Research Topics

  • Investigation of therapeutic approaches for non-alcoholic fatty liver in a mouse model
  • Metabolic phenotyping of mouse models in the context of adioposity and diabetes research

Key Publications

Gässler, A., Quiclet, C., Kluth, O., Gottmann, P., Schwerbel, K., Helms, A., Stadion, M., Wilhelmi, I., Jonas, W., Ouni, M., Mayer, F., Spranger, J., Schürmann, A., Vogel, H.: Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells. Mol Met in press (E-pub ahead of print), (Brief Communication) (2020).

Schwerbel, K., Kamitz, A., Krahmer, N., Hallahan, N., Jähnert, M., Gottmann, P., Lebek, S., Schallschmidt, T., Arends, D., Schumacher, F., Kleuser, B., Haltenhof, T., Heyd, F., Gancheva, S., Broman, K. W., Roden, M., Joost, H.-G., Chadt, A., Al-Hasani, H., Vogel, H., Jonas, W., Schürmann, A.: Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation. J Hepatol in press (E-pub ahead of print) (2020).

Matthaeus, C., Lahmann, I., Kunz, S., Jonas, W., Melo, A. A., Lehmann, M., Larsson, E., Lundmark, R., Kern, M., Bluher, M., Olschowski, H., Kompa, J., Brugger, B., Muller, D. N., Haucke, V., Schurmann, A., Birchmeier, C., Daumke, O.: EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake. PNAS 117(13), 7471-7481 (2020).

Vogel, H., Kamitz, A., Hallahan, N., Lebek, S., Schallschmidt, T., Jonas, W., Jähnert, M., Gottmann, P., Zellner, L., Kanzleiter, T., Damen, M., Altenhofen, D., Burkhardt, R., Renner, S., Dahlhoff, M., Wolf, E., Müller, T. D., Blüher, M., Joost, H.-G., Chadt, A., Al-Hasani, H., Schürmann, A.: A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and type 2 diabetes. Hum. Mol. Genet. 27, 3099-3113 (2008).

Henkel, J., Coleman, C. D., Schraplau, A., Jöhrens, K., Weiss, T. S., Jonas, W., Schürmann, A., Püschel, G. P.: Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model. Sci. Rep. 8(1):16127 (2018).

Kammel, A., Saussenthaler, S., Jähnert, M., Jonas, W., Stirm, L., Hoeflich, A., Staiger, H., Fritsche, A., Häring, H. U., Joost, H.-G., Schürmann, A., Schwenk, R. W.: Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice. Hum. Mol. Genet. 25, 2588-2599 (2016).

Jonas, W., Lietzow, J., Wohlgemuth, F., Hoefig, C. S., Wiedmer, P., Schweizer, U., Köhrle, J., Schürmann, A.: 3,5-Diiodo-L-thyronine (3,5-T2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice. Endocrinology 156, 389-399 (Open Access) (2015).

Vogel, H., Montag, D., Kanzleiter, T., Jonas, W., Matzke, D., Scherneck, S., Chadt, A., Töle, J., Kluge, R., Joost, H.-G., Schürmann, A.: An interval of the obesity QTL Nob3.38 within a QTL hotspot on chromosome 1 modulates behavioral phenotypes. PLoS ONE 8(1):e53025 (2013).