About

Prof. Dr. Tilman Grune has been the Scientific Director of the institute, Professor for Molecular Toxicology at the University of Potsdam, and the head of the Department of Molecular Toxicology at the DIfE since 2014. His research is directed towards the damage of proteins in cells and tissues during aging and induced by metabolic or redox challenges. Specifically, his department aims to identify, how nutrition may influence the generation and degradation of these damaged proteins.

Tilman Grune is author and co-author of several books and over 400 publications. He is founding editor and editor-in-chief of Redox Biology, the leading journal in this research field. At the same time, he is on the editorial board of several renown scientific journals and is reviewer for numerous journals and funding bodies. As an internationally highly respected scientist, Tilman Grune received an honorary doctorate from the University of Buenos Aires in 2013. In 2019, the Society of Free Radical Research - Europe (SFRR-E) presented him with the SFRR-E Annual Award for his work on "Oxidative damage, proteolysis and protein aggregates". Since the beginning of 2020, Tilman Grune has also been Professor of Physiological Chemistry and Cellular Biochemistry at the University of Vienna.

The toxicologist is active in various advisory boards and expert committees, for example as a member of the Senate Commission of the German Research Foundation for the health assessment of food. The scientist also provides advice on political issues in the form of short-term statements or of evaluations considering long-term developments. He also plays a leading role in major lighthouse projects, e.g. as spokesman for the competence cluster for nutritional science NutriAct.

Key Publications

Grune, T.: Oxidized protein aggregates: Formation and biological effects. Free Radic. Biol. Med 150, 120-124 (2020). [Open Access]

Press, M., Jung, T., König, J., Grune, T., Höhn, A.: Protein aggregates and proteostasis in aging: Amylin and β-cell function. Mech. Ageing Dev. 177, 46-54 (2019). [Open Access]

Nowotny, K., Schröter, D., Schreiner, M., Grune, T.: Dietary advanced glycation end products and their relevance for human health. Ageing Res. Rev. 47, 55-66 (2018). [Open Access]

Kochlik, B., Grune, T., Weber, D.: New findings of oxidative stress biomarkers in nutritional research. Curr. Opin. Clin. Nutr. Metab. Care 20, 349-359 (2017). [Open Access]

Höhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J.Grune, T., Castro, J. P.: Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol. 11, 482-501 (2017). [Open Access]

Castro, J. P., Jung, T., Grune, T., Siems, W.: 4-Hydroxynonenal (HNE) modified proteins in metabolic diseases. Free Radic. Biol. Med. 111, 309-315 (2017). [Open Access]

Egea, J., Fabregat, I., Frapart, Y. M., [...],Grune, T., Lamas, S., Schmidt, H. H. H. W., Di Lisa, F., Daiber, A.: European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol. 13, 94-162, (Corrigendum: Redox Biol. 14, 694-696 (2017). [Open Access]

Ott, C., Jacobs, K., Haucke, E., Santos, A. N., Grune, T., Simm, A.: Role of advanced glycation end products in cellular signaling. Redox Biol. 2, 411-429 (2014).

Höhn, A., Jung, T., Grune, T.: Pathophysiological importance of aggregated damaged proteins. Free Radic. Biol. Med. 71, 70-89 (2014).

Jung, T., Catalgol, B., Grune, T.: The proteasomal system. Mol. Asp. Med. 30 (4), 191-296 (2009).