density, and their associations with cognitive performances among older adults. Invest. Ophthalmol. Vis. Sci. 59, 1828-1835 (2018). [Open Access]

Ciccarone, F., Valentini, E., Malavolta, M., Zampieri, M., Bacalini, M. G., Calabrese, R., Guastafierro, T., Reale, A., Franceschi, C., Capri, M., Breusing, N., Grune, T., Moreno-Villanueva, M., Bürkle, A., Caiafa, P.: DNA hydroxymethylation levels are altered in blood cells from Down syndrome persons enrolled in the MARK-AGE project. J. Gerontol. A / Biol. Sci. Med. Sci. 73, 737-744 (2018). [Open Access]

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Bürkle, A., Moreno-Villanueva, M., Grune, T., Weber, D., Stuetz, W., Gonos, E. S., Schön, C., Grubeck-Loebenstein, B., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Franceschi, C., Hervonen, A., Slagboom, E., Ciccarone, F., Zampieri, M., Caiafa, P., Jansen, E., Dollé, M. E. T., Breusing, N., Mocchegiani, E., Malavolta, M.: Zinc-induced Metallothionein in centenarian offspring from a large European population: the MARK-AGE Project. J. Gerontol. A / Biol. Sci. Med. Sci. 73, 745-753 (2018).

Grune, J., Blumrich, A., Brix, S., Jeuthe, S., Drescher, C., Grune, T., Foryst-Ludwig, A., Messroghli, D., Kuebler, W. M., Ott, C., Kintscher, U.: Evaluation of a commercial multi-dimensional echocardiography technique for ventricular volumetry in small animals. Cardiovasc. Ultrasound 16(1):10 (2018). [Open Access]

Henkel, J., Alfine, E., Saín, J., Jöhrens, K., Weber, D., Castro, J. P., König, J., Stuhlmann, C., Vahrenbrink, M., Jonas, W., Kleinridders, A., Püschel, G. P.: Soybean oil-derived poly-unsaturated fatty acids enhance liver damage in NAFLD induced by dietary cholesterol. Nutrients 10(9): 1326 (2018). [Open Access]

Hüser, S., Guth, S., Joost, H. G., Soukup, S. T., Köhrle, J., Kreienbrock, L., Diel, P., Lachenmeier, D. W., Eisenbrand, G., Vollmer, G., Nöthlings, U., Marko, D., Mally, A., Grune, T., Lehmann, L., Steinberg, P., Kulling, S. E.: Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation. Arch. Toxicol. 92, 2703-2748 (2018). [Open Access]

Weinberger, B., Keller, M., Putzer, C., Breitenberger, D., Koller, B., Fiegl, S., Moreno-Villanueva, M., Bernhardt, J., Franceschi, C., Voutetakis, K., Gonos, E. S., Hurme, M., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Grune, T., Breusing, N., Bürkle, A., Grubeck-Loebenstein, B.: Protection against Tetanus and Diphtheria in Europe: The impact of age, gender and country of origin based on data from the MARK-AGE Study. Exp. Gerontol. 105, 109-112 (2018).

Egea, J., Fabregat, I., Frapart, Y. M., .... Grune, T., Lamas, S., Schmidt, H. H. H. W., Di Lisa, F., Daiber, A.: European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol. 13, 94-162, (Corrigendum: Redox Biol. 14, 694-696 (2018) (2017). [Open Access]

Griesser, E., Vemula, V., Raulien, N., Wagner, U., Reeg, S., Grune, T., Fedorova, M.: Cross-talk between lipid and protein carbonylation in a dynamic cardiomyocyte model of mild nitroxidative stress. Redox Biol. 11, 438-455 (2017). [Open Access]

Henkel, J., Coleman, C. D., Schraplau, A., Jӧhrens, K., Weber, D., Castro, J. P., Hugo, M., Schulz, T. J., Krämer, S., Schürmann, A., Püschel, G. P.: Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol. Mol. Med. 23, 70-82 (Open Access) (2017). [Open Access]

Kipp, A. P., Deubel, S., Arnér, E., Johansson, K.: Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells. Redox Biol. 12, 403-409 (2017). [Open Access]

Lennicke, C., Rahn, J., Kipp, A. P., Dojčinović, B. P., Müller, A. S., Wessjohann, L. A., Lichtenfels, R., Seliger, B.: Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice. Biochim. Biophys. Acta./General. Subj. 1861, Part A, 3323–3334 (2017).

Markó, L., Mannaa, M., Haschler, T. N., Krämer, S., Gollasch, M.: Renoprotection: focus on TRPV1, TRPV4, TRPC6 and TRPM2. Acta Physiol.(Oxf.) 219, 589-612 (2017). [Open Access]

Pawlowsky, K., Ernst, L. Steitz, J. Stopinski, T. Kögel, B. Henger, A. Kluge, R., Tolba, R.: The Aachen Minipig: Phenotype, genotype, hematological and biochemical characterization, and comparison to the Göttingen Minipig. Eur. Surg. Res. 58, 193-203 (2017).

Zintzsch, A., Noe, E., Reißmann, M., Ullmann, K., Krämer, S., Jerchow, B., Kluge, R., Gösele, C., Nickles, H., Puppe, A., Rülicke, T. Author information: Guidelines on severity assessment and classification of genetically altered mouse and rat lines. Lab. Anim. 51, 573-582 (2017). [Open Access]

Ciccarone, F., Malavolta, M., Calabrese, R., Guastafierro, T., Bacalini, M. G., Reale, A., Franceschi, C., Capri, M., Hervonen, A., Hurme, M., Grubeck-Loebenstein, B., Koller, B., Bernhardt, J., Schӧn, C., Slagboom, P. E., Toussaint, O., Sikora, E., Gonos, E. S., Breusing, N., Grune, T., Jansen, E., Dollé, M., Moreno-Villanueva, M., Sindlinger, T., Bürkle, A., Zampieri, M., Caiafa, P.: Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study. Aging Cell 15, 755-765 (2016). [Open Access]

Issoglio, F. M., Campolo, N., Zeida, A., Grune, T., Radi, R., Estrin, D. A., Bartesaghi, S.: Exploring the catalytic mechanism of human glutamine synthetase by computer simulations. Biochemistry 55, 5907-5916 (2016).

Loof, T., Krämer, S., Gaedeke, J., Neumayer, H.-H., Peters, H.: IL-17 Expression in the Time Course of Acute Anti-Thy1 Glomerulonephritis. PLoS ONE 11(5):e0156480 (2016). [Open Access]

Markó, L., Szijártó, I. A., Filipovic, M. R., Kaßmann, M., Balogh, A., Park, J.-K., Przybyl, L., N’diaye, G., Krämer, S., Anders, J., Ishii, I., Müller, D. N., Gollasch, M.: Role of cystathionine gamma-Lyase in immediate renal impairment and inflammatory response in acute ischemic kidney injury. Sci. Rep. 6:27517 (2016). [Open Access]

Rakers, C., Schumacher, F., Meinl, W., Glatt, H., Kleuser, B., Wolber, G.: In silico prediction of human sulfotransferase 1E1 activity guided by pharmacophores from molecular dynamics simulations. J. Biol. Chem. 291, 58-71 (2016). [Open Access]

Steinbrenner, H., Speckmann, B., Klotz, L. O.: Selenoproteins: Antioxidant selenoenzymes and beyond. Arch. Biochem. Biophys. 595, 113-119 (2016).

Stuetz, W., Carrara, V. I., Mc Gready, R., Lee, S. J., Sriprawat, K., Po, B., Hanboonkunupakarn, B., Grune, T., Biesalski, H. K., Nosten, F. H.: Impact of food rations and supplements on micronutrient status by trimester of pregnancy: cross-sectional studies in the Maela Refugee Camp in Thailand. Nutrients 8(2):66 (2016). [Open Access]

Valentini, E., Zampieri, M., Malavolta, M., Bacalini, M. G., Calabrese, R., Guastafierro, T., Reale, A., Franceschi, C., Hervonen, A., Koller, B., Bernhardt, J., Slagboom, P. E., Toussaint, O., Sikora, E., Gonos, E. S., Breusing, N., Grune, T., Jansen, E., Dollé, M. E., Moreno-Villanueva, M., Sindlinger, T., Bürkle, A., Ciccarone, F., Caiafa, P.: Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study. Aging (Albany NY) 8, 1896-1922 (2016). [Open Access]

Augustyniak, E., Adam, A., Wojdyla, K., Rogowska-Wrzesinska, A., Willetts, R., Korkmaz, A., Atalay, M., Weber, D., Grune, T., Borsa, C., Gradinaru, D., Chand Bollineni, R., Fedorova, M., Griffiths, H. R.: Validation of protein carbonyl measurement: a multi-centre study. Redox Biol. 4, 149-157 (2015). [Open Access]

Baierle, M., Nascimento, S. N., Moro, A. M., Brucker, N., Freitas, F., Gauer, B., Durgante, J., Bordignon, S., Zibetti, M., Trentini, C. M., Duarte, M. M. M. F., Grune, T., Breusing, N., Garcia, S. C.: Relationship between inflammation and oxidative stress and cognitive decline in the institutionalized elderly. Oxid. Med. Cell. Longev. 2015:804198 (2015). [Open Access]

Ehlers, A., Florian, S., Schumacher, F., Meinl, W., Lenze, D., Hummel, M., Heise, T., Seidel, A., Glatt, H., Lampen, A.: The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens. Mol. Nutr. Food Res. 59, 685-697 (2015).

Gerhardt, C., Lier, J. M., Burmühl, S., Struchtrup, A., Deutschmann, K., Vetter, M., Leu, T., Reeg, S., Grune, T., Rüther, U.: The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium. J. Cell Biol. 210, 115-133 (2015). [Open Access]

Høie, A. H., Svendsen, C., Brunborg, G., Glatt, H., Alexander, J., Meinl, W., Husøy, T.: Genotoxicity of three food processing contaminants in transgenic mice expressing human sulfotransferases 1A1 and 1A2 as assessed by the in vivo alkaline single cell gel electrophoresis assay. Environ. Mol. Mutagen. 56, 709-714 (2015). [Open Access]

Japtok, L., Schmitz, E. I., Fayyaz, S., Krämer, S., Hsu, L. J., Kleuser, B.: Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2. FASEB J. 29, 3357-3369 (2015). [Open Access]

Just, J., Jung, T., Friis, N. A., Lykkemark, S., Drasbek, K., Siboska, G., Grune, T., Kristensen, P.: Identification of an unstable 4-hydroxynoneal modification on the 20S proteasome subunit α7 by recombinant antibody technology. Free Radic. Biol. Med. 89, 786-792 (2015). [Open Access]

Stancu, B., Krämer, S., Loof, T., Mika, A., Amann, K., Neumayer, H. H., Peters, H.: Soluble guanylate cyclase stimulator BAY 41-8543 and female sex ameliorate uremic aortic remodeling in a rat model of mild uremia. J. Hypertens. 33, 1907-1921 (2015).

Guth, S., Baum, M., Cartus, A. T., Diel, P., Engel, K. H., Engeli, B., Epe, B., Grune, T., Haller, D., Heinz, V., Hellwig, M., Hengstler, J. G., Henle, T., Humpf, H. U., Jäger, H., Joost, H. G., Kulling, S. E., Lachenmeier, D. W., Lampen, A., Leist, M., Mally, A., Marko, D., Nöthlings, U., Röhrdanz, E., Roth, A., Spranger, J., Stadler, R., Steinberg, P., Vieths, S., Wätjen, W., Eisenbrand, G.: Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value). Food Chem. Toxicol. 173:113632 (2023). [Open Access]

Schebb, N. H., Kühn, H., Kahnt, A. S., Rund, K. M., O''Donnell, V. B., Flamand, N., Peters-Golden, M., Jakobsson, P. J., Weylandt, K. H., Rohwer, N., Murphy, R. C., Geisslinger, G., FitzGerald, G. A., Hanson, J., Dahlgren, C., Alnouri, M. W., Offermanns, S., Steinhilber, D.: Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far?. Front. Pharmacol. 13, 838782 (2022). [Open Access]

Zhao, Y., Jia, M., Chen, W., Liu, Z.: The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function. Free Radic. Biol. Med. 182, 206-218 (2022).

Baldensperger, T., Glomb, M. A.: Pathways of Non-enzymatic Lysine Acylation. Front. Cell. Dev. Biol. 9:664553 (2021). [Open Access]

Braude, S., Holtze, S., Begall, S., Brenmoehl, J., Burda, H., Dammann, P., Del Marmol, D., Gorshkova, E., Henning, Y., Hoeflich, A., Höhn, A., Jung, T., Hamo, D., Sahm, A., Shebzukhov, Y., Šumbera, R., Miwa, S., Vyssokikh, M. Y., von Zglinicki, T., Averina, O., Hildebrandt, T. B.: Surprisingly long survival of premature conclusions about naked mole-rat biology. Biol. Rev. Camb. Philos. Soc. 96(2), 376-393 (2021). [Open Access]

Kehm, R., Baldensperger, T., Raupbach, J., Höhn, A.: Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases. Redox. Biol. 42:101901 (2021). [Open Access]

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., […], Grune, T., […], Höhn, A., […], Ott, C., […], Rong, Y., Sluimer, J. C., Stallings, C. L., Tong, C. K.: Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17(1), 1-382 (2021). [Open Access]

Ojha, S., Bekhit, A., Grune, T., Schlüter, O.: Bioavailability of nutrients from edible insects. Curr. Opin. Food Sci. 41, 240-248 (2021). [Open Access]

Stromsnes, K., Correas, A. G., Lehmann, J., Gambini, J., Olaso-Gonzalez, G.: Anti-Inflammatory Properties of Diet: Role in Healthy Aging. Biomedicines 9(8):922 (2021). [Open Access]

Wiedmer, P., Jung, T., Castro, J. P., Pomatto, L. C. D., Sun, P. Y., Davies, K. J. A., Grune, T.: Sarcopenia – Molecular Mechanisms and Open Questions. Ageing Res. Rev. 65:101200 (2021). [Open Access]

Grune, T.: Oxidized protein aggregates: Formation and biological effects. Free Radic. Biol. Med. 150, 120-124 (2020).

Guth, S., Hüser, S., Roth, A., Degen, G., Diel, P., Edlund, K., Eisenbrand, G., Engel, K.-H., Epe, B., Grune, T., Heinz, V., Henle, T., Humpf, H.-U., Jäger, H., Joost, H.-G., Kulling, S. E., Lampen, A., Mally, A., Marchan, R., Marko, D., Mühle, E., Nitsche, M. A., Röhrdanz, E., Stadler, R., van Thriel, C., Vieths, S., Vogel, R. F., Wascher, E., Watzl, C., Nöthlings, U., Hengstler, J. G.: Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses. Arch. Tox. 94, 1375–1415 (2020). [Open Access]

Höhn, A., Tramutola, A., Cascella, R.: Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress. Oxid. Med. Cell Lon. 2020:5497046 (2020). [Open Access]

Keyhani-Nejad, F., Barbosa Yanez, R. L., Kemper, M., Schueler, R., Pivovarova-Ramich, O., Rudovich, N., Pfeiffer, A. F. H.: Endogenously released GIP reduces and GLP-1 increases hepatic insulin extraction. Peptides 125:170231 (2020).

Fernando, R., Drescher, C., Nowotny, K., Grune, T., Castro, J. P.: Impaired proteostasis during skeletal muscle aging. Free Radic. Biol. Med. 132, 58-66 (2019). [Open Access]

König, J., Grune, T., Ott, C.: Assessing autophagy in murine skeletal muscle: current findings to modulate and quantify the autophagic flux. Curr. Opin. Clin. Nutr. Metab. Care 22(5), 355-362 (2019).

Andrisic, L., Dudzik, D., Barbas, C., Milkovic, L., Grune, T., Zarkovic, N.: Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer. Redox Biol. 14, 47-58 (2018). [Open Access]

Bertz, M., Kühn, K., Koeberle, S. C., Müller, M. F., Hoelzer, D., Thies, K., Deubel, S., Thierbach, R., Kipp, A. P.: Selenoprotein H controls cell cycle progression and proliferation of human colorectal cancer cells. Free Radic. Biol. Med. 127, 98-107 (2018). [Open Access]

Castro, J. P., Wardelmann, K., Grune, T., Kleinridders, A.: Mitochondrial chaperones in the brain: Safeguarding brain health and metabolism?. Front. Endocrinol. 9:196 (2018). [Open Access]

Klaus, S., Pfeiffer, A. F. H., Boeing, H., Laeger, T., Grune, T.: The protein paradox: how much dietary protein is good for health?. Ernaehr. Umsch. 65, 42-47 (2018). [Open Access]

Lichtenberg, D., Pinchuk, I., Weber, D.: Oxidative stress, as assayed by a single test, cannot be used as a diagnostic tool. BioFactors 44, 222-223 (2018).

Nedic Erjavec, G., Konjevod, M., Nikolac Perkovic, M., Svob Strac, D., Tudor, L., Barbas, C., Grune, T., Zarkovic, N., Pivac, N.: Short overview on metabolomic approach and redox changes in psychiatric disorders. Redox Biol. 14, 178-186 (2018). [Open Access]

Nowotny, K., Schröter, D., Schreiner, M., Grune, T.: Dietary advanced glycation end products and their relevance for human health. Ageing Res. Rev. 47, 55-66 (2018). [Open Access]

Schröter, D., Höhn, A.: Role of advanced glycation end-products in carcinogenesis and their therapeutic implications. Curr. Pharm. Des. 24, 5245-5251 (2018). [Open Access]

Castro, J. P., Jung, T., Grune, T., Siems, W.: 4-Hydroxynonenal (HNE) modified proteins in metabolic diseases. Free Radic. Biol. Med. 111, 309-315 (2017). [Open Access]

Höhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J.Grune, T., Castro, J. P.: Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol. 11, 482-501 (2017). [Open Access]

Kaplan, G. S., Torcun, C. C., Grune, T., Ozer, N. K., Karademir, B.: Proteasome inhibitors in cancer therapy: Treatment regimen and peripheral neuropathy as a side effect. Free Radic. Biol. Med. 103, 1–13 (2017).

Kochlik, B., Grune, T., Weber, D.: New findings of oxidative stress biomarkers in nutritional research. Curr. Opin. Clin. Nutr. Metab. Care 20, 349-359 (2017). [Open Access]

Korovila, I., Hugo, M., Castro, J. P., Weber, D., Höhn, A., Grune, T., Jung, T.: Proteostasis, oxidative stress and aging. Redox Biol. 13, 550-567 (2017). [Open Access]

Castro, J. P., Grune, T., Speckmann, B.: The two faces of ROS in adipocyte function and dysfunction. Biol. Chem. 397, 709-724 (2016). [Open Access]

Erusalimsky, J. D., Grillari, J. Grune, T., Jansen-Duerr, P., Lippi, G., Sinclair, A. J., Tegnér, J., Viña, J., Durrance-Bagale, A., Miñambres, R., Viegas, M., Rodríguez-Mañas, L.: In search of ’Omics’-based biomarkers to predict risk of frailty and its consequences in older individuals: The FRAILOMIC initiative. Gerontology 62, 182-190 (2016). [Open Access]

Höhn, A., König, J., Jung, T.: Metabolic syndrome, redox state and the proteasomal system. Antioxid. Redox Signal. 25, 902-917 (2016).

Klionsky, D. J., ... Grune, T., ... Zughaier, S. M.: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1-122 (2016).

Pivovarova, O., Höhn, A., Grune, T., Pfeiffer, A. F. H., Rudovich, N.: Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease?. Ann. Med. 48, 614-624 (2016).

Speckmann, B., Steinbrenner, H., Grune, T., Klotz, L. O.: Peroxynitrite: From interception to signaling. Arch. Biochem. Biophys. 595, 153-160 (2016).

Wiedmer, P., Ode, A., Grune, T.: NutriAct - Nutritional intervention: Food patterns, behaviour, and products. Dtsch. Lebensm.-Rundsch. 112, 142-146 (2016).

Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H. J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Dollé, M., Salmon, M., Kristensen, P., Griffiths, H. R., Libert, C., Grune, T., Breusing, N., Simm, A., Franceschi, C., Capri, M., Talbot, D., Caiafa, P., Friguet, B., Slagboom, P. E., Hervonen, A., Hurme, M., Aspinall, R.: MARK-AGE biomarkers of ageing. Mech. Ageing Dev. 151, 2-12 (2015). [Open Access]

Frijhoff, J., Winyard, P. G., Zarkovic, N., Davies, S., Stocker, R., Cheng, D., Knight, A., Taylor, E. L., Oettrich, J., Ruskovska, T., Cipak Gasparovic, A., Cuadrado, A., Weber, D., Poulsen, H. E., Grune, T., Schmidt, H. H. H. W., Ghezzi, P.: Clinical relevance of biomarkers of oxidative stress. Antioxid. Redox Signal. 23, 1144-1170 (2015). [Open Access]

Grune, T.: Insulin-degrading enzyme: is it suitable for diabetes treatment?. Cell Cycle 14, 2553 (Comment) (Open Access) (2015). [Open Access]

Jansen, E., Beekhof, P., Cremers, J., Weinberger, B., Fiegl, S., Toussaint, O., Bernhard, J., Gonos, E., Capri, M., Franceschi, C., Sikora, E., Moreno-Villanueva, M., Breusing, N., Grune, T., Bürkle, A., Dollé, M. E. T.: Quality control data of physiological and immunological biomarkers measured in serum and plasma. Mech. Ageing Dev. 151, 54-59 (2015). [Open Access]

Kipp, A. P., Strohm, D., Brigelius-Flohé, R., Schomburg, L., Bechthold, A., Leschik-Bonnet, E., Heseker, H.: Revised reference values for selenium intake. J. Trace Elem. Med. Biol. 32, 195-199 (2015). [Open Access]

Moreno-Villanueva, M., Capri, M., Breusing, N., Siepelmeyer, A., Sevini, F., Ghezzo, A., de Craen, A. J. M., Hervonen, A., Hurme, M., Schön, C., Grune, T., Franceschi, C., Bürkle, A.: MARK-AGE standard operating procedures (SOPs): A successful effort. Mech. Ageing Dev. 151, 18-25 (2015). [Open Access]

Nowotny, K., Jung, T., Höhn, A., Weber, D., Grune, T.: Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules 5, 194-222 (2015). [Open Access]

Reeg, S., Grune, T.: Protein oxidation in aging: Does it play a role in aging progression? Antioxid. Redox Signal. 23, 239-255 (2015). [Open Access]

Speckmann, B., Grune, T.: Epigenetic effects of selenium and their implications for health. Epigenetics 10, 179-190 (2015). [Open Access]

Weber, D., Davies, M. J., Grune, T.: Determination of protein carbonyls in plasma, cell extracts, tissue homogenates, isolated proteins: Focus on sample preparation and derivatization conditions. Redox Biol. 5, 367-380 (2015). [Open Access]

König, J., Jung, T., Grune, T.: Protein Carbonylation in Aging and Senescence. In: Ros, J. (ed.) Protein Carbonylation: Principles, Analysis, and Biological Implications. Wiley, Hoboken, pp 272–290 (2017).

Reeg, S., Grune, T.: Protein Oxidation in Toxicology. In: Roberts, S. M., Kehrer, J. P., Klotz, L.-O. (eds.) Studies on Experimental Toxicology and Pharmacology (Oxidative Stress in Applied Basic Research and Clinical Practice). Humana Press, pp. 81-102 (2015).

Bürkle, A., Grune, T.: Biomarkers of Human Ageing. (Mechanisms of Ageing and Development; Special Issue) Elsevier (2015).

Eisenbrand, G., Baum, M., Cartus, A. T., Diel, P., Engel, K.-H., Engeli, B., Epe, B., Grune, T., Guth, S., Haller, D., Heinz, V., Hellwig, M., Hengstler, J. G., Henle, T., Humpf, H.-U., Jäger, H., Joost, H.-G., Kulling, S., Lachenmeier, D. W., Lampen, A., Leist, M., Mally, A., Marko, D., Nöthlings, U., Röhrdanz, E., Roth, A., Spranger, J., Stadler, R., Vieths, S., Wätjen, W., Steinberg, P.: Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—a hypothesis. Arch. Toxicol. 96(6), 1905-1914 (Editorial) (2022).

Guth, S., Hüser, S., Roth, A., Degen, G., Diel, P., Edlund, K., Eisenbrand, G., Engel, K. H., Epe, B., Grune, T., Heinz, V., Henle, T., Humpf, H. U., Jäger, H., Joost, H. G., Kulling, S. E., Lampen, A., Mally, A., Marchan, R., Marko, D., Mühle, E., Nitsche, M. A., Röhrdanz, E., Stadler, R., van Thriel, C., Vieths, S., Vogel, R. F., Wascher, E., Watzl, C., Nöthlings, U., Hengstler, J. G.: Contribution to the ongoing discussion on fluoride toxicity. Arch. Toxicol. 95(7), 2571–2587 (Editorial) (2021). [Open Access]

Weber, D., Grune, T.: Special issue on ’Biomarkers of Oxidative Stress, Aging and Nutrition in Human Studies’. Redox. Biol. 45:102059 (2021). [Open Access]

Sadowska-Bartosz, I., Bartosz, G., Grune, T., Sereikaite, J.: Role of oxidative, nitrative, and chlorinative protein modifications in aging and age-related diseases. Oxid. Med. Cell. Longev. 2018, Article ID 3267898 (Editorial) (2018). [Open Access]

Kochlik, B., Grune, T., Weber, D.: Ernährungskonzepte für den alternden Menschen. Proteine und Mikronährstoffe im Fokus [Dietary concepts for the elderly]. Diabetologe 13, 433-441 (2017).