Research Topics

  • Dietary Fiber
  • Gut Microbiota
  • Short-Chain Fatty Acids (SCFA)
  • Propionyl-CoA Sources
  • Odd-Chain Fatty Acids (OCFA)
  • Mouse/Human Dietary Intervention Studies

Key Publications

Bishop, C. A., Schulze, M. B., Klaus, S., Weitkunat, K.: The branched-chain amino acids valine and leucine have differential effects on hepatic lipid metabolism. Faseb J. 34(7), 9727-9739 (2020). [Open Access]

Graf, D., Weitkunat, K., Dötsch, A., Liebisch, G., Döring, M., Krüger, R., Vatareck, E., von Coburg, E., Loh, G., Watzl, B.: Specific wheat fractions influence hepatic fat metabolism in diet-induced obese mice. Nutrients 11(10): e2348 (2019). [Open Access]

Yan, X., Wang, Z., Bishop, C. A., Weitkunat, K., Feng, X., Tarbier, M., Luo, J., Friedländer, M. R., Burkhardt, R., Klaus, S., Willnow, T. E., Poy, M. N.: Control of hepatic gluconeogenesis by Argonaute2. Mol. Metab. 18, 15-24 (2018). [Open Access]

Weitkunat, K., Schumann, S., Nickel, D., Hornemann, S., Petzke, K. J., Schulze, M. B., Pfeiffer, A. F. H., Klaus, S.: Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate. Am. J. Clin. Nutr. 105, 1544-1551 (2017).

Weitkunat, K., Stuhlmann, C., Postel, A., Rumberger, S., Fankhänel, M., Woting, A., Petzke, K. J., Gohlke, S., Schulz, T. J., Blaut, M., Klaus, S., Schumann, S.: Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice. Sci. Rep. 7: 6109 (2017). [Open Access]

Weitkunat, K., Schumann, S., Nickel, D., Kappo, K. A., Petzke, K. J., Kipp, A. P., Blaut, M., Klaus, S.: Importance of propionate for the repression of hepatic lipogenesis and improvement of insulin sensitivity in high-fat diet-induced obesity. Mol. Nutr. Food Res. 60, 2611-2621 (2016). [Open Access]

Weitkunat, K., Schumann, S., Petzke, K. J., Blaut, M., Loh, G., Klaus, S.: Effects of dietary inulin on bacterial growth, short-chain fatty acid production and hepatic lipid metabolism in gnotobiotic mice. J. Nutr. Biochem. 26, 929-937 (2015).