Forschungsthemen

  • Proteostase
  • Autophagie
  • Alterung
  • Herzzellfunktion im alternden und metabolisch belasteten Herzen
  • Herzzellkontraktion und Calcium
  • Primäre Kardiomyozyten-Kultur
  • Inflammation

Ausgewählte Publikationen

Ott, C., Pappritz, K., Hegemann, N., John, C., Jeuthe, S., McAlpine, C.S., Iwamoto, Y., Lauryn, J., Klages, J., Klopfleisch, R., Van Linthout, S., Swirski, F., Nahrendorf, M., Kintscher, U., Grune, T., Kuebler, W. M., Grune, J.: Spontaneous Degenerative Aortic Valve Disease in New Zealand Obese Mice. J. Am. Heart Assoc. 10:e023131 (2021). [Open Access]

Hauffe, R., Rath, M., Schell, M., Ritter, K., Kappert, K., Deubel, S., Ott, C., Jähnert, M., Jonas, W., Schürmann, A., Kleinridders, A.: HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue. Mol. Metab. 53:101276 (2021). [Open Access]

Ott, C., Tomasina, F., Campolo, N., Bartesaghi, S., Mastrogiovanni, M., Leyva, A., Batthyany, C., Meinl, W., Grune, T., Radi, R.: Decreased proteasomal cleavage at nitrotyrosine sites in proteins and peptides. Redox Biol. 46:102106 (2021). [Open Access]

Fernando, R., Castro, J. P., Flore, T., Deubel, S., Grune, T., Ott, C.: Age-Related Maintenance of the Autophagy-Lysosomal System Is Dependent on Skeletal Muscle Type. Oxi. Med. Cell. Longev. 2020:4908162 (2020). [Open Access]

Häseli, S., Deubel, S., Jung, T., Grune, T., Ott, C.: Cardiomyocyte Contractility and Autophagy in a Premature Senescence Model of Cardiac Aging. Oxi. Med. Cell Longev. 2020:8141307 (2020). [Open Access]

Grune, T., Ott, C., Häseli, S., Höhn, A., Jung, T.: The “MYOCYTER” – Convert cellular and cardiac contractions into numbers with ImageJ. Sci. Rep. 9:15112 (2019). [Open Access]

Schröter, D., Neugart, S., Schreiner, M., Grune, T., Rohn, S., Ott, C.: Amaranth’s 2-Caffeoylisocitric Acid—An Anti-Inflammatory Caffeic Acid Derivative That Impairs NF-κB Signaling in LPS-Challenged RAW 264.7 Macrophages. Nutrients 11(3):571 (2019). [Open Access]

Ott, C., König, J., Höhn, A., Jung, T., Grune, T.: Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts. Redox Biol. 10, 266-273 (2016). [Open Access]

Ott, C., König, J., Höhn, A., Jung, T., Grune, T.: Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts. Free Radic. Biol. Med. 101, 325-333 (2016). [Open Access]

Ott, C., Jacobs, K., Haucke, E., Navarrete Santos, A., Grune, T., Simm, A.: Role of advanced glycation end products in cellular signaling. Redox Biol. 2, 411-429 (2014). [Open Access]

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