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Image Molekulare Toxikologie

Abteilung Molekulare Toxikologie (MTOX)


Anzahl: 54

Sortiert nach Jahr und alphabetisch nach Erstautor

Abteilung Molekulare Toxikologie


König, J., Ott, C., Hugo, M., Jung, T., Bulteau, A.-L., Grune, T., Höhn, A.: Mitochondrial contribution to lipofuscin formation. Redox Biol. 11, 673-681 (Open Access) (2017).

König, J., Besoke, F., Stuetz, W., Malarski, A., Jahreis, G., Grune, T., Höhn, A.: Quantification of age-related changes of α-tocopherol in lysosomal membranes in murine tissues and human fibroblasts. BioFactors 42, 307-315 (Open Access) (2016).

Ott, C., König, J., Höhn, A., Jung, T., Grune, T.: Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts. Free Radic. Biol. Med. 101, 325-333 (Open Access) (2016).

Ott, C., König, J., Höhn, A., Jung, T., Grune, T.: Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts. Redox Biol. 10, 266-273 (Open Access) (2016).

Reeg, S., Jung, T., Castro, J. P., Davies, K. J., Henze, A., Grune, T.: The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome. Free Radic. Biol. Med. 99, 153-166 (Open Access) (2016).

Stuetz, W., Weber, D., Dollé, M. E. T., Jansen, E., Grubeck-Loebenstein, B., Fiegl, S., Toussaint, O., Bernhardt, J., Gonos, E. S., Franceschi, C., Sikora, E., Moreno-Villanueva, M., Breusing, N., Grune, T., Bürkle, A.: Plasma carotenoids, tocopherols, and retinol in the age-stratified (35–74 Years) general population: A cross-sectional study in six European countries. Nutrients 8:614 (Open Access) (2016).

Weitkunat, K., Schumann, S., Nickel, D., Kappo, K. A., Petzke, K. J., Kipp, A. P., Blaut, M., Klaus, S.: Importance of propionate for the repression of hepatic lipogenesis and improvement of insulin sensitivity in high-fat diet-induced obesity. Mol. Nutr. Food Res. 60, 2611-2621 (Open Access) (2016).

Hiller, F., Besselt, K., Deubel, S., Brigelius-Flohé, R., Kipp, A. P.: GPx2 induction is mediated through STAT transcription factors during acute colitis. Inflamm. Bowel Dis. 21, 2078-2089 (2015).

Hiller, F., Oldorff, L., Besselt, K., Kipp, A. P.: Differential acute effects of selenomethionine and sodium selenite on the severity of colitis. Nutrients 7, 2687-2706 (Open Access) (2015).

Höhn, A., Hartmann, P., Gebhart, V., Sonntag, J., Grune, T., Jung, T.: Actual Isothermal Effects of Water-Filtered Infrared A-Irradiation. Photochem. Photobiol. 91, 887-894 (2015).

Originalarbeiten (korrespondierender Autor nicht vom DIfE)

Prantl, E.-M., Kramer, M., Schmidt, C. K., Knauer, M., Gartiser, S., Shuliakevich, A., Milas, J., Glatt, H., Meinl, W., Hollert, H.: Comparison of in vitro test systems using bacterial and mammalian cells for genotoxicity assessment within the "health-related indication value (HRIV) concept. Environ. Sci. Pollut. Res. Int. in press (E-pub ahead of print) (2017).

Griesser, E., Vemula, V., Raulien, N., Wagner, U., Reeg, S., Grune, T., Fedorova, M.: Cross-talk between lipid and protein carbonylation in a dynamic cardiomyocyte model of mild nitroxidative stress. Redox Biol. 11, 438-455 (Open Access) (2017).

Lennicke, C., Rahn, J., Kipp, A. P., Dojčinović, B. P., Müller, A. S., Wessjohann, L. A., Lichtenfels, R., Seliger, B.: Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice. Biochim. Biophys. Acta./General. Subj. 1861, Part A, 3323–3334 (2017).

Markó, L., Mannaa, M., Haschler, T. N., Krämer, S., Gollasch, M.: Renoprotection: focus on TRPV1, TRPV4, TRPC6 and TRPM2. Acta Physiol.(Oxf) 219, 589-612 (2017).

Ciccarone, F., Malavolta, M., Calabrese, R., Guastafierro, T., Bacalini, M. G., Reale, A., Franceschi, C., Capri, M., Hervonen, A., Hurme, M., Grubeck-Loebenstein, B., Koller, B., Bernhardt, J., Schӧn, C., Slagboom, P. E., Toussaint, O., Sikora, E., Gonos, E. S., Breusing, N., Grune, T., Jansen, E., Dollé, M., Moreno-Villanueva, M., Sindlinger, T., Bürkle, A., Zampieri, M., Caiafa, P.: Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study. Aging Cell 15, 755-765 (Open Access) (2016).

Issoglio, F. M., Campolo, N., Zeida, A., Grune, T., Radi, R., Estrin, D. A., Bartesaghi, S.: Exploring the catalytic mechanism of human glutamine synthetase by computer simulations. Biochemistry 55, 5907-5916 (2016).

Loof, T., Krämer, S., Gaedeke, J., Neumayer, H.-H., Peters, H.: IL-17 Expression in the Time Course of Acute Anti-Thy1 Glomerulonephritis. PLoS One 11(5):e0156480 (Open Access) (2016).

Markó, L., Szijártó, I. A., Filipovic, M. R., Kaßmann, M., Balogh, A., Park, J.-K., Przybyl, L., N’diaye, G., Krämer, S., Anders, J., Ishii, I., Müller, D. N., Gollasch, M.: Role of cystathionine gamma-Lyase in immediate renal impairment and inflammatory response in acute ischemic kidney injury. Sci. Rep. 6:27517 (Open Access) (2016).

Rakers, C., Schumacher, F., Meinl, W., Glatt, H., Kleuser, B., Wolber, G.: In silico prediction of human sulfotransferase 1E1 activity guided by pharmacophores from molecular dynamics simulations. J. Biol. Chem. 291, 58-71 (Open Access) (2016).

Steinbrenner, H., Speckmann, B., Klotz, L. O.: Selenoproteins: Antioxidant selenoenzymes and beyond. Arch. Biochem. Biophys. 595, 113-119 (2016).

Stuetz, W., Carrara, V. I., Mc Gready, R., Lee, S. J., Sriprawat, K., Po, B., Hanboonkunupakarn, B., Grune, T., Biesalski, H. K., Nosten, F. H.: Impact of food rations and supplements on micronutrient status by trimester of pregnancy: cross-sectional studies in the Maela Refugee Camp in Thailand. Nutrients 8(2):66 (Open Access) (2016).

Valentini, E., Zampieri, M., Malavolta, M., Bacalini, M. G., Calabrese, R., Guastafierro, T., Reale, A., Franceschi, C., Hervonen, A., Koller, B., Bernhardt, J., Slagboom, P. E., Toussaint, O., Sikora, E., Gonos, E. S., Breusing, N., Grune, T., Jansen, E., Dollé, M. E., Moreno-Villanueva, M., Sindlinger, T., Bürkle, A., Ciccarone, F., Caiafa, P.: Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study. Aging (Albany NY) 8, 1896-1922 (Open Access) (2016).

Augustyniak, E., Adam, A., Wojdyla, K., Rogowska-Wrzesinska, A., Willetts, R., Korkmaz, A., Atalay, M., Weber, D., Grune, T., Borsa, C., Gradinaru, D., Chand Bollineni, R., Fedorova, M., Griffiths, H. R.: Validation of protein carbonyl measurement: a multi-centre study. Redox Biol. 4, 149-157 (Open Access) (2015).

Baierle, M., Nascimento, S. N., Moro, A. M., Brucker, N., Freitas, F., Gauer, B., Durgante, J., Bordignon, S., Zibetti, M., Trentini, C. M., Duarte, M. M. M. F., Grune, T., Breusing, N., Garcia, S. C.: Relationship between inflammation and oxidative stress and cognitive decline in the institutionalized elderly. Oxid. Med. Cell. Longev. 2015:804198 (Open Access) (2015).

Ehlers, A., Florian, S., Schumacher, F., Meinl, W., Lenze, D., Hummel, M., Heise, T., Seidel, A., Glatt, H., Lampen, A.: The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens. Mol. Nutr. Food Res. 59, 685-697 (2015).

Gerhardt, C., Lier, J. M., Burmühl, S., Struchtrup, A., Deutschmann, K., Vetter, M., Leu, T., Reeg, S., Grune, T., Rüther, U.: The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium. J. Cell Biol. 210, 115-133 (2015).

Høie, A. H., Svendsen, C., Brunborg, G., Glatt, H., Alexander, J., Meinl, W., Husøy, T.: Genotoxicity of three food processing contaminants in transgenic mice expressing human sulfotransferases 1A1 and 1A2 as assessed by the in vivo alkaline single cell gel electrophoresis assay. Environ. Mol. Mutagen. 56, 709-714 (2015).

Japtok, L., Schmitz, E. I., Fayyaz, S., Krämer, S., Hsu, L. J., Kleuser, B.: Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2. FASEB J. 29, 3357-3369 (2015).

Just, J., Jung, T., Friis, N. A., Lykkemark, S., Drasbek, K., Siboska, G., Grune, T., Kristensen, P.: Identification of an unstable 4-hydroxynoneal modification on the 20S proteasome subunit α7 by recombinant antibody technology. Free Radic. Biol. Med. 89, 786-792 (Open Access) (2015).

Stancu, B., Krämer, S., Loof, T., Mika, A., Amann, K., Neumayer, H. H., Peters, H.: Soluble guanylate cyclase stimulator BAY 41-8543 and female sex ameliorate uremic aortic remodeling in a rat model of mild uremia. J. Hypertens. 33, 1907-1921 (2015).

Fayyaz, S., Henkel, J., Japtok, L., Krämer, S., Damm, G., Seehofer, D., Püschel, G. P., Kleuser, B.: Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. Diabetologia 57, 373-382 (2014).


Castro, J. P., Jung, T., Grune, T., Siems, W.: 4-Hydroxynonenal (HNE) modified proteins in metabolic diseases. Free Radic. Biol. Med. in press (E-Pub ahead of print), (Open Access) (2017).

Höhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J.Grune, T., Castro, J. P.: Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol. 11, 482-501 (Open Access) (2017).

Kaplan, G. S., Torcun, C. C., Grune, T., Ozer, N. K., Karademir, B.: Proteasome inhibitors in cancer therapy: Treatment regimen and peripheral neuropathy as a side effect. Free Radic. Biol. Med. 103, 1–13 (2017).

Castro, J. P., Grune, T., Speckmann, B.: The two faces of ROS in adipocyte function and dysfunction. Biol. Chem. 397, 709-724 (Open Access) (2016).

Erusalimsky, J. D., Grillari, J. Grune, T., Jansen-Duerr, P., Lippi, G., Sinclair, A. J., Tegnér, J., Viña, J., Durrance-Bagale, A., Miñambres, R., Viegas, M., Rodríguez-Mañas, L.: In search of ’Omics’-based biomarkers to predict risk of frailty and its consequences in older individuals: The FRAILOMIC initiative. Gerontology 62, 182-190 (2016).

Höhn, A., König, J., Jung, T.: Metabolic syndrome, redox state and the proteasomal system. Antioxid. Redox Signal. 25, 902-917 (2016).

Klionsky, D. J., ... Grune, T., ... Zughaier, S. M.: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1-122 (Open Access) (2016).

Pivovarova, O., Höhn, A., Grune, T., Pfeiffer, A. F. H., Rudovich, N.: Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease?. Ann. Med. 48, 614-624 (2016).

Speckmann, B., Steinbrenner, H., Grune, T., Klotz, L. O.: Peroxynitrite: From interception to signaling. Arch. Biochem. Biophys. 595, 153-160 (2016).

Wiedmer, P., Ode, A., Grune, T.: NutriAct - Nutritional intervention: Food patterns, behaviour, and products. Dtsch. Lebensmitt. Rundsch. 112, 142-146 (2016).

Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H. J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Dollé, M., Salmon, M., Kristensen, P., Griffiths, H. R., Libert, C., Grune, T., Breusing, N., Simm, A., Franceschi, C., Capri, M., Talbot, D., Caiafa, P., Friguet, B., Slagboom, P. E., Hervonen, A., Hurme, M., Aspinall, R.: MARK-AGE biomarkers of ageing. Mech. Ageing Dev. 151, 2-12 (Open Access) (2015).

Frijhoff, J., Winyard, P. G., Zarkovic, N., Davies, S., Stocker, R., Cheng, D., Knight, A., Taylor, E. L., Oettrich, J., Ruskovska, T., Cipak Gasparovic, A., Cuadrado, A., Weber, D., Poulsen, H. E., Grune, T., Schmidt, H. H. H. W., Ghezzi, P.: Clinical relevance of biomarkers of oxidative stress. Antioxid. Redox Signal. 23, 1144-1170 (Open Access) (2015).

Grune, T.: Insulin-degrading enzyme: is it suitable for diabetes treatment?. Cell Cycle 14, 2553 (Comment) (Open Access) (2015).

Jansen, E., Beekhof, P., Cremers, J., Weinberger, B., Fiegl, S., Toussaint, O., Bernhard, J., Gonos, E., Capri, M., Franceschi, C., Sikora, E., Moreno-Villanueva, M., Breusing, N., Grune, T., Bürkle, A., Dollé, M. E. T.: Quality control data of physiological and immunological biomarkers measured in serum and plasma. Mech. Ageing Dev. 151, 54-59 (Open Access) (2015).

Kipp, A. P., Strohm, D., Brigelius-Flohé, R., Schomburg, L., Bechthold, A., Leschik-Bonnet, E., Heseker, H.: Revised reference values for selenium intake. J. Trace Elem. Med. Biol. 32, 195-199 (Open Access) (2015).

Moreno-Villanueva, M., Capri, M., Breusing, N., Siepelmeyer, A., Sevini, F., Ghezzo, A., de Craen, A. J. M., Hervonen, A., Hurme, M., Schön, C., Grune, T., Franceschi, C., Bürkle, A.: MARK-AGE standard operating procedures (SOPs): A successful effort. Mech. Ageing Dev. 151, 18-25 (Open Access) (2015).

Nowotny, K., Jung, T., Höhn, A., Weber, D., Grune, T.: Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules 5, 194-222 (Open Access) (2015).

Reeg, S., Grune, T.: Protein oxidation in aging: Does it play a role in aging progression?. Antioxid. Redox Signal. 23, 239-255 (Open Access) (2015).

Speckmann, B., Grune, T.: Epigenetic effects of selenium and their implications for health. Epigenetics 10, 179-190 (Open Access) (2015).

Weber, D., Davies, M. J., Grune, T.: Determination of protein carbonyls in plasma, cell extracts, tissue homogenates, isolated proteins: Focus on sample preparation and derivatization conditions. Redox. Biol. 5, 367-380 (Open Access) (2015).

Sadowska-Bartosz, I., Ott, C., Grune, T., Bartosz, G.: Posttranslational protein modifications by reactive nitrogen and chlorine species and strategies for their prevention and elimination. Free Radic. Res. 48, 1267-1284 (2014).


Reeg, S., Grune, T.: Protein Oxidation in Toxicology. In: Roberts, S. M., Kehrer, J. P., Klotz, L.-O. (eds.) Studies on Experimental Toxicology and Pharmacology (Oxidative Stress in Applied Basic Research and Clinical Practice). Humana Press, pp. 81-102 (2015).


Bürkle, A., Grune, T.: Biomarkers of Human Ageing. (Mechanisms of Ageing and Development; Special Issue) Elsevier (2015).

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