Forschungsthemen

  • Proteostase
  • Autophagie
  • Alterung
  • Herzzellfunktion im alternden und metabolisch belasteten Herzen
  • Herzzellkontraktion und Calcium
  • Primäre Kardiomyozyten-Kultur
  • Inflammation

Ausgewählte Publikationen

Ott, C., Pappritz, K., Hegemann, N., John, C., Jeuthe, S., McAlpine, C.S., Iwamoto, Y., Lauryn, J., Klages, J., Klopfleisch, R., Van Linthout, S., Swirski, F., Nahrendorf, M., Kintscher, U., Grune, T., Kuebler, W.M. and Grune, J.: Spontaneous Degenerative Aortic Valve Disease in New Zealand Obese Mice. Journal of the American Heart Association, 10:e023131. IF 5.501 (2021)

Hauffe, R., Rath, M., Schell, M., Ritter, K., Kappert, K., Deubel, S., Ott, C., Jähnert, M., Jonas, W., Schürmann, A., Kleinridders, A.: HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue. Mol Metab., Nov; 53: 101276.IF 7.422 (2021)

Ott, C., Tomasina, F., Campolo, N., Bartesaghi, S., Mastrogiovanni, M., Leyva, A., Batthyány, C., Meinl, W., Grune, T., Radi, R.: Decreased proteasomal cleavage at nitrotyrosine sites in proteins and peptides. Redox Biol., Oct; 46: 102106. IF 11.9 (2021)

Fernando, R., Castro, J. P., Flore, T., Deubel, S., Grune, T., Ott, C.: Age-Related Maintenance of the Autophagy-Lysosomal System Is Dependent on Skeletal Muscle Type. Oxi. Med. Cell. Longev. 2020: 4908162 (2020). [Open Access]

Häseli, S., Deubel, S., Jung, T., Grune, T., Ott, C.: Cardiomyocyte Contractility and Autophagy in a Premature Senescence Model of Cardiac Aging. Oxi Med and Cell Long 2020: 8141307 (2020). [Open Access]

Grune, T., Ott, C., Häseli, S., Höhn, A., Jung, T.: The “MYOCYTER” – Convert cellular and cardiac contractions into numbers with ImageJ. Sci. Rep. 9: 15112 (2019). [Open Access]

Schröter, D., Neugart, S., Schreiner, M., Grune, T., Rohn, S., Ott, C.: Amaranth’s 2-Caffeoylisocitric Acid—An Anti-Inflammatory Caffeic Acid Derivative That Impairs NF-κB Signaling in LPS-Challenged RAW 264.7 Macrophages. Nutrients 11(3): 571 (2019). [Open Access]

Ott, C., König, J., Höhn, A., Jung, T., Grune, T.: Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts. Red. Bio. 10, 266-273 (2016). [Open Access]

Ott, C., König, J., Höhn, A., Jung, T., Grune, T.: Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts. Free Rad. Bio. Med. 101, 325-333 (2016). [Open Access]

Ott, C., Jacobs, K., Haucke, E., Navarrete Santos, A., Grune, T., Simm, A.: Role of advanced glycation end products in cellular signaling. Red. Bio. 2, 411-429 (2014). [Open Access]