Prof. Dr. Annette Schürmann

Leiterin Abteilung Experimentelle Diabetologie

Tel.: +49 33200 88 - 2368
E-Mail: schuermann@dife.de

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Forschungsinstitute:

• Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
• Deutsche Diabetes-Zentrum Düsseldorf
• Helmholtz Zentrum München – Deutsches Forschungszentrum für Gesundheit und Umwelt

Universitäten:

• Institut für Diabetesforschung und Metabolische Erkrankungen des Helmholtz Zentrum München an der Eberhard-Karls-Universität Tübingen
• Paul-Langerhans-Institut Dresden des Helmholtz Zentrum München am Universitätsklinikum Carl Gustav Carus der TU Dresden
• Assoziierte Partner: Einzelne Forschungsgruppen der Universitäten in Heidelberg, Köln, Leipzig, Lübeck und München

Die Ziele, die das DIfE in Kooperation mit den DZD-Partnern der anderen Zentren verfolgt, sind:

• die Pathogenese des Typ-2-Diabetes unter Berücksichtigung von Subtypen und Komplikationen besser zu verstehen, 
• mit Hilfe von metabolischen, genetischen und epigenetischen Markern Risikopersonen der verschiedenen Subtypen zu identifizieren, 
• zu klären, welche Faktoren einen Betazell-Untergang begünstigen und wie eine Inselzellregeneration induziert werden kann,
• herauszufinden, wie eine neuronale Insulinresistenz entsteht und welche Rolle psychologische und neurologische Mechanismen bei der Nahrungsauswahl spielen. 

Aga, H., Soultoukis, G., Stadion, M., Garcia-Carrizo, F., Jähnert, M., Gottmann, P., Vogel, H., Schulz, T. J., Schürmann, A.: Distinct Adipogenic and Fibrogenic Differentiation Capacities of Mesenchymal Stromal Cells from Pancreas and White Adipose Tissue. Int. J. Mol. Sci. 23(4):2108 (2022). [Open Access]

Birukov, A., Polemiti, E., Jäger, S., Stefan, N., Schulze, M. B.: Fetuin-A and risk of diabetes-related vascular complications: a prospective study. Cardiovasc. Diabetol. 21(1), 6 (2022). [Open Access]

Eichelmann, F., Sellem, L., Wittenbecher, C., Jäger, S., Kuxhaus, O., Prada, M., Cuadrat, R., Jackson, K. G., Lovegrove, J. A., Schulze, M. B.: Deep Lipidomics in Human Plasma - Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation. Circulation 146(1), 21-35 (2022). [Open Access]

Jonas, W., Kluth, O., Helms, A., Voß, S., Jähnert, M., Gottmann, P., Speckmann, T., Knebel, B., Chadt, A., Al-Hasani, H., Schürmann, A., Vogel, H.: Identification of Novel Genes Involved in Hyperglycemia in Mice. Int. J. Mol. Sci. 23(6):3205 (2022). [Open Access]

Kirschner, K. M., Foryst-Ludwig, A., Gohlke, S., Li, C., Flores, R. E., Kintscher, U., Schupp, M., Schulz, T. J., Scholz, H.: Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet. Diabetologia 65, 528–540 (2022). [Open Access]

Prada, M., Wittenbecher, C., Eichelmann, F., Wernitz, A., Kuxhaus, O., Kröger, J., Weikert, C., Schulze, M. B.: Plasma Industrial and Ruminant Trans Fatty Acids and Incident Type 2 Diabetes in the EPIC-Potsdam Cohort. Diabetes Care 45(4), 845–853 (2022). [Open Access]

Birukov, A., Cuadrat, R., Polemiti, E., Eichelmann, F., Schulze, M. B.: Advanced glycation end-products, measured as skin autofluorescence, associate with vascular stiffness in diabetic, pre-diabetic and normoglycemic individuals: a cross-sectional study. Cardiovasc. Diabetol. 20:110 (2021). [Open Access]

Fröhlich, E., Madipakkam, A. R., Craffonara, B., Bolte, C., Muth, A.-K., Park, S. Q: A short humorous intervention protects against subsequent psychological stress and attenuates cortisol levels without affecting attention. Sci. Rep. 11(1):7284 (2021). [Open Access]

Fröhlich, E., Samaan, L., Matsuzaki, R., Park, S. Q.: Humor and Hunger Affect the Response Toward Food Cues. Front. Psychol. 12:680508 (2021). [Open Access]

Gohlke, S., Mancini, C., Garcia-Carrizo, F., Schulz, T. J.: Loss of the ciliary gene Bbs4 results in defective thermogenesis due to metabolic inefficiency and impaired lipid metabolism. Faseb J. 35(11):e21966 (2021). [Open Access]

Hauffe, R., Rath, M., Schell, M., Ritter, K., Kappert, K., Deubel, S., Ott, C., Jähnert, M., Jonas, W., Schürmann, A., Kleinridders, A.: HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue. Mol. Metab. 53:101276 (2021). [Open Access]

Kabisch, S., Honsek, C., Kemper, M., Gerbracht, C., Arafat, A. M., Birkenfeld, A. L., Dambeck, U., Osterhoff, M. A., Weickert, M. O., Pfeiffer, A. F. H.: Dose-dependent effects of insoluble fibre on glucose metabolism: a stratified post hoc analysis of the Optimal Fibre Trial (OptiFiT). Acta Diabetol. 58, 1649-1658 (2021). [Open Access]

Kabisch, S., Markova, M., Hornemann, S., Sucher, S., Pivovarova-Ramich, O., Machann, J., Hierholzer, J., Rohn, S., Pfeiffer, A. F. H.: Liver fat scores do not reflect interventional changes in liver fat content induced by high-protein diets. Sci. Rep. 11(1):8843 (2021). [Open Access]

Kehm, R., Baldensperger, T., Raupbach, J., Höhn, A.: Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases. Redox. Biol. 42:101901 (2021). [Open Access]

Korovila, I., Höhn, A., Jung, T., Grune, T., Ott, C.: Reduced Liver Autophagy in High-Fat Diet Induced Liver Steatosis in New Zealand Obese Mice. Antioxidants 10(4):501 (2021). [Open Access]

Liu, L., Artigas, S., Ulrich, A., Tardu, J., Wilms, B., Koletzko, B., Schmid, S. M., Park, S. Q.: Eating to dare - Nutrition impacts human risk decision and related brain function. Neuroimage 233:117951 (2021). [Open Access]

Mancini, C., Gohlke, S., Garcia-Carrizo, F., Zagoriy, V., Stephanowitz, H., Schulz, T. J.: Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways. Sci. Rep. 11(1):19928 (2021). [Open Access]

Muth, A.-K., Park, S. Q.: The impact of dietary macronutrient intake on cognitive function and the brain. Clin. Nutr. 40(6), 3999-4010 (2021).

Terenzi, D., Liu, L., Bellucci, G., Park, S. Q.: Determinants and modulators of human social decisions. Neurosci. Biobehav. Rev. 128, 383-393 (2021). [Open Access]

Wardelmann, K., Rath, M., Castro, J. P., Blümel, S., Schell, M., Hauffe, R., Schumacher, F., Flore, T., Ritter, K., Wernitz, A., Hosoi, T., Ozawa, K., Kleuser, B., Weiß, J., Schürmann, A., Kleinridders, A.: Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus. Antioxidants 10(5):711 (2021). [Open Access]

Wilhelmi, I., Grunwald, S., Gimber, N., Popp, O., Dittmar, G., Arumughan, A., Wanker, E. E., Laeger, T., Schmoranzer, J., Daumke, O., Schürmann, A.: The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells. Mol. Metab. 45:101151 (2021). [Open Access]

Wilhelmi, I., Neumann, A., Jähnert, M., Ouni, M., Schürmann, A.: Enriched Alternative Splicing in Islets of Diabetes-Susceptible Mice. Intern. J. Mol. Sci. 22(16):8597 (2021). [Open Access]

Wittenbecher, C., Eichelmann, F., Toledo, E., Guasch-Ferre, M., Ruiz-Canela, M., Li, J., Arós Borau, F., Lee, C. H., Liang, L., Salas-Salvadó, J., Clish, C. B., Schulze, M. B., Martínez-González, M. A., Hu, F. B.: Lipid Profiles and Heart Failure Risk: Results from Two Prospective Studies. Circ. Res. 128(3), 309–320 (2021). [Open Access]

Barbosa-Yanez, R. L., Markova, M., Dambeck, U., Honsek, C., Machann, J., Schüler, R., Kabisch, S., Pfeiffer, A. F. H.: Predictive effect of GIPR SNP rs10423928 on glucose metabolism liver fat and adiposity in prediabetic and diabetic subjects. Peptides 125:170237 (2020)

Brown, E. C., Park, S. Q.: Obesity and addiction. Nat. Hum. Behav. 4, 10-11 (2020).

Fernando, R., Wardelmann, K., Deubel, S., Kehm, R., Jung, T., Mariotti, M., Vasilaki, A., Gladyshev, V. N., Kleinridders, A., Grune, T., Castro, J. P.: Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration. Redox Biol. 32:101507 (2020).

Gässler, A., Quiclet, C., Kluth, O., Gottmann, P., Schwerbel, K., Helms, A., Stadion, M., Wilhelmi, I., Jonas, W., Ouni, M., Mayer, F., Spranger, J., Schürmann, A., Vogel, H.: Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells. Mol. Metab. 41:101042 (Brief Communication) (2020).

Hauffe, R., Stein, V., Chudoba, C., Flore, T., Rath, M., Ritter, K., Schell, M., Wardelmann, K., Deubel, S., Kopp, J. F., Schwarz, M., Kappert, K., Blüher, M., Schwerdtle, T., Kipp, A. P., Kleinridders, A.: GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity. JCI Insight 5(11):e136283 (2020).

Kessler, K., Gerl, M. J., Hornemann, S., Damm, M., Klose, C., Petzke, K. J., Kemper, M., Weber, D., Rudovich, N., Grune, T., Simons, K., Kramer, A., Pfeiffer, A. F. H. , Pivovarova-Ramich, O.: Shotgun lipidomics discovered diurnal regulation of lipid metabolism linked to insulin sensitivity in non-diabetic men. J. Clin. Endocrinol. Metab. 105(5), 1501–1514 (2020).

Keyhani-Nejad, F., Barbosa Yanez, R. L., Kemper, M., Schueler, R., Pivovarova-Ramich, O., Rudovich, N., Pfeiffer, A. F. H.: Endogenously released GIP reduces and GLP-1 increases hepatic insulin extraction. Peptides 125:170231 (2020).

Markova, M., Koelman, L., Hornemann, S., Pivovarova, O., Sucher, S., Machann, J., Rudovich, N., Thomann, R., Schneeweiss, R., Rohn, S., Pfeiffer, A. F. H., Aleksandrova, K.: Effects of plant and animal high protein diets on immune-inflammatory biomarkers: a 6-week intervention trial. Clin. Nutr. 39(3), 862-869 (2020).

Mühlenbruch, K., Zhuo, X., Bardenheier, B., Shao, H., Laxy, M., Icks, A., Zhang, P., Gregg, E. W., Schulze, M. B.: Selecting the optimal risk threshold of diabetes risk scores to identify high-risk individuals for diabetes prevention: a cost-effectiveness analysis. Acta Diabetol. 57(4), 447–454 (2020).

Pfeiffer, A. F. H., Pedersen, E., Schwab, U., Riserus, U., Aas, A. M., Uusitupa, M., Thanopoulou, A., Kendall, C., Sievenpiper, J. L., Kahleova, H., Rahelic, D., Salas-Salvado, J., Gebauer, S., Hermansen, K.: The Effects of Different Quantities and Qualities of Protein Intake in People with Diabetes Mellitus. Nutrients 12(2):365 (2020).

Schwerbel, K., Kamitz, A., Krahmer, N., Hallahan, N., Jähnert, M., Gottmann, P., Lebek, S., Schallschmidt, T., Arends, D., Schumacher, F., Kleuser, B., Haltenhof, T., Heyd, F., Gancheva, S., Broman, K. W., Roden, M., Joost, H.-G., Chadt, A., Al-Hasani, H., Vogel, H., Jonas, W., Schürmann, A.: Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation. J. Hepatol. 73(4), 771-782 (2020).

Wittenbecher, C., Stambuk, T., Kuxhaus, O., Rudman, N., Vuckovic, F., Stambuk, J., Schiborn, C., Rahelic, D., Dietrich, S., Gornik, O., Perola, M., Boeing, H., Schulze, M. B., Lauc, G.: Plasma N-Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study. Diabetes Care 43(3), 661-668 (2020).

Castaño-Martinez, T., Schumacher, F., Schumacher, S., Kochlik, B., Weber, D., Grune, T., Biemann, R., McCann, A., Abraham, K., Weikert, C., Kleuser, B., Schürmann, A., Laeger, T.: Methionine restriction prevents onset of type 2 diabetes in NZO mice. FASEB J. 33, 7092–7102 (2019).

Dietrich, S., Jacobs, S., Zheng, J.-S., Meidtner, K., Schwingshackl, L., Schulze, M. B.: Gene-lifestyle interaction on risk of type 2 diabetes: A systematic review. Obes. Rev. 20, 1557-1571 (2019).

Eichelmann, F., Schulze, M. B., Wittenbecher, C., Menzel, J., Weikert, C., di Giuseppe, R., Biemann, R., Isermann, B., Fritsche, A., Boeing, H., Aleksandrova, K.: Chemerin as a biomarker linking inflammation and cardiovascular diseases. J. Am. Coll. Cardiol. 73, 378-379 (2019).

Gancheva, S., Ouni, M., Jelenik, T., Koliaki, C., Szendroedi, J., Toledo, F. G. S., Markgraf, D. F., Pesta, D. H., Mastrototaro, L., De Filippo, E., Herder, C., Jähnert, M., Weiss, J., Strassburger, K., Schlensak, M., Schürmann, A., Roden, M.: Dynamic changes of muscle insulin sensitivity after metabolic surgery. Nat. Commun. 10(1):4179 (2019).

Gohlke, S., Zagoriy, V., Cuadros Inostroza, A., Méret, M., Mancini, C., Japtok, L., Schumacher, F., Kuhlow, D., Graja, A., Stephanowitz, H., Jähnert, M., Krause, E., Wernitz, A., Petzke, K.-J., Schürmann, A., Kleuser, B., Schulz, T. J.: Identification of functional lipid metabolism biomarkers of brown adipose tissue aging. Mol. Metab. 24, 1-17 (2019).

Graja, A., Gohlke, S., Schulz, T. J.: Aging of Brown and Beige/Brite Adipose Tissue. In: Pfeifer, A., Klingenspor, M., Herzig, S. (eds.) Brown Adipose Tissue (Handb. Exp. Pharmacol.; 251), pp. 55-72 (2019).

Hill, C. M., Laeger, T., Dehner, M., Albarado, D. C., Clarke, B., Wanders, D., Burke, S. J., Collier, J. J., Qualls-Creekmore, E., Solon-Biet, S. M., Simpson, S. J., Berthoud, H.-R., Münzberg, H., Morrison, C. D.: FGF21 signals protein status to the brain and adaptively regulates food choice and metabolism. Cell Rep. 27, 2934-2947.e3 (2019).

Kabisch, S., Meyer, N. M. T., Honsek, C., Gerbracht, C., Dambeck, U., Kemper, M., Osterhoff, M. A., Birkenfeld, A. L., Arafat, A. M., Hjorth, M. F., Weickert, M. O., Pfeiffer, A. F. H.: Fasting glucose state determines metabolic response to supplementation with insoluble cereal fibre: a secondary analysis of the Optimal Fibre Trial (OptiFiT). Nutrients 11: e2385 (2019).

Kehm, R., Rückriemen, J., Weber, D., Deubel, S., Grune, T., Höhn, A.: Endogenous advanced glycation end products in pancreatic islets after short-term carbohydrate intervention in obese, diabetes-prone mice. Nutr. Diabetes 9(1):9 (2019).

Kluth, O., Stadion, M., Gottmann, P., Aga, H., Jähnert, M., Scherneck, S., Vogel, H., Krus, U., Seelig, A., Ling, C., Gerdes, J., Schürmann, A.: Decreased Expression of cilia genes in pancreatic islets as a risk factor for type 2 diabetes in mice and humans. Cell Rep. 26, 3027-3036.e3 (2019).

Quiclet, C., Dittberner, N., Gässler, A., Stadion, M., Gerst, F., Helms, A., Baumeier, C., Schulz, T. J., Schürmann, A.: Pancreatic adipocytes mediate hypersecretion of insulin in diabetes-susceptible mice. Metabolism. 97, 9-17 (2019).

Schulze, M. B.: Metabolic health in normal-weight and obese individuals. Diabetologia 62, 558-566 (2019).

Wardelmann, K., Blümel, S., Rath, M., Alfine, E., Chudoba, C., Schell, M., Cai, W., Hauffe, R., Warnke, K., Flore, T., Ritter, K., Weiß, J., Kahn, C. R., Kleinridders, A.: Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain. Mol. Metab. 21, 68-81 (2019).

Wittenbecher, C., Ouni, M., Kuxhaus, O., Jähnert, M., Gottmann, P., Teichmann, A., Meidtner, K., Kriebel, J., Grallert, H., Pischon, T., Boeing, H., Schulze, M. B., Schürmann, A.: Insulin-like growth factor binding protein 2 (IGFBP-2) and the risk of developing type 2 diabetes. Diabetes 68, 188-197 (2019).

Zaharia, O. P., Strassburger, K., Strom, A., Bönhof, G. J., Karusheva, Y., Antoniou, S., Bódis, K., Markgraf, D. F., Burkart, V., Müssig, K., Hwang, J.-H., Asplund, O., Groop, L., Ahlqvist, E., Seissler, J., Nawroth, P., Kopf, S., Schmid, S. M., Stumvoll, M., Pfeiffer, A. F. H., Kabisch, S., Tselmin, S., Häring, H. U., Ziegler, D., Kuss, O., Szendroedi, J., Roden, M.: German Diabetes Study Group: Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. Lancet Diabetes Endocrinol. 7, 684-694 (2019).

Cai, W., Xue, C., Sakaguchi, M., Konishi, M., Shirazian, A., Ferris, H. A., Li, M. E., Yu, R., Kleinridders, A., Pothos, E. N., Kahn, C. R.: Insulin regulates astrocyte gliotransmission and modulates behavior. J. Clin. Invest. 128, 2914-2916 (2018).

Eckel, N., Li, Y., Kuxhaus, O., Stefan, N., Hu, F. B., Schulze, M. B.: Transition from metabolic healthy to unhealthy phenotypes and association with cardiovascular disease risk across BMI categories in 90 257 women (the Nurses’ Health Study): 30 year follow-up from a prospective cohort study. Lancet Diabetes Endocrinol. 6, 714-724 (2018).

Gottmann, P., Ouni, M., Sausenthaler, S., Roos, J., Stirm, L., Jähnert, M., Kamitz, A., Hallahan, N., Jonas, W., Fritsche, A., Häring, H.-U., Staiger, H., Blüher, M., Fischer-Posovszky, P., Vogel, H., Schürmann, A.: A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes. Mol. Metab. 11, 145-159 (2018).

Graja, A., Garcia-Carrizo, F., Jank, A.-M., Gohlke, S., Ambrosi, T. H., Jonas, W., Ussar, S., Kern, M., Schürmann, A., Aleksandrova, K., Blüher, M., Schulz, T. J.: Loss of periostin occurs in aging adipose tissue of mice and its genetic ablation impairs adipose tissue lipid metabolism. Aging Cell 17: e12810 (2018).

Kehm, R., König, J., Nowotny, K., Jung, T., Deubel, S., Gohlke, S., Schulz, T. J., Höhn, A.: Age-related oxidative changes in pancreatic islets are predominantly located in the vascular system. Redox Biol. 15, 387-393 (2018).

Kleinridders, A., Ferris, H. A., Tovar, S.: Editorial: Crosstalk of mitochondria with brain insulin and leptin signaling. Front. Endocrinol. (Lausanne) 9:761 (2018).

Kleinridders, A., Ferris, H. E., Reyzer, M. L., Rath, M., Soto, M., Manier, M. L., Spraggins, J., Yang, Z., Stanton, R.C., Caprioli, R. M., Kahn, R.: Regional differences in brain glucose metabolism determined by imaging mass spectrometry. Mol. Metab. 12, 113-121 (2018).

Kröger, J., Meidtner, K., Stefan, N., Guevara, M., Kerrison, N. D., Ardanaz, E., Aune, D., Boeing, H., Dorronsoro, M., Dow, C., Fagherazzi, G., Franks, P. W., Freisling, H., Gunter, M. J., Huerta, J. M., Kaaks, R., Key, T. J., Khaw, K.-T., Krogh, V., Kühn, T., Mancini, F. R., Mattiello, A., Nilsson, P. M., Olsen, A., Overvad, K., Palli, D., Quirós, J. R., Rolandsson, O., Sacerdote, C., Sala, N., Salamanca-Fernández, E., Sluijs, I., Spijkerman, A. M., Tjonneland, A., Tsilidis, K. K., Tumino, R., van der Schouw, Y. T., Forouhi, N. G., Sharp, S. J., Langenberg, C., Riboli, E., Schulze, M. B., Wareham, N. J.: Circulating fetuin-A and risk of type 2 diabetes: A mendelian randomization analysis. Diabetes 67, 1200-1205 (2018).

Laeger, T., Castaño-Martinez, T., Werno, M. W., Japtok, L., Baumeier, C., Jonas, W., Kleuser, B., Schürmann, A.: Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes. Diabetologia 61, 1459-1469 (2018).

Li, S. X., Imamura, F., Schulze, M. B., Zheng, J., Ye, Z., Agudo, A., Ardanaz, E., Aune, D., Boeing, H., Dorronsoro, M., Dow, C., Fagherazzi, G., Grioni, S., Gunter, M. J., Huerta, J. M., Ibsen, D. B., Jakobsen, M. U., Kaaks, R., Key, T. J., Khaw, K.-T., Kyrø, C., Mancini, F. R., Molina-Portillo, E., Murphy, N., Nilsson, P. M., Onland-Moret, N. C., Palli, D., Panico, S., Poveda, A., Quirós, J. R., Ricceri, F., Sluijs, I., Spijkerman, A. M. W., Tjonneland, A., Tumino, R., Winkvist, A., Langenberg, C., Sharp, S. J., Riboli, E., Scott, R. A., Forouhi, N. G., Wareham, N. J.: Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries. Diabetologia 61, 1325-1332 (2018).

Meidtner, K., Podmore, C., Kröger, J., van der Schouw, Y. T., Bendinelli, B., Agnoli, C., Arriola, L., Barricarte, A., Boeing, H., Cross, A. J., Dow, C., Ekblom, K., Fagherazzi, G., Franks, P. W., Gunter, M. J., Huerta, J. M., Jakszyn, P., Jenab, M., Katzke, V. A., Key, T. J., Khaw, K. T., Kühn, T., Kyrø, C., Mancini, F. R., Melander, O., Nilsson, P. M., Overvad, K., Palli, D., Panico, S., Quirós, J. R., Rodriguez-Barranco, M., Sacerdote, C., Sluijs, I., Stepien, M., Tjonneland, A., Tumino, R., Forouhi, N. G., Sharp, S. J., Langenberg, C., Schulze, M. B., Riboli, E., Wareham, N. J.: Interaction of dietary and genetic factors influencing body iron status and risk of type 2 diabetes within the EPIC-InterAct study. Diabetes Care 41, 277-285 (author manuscript free at PMC6130703) (2018).

Mühlenbruch, K., Paprott, R., Joost, H.-G., Boeing, H., Heidemann, C., Schulze, M. B.: Derivation and external validation of a clinical version of the German Diabetes Risk Score (GDRS) including measures of HbA1c. BMJ Open Diabetes Res. Care 6;6(1):e000524 (2018).

Schallschmidt, T., Lebek, S., Altenhofen, D., Damen, M., Schulte, Y., Knebel, B., Herwig, R., Rasche, A., Stermann, T., Kamitz, A., Hallahan, N., Jähnert, M., Vogel, H., Schürmann, A., Chadt, A., Al-Hasani, H.: Two novel candidate genes for insulin secretion identified by comparative genomics of multiple backcross mouse populations. Genetics 210, 1527-1542 (2018).

Stadion, M., Schwerbel, K., Graja, A., Baumeier, C., Rödiger, M., Jonas, W., Wolfrum, C., Staiger, H., Fritsche, A., Häring, H.-U., Klöting, N., Blüher, M., Fischer-Posovszky, P., Schulz, T. J., Joost, H.-G., Vogel, H., Schürmann, A.: Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans. Diabetologia 61, 1167-1179 (2018).

Trefflich, I., Jahn, C., Jannasch, F., Jäger, S., Schulze, M. B., Mühlenbruch, K.: Application of diabetes risk scores in health checkups. A comparison of the German Diabetes Risk Score (GDRS) and FINDRISK test. Ernaehr. Umsch. 65, 180-186 (2018).

Vogel, H., Kamitz, A., Hallahan, N., Lebek, S., Schallschmidt, T., Jonas, W., Jähnert, M., Gottmann, P., Zellner, L., Kanzleiter, T., Damen, M., Altenhofen, D., Burkhardt, R., Renner, S., Dahlhoff, M., Wolf, E., Müller, T. D., Blüher, M., Joost, H.-G., Chadt, A., Al-Hasani, H., Schürmann, A.: A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and type 2 diabetes. Hum. Mol. Genet. 27, 3099-3113 (2018).

Ambrosi, T. H., Scialdone, A., Graja, A., Gohlke, S., Jank, A.-M., Bocian, C., Woelk, L., Fan, H., Logan, D. W., Schürmann, A., Saraiva, L. R., Schulz, T. J.: Adipocyte accumulation in the bone marrow during obesity and aging impairs stem cell-based hematopoietic and bone regeneration. Cell Stem Cell 20, 771-784 (2017).

Ambrosi, T. H., Schulz, T. J.: The emerging role of bone marrow adipose tissue in bone health and dysfunction. J. Mol. Med. (Berl) 95, 1291-1301 (2017).

Baumeier, C., Schlüter, L., Saussenthaler, S., Laeger, T., Rödiger, M., Alaze, S. A., Fritsche, L., Häring, H.-U., Stefan, N., Fritsche, A., Schwenk, R. W., Schürmann, A.: Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease. Mol. Metab. 6, 1254–1263 (2017).

Höhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J.Grune, T., Castro, J. P.: Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol. 11, 482-501 (2017).

Jäger, S., Wahl, S., Kröger, J., Sharma, S., Hoffmann, P., Floegel, A., Pischon, T., Prehn, C., Adamski, J., Müller-Nurasyid, M., Waldenberger, M., Strauch, K., Peters, A., Gieger, C., Suhre, K., Grallert, H., Boeing, H., Schulze, M. B., Meidtner, K.: Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes. Sci. Rep. 7:6037 (2017).

Laeger, T., Baumeier, C., Wilhelmi, I., Würfel, J., Kamitz, A., Schürmann, A.: FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes. Diabetologia 60, 2274–2284 (2017).