Research Topics

  • Molecular biology
  • Epigenetic and metabolism
  • Obesity
  • Type 2 diabetes

Selected Publications

Wilhelmi, I., Neumann, A., Jähnert, M., Ouni, M., Schürmann, A.: Enriched Alternative Splicing in Islets of Diabetes-Susceptible Mice. Intern. J. Mol. Sci. 22(16):8597 (2021). [Open Access]

Ouni, M., Gottmann, P., Westholm, E., Schwerbel, K., Jähnert, M., Stadion, M., Rittig, K., Vogel, H., Schürmann, A.: MiR-205 is upregulated in islets of diabetes-susceptible mice and targets the diabetes gene Tcf7l2. Acta Physiol. 232(4):e13693 (2021). [Open Access]

Ouni, M., Saussenthaler, S., Eichelmann, F., Jähnert, M., Stadion, M., Wittenbecher, C., Rönn, T., Zellner, L., Gottmann, P., Ling, C., Schulze, M. B., Schürmann, A.: Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes. Diabetes 69(11), 2503-2517 (2020).

Gässler, A., Quiclet, C., Kluth, O., Gottmann, P., Schwerbel, K., Helms, A., Stadion, M., Wilhelmi, I., Jonas, W., Ouni, M., Mayer, F., Spranger, J., Schürmann, A., Vogel, H.: Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells. Mol. Metab. 41:101042 (Brief Communication) (2020). [Open Access]

Ouni, M., Schürmann, A.: Epigenetic contribution to obesity. Mamm Genome 31, 134–145 (2020). [Open Access]

Gottmann, P., Ouni, M., Zellner, L., Jahnert, M., Rittig, K., Walther, D., Schürmann, A.: Polymorphisms in miRNA binding sites involved in metabolic diseases in mice and humans. Sci. Rep. 10(1):7202 (2020). [Open Access]

Gancheva, S., Ouni, M., Jelenik, T., Koliaki, C., Szendroedi, J., Toledo, F. G. S., Markgraf, D. F., Pesta, D. H., Mastrototaro, L., De Filippo, E., Herder, C., Jähnert, M., Weiss, J., Strassburger, K., Schlensak, M., Schürmann, A., Roden, M.: Dynamic changes of muscle insulin sensitivity after metabolic surgery. Nat. Commun. 10(1):4179 (2019).

Saussenthaler, S., Ouni, M., Baumeier, C., Schwerbel, K., Gottmann, P., Christmann, S., Laeger, T., Schürmann, A.: Epigenetic regulation of hepatic Dpp4 expression in response to dietary protein. J. Nutr. Biochem. 63, 109-116 (2019).

Wittenbecher, C., Ouni, M., Kuxhaus, O., Jähnert, M., Gottmann, P., Teichmann, A., Meidtner, K., Kriebel, J., Grallert, H., Pischon, T., Boeing, H., Schulze, M. B., Schürmann, A.: Insulin-like growth factor binding protein 2 (IGFBP-2) and the risk of developing type 2 diabetes. Diabetes 68, 188-197 (2019).

Gottmann, P., Ouni, M., Saussenthaler, S., Roos, J., Stirm, L., Jähnert, M., Kamitz, A., Hallahan, N., Jonas, W., Fritsche, A., Häring, H.U., Staiger, H., Blüher, M., Fischer-Posovszky, P., Vogel, H., Schürmann, A.: A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes. Mol. Metab. 11, 145-159 (2018). [Open Access]

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