Research Focus 1 investigates the underlying complex mechanisms of pathological overweight and its secondary diseases, most of which are not yet fully understood.

More than half of the adults in Germany are overweight and almost a quarter are even obese. Especially the consequences of severe overweight are problematic: the World Health Organization regards obesity as one of the main causes of cardiovascular diseases and diabetes as well as certain types of cancer. In Germany, currently more than seven million people have type 2 diabetes, and the trend is rising. The affected individuals react inadequately to the hormone insulin, which leads to elevated blood glucose levels. This can cause strokes, heart attacks, retinal damage, kidney damage and neuropathy. The life expectancy and quality of life of people with type 2 diabetes are significantly reduced. Lifestyle factors play an important role, but are only a contributing factor for the development of the disease. The aim of the scientists within Research Focus I is to elucidate the causes of obesity and type 2 diabetes as well as to develop protective and preventive nutrition strategies.