Research Topics

• Pathophysiology of the Metabolic Syndrome and Type 2 Diabetes
• Genetic and Epigenetic Alterations Contributing to Obesity and Beta Cell Failure
• Role of Different Diets and Nutritional Components and their Protective Effects on Obesity and Diabetes
• Vesicular Transport Processes Involved in Insulin Secretion from Beta Cells

Selected Publications

Schwerbel, K., Kamitz, A., Krahmer, N., Hallahan, N., Jähnert, M., Gottmann, P., Lebek, S., Schallschmidt, T., Arends, D., Schumacher, F., Kleuser, B., Haltenhof, T., Heyd, F., Gancheva, S., Broman, K. W., Roden, M., Joost, H.-G., Chadt, A., Al-Hasani, H., Vogel, H., Jonas, W., Schürmann, A.: Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation. J. Hepatol. 73(4), 771-782 (2020). [Open Access]

Gancheva, S., Ouni, M., Jelenik, T., Koliaki, C., Szendroedi, J., Toledo, F. G. S., Markgraf, D. F., Pesta, D.H., Mastrototaro, L., De Filippo, E., Herder, C., Jähnert, M., Weiss, J., Strassburger, K., Schlensak, M., Schürmann, A., Roden, M.: Dynamic changes of muscle insulin sensitivity after metabolic surgery. Nat. Commun. 10:4179 (2019). [Open Access]

Kluth, O., Stadion, M., Gottmann, P., Aga, H., Jähnert, M., Scherneck, S., Vogel, H., Krus, U., Seelig, A., Ling, C., Gerdes, J., Schürmann, A.: Decreased Expression of cilia genes in pancreatic islets as a risk factor for type 2 diabetes in mice and humans. Cell Rep. 26(11), 3027-3036.e3 (2019). [Open Access]

Wittenbecher, C., Ouni, M., Kuxhaus, O., Jähnert, M., Gottmann, P., Teichmann, A., Meidtner, K., Kriebel, J., Grallert, H., Pischon, T., Boeing, H., Schulze, M. B., Schürmann, A.: Insulin-like growth factor binding protein 2 (IGFBP-2) and the risk of developing type 2 diabetes. Diabetes 68, 188-197 (2019). [Open Access]

Gottmann, P., Ouni, M., Sausenthaler, S., Roos, J., Stirm, L., Jähnert, M., Kamitz, A., Hallahan, N., Jonas, W., Fritsche, A., Häring, H.-U., Staiger, H., Blüher, M., Fischer-Posovszky, P., Vogel, H., Schürmann, A.: A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes. Mol. Metab. 11, 145-159 (2018). [Open Access]

Laeger, T., Castaño-Martinez, T., Werno, M. W., Japtok, L., Baumeier, C., Jonas, W., Kleuser, B., Schürmann, A.: Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes. Diabetologia 61, 1459-1469 (2018). [Open Access]

Rödiger, M., Werno, M. W., Wilhelmi, I., Baumeier, C., Hesse, D., Wettschureck, N., Offermanns, S., Song, K., Krauß, M., Schürmann, A.: Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes. Mol. Metab. 8, 167-179 (2018). [Open Access]

Stadion, M., Schwerbel, K., Graja, A., Baumeier, C., Rödiger, M., Jonas, W., Wolfrum, C., Staiger, H., Fritsche, A., Häring, H.-U., Klöting, N., Blüher, M., Fischer-Posovszky, P., Schulz, T. J., Joost, H.-G., Vogel, H., Schürmann, A.: Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans. Diabetologia 61, 1167-1179 (2018). [Open Access]

Vogel, H., Kamitz, A., Hallahan, N., Lebek, S., Schallschmidt, T., Jonas, W., Jähnert, M., Gottmann, P., Zellner, L., Kanzleiter, T., Damen, M., Altenhofen, D., Burkhardt, R., Renner, S., Dahlhoff, M., Wolf, E., Müller, T. D., Blüher, M., Joost, H.-G., Chadt, A., Al-Hasani, H., Schürmann, A.: A collective diabetes cross in combination with a computational framework to dissect the genetics of human obesity and type 2 diabetes. Hum. Mol. Genet. 27, 3099-3113 (2018). [Open Access]

Baumeier, C., Saussenthaler, S., Kammel, A., Jähnert, M., Schlüter, L., Hesse, D., Canouil, M., Lobbens, S., Caiazzo, R., Raverdy, V., Pattou, F., Nilsson, E., Pihlajamäki, J., Ling, C., Froguel, P., Schürmann, A., Schwenk, R. W.: Hepatic DPP4 DNA-methylation associates with fatty liver. Diabetes 6, 25-35 (2017). [Open Access]