Research Topics

  • Brain Development
  • Neural Circuits
  • Melanocortin System
  • Maternal Programming of Brain Development
  • Central Control of Metabolism
  • Maternal Nutrition (Obesity and Diabetes)
  • Neural Circuit Interaction

Key Publications

Lippert, R. N., Hess, S., Klemm, P., Burgeno, L. M., Jahans-Price, T., Walton, M. E., Kloppenburg, P., Brüning, J. C.: Maternal high fat diet during lactation reprograms the dopaminergic circuitry in mice. J. Clin. Inv. 130(7), 3761-3776 (2020).

Edwin Thanarajah, S., Backes, H., Di Feliceantonio, A. G., Albus, K., Cremer, A., Hanssen, R., Lippert, R. N., Cornely, O., Small, D. M., Brüning, J. C., Tittgemeyer, M.: Food intake recruits segregated orosensory and post-ingestive dopaminergic neural circuits to affect eating desire in humans. Cell Metab. 29(3), 695-706.e4 (2019).

Lippert, R. N., Cremer, A., Edwin Thanarajah, S., Korn, C., Jahans-Price, T., Tittgemeyer, M., Brüning, J. C., Walton, M. E., Backes, H.: Time-dependent assessment of stimulus-evoked regional dopamine release. Nat. Com. 10: 336 (2019).

Ruud, J., Alber, J., Tokarsks, A., Engström-Ruud, L., Nolte, H., Biglari, N., Lippert, R., Lautenschlager, Ä., Cieslak, P. E., Szumiec, L., Hess, M. E., Brönneke, H. S., Krüger, M., Nissbrandt, H., Korotkova, T., Silberberg, G., Parkitna, J. R., Brüning, J. C.: The fat mass and obesity-associates protein (FTO) regulates locomotor responses to novelty via D2R medium spiny neurons. Cell Rep. 27(11), 3182-3198.e9 (2019).

Ghamari-Langroudi, M., Cakir, I., Lippert, R. N., Litt, M. J., Sweeney, P., Ellacott, K. L. J., Cone, R. D.: Regulation of energy rheostasis by the melanocortin-3 receptor.  Sci. Adv. 4(8): eaat0866 (2018).

Leung, W., et al.: Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. G3 (Bethesda) 5(5), 719-740 (2015).

Buckman, L. B., Thompson, M. M., Lippert, R. N., Blackwell, T. S., Yull, F. E., Ellacott, K. L. J.: Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice. Mol. Met. 4(1), 58–63 (2014).

Lippert, R. N., Ellacott, K. L. J., Cone, R. D.: Gender-specific roles for the melanocortin 3 receptor in the regulation of food intake and preference in mice. Endocrin. 155(5), 1718-1727 (2014).

Renquist, B. J., Lippert, R. N., Sebag, J. A., Ellacott, K. L. J., Cone, R. D.: Physiological roles of the melanocortin MC3 receptor. Euro. J. Pharm. 660(1), 13–20 (2011).