Research Topics

  • Proteostasis
  • Autophagy
  • Aging
  • Metabolic Dysfunction
  • Cardiomyocyte Contractility and Calcium
  • Primary Cardiomyocyte Culture
  • Inflammation
  • Lycopene

Key Publications

Fernando, R., Castro, J. P., Flore, T., Deubel, S., Grune, T., Ott, C.: Age-Related Maintenance of the Autophagy-Lysosomal System Is Dependent on Skeletal Muscle Type. Oxi. Med. Cell. Longev. 2020: 4908162 (2020). [Open Access]

Häseli, S., Deubel, S., Jung, T., Grune, T., Ott, C.: Cardiomyocyte Contractility and Autophagy in a Premature Senescence Model of Cardiac Aging. Oxi Med and Cell Long 2020: 8141307 (2020). [Open Access]

Grune, T., Ott, C., Häseli, S., Höhn, A., Jung, T.: The “MYOCYTER” – Convert cellular and cardiac contractions into numbers with ImageJ. Sci. Rep. 9: 15112 (2019). [Open Access]

Schröter, D., Neugart, S., Schreiner, M., Grune, T., Rohn, S., Ott, C.: Amaranth’s 2-Caffeoylisocitric Acid—An Anti-Inflammatory Caffeic Acid Derivative That Impairs NF-κB Signaling in LPS-Challenged RAW 264.7 Macrophages. Nutrients 11(3): 571 (2019). [Open Access]

Ott, C., König, J., Höhn, A., Jung, T., Grune, T.: Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts. Red. Bio. 10, 266-273 (2016). [Open Access]

Ott, C., König, J., Höhn, A., Jung, T., Grune, T.: Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts. Free Rad. Bio. Med. 101, 325-333 (2016). [Open Access]

Ott, C., Jacobs, K., Haucke, E., Navarrete Santos, A., Grune, T., Simm, A.: Role of advanced glycation end products in cellular signaling. Red. Bio. 2, 411-429 (2014). [Open Access]