Prof. Dr. Tilman Grune has been the Scientific Director of the institute, Professor for Molecular Toxicology at the University of Potsdam, and the head of the Department of Molecular Toxicology at the DIfE since 2014. His research is directed towards the damage of proteins in cells and tissues during aging and induced by metabolic or redox challenges. Specifically, his department aims to identify, how nutrition may influence the generation and degradation of these damaged proteins.

Tilman Grune is author and co-author of several books and over 400 publications. He is founding editor and editor-in-chief of Redox Biology, the leading journal in this research field. At the same time, he is on the editorial board of several renown scientific journals and is reviewer for numerous journals and funding bodies. As an internationally highly respected scientist, Tilman Grune received an honorary doctorate from the University of Buenos Aires in 2013. In 2019, the Society of Free Radical Research - Europe (SFRR-E) presented him with the SFRR-E Annual Award for his work on "Oxidative damage, proteolysis and protein aggregates". Since the beginning of 2020, Tilman Grune has also been Professor of Physiological Chemistry and Cellular Biochemistry at the University of Vienna.

The toxicologist is active in various advisory boards and expert committees, for example as a member of the Senate Commission of the German Research Foundation for the health assessment of food. The scientist also provides advice on political issues in the form of short-term statements or of evaluations considering long-term developments. He also plays a leading role in major lighthouse projects, e.g. as spokesman for the competence cluster for nutritional science NutriAct.

Selected Publications

Stokes, C. S., Weber, D., Wagenpfeil, S., Stuetz, W., Moreno-Villanueva, M., Dollé, M. E. T., Jansen, E., Gonos, E. S., Bernhardt, J., Grubeck-Loebenstein, B., Fiegl, S., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Capri, M., Hervonen, A., Slagboom, P. E., Breusing, N., Frank, J., Bürkle, A., Franceschi, C., Grune, T.: Association between fat-soluble vitamins and self-reported health status: a cross-sectional analysis of the MARK-AGE cohort. Br. J. Nutr. 128(3), 433-443 (2022). [Open Access]

Ott, C., Pappritz, K., Hegemann, N., John, C., Jeuthe, S., McAlpine, C. S., Iwamoto, Y., Lauryn, J. H., Klages, J., Klopfleisch, R., Van Linthout, S., Swirski, F., Nahrendorf, M., Kintscher, U., Grune, T., Kuebler, W. M., Grune, J.: Spontaneous Degenerative Aortic Valve Disease in New Zealand Obese Mice. J. Am. Heart Assoc. 10(23):e023131 (2021). [Open Access]

Ott, C., Tomasina, F., Campolo, N., Bartesaghi, S., Mastrogiovanni, M., Leyva, A., Batthyany, C., Meinl, W., Grune, T., Radi, R.: Decreased proteasomal cleavage at nitrotyrosine sites in proteins and peptides. Redox Biol. 46:102106 (2021). [Open Access]

Kehm, R., Jähnert, M., Deubel, S., Flore, T., König, J., Jung, T., Stadion, M., Jonas, W., Schürmann, A., Grune, T., Höhn, A.: Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: role of Thioredoxin-interacting protein (TXNIP). Red. Bio. 37:101748 (2020). [Open Access]

Raupbach, J., Ott, C., Koenig, J., Grune, T.: Proteasomal degradation of glycated proteins depends on substrate unfolding: Preferred degradation of moderately modified myoglobin. Free Radic. Biol. Med. 152, 516-524 (2020). [Open Access]

Grune, T.: Oxidized protein aggregates: Formation and biological effects. Free Radic. Biol. Med 150, 120-124 (2020). [Open Access]

Kochlik, B., Stuetz, W., Pérès, K., Féart, C., Tegner, J., Rodriguez-Mañas, L., Grune, T., Weber, D.: Associations of plasma 3-methylhistidine with frailty status in French cohorts of the FRAILOMIC initiative. J. Clin. Med. 8(7):1010 (2019). [Open Access]

Pinchuk, I., Weber, D., Kochlik, B., Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Dollé, M. E. T., Jansen, E. H. J. M., Gonos, E. S., Sikora, E., Breusing, N., Gradinaru, D., Sindlinger, T., Moreno-Villanueva, M., Bürkle, A., Grune, T., Lichtenberg, D.: Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study. Redox Biol. 24:101204 (2019). [Open Access]

Ott, C., Jacobs, K., Haucke, E., Santos, A. N., Grune, T., Simm, A.: Role of advanced glycation end products in cellular signaling. Redox Biol. 2, 411-429 (2014).

Jung, T., Catalgol, B., Grune, T.: The proteasomal system. Mol. Asp. Med. 30 (4), 191-296 (2009).