Research Topics

  • Muscle Physiology
  • Metabolism
  • CRISPR-mediated activation of gene expression
  • Obesity and type 2 diabetes
  • Endocrinology
  • Thermoregulation

Key Publications

Nock, S., Johann, K., Harder, L., Wirth, E. K., Renko, K., Hoefig, C.S., Kracke, V., Hackler, J., Engelmann, B., Rauner, M., Koerhle, J., Schomburg, L., Homuth, G., Voelker, U., Brabant, G., Mittag, J.: CD5L constitutes a novel biomarker for integrated hepatic thyroid hormone action. Thyroid 30(6), 908-923 (2020).

Johann, K., Cremer, A. L., Fischer, A. W., Heine, M., Pensado, E. R., Resch, J., Nock, S., Virtue, S., Harder, L., Oelkrug, R., Astiz, M., Brabant, G., Warner, A., Vidal-Puig, A., Oster, H., Boelen, A., López, M., Heeren, J., Backes, H., Mittag, J.: Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption. Cell Rep. 27(11), 3385-3400 (2019). [Open Access]

Gachkar, S., Nock, S., Geissler, C., Ölkrug, R., Johann, K., Resch, J., Rahman, A., Arner, A., Kirchner, H., Mittag J.: Aortic Effects of Thyroid Hormone in Male Mice. J. Mol. Endocr. 62(3), 91-99 (2019). [Open Access]

Johann, K., Reis, M. C., Harder, L., Herrmann, B., Gachkar, S., Mittag, J., Oelkrug, R.: Effects of sildenafil treatment on thermogenesis and glucose homeostasis in diet-induced obese mice. Nutr. Diab. 8(1):9 (2018). [Open Access]

Bartelt, A., Widenmaier, S. B., Schlein, C., Johann, K., Goncalves, R. L. S., Eguchi, K., Fischer, A.W., Parlakgül, G., Snyder, N.A., Nguyen, T. B., Bruns, O. T., Franke, D., Bawendi, M. G., Lynes, M. D., Leiria, L. O., Tseng, Y. H., Inouye, K. E., Arruda, A. P., Hotamisligil, G. S.: Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nature Med. 24(3):292 (2018).

Keipert, S., Ost, M., Johann, K., Imber, F., Jastroch, M., Van Schothorst, E. M., Keijer, J., Klaus, S.: Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine. Am. J. Physio.-Endocr. Metab. 306(5), E469-E482 (2014). [Open Access]