Forschungsthemen

  • Regulation der Insulinsekretion
  • Inselzellbiologie
  • Pathophysiologie des Typ-2-Diabetes

Ausgewählte Publikationen

Sabatini, P.V., Speckmann, T., Lynn, F.C.: Friend and foe: β-cell Ca2+ signaling and the development of diabetes. Mol Metab. 21:1-12. (2019) [Open Access]

Sabatini, P.V., Speckmann, T., Nian, C., Glavas, M.M., Wong, C.K., Yoon, J.S., Kin, T., Shapiro, A.M.J., Gibson, W.T., Verchere, C.B., Lynn, F.C. : Neuronal PAS Domain Protein 4 Suppression of Oxygen Sensing Optimizes Metabolism during Excitation of Neuroendocrine Cells. Cell Rep. 2;22(1):163-174 (2018) [Open Access]

Xu, E.E., Sasaki, S., Speckmann, T., Nian, C., Lynn, F.C.: SOX4 Allows Facultative β-Cell Proliferation Through Repression of Cdkn1a. Diabetes. 66(8):2213-2219 (2017) [Open Access]

Speckmann, T., Sabatini, P.V., Nian, C., Smith, R.G., Lynn, F.C.: Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells. J Biol Chem. 291(6):2682-95 (2016) [Open Access]