Research Topics

    • Mouse Genetics
    • Molecular Biology
    • Obesity
    • Metabolic Phenotyping
    • Food-Reward Behavior

     

    Key Publications

    Jonas, W., Kluth, O., Helms, A., Voß, S., Jähnert, M., Gottmann, P., Speckmann, T., Knebel, B., Chadt, A., Al-Hasani, H., Schürmann, A., Vogel, H.: Identification of Novel Genes Involved in Hyperglycemia in Mice. Int. J. Mol. Sci. 23(6):3205 (2022). [Open Access]

    Aga, H., Hallahan, N., Gottmann, P., Jaehnert, M., Osburg, S., Schulze, G., Kamitz, A., Arends, D., Brockmann, G., Schallschmidt, T., Lebek, S., Chadt, A., Al-Hasani, H., Joost, H.-G., Schürmann, A., Vogel, H.: Identification of Novel Potential Type 2 Diabetes Genes Mediating β-Cell Loss and Hyperglycemia Using Positional Cloning. Front. Genet. 11:567191 (2020). [Open Access]

    Gässler, A., Quiclet, C., Kluth, O., Gottmann, P., Schwerbel, K., Helms, A., Stadion, M., Wilhelmi, I., Jonas, W., Ouni, M., Mayer, F., Spranger, J., Schürmann, A., Vogel, H.: Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells. Mol. Met. 41:101042 (Brief Communication) (2020). [Open Access]

    Schwerbel, K., Kamitz, A., Krahmer, N., Hallahan, N., Jähnert, M., Gottmann, P., Lebek, S., Schallschmidt, T., Arends, D., Schumacher, F., Kleuser, B., Haltenhof, T., Heyd, F., Gancheva, S., Broman, K. W., Roden, M., Joost, H.-G., Chadt, A., Al-Hasani, H., Vogel, H., Jonas, W., Schürmann, A.: Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation. J. Hepatol. 73(4), 771-782 (2020). [Open Access]

    Gottmann, P., Ouni, M., Sausenthaler, S., Roos, J., Stirm, L., Jähnert, M., Kamitz, A., Hallahan, N., Jonas, W., Fritsche, A., Häring, H.-U., Staiger, H., Blüher, M., Fischer-Posovszky, P., Vogel, H.*, Schürmann, A.*: A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes. Mol. Metab. 11, 145-159 (2018). (*contributed equally)

    Vogel, H., Kamitz, A., Hallahan, N., Lebek, S., Schallschmidt, T., Jonas, W., Jähnert, M., Gottmann, P., Zellner, L., Kanzleiter, T., Damen, M., Altenhofen, D., Burkhardt, R., Renner, S., Dahlhoff, M., Wolf, E., Müller, T. D., Blüher, M., Joost, H.-G., Chadt, A., Al-Hasani, H., Schürmann, A.: A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and type 2 diabetes. Hum. Mol. Genet. 27, 3099-3113 (2018). [Open Access]

    Vogel, H., Wolf, S., Rabasa, C., Rodriguez-Pacheco, F., Babaei, C. S., Stöber, F., Goldschmidt, J., DiMarchi, R. D., Finan, B., Tschöp, M. H., Dickson, S. L., Schürmann, A., Skibicka, K. P.: GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight. Neuropharmacology 110, 396-406 (2016). [Open Access]

    Vogel, H., Scherneck, S., Kanzleiter, T., Benz, V., Kluge, R., Stadion, M., Kryvych, S., Blüher, M., Klöting, N., Joost, H.-G., Schürmann, A.: Loss of function of lfi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity. Hum. Mol. Genet. 21, 3845-3857 (2012).

    Vogel, H., Nestler, M., Rüschendorf, F., Block, M.-D., Tischer, S., Kluge, R., Schürmann, A., Joost, H.-G., Scherneck, S.: Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1. Physiol. Genomics 38, 226-232 (Open Access) (2009).