Research Topics

  • Molecular nutrition
  • Non-alcoholic fatty liver disease
  • Obesity and type 2 diabetes
  • Molecular medicine
  • Functional genomics

Selected Publications

Sehgal, R., de Mello, V. D., Männistö, V., Lindström, J., Tuomilehto, J., Pihlajamäki, J., Uusitupa, M.: Indolepropionic Acid, a Gut Bacteria-Produced Tryptophan Metabolite and the Risk of Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease. Nutrients 14(21):4695 (2022). [Open Access]

Sehgal, R., Ilha, M., Vaittinen, M., Kaminska, D., Männistö, V., Kärjä, V., Tuomainen, M., Hanhineva, K., Romeo, S., Pajukanta, P., Pihlajamäki, J., de Mello, V.D.: Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis. Nutrients 13:3509 (2021). [Open Access]

de Mello, V.D., Sehgal, R., Männistö, V., Klåvus, A., Nilsson, E., Perfilyev, A., Kaminska, D., Miao, Z., Pajukanta, P., Ling, C., Hanhineva, K., Pihlajamäki, J.: Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids. Liver Int. 41:754– 763 (2021). [Open Access]

Mathur, R., Sehgal, R., Rajora, P., Sharma, S., Kumar, R., Mathur, S.: Aegle marmelos(L.) Corr. impedes onset of insulin resistance syndrome in rats provided with drinking fructose from weaning to adulthood stages of development: A mechanistic study. Can J Physiol Pharmacol; 95(5): 572-579 (2016).