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Abteilung Pharmakologie (PHA)


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Abteilung Pharmakologie


Dokas, J., Chadt, A., Joost, H.-G., Al-Hasani, H.: Tbc1d1 deletion suppresses obesity in leptin-deficient mice. Int. J. Obes. 40, 1242-1249 (2016).

Kluth, O., Matzke, D., Kamitz, A., Jähnert, M., Vogel, H., Scherneck, S., Schulze, M., Staiger, H., Machicao, F., Häring, H. U., Joost, H.-G., Schürmann, A.: Identification of four mouse diabetes candidate genes altering β-cell proliferation. PLoS Genet. 11(9):e1005506 (Open Access) (2015).

Voigt, A., Katterle, Y., Kahle, M., Kluge, R., Schürmann, A., Joost, H. G., Klaus, S.: Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity. Genes Nutr. 10(6):57 (Open Access) (2015).

Wittenbecher, C., Mühlenbruch, K., Kröger, J., Jacobs, S., Kuxhaus, O., Floegel, A., Fritsche, A., Pischon, T., Prehn, C., Adamski, J., Joost, H.-G., Boeing, H., Schulze, M. B.: Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes. Am. J. Clin. Nutr. 101, 1241-1250 (Open Access) (2015).

Keipert, S., Ost, M., Johann, K., Imber, F., Jastroch, M., van Schothorst, E. M., Keijer, J., Klaus, S.: Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through induction of FGF21 as a myokine. Am. J. Physiol./Endocrinol. Metab. 306, E469-E482 (2014).

Kluth, O., Matzke, D., Schulze, G., Schwenk, R. W., Joost, H.-G., Schürmann, A.: Differential transcriptome analysis of diabetes-resistant and -sensitive mouse islets reveals significant overlap with human diabetes susceptibility genes. Diabetes 63, 4230-4238 (2014).

Mühlenbruch, K., Joost, H.-G., Boeing, H., Schulze, M. B.: Prediction of risk for type 2 diabetes in the German population with the updated DRT (DIfE-GERMAN DIABETES-RISK-TEST) = Vorhersage des Risikos für Typ-2-Diabetes in der deutschen Bevölkerung mit dem aktualisierten DRT (DIfE-DEUTSCHER DIABETES-RISIKO-TEST®). Ernaehr. Umsch. 61, 90-93 (2014).

Mühlenbruch, K., Ludwig, T., Jeppesen, C., Joost, H.-G., Rathmann, W., Meisinger, C., Peters, A., Boeing, H., Thorand, B., Schulze, M. B.: Update of the German Diabetes Risk Score and external validation in the German MONICA/KORA study. Diabetes Res. Clin. Pract. 104, 459-466 (2014).

Stefan, N., Sun, Q., Fritsche, A., Machann, J., Schick, F., Gerst, F., Jeppesen, C., Joost, H.-G., Hu, F. B., Boeing, H., Ullrich, S., Häring, H.-U., Schulze, M. B.: Impact of the adipokine adiponectin and the hepatokine fetuin-A on the development of type 2 diabetes: prospective cohort- and cross-sectional phenotyping studies. PLoS ONE 9(3): e92238 (Open Access) (2014).

di Giuseppe, R., Pechlivanis, S., Fisher, E., Arregui, M., Weikert, B., Knüppel, S., Buijsse, B., Fritsche, A., Willich, S. N., Joost, H.-G., Boeing, H., Moebus, S., Weikert, C.: Microsomal triglyceride transfer protein -164 T > C gene polymorphism and risk of cardiovascular disease: results from the EPIC-Potsdam case-cohort study. BMC Med. Genet. 14:19 (2013).

Dokas, J., Chadt, A., Nolden, T., Himmelbauer, H., Zierath, J. R., Joost, H.-G., Al-Hasani, H.: Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle. Endocrinology 154, 3502-3514 (2013).

Floegel, A., Stefan, N., Yu, Z., Mühlenbruch, K., Drogan, D., Joost, H.-G., Fritsche, A., Häring, H.-U., Hrabě de Angelis, M., Peters, A., Roden, M., Prehn, C., Wang-Sattler, R., Illig, T., Schulze, M. B., Adamski, J., Boeing, H., Pischon, T.: Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes 62, 639-648 (2013).

Montonen, J., Boeing, H., Fritsche, A., Schleicher, E., Joost, H.-G., Schulze, M. B., Steffen, A., Pischon, T.: Consumption of red meat and whole-grain bread in relation to Biomarkers of obesity, inflammation, glucose metabolism and oxidative stress. Eur. J. Nutr. 52, 337-345 (2013).

Mühlenbruch, K., Heraclides, A., Steyerberg, E. W., Joost, H.-G., Boeing, H., Schulze, M. B.: Assessing improvement in disease prediction using net reclassification improvement: impact of risk cut-offs and number of risk categories. Eur. J. Epidemiol. 28, 25-33 (2013).

Mühlenbruch, K., Jeppesen, C., Joost, H.-G., Boeing, H., Schulze, M. B.: The value of genetic information for diabetes risk prediction - differences according to sex, age, family history and obesity. PLoS ONE 8(5):e64307 (2013).

Vogel, H., Mirhashemi, F., Liehl, B., Taugner, F., Kluth, O., Kluge, R., Joost, H.-G., Schürmann, A.: Estrogen deficiency aggravates insulin resistance and induces β-cell loss and diabetes in female New Zealand obese mice. Horm. Metab. Res. 45, 430-435 (2013).

Arregui, M., Buijsse, B., Stefan, N., Corella, D., Fisher, E., di Giuseppe, R., Coltell, O., Knüppel, S., Aleksandrova, K., Joost, H.-G., Boeing, H., Weikert, C.: Heterogeneity of the stearoyl-CoA desaturase-1 (SCD1) gene and metabolic risk factors in the EPIC-Potsdam study. PLoS ONE 7(11):e48338 (2012).

Hesse, D., Jaschke, A., Kanzleiter, T., Witte, N., Augustin, R., Hommel, A., Püschel, G. P., Petzke, K.-J., Joost, H.-G., Schupp, M., Schürmann, A.: GTPase ARFRP1 is essential for normal hepatic glycogen storage and insulin-like growth factor 1 secretion. Mol. Cell. Biol. 32, 4363-4374 (2012).

Jaschke, A., Chung, B., Hesse, D., Kluge, R., Zahn, C., Moser, M., Petzke, K.-J., Brigelius-Flohé, R., Puchkov, D., Koepsell, H., Heeren, J., Joost, H.-G., Schürmann, A.: The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium. Hum. Mol. Genet. 21, 3128-3142 (2012).

Montonen, J., Boeing, H., Steffen, A., Lehmann, R., Fritsche, A., Joost, H.-G., Schulze, M. B., Pischon, T.: Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. Diabetologia 55, 2613-2621 Open Access (Erratum: 55, 3144) (2012).

Sluik, D., Beulens, J. W., Weikert, C., van Dieren, S., Spijkerman, A. M., van der A., D. L., Fritsche, A., Joost, H.-G., Boeing, H., Nöthlings, U.: Gamma-glutamyltransferase, cardiovascular disease and mortality in individuals with diabetes mellitus. Diabetes Metab. Res. Rev. 28, 284-288 (2012).

Vogel, H., Scherneck, S., Kanzleiter, T., Benz, V., Kluge, R., Stadion, M., Kryvych, S., Blüher, M., Klöting, N., Joost, H.-G., Schürmann, A.: Loss of function of lfi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity. Hum. Mol. Genet. 21, 3845-3857 (2012).

Wiedmer, P., Chaudhary, N., Rath, M., Yi, C.-X., Ananthakrishnan, G., Nogueiras, R., Wirth, E. K., Kirchner, H., Schweizer, U., Jonas, W., Veyrat-Durebex, C., Rohner-Jeanrenaud, F., Schürmann, A., Joost, H.-G., Tschöp, M. H., Perez-Tilve, D.: The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism. Physiol. Behav. 105, 791-799 (2012).

Fisher, E., Schreiber, S., Joost, H.-G., Boeing, H., Döring, F.: A two-step association study identifies CAV2 rs2270188 single nucleotide polymorphism interaction with fat intake in type 2 diabetes risk. J. Nutr. 141, 177-181 (2011).

Floegel, A., Drogan, D., Wang-Sattler, R., Prehn, C., Illig, T., Adamski, J., Joost, H.-G., Boeing, H., Pischon, T.: Reliability of serum metabolite concentrations over a 4-month period using a targeted metabolomic approach. PLoS ONE 6(6):e21103 Open Access (2011).

Kluth, O., Mirhashemi, F., Scherneck, S., Kaiser, D., Kluge, R., Neschen, S., Joost, H.-G., Schürmann, A.: Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure. Diabetologia 54, 605-616 (Open Access) (2011).

Kröger, J., Zieteman, V., Enzenbach, C., Weikert, C., Jansen, E. H. J. M., Döring, F., Joost, H.-G., Boeing, H., Schulze, M. B.: Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study. Am. J. Clin. Nutr. 93, 127-142 (2011).

Mirhashemi, F., Scherneck, S., Kluth, O., Kaiser D., Vogel, H., Kluge, R., Schürmann, A., Neschen, S., Joost, H.-G.: Diet dependence of diabetes in the New Zealand Obese (NZO) mouse: total fat, but not fat quality or sucrose accelerates and aggravates diabetes. Exp. Clin. Endocrinol. Diabetes 119, 167-171 (2011).

Montonen, J., Drogan, D., Joost, H.-G., Boeing, H., Fritsche, A., Schleicher, E., Schulze, M. B., Pischon, T.: Estimation of the contribution of biomarkers of different metabolic pathways to risk of type 2 diabetes. Eur. J. Epidemiol. 26, 29-38 (2011).

Wiedmer, P., Strasser, F., Horvath, T. L., Blum, D., DiMarchi, R., Lutz, T., Schürmann, A., Joost, H.-G., Tschöp, M. H., Tong, J.: Ghrelin-induced hypothermia: a physical basis but no clinical risk. Physiol. Behav. 105, 43-51 (2011).

Dreja, T., Jovanovic, Z., Rasche, A., Kluge, R., Herwig, R., Tung, Y. C. L., Joost, H.-G., Yeo, G. S. H., Al-Hasani, H.: Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome. Diabetologia 53, 309-320 (Open Access) (2010).

Hesse, D., Hommel, A., Jaschke, A., Moser, M., Bernhardt, U., Zahn, C., Kluge, R., Wittschen, P., Gruber, A. D., Al-Hasani, H., Joost, H.-G., Schürmann, A.: Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1. Biochem. Biophys. Res. Commun. 394, 896-903 (2010).

Hommel, A., Hesse, D., Völker, W., Jaschke, A., Moser, M., Engel, T., Blüher, M., Zahn, C., Chadt, A., Ruschke, K., Vogel, H., Kluge, R., Robenek, H., Joost, H.-G., Schürmann, A.: The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis. Mol. Cell. Biol. 30, 1231-1242 (2010).

Schulze, M. B., Fritsche, A., Boeing, H., Joost, H. G.: Fasting plasma glucose and type 2 diabetes risk: a non-linear relationship. Diabet. Med. 27, 473-476 (2010).

Fisher, E., Boeing, H., Fritsche, A., Doering, F., Joost, H.-G., Schulze, M. B.: Whole-grain consumption and transcription factor-7-like 2 (TCF7L2) rs7903146: gene-diet interaction in modulating type 2 diabetes risk. Br. J. Nutr. 101, 478-481 (2009).

Fisher, E., Stefan, N., Saar, K., Drogan, D., Schulze, M. B., Fritsche, A., Joost, H.-G., Häring, H.-U., Hubner, N., Boeing, H., Weikert, C.: Association of AHSG gene polymorphisms with Fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study. Circ. Cardiovasc. Genet. 2, 607-613 (2009).

Heidemann, C., Boeing, H., Pischon, T., Nöthlings, U., Joost, H.-G., Schulze, M. B.: Association of a diabetes risk score with risk of myocardial infarction, stroke, specific types of cancer, and mortality: a prospective study in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort. Eur. J. Epidemiol. 24, 281-288 (2009).

Scherneck, S., Nestler, M., Vogel, H., Blüher, M., Block, M.-D., Diaz, M. B., Herzig, S., Schulz, N., Teichert, M., Tischer, S., Al-Hasani, H., Kluge, R., Schürmann, A., Joost, H. G.: Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. PLoS Genet. 5(7): e1000541, (Open Access) (2009).

Schulze, M. B., Weikert, C., Pischon, T., Bergmann, M. M., Al-Hasani, H., Schleicher, E., Fritsche, A., Häring, H.-U., Boeing, H., Joost, H.-G.: Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam study. Diabetes Care 32, 2116-2119 (2009).

Vogel, H., Nestler, M., Rüschendorf, F., Block, M.-D., Tischer, S., Kluge, R., Schürmann, A., Joost, H.-G., Scherneck, S.: Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1. Physiol. Genomics 38, 226-232 (Open Access) (2009).

Ford, E. S., Schulze, M. B. , Bergmann, M. M. , Thamer, C., Joost, H.-G., Boeing, H.: Liver enzymes and incident diabetes: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. Diabetes Care 31, 1138-1143 (2008).

Ford, E. S., Schulze, M. B., Pischon, T., Bergmann, M. M., Joost, H.-G., Boeing, H.: Metabolic syndrome and risk of incident diabetes: findings from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study. Cardiovasc. Diabetol. 7(1):35 (Open Access) (2008).

Mirhashemi, F., Kluth, O., Scherneck, S., Vogel, H., Kluge, R., Schürmann, A., Joost, H.-G., Neschen, S.: High-fat, carbohydrate-free diet markedly aggravates obesity but prevents β-cell loss and diabetes in the obese, diabetes-susceptible db/db strain. Obes. Facts 1, 292-297 (2008).

Neschen, S., Katterle, Y., Richter, J., Augustin, R., Scherneck, S., Mirhashemi, F., Schürmann, A., Joost, H.-G., Klaus, S.: Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover and insulin sensitivity in vivo. Physiol. Genomics 33, 333-340 (2008).

Schulze, M. B., Boeing, H., Häring, H.-U., Fritsche, A, Joost, H.-G.: Validierung des Deutschen Diabetes-Risiko-Scores mit metabolischen Risikofaktoren für Typ-2-Diabetes [Validation of the German Diabetes Risk Score with metabolic risk factors for type 2 diabetes]. Dtsch. Med. Wochenschr. 133, 878-883 (2008).

Stefan, N., Fritsche, A., Weikert, C., Boeing, H., Joost, H.-G., Häring, H.-U., Schulze, M. B.: Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes 57, 2762-2767 (2008).

Weikert, C., Stefan, N., Schulze, M. B., Pischon, T., Berger, K., Joost, H.-G., Häring, H.-U., Boeing, H., Fritsche, A.: Plasma fetuin-A levels and the risk of myocardial infarction and ischemic stroke. Circulation 118, 2555-2562 (2008).

Jürgens, H. S., Neschen, S., Ortmann, S., Scherneck, S., Schmolz, K., Schüler, G., Schmidt, S., Blüher, M., Klaus, S., Perez-Tilve, D., Tschöp, M. H., Schürmann, A., Joost, H.-G.: Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction. Diabetologia 50, 1481-1489 (2007).

Nogueiras, R., Pfluger, P., Tovar, S., Arnold, M., Mitchell, S., Morris, A., Perez-Tilve, D., Vázquez, M. J., Wiedmer, P., Castañeda, T. R., DiMarchi, R., Tschöp, M., Schurmann, A., Joost, H.-G., Williams, L. M., Langhans, W., Diéguez, C.: Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology 148, 21-26 (2007).

Nogueiras, R., Wiedmer, P., Perez-Tilve, D., Veyrat-Durebex, C., Keogh, J. M., Sutton, G. M., Pfluger, P. T., Castaneda, T. R., Neschen, S., Hofmann, S. M., Howles, P. N., Morgan, D. A., Benoit, S. C., Szanto, I., Schrott, B., Schürmann, A., Joost, H.-G., Hammond, C., Hui, D. Y., Woods, S. C., Rahmouni, K., Butler, A. A., Farooqi, I. S., O´Rahilly, S., Rohner-Jeanrenaud, F., Tschöp, M. H.: The central melanocortin system directly controls peripheral lipid metabolism. J. Clin. Invest. 117, 3475-3488 (2007).

Schulze, M. B., Al-Hasani, H., Boeing, H., Fisher, E., Döring, F., Joost, H.-G.: Variation in the HHEX-IDE gene region predisposes to type 2 diabetes in the prospective, population-based EPIC-Potsdam cohort. Diabetologia 50, 2405-2407 (2007).

Schulze, M. B., Hoffmann, K., Boeing, H., Linseisen, J., Rohrmann, S., Möhlig, M., Pfeiffer, A. F. H., Spranger, J., Thamer, C., Häring, H.-U., Fritsche, A., Joost, H.-G.: An accurate risk score based on anthropometric, dietary, and lifestyle factors to predict the development of type 2 diabetes. Diabetes Care 30, 510-515 (2007).

Jürgens, H. S., Schürmann, A., Kluge, R., Ortmann, S., Klaus, S., Joost, H.-G. , Tschöp, M. H.: Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice. Physiol. Genomics 25, 234-241 (2006).

Jürgens, H., Haass, W., Castaneda, T. R., Schürmann, A., Koebnick, C., Dombrowski, F., Otto, B., Nawrocki, A. R., Scherer, P. E., Spranger, J., Ristow, M., Joost, H.-G., Havel, P. J., Tschöp, M. : Consuming fructose-sweetened beverages increases body adiposity in mice. Obes. Res. 13, 1146-1156 (2005).

Becker, W., Kluge, R., Kantner, T., Linnartz, K., Korn, M., Tschank, G., Plum, L., Giesen, K., Joost, H.-G.: Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis. J. Mol. Endocrinol. 32, 195-208 (2004).

Gaster, M., Handberg, A., Schürmann, A., Joost, H.-G., Beck-Nielsen, H., Schroder, H. D.: GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern. Pflugers Arch. 448, 105-113 (2004).

Helmling, S., Maasch, C., Eulberg, D., Buchner, K., Schröder, W., Lange, C., Vonhoff, S., Wlotzka, B., Tschöp, M. H., Rosewitz, S., Klussmann, S.: Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer. Proc. Natl. Acad. Sci. 101, 13174-13179 (2004).

Moser, M., Li, Y., Vaupel, K., Kretzschmar, D., Kluge, R., Glynn, P., Buettner, R.: Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice. Mol. Cell. Biol. 24, 1667-1679 (2004).

Orth, H. M., Krüger, K. D., Schmoll, D., Grempler, R., Scherbaum W. A., Joost, H.-G., Bornstein, S. R., Barthel, A.: Cellular models for the analysis of signaling by protein kinase B and the forkhead transcription factor FKHR (Foxo1a). Regul. Pept. 121, 19-24 (2004).

Otto, B., Tschöp, M., Heldwein, W., Pfeiffer, A. F., Diederich, S.: Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans. Eur. J. Endocrinol. 151, 113-117 (2004).

Rudlowski, C., Moser, M., Becker, A. J., Rath, W., Buttner, R., Schroder, W., Schürmann, A.: GLUT1 mRNA and protein expression in ovarian borderline tumors and cancer. Oncology 66, 404-410 (2004).

Tang-Christensen, M., Vrang, N., Ortmann, S., Bidlingmaier, M., Horvath, T., Tschöp, M.: Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology 145, 4645-4652 (2004).

Tschöp, M., Castaneda, T. R., Joost, H.-G., Thöne-Reineke, C., Ortmann, S., Klaus, S., Hagan, M. M., Chandler, P. C., Oswald, K. D., Benoit, S. C., Seeley, R. J., Kinzig, K. P., Moran, T. H., Beck-Sickinger, A. G., Koglin, N., Rodgers, R. J., Blundell, J. E., Ishii, Y., Beattie, A. H., Holch, P., Allison, D. B., Raun, K., Madsen, K., Wulff, B. S., Stidsen, C. E., Birringer, M., Kreuzer, O. J., Schindler, M., Arndt, K., Rudolf, K., Mark, M., Deng, X. Y., Withcomb, D. C., Halem, H., Taylor, J., Dong, J., Datta, R., Culler, M., Craney, S., Flora, D., Smiley, D., Heiman, M. L.: Physiology: does gut hormone PYY3-36 decrease food intake in rodents. Nature 430(6996), 165 (2004).

Bosch, R. R., Bazuine, M., Wake, M. M., Span, P. N., Olthaar, A. J., Schürmann, A., Maassen, J. A., Hermus, A. R., Willems, P. H., Sweep, C. G.: Inhibition of protein kinase CβII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane. Mol. Endocrinol. 17, 1230-1239 (2003).

Bunt, J. C., Salbe, A. D., Tschöp, M. H., DelParigi, A., Dayschild, P., Tataranni, P. A.: Cross-sectional and prospective relationships of fasting plasma ghrelin concentrations with anthropometric measures in Pima India children. J. Clin. Endocrinol. Metab. 88, 3756-3761 (2003).

Cota, D., Marsicano, G., Tschöp, M., Grübler, Y., Flachskamm, C., Schubert, M., Auer, D., Yassouridis, A., Thöne-Reineke, C., Ortmann, S., Tomassoni, F., Cervino, C., Nisoli, E., Linthorst, A. C. E., Pasquali, R., Lutz, B., Stalla, G. K., Pagotto, U.: The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J. Clin. Invest. 112, 423-431 (2003).

Gambineri, A., Pagotto, U., Tschöp, M., Vicennati, V., Manicardi, E., Carcello, A., Cacciari, M., De Lasio, R., Pasquali, R.: Anti-androgen treatment increases circulating ghrelin levels in obese women with polycystic ovary syndrome. J. Endocrinol. Invest. 26, 629-634 (2003).

Giesen, K., Plum, L., Kluge, R., Ortlepp, J., Joost, H.-G.: Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5. Biochem. Biophys. Res. Commun. 304, 812-817 (2003).

Kortylewski, M., Feld, F., Krüger, K.-D., Bahrenberg, G., Roth, R. A., Joost, H.-G., Heinrich, P. C., Behrmann, I., Barthel, A.: Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism. J. Biol. Chem. 278, 5242-5249 (2003).

Leder, S., Czajkowska, H., Maenz, B., De Graaf, K., Barthel, A., Joost, H.-G., Becker, W.: Alternative splicing variants of dual specific tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties. Biochem. J. 372, 881-888 (2003).

Pagotto, U., Gambineri, A., Pelusi, C., Genghini, S., Cacciari, M., Otto, B., Castaneda, T., Tschöp, M., Pasquali, R.: Testosterone replacement therapy restores normal ghrelin in hypogonadal men. J. Clin. Endocrinol. Metab. 88, 4139-4143 (2003).

Spranger, J., Ristow, M., Otto, B., Heldwein, W., Tschöp, M., Pfeiffer, A. F. H., Möhlig, M.: Post-prandial decrease of human plasma ghrelin in the absence of insulin. J. Endocrinol. Invest. 26, RC19-RC22 (2003).

von Groote-Bidlingmaier, F., Schmoll, D., Orth, H. M., Joost, H.-G., Becker, W., Barthel, A.: DYRK1 is a co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. Biochem. Biophys. Res. Commun. 300, 764-769 (2003).

Wiechmann, S., Czajkowska, H., de Graaf, K., Grötzinger, J., Joost, H.-G., Becker, W.: Unusual function of the activation loop in the protein kinase DYRK1A. Biochem. Biophys. Res. Commun. 302, 403-408 (2003).

Bahrenberg, G., Behrmann, I., Barthel, A., Hekerman, P., Heinrich, P. C., Joost, H.-G., Becker, W.: Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for janus kinase/signal transducer and activator of transcription activation by receptor heterodimers. Mol. Endocrinol. 16, 859-872 (2002).

Barthel, A., Schmoll, D., Krüger, K.-D., Roth, R. A., Joost, H.-G.: Regulation of the forkhead transcription factor FKHR (FOXO1a) by glucose starvation and AICAR, an activator of AMP-activated protein kinase. Endocrinology 143, 3183-3186 (2002).

Joost, H.-G., Bell, G. I., Best, J. D., Birnbaum, M. J., Charron, M. J., Chen, Y. T., Doege, H., James, D. E., Lodish, H. F., Moley, K. H., Moley, J. F., Mueckler, M., Rogers, S., Schürmann, A., Seino, S., Thorens, B.: Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. Am. J. Physiol./Endocrinol. Metab. 282, E974-E976 (2002).

Möhlig, M., Spranger, J., Otto, B., Ristow, M., Tschöp, M., Pfeiffer, A. F.: Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans. J. Endocrinol. Invest. 25, RC36-38 (2002).

Mueller, A. G., Moser, M., Kluge, R., Leder, S., Blum, M., Büttner, R., Joost, H.-G., Schürmann, A.: Embryonic lethality caused by apoptosis during gastrulation in mice lacking the gene of the ADP-ribosylation factor-related protein 1. Mol. Cell. Biol. 22, 1488-1494 (2002).

Ortlepp, J. R., Breuer, J., Eitner, F., Kluge, K., Kluge, R., Floege, J., Hollweg, G., Hanrath, P., Joost, H.-G.: Inhibition of the renin-angiotensin system ameliorates genetically determined hyperinsulinemia. Eur. J. Pharmacol. 436, 145-150 (2002).

Pass, G. J., Becker, W., Kluge, R., Linnartz, K., Plum, L., Giesen, K., Joost, H.-G.: Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione S-transferase isoforms in a New Zealand obese-derived mouse backcross population. J. Pharmacol. Exp. Ther. 302, 442-450 (2002).

Plum, L., Giesen, K., Kluge, R., Junger, E., Linnartz, K., Schürmann, A., Becker, W., Joost, H.-G.: Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat. Diabetologia 45, 823-830 (2002).

Originalarbeiten (korrespondierender Autor nicht vom DIfE)

Stermann, T., Menzel, F., Weidlich, C., Jeruschke, K., Weiss, J., Altenhofen, D., Benninghoff, T., Pujol, A., Bosch, F., Rustenbeck, I., Ouwens, D. M., Thoresen, G. H., de Wendt, C., Lebek, S., Schallschmidt, T., Kragl, M., Lammert, E., Chadt, A., Al-Hasani, H.: Deletion of the RabGAP TBC1D1 leads to enhanced insulin secretion and fatty acid oxidation in islets from male mice. Endocrinology 159, 1748-1761 (2018).

Zhou, Z., Menzel, F., Benninghoff, T., Chadt, A., Du, C., Holman, G. D., Al-Hasani, H.: Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking. FEBS Letters 591, 88-96 (Open Access) (2017).

Chadt, A., Immisch, A., de Wendt, C., Springer, C., Zhou, Z., Stermann, T., Holman, G. D., Loffing-Cueni, D., Loffing, J., Joost, H. G., Al-Hasani, H.: Deletion of both Rab-GTPase-activating proteins TBC14KO and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport. Diabetes 64, 746-759, Erratum 64, 1492 (Open Access) (2015).

Habermeyer, M., Roth, A., Guth, S., Diel, P., Engel, K.-H., Epe, B., Fürst, P., Heinz, V., Humpf, H.-U., Joost, H.-G., Knorr, D., de Kok, T., Kulling, S., Lampen, A., Marko, D., Rechkemmer, G., Rietjens, I., Stadler, R. H., Vieths, S., Vogel, R., Steinberg, P., Eisenbrand, G.: Nitrate and nitrite in the diet: How to assess their benefit and risk for human health. Mol. Nutr. Food Res. 59, 106-128 (2015).

Mannaa, M., Krämer, S., Boschmann, M., Gollasch, M.: mTOR and the regulation of energy homeostasis. J. Mol. Med. 91, 1167-1175 (2013).

Tischer, K., Kleinsteuber, S., Schleinitz, K. M., Fetzer, I., Spott, O., Stange, F., Lohse, U., Franz, J., Neumann, F., Gerling, S., Schmidt, C., Hasselwander, E., Harms, H., Wendeberg, A.: Microbial communities along biogeochemical gradients in a hydrocarbon-contaminated aquifer. Environ. Microbiol. 15, 2603-2615 (2013).

Zavaritskaya, O., Zhuravleva, N., Schleifenbaum, J., Gloe, T., Devermann, L., Kluge, R., Mladenov, M., Frey, M., Gagov, H., Fésüs, G., Gollasch, M., Schubert, R.: Role of KCNQ channels in skeletal muscle arteries and periadventitial vascular dysfunction. Hypertension 61, 151-159 (2013).

Bauer, C., Kleinjung, F., Rutishauser, D., Panse, C., Chadt, A., Dreja, T., Al-Hasani, H., Reinert, K., Schlapbach, R., Schuchhardt, J. : PPINGUIN: Peptide profiling guided identification of proteins improves quantitation of iTRAQ ratios. BMC Bioinformatics 13: 34 (2012).

van Dieren, S., Nöthlings, U., van der Schouw, Y. T., Spijkerman, A. M. W., Rutten, G. E. H. M., van der A, D. L., Sluik, D., Weikert, C., Joost, H. G., Boeing, H., Beulens, J. W. J.: Non-fasting lipids and risk of cardiovascular disease in patients with diabetes mellitus. Diabetologia 54, 73-77 (Open Access) (2011).

Horvath, T. L., Sarman, B., García-Cáceres, C., Enriori, P. J., Sotonyi, P., Shanabrough, M., Borok, E., Argente, J., Chowen, J. A., Perez-Tilve, D., Pfluger, P. T., Brönneke, H. S., Levin, B. E., Diano, S., Cowley, M. A., Tschöp, M. H.: Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proc. Natl. Acad. Sci. 107, 14875-14880 (2010).

Balwierz, A., Polus, A., Razny, U., Wator, L., Dyduch, G., Tomaszewska, R., Scherneck, S., Joost, H.-G., Dembinska-Kiec, A.: Angiogenesis in the New Zealand obese mouse model fed with high fat diet. Lipids Health Dis. 8:13, (Open Access) (2009).

Matthaei, S., Bierwirth, R., Fritsche, A., Gallwitz, B., Häring, H.-U., Joost, H.-G., Kellerer, M., Kloos, C., Kunt, T., Nauck, M., Schernthaner, G., Siegel, E., Thienel, F.: Medical antihyperglycaemic treatment of type 2 diabets mellitus. Update of the evidence-based guideline of the German Diabetic Association. Exp. Clin. Endocrinol. Diabetes 117, 522-557 (Open Access) (2009).

Laakso, M., Zilinskaite, J., Hansen, T., Boesgaard, T. W., Vänttinen, M., Stancáková, A., Jansson, P.-A., Pellmé, F., Holst, J. J., Kuulasmaa, T., Hribal, M. L., Sesti, G., Stefan, N., Fritsche, A., Häring, H., Pedersen, O., Smith, U.; EUGENE2 Consortium (amongst others Joost, H.-G. as collaborator): Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study. Diabetologia 51, 502-511 (2008).

Pfluger, P. T., Kirchner, H., Günnel, S., Schrott, B., Perez-Tilve, D., Fu, S., Benoit, S. C., Horvath, T., Joost, H.-G., Wortley, K. E., Sleeman, M. W., Tschöp, M. H.: Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. Am. J. Physiol./Gastrointest. Liver Physiol. 294, G610-G618 (2008).

Stancáková, A., Pihlajamäki, J., Kuusisto, J., Stefan, N., Fritsche, A., Häring, H., Andreozzi, F., Succurro, E., Sesti, G., Boesgaard, T. W., Hansen, T., Pedersen, O., Jansson, P. A., Hammarstedt, A., Smith, U., Laakso, M.; EUGENE2 Consortium (amongst others Joost, H.-G. as collaborator): Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. J. Clin. Endocrinol. Metab. 93, 1924-1930 (2008).

Wator, L., Razny, U., Balwierz, A., Polus, A., Joost, H.-G., Dyduch, G., Tomaszewska, R., Dembinska-Kiec, A.: Impaired leptin activity in New Zealand obese mice: model of angiogenesis. Genes Nutr. 3, 177-180 (2008).

Fésüs, G., Dubrovska, G., Gorzelniak, K., Kluge, R., Huang, Y., Luft, F. C., Gollasch, M.: Adiponectin is a novel humoral vasodilator. Cardiovasc. Res. 75, 719-727 (2007).

Manolescu, A. R., Augustin, R., Moley, K., Cheeseman, C.: A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity. Mol. Membr. Biol. 24, 455-463 (2007).

Pfluger, P. T., Kampe, J., Castaneda, T. R., Vahl, T., D'Alessio, D. A., Kruthaupt, T., Benoit, S. C., Cuntz, U., Rochlitz, H. J., Moehlig, M., Pfeiffer, A. F. H., Koebnick, C., Weickert, M. O., Spranger, J., Tschöp, M. H.: Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. J. Clin. Endocrinol. Metab. 92, 583-588 (2007).

Sakkou, M., Wiedmer, P., Anlag, K., Hamm, A., Seuntjens, E., Ettwiller, L., Tschöp, M. H., Treier, M.: A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior. Cell Metab. 5, 450-463 (2007).

Biebermann, H., Castañeda, T. R., van Landeghem, F., von Deimling, A., Escher, F., Brabant, G., Hebebrand, J., Hinney, A., Tschöp, M. H., Grüters, A., Krude, H.: A role for β-melanocyte-stimulating hormone in human body-weight regulation. Cell Metab. 3, 141-146 (2006).

Kampe, J., Wiedmer, P., Pfluger, P., Castaneda, T. R., Burget, L., Mondala, H., Kerr, J., Liaw, C., Oldfield, B. J., Tschöp, M. H., Bagnol, D.: Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat. Brain Res. 1119, 133-149 (2006).

Theander-Carrillo, C., Wiedmer, P., Cettour-Rose, P., Nogueiras, R., Perez-Tilve, D., Pfluger, P., Castaneda, T. R., Muzzin, P., Schürmann, A., Szanto, I., Tschöp, M., Rohner-Jeanrenaud, F.: Ghrelin action in the brain controls adipocyte metabolism. J. Clin. Invest. 116, 1983-1993 (2006).

Hekerman, P., Zeidler, J., Bamberg-Lemper, S., Knobelspies, H., Lavens, D., Tavernier, J., Joost, H.-G., Becker, W.: Pleiotrpy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. FEBS J. 272, 109-119 (2005).

Osswald, C., Baumgarten, K., Stümpel, F., Gorboulev, V., Akimjanova, M., Knobeloch, K.-P., Horak, I., Kluge, R., Joost, H.G., Koepsell, H.: Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol. Cell. Biol. 25, 78-87 (2005).

Tovar, S., Nogueiras, R., Tung, L. Y. C., Castañeda, T. R., Vázquez, M. J., Morris, A., Williams, L. M., Dickson, S. L., Diéguez, C.: Central administration of resistin promotes short-term satiety in rats. Eur. J. Endocrinol. 153, R1-R5 (2005).


Landgraf, R., Kellerer, M., Aberle, J., Fach, E.-M., Gallwitz, B., Hamann, A., Joost, H.-G., Klein, H., Muller-Wieland, D., Nauck, M. A., Reuter, H.-M., Schreiber, S., Siegel, E.,: Type 2 Diabetes Treatment. Diabetol. Stoffwechs. 13(S2), S144-S165 (2018).

Joost, H.-G., Heseker, H.: Aufarbeitung: Geschichte der deutschen ernährungswissenschaftlichen Gesellschaften DGEF und DGE [Revision: History of the German food-scientific Societies GSFR and GSN]. Ernaehr. Umsch. 63, M657-M661 (Open Access) (2016).

Joost, H.-G.: Vitaminforschung und Supplementierung im nationalsozialistischen Deutschland: eine Einordnung im internationalen Vergleich. Ernaehr. Umsch. 61, M147-M153 (2014).

Joost, H.-G.: Diabetes and cancer: Epidemiology and potential mechanisms. Diab. Vasc. Dis. Res. 11, 390-394 (Open Access) (2014).

Joost, H.-G., Schürmann, A.: The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models. Mamm. Genome 25, 401-412 (Open Access) (2014).

Gollasch, M., Mannaa, M., Enghard, P., Krämer, S. Wu, K., Rudolph, B.: Diabetische Nephropathie: Neues zur Pathogenese. Nieren- und Hochdruckkrankheiten 42, 359-368 (2013).

Joost, H.-G.: Nutrition: Red meat and T2DM - the difficult path to a proof of causality. Nat. Rev. Endocrinol. 9, 509-511 (2013).

Häring, H.-U., Hrabé de Angelis, M., Joost, H.-G., Roden, M., Solimena, M.: Forschen für eine Zukunft ohne Diabetes. Deutsches Zentrum für Diabetesforschung. Diabetes aktuell 10, 106-110 (2012).

Joost, H.-G.: Molekulare Grundlagen des Zusammenhangs zwischen Krankheitsentstehung und Ernährung: Was kann die Grundlagenforschung für Prävention und Therapie leisten?. Aktuel. Ernaehr. Med. 37, 277-281 (2012).

Joost, H.-G.: The genetic basis of obesity and type 2 diabetes: lessons from the New Zealand obese mouse a polygenic model of the metabolic syndrome. In: Meyerhof, W., Beisiegel, U., Joost, H.-G. (eds.) Sensory and Metabolic Control of Energy Balance (Results and Problems in Cell Differentiation; 52), Springer, pp 1-11 (2010).

Scherneck, S., Vogel, H., Nestler, M., Kluge, R., Schürmann, A., Joost, H.-G.: Role of zinc finger transcription factor Zfp69 in body fat storage and diabetes susceptibility of mice. In: Meyerhof, W., Beisiegel, U., Joost, H.-G. (eds.) Sensory and Metabolic Control of Energy Balance (Results and Problems in Cell Differentiation; 52), Springer, pp 57-68 (2010).

Schulze, M. B., Rathmann, W., Giani, G., Joost, H.-G.: Diabetesprävalenz: Verlässliche Schätzungen stehen noch aus. Dtsch. Arztebl. 107, A1694-A1696 (2010).

Joost, H.-G.: Pathogenesis, risk assessment and prevention of type 2 diabetes mellitus. Obes. Facts 1, 128-137 (2008).

Joost, H.-G., Gibney, M. J., Cashman, K. D., Görman, U., Hesketh, J. E., Mueller, M., van Ommen, B., Williams, C. M., Mathers, J. C.: Personalised nutrition: status and perspectives. Br. J. Nutr. 98, 26-31 (2007).

Wiedmer, P., Nogueiras, R., Broglio, F., D´Alessio, D., Tschöp, M. H.: Ghrelin, obesity and diabetes. Nat. Clin. Pract. Endocrinol. Metab. 3, 705-712 (2007).

Joost, H.-G.: Die komplexe Pathogenese des Typ-2-Diabetes-mellitus. Aktuel. Ernaehr. Med. 31 (Suppl.1), S37-S41 (2006).

Al-Hasani, H., Joost, H.-G.: Nutrition-/diet-induced changes in gene expression in white adipose tissue. Best Pract. Res./Clin. Endocrinol. Metab. 19, 589-603 (2005).

Boggiano, M. M., Chandler, P. C., Oswald, K. D., Rodgers, R. J., Blundell, J. E., Ishii, Y., Beattie, A. H., Holch, P., Allison, D. B., Schindler, M., Arndt, K., Rudolf, K., Mark, M., Schoelch, C., Joost, H. G., Klaus, S., Thöne-Reineke, C., Benoit, S. C., Seeley, R. J., Beck-Sickinger, A. G., Koglin, N., Raun, K., Madsen, K., Wulff, B. S., Stidsen, C. E., Birringer, M., Kreuzer, O. J., Deng, X. Y., Whitcomb, D. C., Halem, H., Taylor, J., Dong, J., Datta, R., Culler, M., Ortmann, S., Castaneda, T. R., Tschöp, M.: PYY3-36 as an anti-obesity drug target. Obes. Rev. 6, 307-322 (2005).

Kaput, J., Ordovas, J. M., Ferguson, L., van Ommen, B., Rodriguez, R. L., Allen, L., Ames, B. N., Dawson, K., German B., Krauss, R., Malyj, W., Archer, M. C., Barnes, S., Bartholomew, A., Birk, R., van Bladeren, P., Bradford, K. J., Brown, K. H., Caetano, R., Castle, D., Chadwick, R., Clarke, S., Clément, K., Cooney, C. A., Corella, D., Manica da Cruz, I. B., Daniel, H., Duster, T., Ebbesson, S. O. E., Elliott, R., Fairweather-Tait, S., Felton, J., Fenech, M., Finley, J. W., Fogg-Johnson, N., Gill-Garrison, R., Gibney, M. J., Gillies, P. J., Gustafsson, J.-A., Hartmann IV, J. L., He, L., Hwang, J.-K., Jais, J.-P., Jang, Y., Joost, H., Junien, C., Kanter, M., Kibbe, W. A., Koletzko, B., Korf, B. R., Kornman, K., Krempin, D. W., Langin, D., Lauren, D. R., Lee, J. H., Leveille, G. A., Lin, S.-J., Mathers, J., Mayne, M., McNabb, W., Milner, J. A., Morgan, P., Muller, M., Nikolsky, Y., van der Ouderaa, F., Park, T., Pensel, N., Perez-Jimenez, F., Poutanen, K., Roberts, M., Saris, W. H. M., Schuster, G., Shelling, A. N., Simopoulos, A. P., Southon, S., Shyong Tai, E., Towne, B., Trayhurn, P., Uauy, R., Visek, W. J., Warden, C., Weiss, R., Wiencke, J., Winkler, J., Wolff, G. J., Zhao-Wilson, X., Zucker, J.-D.: The case for strategic international alliances to harness nutritional genomis for public and personal health. Br. J. Nutr. 94, 623-632 (2005).

Scheepers, A., Joost, H.-G., Schürmann, A.: The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN J. Parenter. Enteral Nutr. 28, 364-371 (2004).

Horvath, T. L., Castaneda, T., Tang-Christensen, M., Pagotto, U., Tschöp, M.: Ghrelin as a potential anti-obesity target. Curr. Pharm. Des. 9, 1383-1395 (2003).

Horvath, T. L., Diano, S., Tschöp, M.: Ghrelin in hypothalamic regulation of energy balance. Curr. Top. Med. Chem. 3, 921-927 (2003).


Joost, H.-G.: Wechselwirkungen von Antidiabetika mit anderen Arnzeistoffen. In: Schatz, H., Pfeiffer, A. F. H. (Hrsg.) Diabetologie kompakt. Grundlagen und Praxis. 5. Aufl., Springer, Berlin Heidelberg, S. 179-181 (2014).

Kluge, R., Scherneck, S., Schürmann, A., Joost, H.-G.: Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: a model of the human metabolic syndrome. In: Joost, H.-G., Al-Hasani, H., Schürmann, A. (eds.) Animal Models in Diabetes Research (Methods in Molecular Biology; 933), Humana Press, pp. 59-73 (2012).

Joost, H.-G.: Gerne und ernährungsbedingte Krankheiten. In: Schärer-Züblin, E. V. (Hrsg.) Forschung und Ernährung - ein Dialog. Alimentarium, Wiley-Blackwell, Weinheim, 2009, S. 214-216 (2009).

Joost, H.-G.: Personalized Prevention of Type 2 Diabetes. In: Kok, F., Bowman, L., Desiere, F. (eds.) Personalized Nutrition. Principles and Applications. CRC Press, Boca Raton,Fl., Chapter 6 , pp 61-74 (2008).

Joost, H.-G.: Ernährung und Gene: Bestimmen unsere Erbanlagen, was wir essen?. Jahrbuch 2006 der Deutschen Akademie der Naturforscher Leopoldina (Halle/Saale) LEOPOLDINA (R. 3) 52, 409-414 (2007).

Joost, H.-G.: Therapie mit Sexualhormonen. In: Lemmer, B., Brune, K. (Hrsg.) Pharmakotherapie/Klinische Pharmakologie. 12. Auflage, Springer Verlag, Berlin, S. 197-208 (2004).

Joost, H.-G.: Diabetes mellitus. In: Lemmer, B., Brune, K. (Hrsg.) Pharmakotherapie/Klinische Pharmakologie. 12. Auflage, Springer Verlag, Berlin, S. 407-417 (2004).

Joost, H.-G., Mengel, K.: Antidiabetika. In: Schwabe, U., Paffrath, D. (Hrsg.) Arzneiverordnungsreport 2004. Springer Verlag, Berlin, S. 300-317 (2004).

Barthel, A. Joost, H.-G.: Insulin receptor. In: Rosenthal, W., Offermanns, S. (eds.) Encyclopedia of Molecular Pharmacology. Springer Verlag, Berlin, pp 493-498 (2003).

Becker, W., Joost, H.-G.: Appetite control. In: Rosenthal, W., Offermanns, S. (eds.) Encyclopedia of Molecular Pharmacology. Springer Verlag, Berlin, pp 142-147 (2003).

Joost, H.-G.: Diabetes. In: Rosenthal, W., Offemrmanns, S. (eds.) Encyclopedia of Molecular Pharmacology. Springer Verlag, Berlin, pp 298.303 (2003).

Joost, H.-G., Mengel, K.: Antidiabetika. In: Schwabe, U., Paffrath, D. (Hrsg.) Arzneiverordnungsreport 2003. Springer Verlag, Berlin, S. 210-227 (2003).

Joost, H.-G.: Metabolisches Syndrom und Typ-2-Diabetes: Interaktion von Genen und Lebensbedingungen. In: Rosenthal, A., Wahn, U., Wolf, H. (Hrsg.) Einfluss von Genomprojekt und Pharmacogenetics auf die medizinische Entwicklung. Schattauer, Stuttgart, S. 69-87 (2002).

Plum, L., Giesen, K., Kluge, R., Joost, H.-G.: Identification of susceptibility loci for obesity, insulin resistance, and hyperglycemia in a backcross model of New Zealand obese (NZO) and lean SJL mice. In: Federwisch, M., Dieken, M. L., De Meyts, P. (eds.) Insulin and related proteins: From structure to function and pharmacology. Kluwer Academic Publishers, Dordrecht, pp 177-188 (2002).

Joost, H.-G., Mengel, K.: Antidiabetika. In: Schwabe, U., Paffrath, D. (Hrsg.) Arzneiverordnungsreport 2001. Springer Verlag, Berlin, S. 163-177 (2001).


Joost, H.-G.: Appetite Control. Handbook of Pharmacology, Vol. 209, Springer, Berlin Heidelberg (2012).

Joost, H.-G., Al-Hasani, H., Schürmann, A.: Animal Models in Diabetic Research. (Methods in Molecular Biology; 933) Humana Press (2012).

Meyerhof, W., Beisiegel, U., Joost, H.-G.: Sensory and Metabolic Control of Energy Balance . (Results and Problems in Cell Differentiation; 52) Springer (2010).

Brigelius-Flohé, R., Joost, H.-G.: Nutritional Genomics. Impact on Health and Disease. Wiley-VCH, Weinheim, (2006).

sonstige Arbeiten

Gerlach, S., Joost, H.-G.: German reduction strategy on salt, sugar and saturated fat (2016). Position paper of diabetesDE – German Diabetes Aid. Ernaehr. Umsch. 63, 88-91 (Open Access) (2016).

Landgraf, R., Kellerer, M., Fach, E., Gallwitz, B., Hamann, A., Joost, H.-G., Klein, H. H., Muller-Wieland, D., Nauck, M. A., Reuter, H. M., Schreiber, S., Siegel, E.: Praxisempfehlungen DDG/DGIM. Therapie des Typ-2-Diabetes [Practical recommendations GDS/GSIM. Therapy of type-2-diabetes]. Diabetol. Stoffw. 11, S117-S129 (2016).

Landgraf, R., Kellerer, M., Fach, E., Gallwitz, B., Hamann, A., Joost, H. G., Klein, H. H., Müller-Wieland, D., Nauck, M. A., Reuter, H.-M., Schreiber, S., Siegel, E., Matthaei, S.: Praxisempfehlungen DDG/DGIM. Therapie des Typ-2-Diabetes. Diabetologie Stoffwechsel 8, S2, S146-S158 (2013).

Joost, H. G.: Ist eine Diabetes-Diagnose mit dem HbA1C möglich? Pro [Is Hba1C suitable for diagnosis of diabetes? Pro]. Dtsch. Med. Wochenschr. 136, 1128 (2011).

Brückel, J., Joost, H.-G., Kerner, W., Müller, U. A., Schleicher, E., Schulze, M., Ziegler, A.: Stellungnahme der Deutschen Diabetes Gesellschaft, diabetesDE und des Kompetenznetzes Diabetes mellitus zur Verwendung des HbA1c-Wertes als Biomarker zur Diabetesdiagnose. Deutsche Diabetes Gesellschaft, (2010).

Joost, H.-G., Fritsche, A., Häring, H.-U., Pfeiffer, A. F. H., Roden, M., Schulze, M. B.: Risikobestimmung wird präzisiert. Ein Diskussionsbeitrag. Dtsch. Arztebl. 107, C 511-C 513 (2010).

Joost, G.-H.: Individualisierte Prävention des Typ-2-Diabetes durch Ernährungsintervention nach phänotypischen und genotypischen Prädiktoren. In: Geniessen und trotzdem gesund essen - und das ein Leben lang. 12. Dreiländertagung der Schweizerischen, Deutschen und Österreichischen Gesellschaften für Ernährung, Zürich, 2008, S. 50-52 (2009).

Joost, H.-G.: "Ich bin über die Wirckung einer so kleinen Quantität Saltz erstaunt" Lichtenbergs Korrespondenz mit Ferdinand Wurzer über die Wirkung von `Potasse muriatique oxygenée`. In: Joost, U., Neumann, A. (Hrsg.) Lichtenberg-Jahrbuch 2008. Universitätsverlag Winter, Heidelberg,, S. 177-188 (2008).

Joost, H.-G.: Zellversagen bei Typ 2 Diabetes: Lipotoxizität oder Glucotoxizität?. Proc. German Nutr. Soc. 9, 23-27 (2007).

Joost, H.-G.: Prevention of complex diseases by genotype-based nutrition: realistic concept or fiction?. J. Mol. Med. 85, 103-105 (Editorial) (2007).

Joost, H.-G., Tschöp, M. H.: NO to obestiy: does nitric oxide regulate fat oxidation and insulin sensitivity?. Endocrinology 148, 4545-4547 (2007).

Joost, H.G.: Präventives Potenzial von Obst und Gemüse bei Diabetes mellitus. Proc. German Nutr. Soc. 11, 14-18 (2007).

Schulze, M. B., Häring, H.-U., Pfeiffer, A. F. H., Joost, H.-G.: An accurate risk score based on anthropometric, dietary, and lifestyle factors to predict the development of type 2 diabetes. Diabetes Care 30, e88 (Letter) (2007).

Schulze, M. B., Hoffmann, K., Boeing, H., Joost, H.-G.: Der Deutsche Diabetes-Risiko-Score (DRS). Ernaehr. Umsch. 54, 122-127 (2007).

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