Research Topics

• Oxidative stress
• Nutrition
• Inflammation
• Adipocyte differentiation

Selected Publications

Regdon, Z., Demény, M., Kovács, K., Hajnády, Z., Nagy-Pénzes, M., Bakondi, E., Kiss, A., Hegedűs, C., Virág, L.: High-content screening identifies inhibitors of oxidative stress-induced parthanatos: cytoprotective and anti-inflammatory effects of ciclopirox. Br. J. Pharmacol. 178(5), 1095-1113 (2022). [Open Access]

El-Hamoly, T., Hajnády, Z., Nagy-Pénzes, M., Bakondi, E., Regdon, Z., Demény, M., Kovács, K., Hegedűs, C., El-Rahman Sahar S., A., Szabó, E., Maléth, J., Hegyi, P., Virág, L.: Poly(ADP-Ribose) Polymerase 1 Promotes Inflammation and Fibrosis in a Mouse Model of Chronic Pancreatitis. Int. J. Mol. Sci. 22(7):3593 (2021). [Open Access]    

Bakondi, E., Singh, S. B., Hajnády, Z., Nagy-Pénzes, M., Regdon, Z., Kovács, K., Hegedűs, C., Madácsy, T., Maléth, J., Hegyi, P., Demény, M.Á., Nagy, T., Kéki, S., Szabó, É., Virág, L.: Spilanthol Inhibits Inflammatory Transcription Factors and iNOS Expression in Macrophages and Exerts Anti-inflammatory Effects in Dermatitis and Pancreatitis. Int. J. Mol. Sci. 20(17):4308 (2019). [Open Access]

Bodnár, E., Bakondi, E., Kovács, K., Hegedűs, C., Lakatos, P., Robaszkiewicz, A., Regdon, Z., Virág, L., Szabó, É.: Redox Profiling Reveals Clear Differences between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds. Oxid. Med. Cell. Longev. 2018:5286785 (2018). [Open Access]

Géhl, Z., Bakondi, E., Resch, M.D., Hegedűs, C., Kovács, K., Lakatos, P,, Szabó, A., Nagy, Z., Virág, L.: Diabetes-induced oxidative stress in the vitreous humor. Redox Biol. 9, 100-103 (2016). [Open Access]

Robaszkiewicz, A., Valkó, Z., Kovács, K., Hegedűs, C., Bakondi, E., Bai, P., Virág, L.: The role of p38 signaling and poly(ADP-ribosyl)ation-induced metabolic collapse in the osteogenic differentiation-coupled cell death pathway. Free Radic. Biol. Med. 76, 69-79 (2014).

Bakondi, E., Catalgol, B., Bak, I., Jung, T., Bozaykut, P., Bayramicli, M., Ozer, N.K., Grune, T.: Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activity. Free Radic. Biol. Med. 50(1), 86-92 (2011).

Zákány, R., Bakondi, E., Juhász, T., Matta, C., Szíjgyártó, Z., Erdélyi, K., Szabó, E., Módis, L., Virág, L., Gergely, P.: Oxidative stress-induced poly(ADP-ribosyl)ation in chick limb bud-derived chondrocytes. Int. J. Mol. Med. 19(4), 597-605 (2007).

Bakondi, E., Gönczi, M., Szabó, E., Bai, P., Pacher, P., Gergely, P., Kovács, L., Hunyadi, J., Szabó, C., Csernoch, L., Virág, L.: Role of intracellular calcium mobilization and cell-density-dependent signaling in oxidative-stress-induced cytotoxicity in HaCaT keratinocytes. J. Invest. Dermatol. 121(1), 88-95 (2003). [Open Access]