Forschungsthemen

  • Einfluss verschiedener Diäten und Analyse möglicher protektiver Effekte von Nahrungskomponenten
  • Regulation der Nahrungsaufnahme, Körpergewicht-Homöostase, Wachstum und Stoffwechsel

Ausgewählte Publikationen

McNulty, M. A., Goupil, B. A., Albarado, D. C., Castano-Martinez, T., Ambrosi, T. H., Puh, S., Schulz, T. J., Schürmann, A., Morrison, C. D., Laeger, T.: FGF21, not GCN2, influences bone morphology due to dietary protein restrictions. Bone Rep 12:100241 (2020). [Open Access]

Castaño-Martinez, T., Schumacher, F., Schumacher, S., Kochlik, B., Weber, D., Grune, T., Biemann, R., McCann, A., Abraham, K., Weikert, C., Kleuser, B., Schürmann, A., Laeger, T.: Methionine restriction prevents onset of type 2 diabetes in NZO mice. FASEB J 33, 7092–7102 (2019). [Open Access]

Hill, C. M., Laeger, T., Dehner, M., Albarado, D. C., Clarke, B., Wanders, D., Burke, S. J., Collier, J. J., Qualls-Creekmore, E., Solon-Biet, S. M., Simpson, S. J., Berthoud, H.-R., Münzberg, H., Morrison, C. D.: FGF21 signals protein status to the brain and adaptively regulates food choice and metabolism. Cell Rep 27, 2934-2947.e3 (2019). [Open Access]

Saussenthaler, S., Ouni, M., Baumeier, C., Schwerbel, K., Gottmann, P., Christmann, S., Laeger, T., Schürmann, A.: Epigenetic regulation of hepatic Dpp4 expression in response to dietary protein. J Nutr Biochem 63, 109-116 (2019).

Laeger, T., Castaño-Martinez, T., Werno, M. W., Japtok, L., Baumeier, C., Jonas, W., Kleuser, B., Schürmann, A.: Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes. Diabetologia 61, 1459-1469 (2018). [Open Access]

Laeger, T., Baumeier, C., Wilhelmi, I., Würfel, J., Kamitz, A., Schürmann, A.: FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes. Diabetologia 60, 2274–2284 (2017). [Open Access]

Laeger, T., Albarado, D. C., Burke, S. J., Trosclair, L., Hedgepeth, J. W., Berthoud, H. R., Gettys, T. W., Collier, J. J., Münzberg, H., Morrison, C. D.: Metabolic responses to dietary protein restriction require an increase in FGF21 that is delayed by the absence of GCN2. Cell Rep 16, 707-716 (2016). [Open Access]

Henagan, T.M., Laeger, T., Navard, A.M., Albarado, D.C., Noland, R.C., Stadler, K., Elks, C.M., Burk, D., Morrison, C.D.: Hepatic autophagy contributes to the metabolic response to dietary protein restriction. Metabolism 65(6): 805-815 (2016).

Laeger, T., Henagan, T.M., Albarado, D.C., Redman, L.M., Bray, G.A., Noland, R.C., Münzberg, H., Hutson, S., Gettys, T.W., Schwartz, M.W., Morrison, C.D.: FGF21 is an endocrine signal of protein restriction. J Clin Invest 124(9): 3913-3922 (2014). [Open Access]

Laeger, T., Reed, S.D., Henagan, T.M., Fernandez, D.H., Taghavi, M., Addington, A., Münzberg, H., Martin, R.J., Hutson, S.M., Morrison, C.D.: Leucine acts in the brain to suppress food intake but does not function as a physiological signal of low dietary protein. Am J Physiol Regul Integr Comp Physiol 307(3): R310-20 (2014). [Open Access]