Research Topics

  • Intestinal Microbiota
  • Microbe-Host-Interactions
  • Dietary Fiber
  • Bile Acid Metabolism
  • Prevention of colorectal cancer
  • Nutrition transition in sub-Saharan Africa

Key Publications

Ocvirk, S. & O’Keefe, S. J. D.: Dietary fat, bile acid metabolism and colorectal cancer. Semin. Cancer Biol. 73, 347–355 (2021).

Ocvirk, S., Wilson, A. S., Posma, J. M., Li, J. V., Koller, K. R., Day, G. M., Flanagan, C. A., Otto, J. E., Sacco, P. E., Sacco, F. D., Sapp, F. R., Wilson, A. S., Newton, K., Brouard, F., DeLany, J. P., Behnning, M., Appolonia, C. N., Soni, D., Bhatti, F., Methe, B., Fitch, A., Morris, A., Gaskins, H. R., Kinross, J., Nicholson, J. K., Thomas, T. K., O’Keefe, S. J. D.: A prospective cohort analysis of gut microbial co-metabolism in Alaska Native and rural African people at high and low risk of colorectal cancer. Am. J. Clin. Nutr. 111(2), 406–419 (2020).

Katsidzira, L., Ocvirk, S., Wilson, A., Li, J., Mahachi, C. B., Soni, D., DeLany, J., Nicholson, J. K., Zoetendal, E. G., O’Keefe, S. J. D.: Differences in fecal gut microbiota, short-chain fatty acids and bile acids link colorectal cancer risk to dietary changes associated with urbanization among Zimbabweans. Nutr. Cancer. 71, 1313-1324 (2019).

Ocvirk S., O’Keefe S. J. D.: Influence of Bile Acids on Colorectal Cancer Risk: Potential Mechanisms Mediated by Diet - Gut Microbiota Interactions. Curr. Nutr. Rep. 6(4), 315–22 (2017).