Forschungsthemen

  • Energiestoffwechsel
  • Mitohormesis & Mitochondrien-Dysfunktion
  • Interorgan-Kommunikation
  • Metabolische Rolle von Zytokinen & Metaboliten
  • Ernährung, Sport & Homöostase im Skelettmuskel

Ausgewählte Publikationen

Keipert, S., Ost, M.: Stress-induced FGF21 and GDF15 in obesity and obesity resistance. Trends Endocrinol Metab. Nov.32(11), 904-915 (2021)

Herpich, C., Franz, K., Klaus, S., Müller-Werdan, U., Ost, M.#, and Norman, K.#: Age-related fatigue is associated with reduced mitochondrial function in peripheral blood mononuclear cells. Exp Gerontol. Volume 144, 111177 (2020) #senior author

Wie, X., Franke, J., Ost, M., Wardelmann, K., Börno, S., Timmermann, B., Meierhofer, D., Kleinridders, A., Klaus, S., and Stricker, S.: Cell autonomous requirement of neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis. Journal of Cachexia, Sarcopenia and Muscle, 11(6):1758-1778 (2020)

Ost, M.*,#, Gil, C.I.*, Coleman, V., Keipert, S., Efstathiou, S., Vidic, V., Weyers, M., and Klaus, S.# Muscle-derived GDF15 promotes diurnal anorexia during mitochondrial dysfunction, EMBO Reports 21:3 e48804 (2020) *equally contributed #senior author

Gil, C.I.,*, Ost, M.*, Kasch, J., Schumann, S., Heider, S. and Klaus, S.: Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice. Scientific Reports. 9, 20120 (2019) *equally contributed

Coleman, V., Sa-Nguanmoo, P., Koenig, J., Schulz, T.J., Grune, T., Klaus, S., Kipp, A.P., Ost, M.#: Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling. Scientific Reports, 8:2446 (2018) #senior author

Keipert, S., Kutschke, M., Ost, M., Schwarzmayr, T., van Schothorst, E.M., Lamp, D., Brachthäuser, L., Hamp, I., Mazibuko, S.E., Hartwig, S., Lehr, S., Graf, E., Plettenburg, O., Neff, F., Tschöp, M.H., Jastroch, M.: Long-Term Cold Adaptation Does Not Require FGF21 or UCP1. Cell Metabolism 26(2):437-446 e435 (2017)

Ost, M.*, Coleman, V.*, Voigt, A., van Schothorst, E.M., Keipert, S., van der Stelt, I., Ringel, S., Graja, A., Ambrosi, T., Kipp, A.P., Jastroch, M., Schulz, T.J., Keijer, J., and Klaus, S.:  Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action. Molecular Metabolism, 5(2): p. 79-90 (2015) *equally contributed

Ost, M., Keipert, S., van Schothorst, E.M., Donner, V., van der Stelt, I., Kipp, A.P., Petzke, K.J., Jove, M., Pamplona, R., Portero-Otin, M., Keijer, J., Klaus, S.: Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux. FASEB J fj.14-261503 (2015)

Keipert, S.*, Ost, M.*, Johann, K., Imber, F., Jastroch, M., van Schothorst, E.M., Keijer, J., Klaus, S.: Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine. Am J Physiol Endocrinol Metab 306: E469-E482 (2014) *equally contributed