Research Topics

  • Cellbiological Aspects of Insulin Secretion
  • Protein Trafficking
  • Formation and Movement of Insulin Containing Granules

Key Publications

Gässler, A., Quiclet, C., Kluth, O., Gottmann, P., Schwerbel, K., Helms, A., Stadion, M., Wilhelmi, I., Jonas, W., Ouni, M., Mayer, F., Spranger, J., Schürmann, A., Vogel, H.: Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells. Mol Met in press (E-pub ahead of print), (Brief Communication) (2020). [Open access]

Sztul, E., Chen, P. W., Casanova, J. E., Cherfils, J., Dacks, J. B., Lambright, D. G., Lee, F. S., Randazzo, P. A., Santy, L. C., Schürmann, A., Wilhelmi, I., Yohe, M. E., Kahn, R. A.: ARF GTPases and their GEFs and GAPs: concepts and challenges. Mol. Biol. Cell 30, 1249-1271 (2019).

Neumann, A., Schindler, M., Olofsson, D., Wilhelmi, I., Schürmann, A., Heyd, F.: Genome-wide identification of alternative splicing events that regulate protein transport across the secretory pathway. J. Cell Sci. 132:jcs230201 (2019).

Song, K., Gras, C., Capin, G., Gimber, N., Lehmann, M., Mohd, S., Puchkov, D., Rödiger, M., Wilhelmi, I., Daumke, O., Schmoranzer, J., Schürmann, A., Krauss, M.: A SEPT1-based scaffold is required for Golgi integrity and function. J. Cell Sci. 132(3): jcs225557 (2019). [Open Access]

Werno, M. W., Wilhelmi, I., Kuropka, B., Ebert, F., Freund, C., Schürmann, A.: The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells. Biochem. Biophys. Res. Commun. 506, 259-265 (2018). [Open Access]

Rödiger, M., Werno, M. W., Wilhelmi, I., Baumeier, C., Hesse, D., Wettschureck, N., Offermanns, S., Song, K., Krauß, M., Schürmann, A.: Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes. Mol. Metab. 8, 167-179 (2018). [Open Access]

Wilhelmi, I., Kanski, R., Neumann, A., Herdt, O., Hoff, F., Jacob, R., Preußner, M., Heyd, F.: Sec16 alternative splicing dynamically controls COPII transport efficiency. Nat Commun. 7:12347 (2016). [Open Access]