Head of Animal Facility:
Dr. Anja Voigt
Dr. Christine Krüger
Veterinary Head and Animal Welfare Officer:
Dr. Christine Krüger
Printversion of: http://www.www.dife.de/forschung/zentrale-einrichtungen/max-rubner-labor/index.php
Status: 19.04.2019 10:18:41
At the Max Rubner Laboratory (MRL), DIfE’s central animal housing facility, special strains of mice and rats are established and characterized for investigating the molecular and metabolic bases of nutrition-related diseases. The aim of all these studies is to provide a scientific basis for developing new approaches to prevention and treatment of diseases related to nutrition and for making dietary recommendations.
The MRL has space for modern animal housing and functional rooms. The complex technical facilities enable the maintenance of high hygienic standards and of the requirements for keeping germ-free animals. Researchers use sensitive instruments for highly standardized measurements of the basal metabolic rate or body composition, for example.
The MRL animal welfare officer advises researchers on aspects of animal welfare laws, paperwork, and experimental procedures, ever mindful of the 3R concept (Replace, Reduce, Refine). Caretakers and technicians also provide practical support. Junior scientists are trained in special certified courses and scientists experienced in animal experiments regularly participate in further training measures. MRL also offers apprenticeships for animal caretakers and biological lab technicians.
The structural and technical prerequisites of MRL, along with the close cooperation of scientists and animal-research personnel, allow implementation of the following techniques for investigating DIfE research issues.
Special techniques at MRL:
Breeding of special genetic strains of mice
Breeding and care of gnotobiotic mice
Manufacturing of special pelletized compound feeds
Recording of the time and quantity of nutrient and water uptake
Noncontact monitoring of body temperature and physical activity
Determination of energy expenditure and metabolic turnover (indirect calorimetry) under various ambient temperatures
Quantitative determination of metabolic substances and products
Body composition analysis of live animals using dual-energy X-ray absorptiometry (DEXA) and nuclear magnetic resonance (NMR)
Measurement of fat distribution in organs and tissues using computed tomography (CT)
Implantation of transponders and micropumps for continuous measurement of various parameters and application of active substances
Investigation of taste perception and transduction in mice using specific preference tests
Behavioral studies to investigate the influence of specific dietary components on the aging process