Research Topics

  • Aging
  • Nutrition
  • Metabolic Stress
  • Typ 2 Diabetes
  • Islets of Langerhans
  • Cellular Senescence
  • Proteostasis

Key Publications

Fernando, R., Wardelmann, K., Deubel, S., Kehm, R., Jung, T., Mariotti, M., Vasilaki, A., Gladyshev, V. N., Kleinridders, A., Grune, T., Castro, J. P.: Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration. Redox Biol 32: 101507 (2020).

Jin, C. J., Baumann, A., Brandt, A., Engstler, A. J., Nier, A., Hege, M., Schmeer, C., Kehm, R., Hohn, A., Grune, T., Witte, O. W., Bergheim, I.: Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels. Am J Physiol Gastrointest Liver Physiol 318(4), G736-G747 (2020).

Brandt, A., Hernández-Arriaga, A., Kehm, R., Sánchez, V., Jin, C. J., Nier, A., Baumann, A., Camarinha-Silva, A., Bergheim, I.: Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine. Sci. Rep. 9(1):6668 (2019).

Kehm, R., Rückriemen, J., Weber, D., Deubel, S., Grune, T., Höhn, A.: Endogenous advanced glycation end products in pancreatic islets after short-term carbohydrate intervention in obese, diabetes-prone mice. Nutr. Diabetes 9(1):9 (2019). [Open Access]

Kehm, R., König, J., Nowotny, K., Jung, T., Deubel, S., Gohlke, S., Schulz, T. J., Höhn, A.: Age-related oxidative changes in pancreatic islets are predominantly located in the vascular system. Redox Biol. 15, 387-393 (2018). [Open Access]

Grune, T., Kehm, R., Höhn, A., Jung, T.: "Cyt/Nuc", a customizable and documenting ImageJ macro for evaluation of protein distributions between cytosol and nucleus. Biotechnol. J. 13:1700652 (2018). [Open Access]

Höhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J.Grune, T., Castro, J. P.: Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol. 11, 482-501 (2017). [Open Access]