Research Topics

• Insulin resistence
• Exercise metabolism
• Exercise-induced insulin sensitivity
• Skeletal muscle metabolism

Selected Publications

Lundsgaard, A. M., Fritzen, A. M., Sjøberg, K. A., Kleinert, M., Richter, E. A., Kiens, B.: Small Amounts of Dietary Medium-Chain Fatty Acids Protect Against Insulin Resistance During Caloric Excess in Humans. Diabetes 70(1), 91-98 (2021).

Jall, S., De Angelis, M., Lundsgaard, A. M., Fritzen, A. M., Nicolaisen, T. S., Klein, A. B., Novikoff, A., Sachs, S., Richter, E. A., Kiens, B., Schramm, K. W., Tschöp, M. H., Stemmer, K., Clemmensen, C., Müller, T. D., Kleinert, M.: Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in diet-induced obese mice. Diabetologia 63(6), 1236-1247 (2020). [Open Access]

Lundsgaard, A. M., Fritzen, A. M., Nicolaisen, T. S., Carl, C. S., Sjøberg, K. A., Raun, S. H., Klein, A. B., Sanchez-Quant, E., Langer, J., Ørskov, C., Clemmensen, C., Tschöp, M. H., Richter, E. A., Kiens, B., Kleinert, M.: Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation. J. Lipid. Res. 61(1), 10-19 (2020). [Open Access]

Kleinert, M., Parker, B. L., Jensen, T. E., Pham, P., Han, X., James, D. E., Richter, E. A., Sylow, L.: Quantitative proteomic characterization of cellular pathways associated with altered insulin sensitivity in skeletal muscle following high-fat diet feeding and exercise training. Sci. Rep. 8(1):10723 (2018). [Open Access]

Kleinert, M., Kotzbeck, P., Altendorfer-Kroath, T., Birngruber, T., Tschöp, M. H., Clemmensen, C.: Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood-brain barrier in leptin resistant mice. Mol. Metab. 13, 77-82 (2018). [Open Access]

Kleinert, M., Clemmensen, C., Sjøberg, K. A., Carl, C. S., Jeppesen, J. F., Wojtaszewski, J. F. P., Kiens, B., Richter, E. A.: Exercise increases circulating GDF15 in humans. Mol. Metab. 9, 187-191 (2018). [Open Access]

Kleinert, M., Clemmensen, C., Hofmann, S., Moore, M., Renner, S., Woods, S., Beckers, J., Hrabe de Angelis, M., Schürmann, A., Bakhti, M., Klingenspor, M., Heiman, M., Cherrington, A. D., Ristow, M., Lickert, H., Wolf, E., Havel, P. J., Müller, T. D., Tschöp, M. H.: Animal Models of Obesity and Diabetes. Nat. Rev. Endocrinol. 14(3), 140-162 (2018). [Open Access]

Kleinert, M., Parker, B. L, Fritzen, A. M., Knudsen, J. R., Jensen, T. E., Kjøbsted, R., Sylow, L., Ruegg, M., James, D. E., Richter, E. A.: Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice. J. Physiol. 595(14), 4845-4855 (2017). [Open Access]

Kleinert, M., Parker, B. L., Chaudhuri, R., Fazakerley, D. J., Serup, A., Thomas, K. C., Krycer, J. R., Sylow, L., Fritzen, A. M., Hoffman, N. J., Jeppesen, J., Schjerling, P., Ruegg, M. A., Kiens, B., James, D. E., Richter, E. A.: mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3. Mol. Metab. 5(8), 646-655 (2016). [Open Access]

Kleinert, M., Sylow, L., Fazakerley, D. J., Krycer, J. R., Thomas, K. C., Oxbøll, A. J., Jordy, A. B., Jensen, T. E., Yang, G., Schjerling, P., Kiens, B., James, D. E., Ruegg, M. A., Richter, E. A.: Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo. Mol. Metab. 3(6), 630-41 (2014). [Open Access]