Genetics of Obesity (GOB)
Profile
Obesity and its complications such as fatty liver, type 2 diabetes and cardiovascular disorders are complex metabolic diseases that are polygenic and develop due to increased food intake and reduced physical activity. The genes identified so far can only explain a small part of the hereditary component of these diseases. Therefore, our group aims to gain further insights into the genetic factors and to investigate whether different interventions, such as intermittent fasting and exercise, can alter the expression of these genes.
Team

Dr. Heike Vogel
Head of the Research Groupphone: +49 33 200 88 - 4545
e-mail: heikevogel@dife.de

Stefanie Fertig
Doctoral studentphone: +49 33 200 88 - 2377
e-mail: stefanie.fertig@dife.de

Omar Baritello
Doctoral student (guest)phone: +49 33 200 88 - 2140
e-mail: omar.baritello@dife.de

Josefine Würfel
Laboratory assistantphone: +49 33 200 88 - 2328
e-mail: josefine.wuerfel@dife.de

Julia Rominger
Master studentphone: +49 33 200 88 - 2286
e-mail: julia.rominger@dife.de
Cross group collaboration
The group "Genetics of Obesity" is part of the junior research group "Molecular and Clinical Life Science of Metabolic Diseases" (SMD), which was initiated in 2021 in cooperation with the University of Potsdam and is headed by Dr. Heike Vogel. The international and interdisciplinary SMD junior research group is affiliated with the Health Sciences Network at the Faculty of Health Sciences. The group includes a total of seven PhD students, each associated to various departments of the Faculty of Human Sciences, the Faculty of Science, the Faculty of Health Sciences and the DIfE. The PhD students are each supported by an experienced postdoc (tandem partner). The different PhD projects of the junior group focus, among other things, on mechanisms and moderators of metabolic diseases that could facilitate or influences the development of sarcopenia. The University of Potsdam reported on the group in its magazine "Portal Wissen - Eins 2021": OLD AGE WITHOUT FRAGILITY - Young researchers are investigating how the interplay of genes, nutrition, and exercise can influence muscle loss as we age.
Overview of the other SMD projects:
Location
DIfE (Depatment of Experimental Diabetology)
Supervisor
Prof. Dr. Annette Schürmann
Tandem partner
Dr. Meriem Ouni
Doctoral student
Leona Kovac
The aim of the PhD thesis is to investigate the changes in skeletal muscle gene expression and epigenome in obese individuals after bariatric surgery compared to lean controls. In addition, the effect of four weeks of training on the muscle expression profile and epigenome will be investigated in mice and humans. Other intervention methods (e.g. training, intermittent fasting, caloric restriction, protein restriction) will be compared between obese and lean mouse models to identify a possible treatment strategies that induces beneficial effects comparable to those observed after bariatric surgery.
Location
University of Potsdam, Faculty of Human Sciences, Chair of Social and Preventive Medicine
Supervisor
Prof. Dr. Dr. Michael A. Rapp
Tandem partner
Dr. Andreas Heißel
Doctoral student
Darlene Heinen
In this project, the researchers are investigating the influence of sarcopenia on the risk of depressive disorders and the effects of sports therapy interventions on the risk of depression and the degree of depressiveness. In order to establish hypotheses and describe the relationships between sarcopenia, depressiveness and the course of the disease, the researchers will analyse data from the following two studies:
- Randomised controlled intervention study SPEeD: Sports therapy and psychotherapy - an evaluation study with depression patients (Heinzel et al., 2018)
- Prospective, cluster-randomised, partially blinded care study STEP.De: Sports therapy for depression (Heissel et al., 2020)
Location
University of Potsdam, Faculty of Human Sciences, Professorship for rehabilitation medicine
Supervisor
Prof. Dr. Heinz Völler
Tandem partner
Dr. Annett Salzwedel
Doctoral student
Omar Baritello
The project aims to investigate which frailty assessment is the best predictor of short and mid-term outcome (e.g. survival, mortality, neurological deficits, length-of-stay at ICU/in- hospital, quality-of-life etc.) for older patients eligible for cardiac surgery or transcatheter treatment. Further, it will be studied if a frailty index might be implemented in cardiac clinical prediction models (e.g. EuroSCORE, ACC) and how its outcomes will affect the clinicians' decision.
Location
University of Potsdam, Faculty of Human Sciences, Professorship for Medical sociology and psychobiology
Supervisor
Prof. Dr. Pia-Maria Wippert
Tandem partner
Dr. Linn Kühl
Doctoral student
Sanne Houtenbos
First, the aim of this project is to provide meta-analysis of the existing evidence regarding the influence of various exercise types on osteoporosis in depressed patients (underlying mechanisms, mediators and moderators). Subsequently, differences in the miRNA profile will be investigated in the plasma of individuals with psychological stress compared to non-affected controls. Third and lastly, the newly gained knowledge will be implemented in an exercise intervention for depressed people with osteoporosis to develop further therapy options.
Location
University of Potsdam, Outpatient Clinic, Professorship for Sports Medicine and Sports Orthopedics
Supervisor
Prof. Dr. Frank Mayer
Tandem partner
Dr. Tilman Engel
Doctoral student
Dominik Sonnenburg
The PhD project aims to verify the feasibility and effectiveness of a high-load eccentric training compared to traditional concentric resistance/strength training to improve muscle strength and coordination in combination with a nutritional intervention in older, overweight, physical inactive people. In addition, the potential effect of specific diets on changes in muscle quantity, quality and health-promoting effects (e.g. lipid profile, inflammation) in combination with a time-limited high-load exercise will be studied.
Location
University of Potsdam, Institute of Nutritional Science, Professorship of Biochemistry of nutrition
Supervisor
Prof. Dr. Gerhard P. Püschel
Tandempartnerin
Prof. Dr. Janin Henkel-Oberländer
Doctoral student
Sonja Kuipers
The aim of this project is to characterize the contribution of Cox2-dependent prostanoids such as PGE2 in the pathogenesis of high-fat, high-cholesterol diet-induced steatohepatitis (NASH). For this purpose, feeding studies in mice with specific deletion of Cox2 in hepatocytes, macrophages or both cell types will be used, as well as corresponding wild-type controls. Furthermore, the influence of the high-fat, high-cholesterol diet on the development of sarcopenia will be investigated in the above-mentioned wild-type control mice.
Publications of the Research Group
We are currently working on a solution for the implementation of our publication database. Until then, you can get an overview with the researchers' ORCID and customized search details on PubMed. Thank you for your understanding! We will be happy to assist you in your search. Please contact our Literature Service: literaturservice@dife.de.