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Stand: 21.11.2017 11:21:16

Image Molekulare Toxikologie

Abteilung Molekulare Toxikologie (MTOX)

Publikationen

Anzahl: 68

Sortiert nach Jahr und alphabetisch nach Erstautor

Abteilung Molekulare Toxikologie

Originalarbeiten

Ott, C., Jung, T., Grune, T., Höhn, A.: SIPS as a model to study age-related changes in proteolysis and aggregate formation. Mech. Ageing Dev. in press (E-Pub ahead of print), (Open Access) (2017).

Hugo, M., Martínez, A., Trujillo, M., Estrada, D., Mastrogiovanni, M., Linares, E., Augusto, O., Issoglio, F., Zeida, A., Estrín, D. A., Heijnen, H. F. G., Piacenza, L., Radi, R.: Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP). PNAS 114, E1326-E1335 (2017).

Kochlik, B., Grune, T., Weber, D.: New findings of oxidative stress biomarkers in nutritional research. Curr. Opin. Clin. Nutr. Metab. Care. 20, 349-359 (Open Access) (2017).

König, J., Ott, C., Hugo, M., Jung, T., Bulteau, A.-L., Grune, T., Höhn, A.: Mitochondrial contribution to lipofuscin formation. Redox Biol. 11, 673-681 (Open Access) (2017).

Speckmann, B., Schulz, S., Hiller, F., Hesse, D., Schumacher, F., Kleuser, B., Geisel, J., Obeid, R., Grune, T., Kipp, A. P.: Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice. J. Nutr. Biochem. 48, 112-119 (Open Access) (2017).

Weber, D. Stuetz, W., Toussaint, O., Debacq-Chainiaux, F., Dollé, M. E. T., Jansen, E., Gonos, E. S., Franceschi, C., Sikora, E., Hervonen, A., Breusing, N., Sindlinger, T., Moreno-Villanueva, M., Bürkle, A., Grune, T.: Associations between specific redox biomarkers and age in a large European cohort: The MARK-AGE Project. Oxid. Med. Cell. Longev. 2017: 1401452 (Open Access) (2017).

König, J., Besoke, F., Stuetz, W., Malarski, A., Jahreis, G., Grune, T., Höhn, A.: Quantification of age-related changes of α-tocopherol in lysosomal membranes in murine tissues and human fibroblasts. BioFactors 42, 307-315 (Open Access) (2016).

Ott, C., König, J., Höhn, A., Jung, T., Grune, T.: Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts. Free Radic. Biol. Med. 101, 325-333 (Open Access) (2016).

Ott, C., König, J., Höhn, A., Jung, T., Grune, T.: Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts. Redox Biol. 10, 266-273 (Open Access) (2016).

Reeg, S., Jung, T., Castro, J. P., Davies, K. J., Henze, A., Grune, T.: The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome. Free Radic. Biol. Med. 99, 153-166 (Open Access) (2016).

Stuetz, W., Weber, D., Dollé, M. E. T., Jansen, E., Grubeck-Loebenstein, B., Fiegl, S., Toussaint, O., Bernhardt, J., Gonos, E. S., Franceschi, C., Sikora, E., Moreno-Villanueva, M., Breusing, N., Grune, T., Bürkle, A.: Plasma carotenoids, tocopherols, and retinol in the age-stratified (35–74 Years) general population: A cross-sectional study in six European countries. Nutrients 8:614 (Open Access) (2016).

Weitkunat, K., Schumann, S., Nickel, D., Kappo, K. A., Petzke, K. J., Kipp, A. P., Blaut, M., Klaus, S.: Importance of propionate for the repression of hepatic lipogenesis and improvement of insulin sensitivity in high-fat diet-induced obesity. Mol. Nutr. Food Res. 60, 2611-2621 (Open Access) (2016).

Hiller, F., Besselt, K., Deubel, S., Brigelius-Flohé, R., Kipp, A. P.: GPx2 induction is mediated through STAT transcription factors during acute colitis. Inflamm. Bowel Dis. 21, 2078-2089 (2015).

Hiller, F., Oldorff, L., Besselt, K., Kipp, A. P.: Differential acute effects of selenomethionine and sodium selenite on the severity of colitis. Nutrients 7, 2687-2706 (Open Access) (2015).

Höhn, A., Hartmann, P., Gebhart, V., Sonntag, J., Grune, T., Jung, T.: Actual Isothermal Effects of Water-Filtered Infrared A-Irradiation. Photochem. Photobiol. 91, 887-894 (2015).

Originalarbeiten (korrespondierender Autor nicht vom DIfE)

Ciccarone, F., Valentini, E., Malavolta, M., Zampieri, M., Bacalini, M. G., Calabrese, R., Guastafierro, T., Reale, A., Franceschi, C., Capri, M., Breusing, N., Grune, T., Moreno-Villanueva, M., Bürkle, A., Caiafa, P.: DNA hydroxymethylation levels are altered in blood cells from Down syndrome persons enrolled in the MARK-AGE project. J. Gerontol. A / Biol. Sci. Med. Sci. in press (E-pub ahead of print) (2017).

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Bürkle, A., Moreno-Villanueva, M., Grune, T., Weber, D., Stuetz, W., Gonos, E. S., Schön, C., Grubeck-Loebenstein, B., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Franceschi, C., Hervonen, A., Slagboom, E., Ciccarone, F., Zampieri, M., Caiafa, P., Jansen, E., Dollé, M. E. T., Breusing, N., Mocchegiani, E., Malavolta, M.: Zinc-induced Metallothionein in centenarian offspring from a large European population: the MARK-AGE Project. J. Gerontol. A / Biol. Sci. Med. Sci. in press (E-pub ahead of print) (2017).

Egea, J., Fabregat, I., Frapart, Y. M., .... Grune, T., Lamas, S., Schmidt, H. H. H. W., Di Lisa, F., Daiber, A.: European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol. 13, 94-162 (Open Access) (2017).

Griesser, E., Vemula, V., Raulien, N., Wagner, U., Reeg, S., Grune, T., Fedorova, M.: Cross-talk between lipid and protein carbonylation in a dynamic cardiomyocyte model of mild nitroxidative stress. Redox Biol. 11, 438-455 (Open Access) (2017).

Henkel, J., Coleman, C. D., Schraplau, A., Jӧhrens, K., Weber, D., Castro, J. P., Hugo, M., Schulz, T. J., Krämer, S., Schürmann, A., Püschel, G. P.: Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol. Mol. Med. 23, 70-82 (Open Access) (2017).

Kipp, A. P., Deubel, S., Arnér, E., Johansson, K.: Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells. Redox Biol. 12, 403-409 (Open Access) (2017).

Lennicke, C., Rahn, J., Kipp, A. P., Dojčinović, B. P., Müller, A. S., Wessjohann, L. A., Lichtenfels, R., Seliger, B.: Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice. Biochim. Biophys. Acta./General. Subj. 1861, Part A, 3323–3334 (2017).

Markó, L., Mannaa, M., Haschler, T. N., Krämer, S., Gollasch, M.: Renoprotection: focus on TRPV1, TRPV4, TRPC6 and TRPM2. Acta Physiol.(Oxf) 219, 589-612 (2017).

Ciccarone, F., Malavolta, M., Calabrese, R., Guastafierro, T., Bacalini, M. G., Reale, A., Franceschi, C., Capri, M., Hervonen, A., Hurme, M., Grubeck-Loebenstein, B., Koller, B., Bernhardt, J., Schӧn, C., Slagboom, P. E., Toussaint, O., Sikora, E., Gonos, E. S., Breusing, N., Grune, T., Jansen, E., Dollé, M., Moreno-Villanueva, M., Sindlinger, T., Bürkle, A., Zampieri, M., Caiafa, P.: Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study. Aging Cell 15, 755-765 (Open Access) (2016).

Issoglio, F. M., Campolo, N., Zeida, A., Grune, T., Radi, R., Estrin, D. A., Bartesaghi, S.: Exploring the catalytic mechanism of human glutamine synthetase by computer simulations. Biochemistry 55, 5907-5916 (2016).

Loof, T., Krämer, S., Gaedeke, J., Neumayer, H.-H., Peters, H.: IL-17 Expression in the Time Course of Acute Anti-Thy1 Glomerulonephritis. PLoS One 11(5):e0156480 (Open Access) (2016).

Markó, L., Szijártó, I. A., Filipovic, M. R., Kaßmann, M., Balogh, A., Park, J.-K., Przybyl, L., N’diaye, G., Krämer, S., Anders, J., Ishii, I., Müller, D. N., Gollasch, M.: Role of cystathionine gamma-Lyase in immediate renal impairment and inflammatory response in acute ischemic kidney injury. Sci. Rep. 6:27517 (Open Access) (2016).

Rakers, C., Schumacher, F., Meinl, W., Glatt, H., Kleuser, B., Wolber, G.: In silico prediction of human sulfotransferase 1E1 activity guided by pharmacophores from molecular dynamics simulations. J. Biol. Chem. 291, 58-71 (Open Access) (2016).

Steinbrenner, H., Speckmann, B., Klotz, L. O.: Selenoproteins: Antioxidant selenoenzymes and beyond. Arch. Biochem. Biophys. 595, 113-119 (2016).

Stuetz, W., Carrara, V. I., Mc Gready, R., Lee, S. J., Sriprawat, K., Po, B., Hanboonkunupakarn, B., Grune, T., Biesalski, H. K., Nosten, F. H.: Impact of food rations and supplements on micronutrient status by trimester of pregnancy: cross-sectional studies in the Maela Refugee Camp in Thailand. Nutrients 8(2):66 (Open Access) (2016).

Valentini, E., Zampieri, M., Malavolta, M., Bacalini, M. G., Calabrese, R., Guastafierro, T., Reale, A., Franceschi, C., Hervonen, A., Koller, B., Bernhardt, J., Slagboom, P. E., Toussaint, O., Sikora, E., Gonos, E. S., Breusing, N., Grune, T., Jansen, E., Dollé, M. E., Moreno-Villanueva, M., Sindlinger, T., Bürkle, A., Ciccarone, F., Caiafa, P.: Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study. Aging (Albany NY) 8, 1896-1922 (Open Access) (2016).

Augustyniak, E., Adam, A., Wojdyla, K., Rogowska-Wrzesinska, A., Willetts, R., Korkmaz, A., Atalay, M., Weber, D., Grune, T., Borsa, C., Gradinaru, D., Chand Bollineni, R., Fedorova, M., Griffiths, H. R.: Validation of protein carbonyl measurement: a multi-centre study. Redox Biol. 4, 149-157 (Open Access) (2015).

Baierle, M., Nascimento, S. N., Moro, A. M., Brucker, N., Freitas, F., Gauer, B., Durgante, J., Bordignon, S., Zibetti, M., Trentini, C. M., Duarte, M. M. M. F., Grune, T., Breusing, N., Garcia, S. C.: Relationship between inflammation and oxidative stress and cognitive decline in the institutionalized elderly. Oxid. Med. Cell. Longev. 2015:804198 (Open Access) (2015).

Ehlers, A., Florian, S., Schumacher, F., Meinl, W., Lenze, D., Hummel, M., Heise, T., Seidel, A., Glatt, H., Lampen, A.: The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens. Mol. Nutr. Food Res. 59, 685-697 (2015).

Gerhardt, C., Lier, J. M., Burmühl, S., Struchtrup, A., Deutschmann, K., Vetter, M., Leu, T., Reeg, S., Grune, T., Rüther, U.: The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium. J. Cell Biol. 210, 115-133 (Open Access) (2015).

Høie, A. H., Svendsen, C., Brunborg, G., Glatt, H., Alexander, J., Meinl, W., Husøy, T.: Genotoxicity of three food processing contaminants in transgenic mice expressing human sulfotransferases 1A1 and 1A2 as assessed by the in vivo alkaline single cell gel electrophoresis assay. Environ. Mol. Mutagen. 56, 709-714 (Open Access) (2015).

Japtok, L., Schmitz, E. I., Fayyaz, S., Krämer, S., Hsu, L. J., Kleuser, B.: Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2. FASEB J. 29, 3357-3369 (Open Access) (2015).

Just, J., Jung, T., Friis, N. A., Lykkemark, S., Drasbek, K., Siboska, G., Grune, T., Kristensen, P.: Identification of an unstable 4-hydroxynoneal modification on the 20S proteasome subunit α7 by recombinant antibody technology. Free Radic. Biol. Med. 89, 786-792 (Open Access) (2015).

Stancu, B., Krämer, S., Loof, T., Mika, A., Amann, K., Neumayer, H. H., Peters, H.: Soluble guanylate cyclase stimulator BAY 41-8543 and female sex ameliorate uremic aortic remodeling in a rat model of mild uremia. J. Hypertens. 33, 1907-1921 (2015).

Fayyaz, S., Henkel, J., Japtok, L., Krämer, S., Damm, G., Seehofer, D., Püschel, G. P., Kleuser, B.: Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. Diabetologia 57, 373-382 (2014).

Übersichtsarbeiten

Andrisic, L., Dudzik, D., Barbas, C., Milkovic, L., Grune, T., Zarkovic, N.: Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer. Redox Biol. 14, 47-58 (Open Access) (2017).

Castro, J. P., Jung, T., Grune, T., Siems, W.: 4-Hydroxynonenal (HNE) modified proteins in metabolic diseases. Free Radic. Biol. Med. 111, 309-315 (Open Access) (2017).

Höhn, A., Weber, D., Jung, T., Ott, C., Hugo, M., Kochlik, B., Kehm, R., König, J.Grune, T., Castro, J. P.: Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence. Redox Biol. 11, 482-501 (Open Access) (2017).

Kaplan, G. S., Torcun, C. C., Grune, T., Ozer, N. K., Karademir, B.: Proteasome inhibitors in cancer therapy: Treatment regimen and peripheral neuropathy as a side effect. Free Radic. Biol. Med. 103, 1–13 (2017).

Korovila, I., Hugo, M., Castro, J. P., Weber, D., Höhn, A., Grune, T., Jung, T.: Proteostasis, oxidative stress and aging. Redox Biol. 13, 550-567 (Open Access) (2017).

Nedic Erjavec, G., Konjevod, M., Nikolac Perkovic, M., Svob Strac, D., Tudor, L., Barbas, C., Grune, T., Zarkovic, N., Pivac, N.: Short overview on metabolomic approach and redox changes in psychiatric disorders. Redox Biol. 14, 178-186 (Open Access) (2017).

Castro, J. P., Grune, T., Speckmann, B.: The two faces of ROS in adipocyte function and dysfunction. Biol. Chem. 397, 709-724 (Open Access) (2016).

Erusalimsky, J. D., Grillari, J. Grune, T., Jansen-Duerr, P., Lippi, G., Sinclair, A. J., Tegnér, J., Viña, J., Durrance-Bagale, A., Miñambres, R., Viegas, M., Rodríguez-Mañas, L.: In search of ’Omics’-based biomarkers to predict risk of frailty and its consequences in older individuals: The FRAILOMIC initiative. Gerontology 62, 182-190 (Open Access) (2016).

Höhn, A., König, J., Jung, T.: Metabolic syndrome, redox state and the proteasomal system. Antioxid. Redox Signal. 25, 902-917 (2016).

Klionsky, D. J., ... Grune, T., ... Zughaier, S. M.: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1-122 (Open Access) (2016).

Pivovarova, O., Höhn, A., Grune, T., Pfeiffer, A. F. H., Rudovich, N.: Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease?. Ann. Med. 48, 614-624 (2016).

Speckmann, B., Steinbrenner, H., Grune, T., Klotz, L. O.: Peroxynitrite: From interception to signaling. Arch. Biochem. Biophys. 595, 153-160 (2016).

Wiedmer, P., Ode, A., Grune, T.: NutriAct - Nutritional intervention: Food patterns, behaviour, and products. Dtsch. Lebensmitt. Rundsch. 112, 142-146 (2016).

Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H. J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Dollé, M., Salmon, M., Kristensen, P., Griffiths, H. R., Libert, C., Grune, T., Breusing, N., Simm, A., Franceschi, C., Capri, M., Talbot, D., Caiafa, P., Friguet, B., Slagboom, P. E., Hervonen, A., Hurme, M., Aspinall, R.: MARK-AGE biomarkers of ageing. Mech. Ageing Dev. 151, 2-12 (Open Access) (2015).

Frijhoff, J., Winyard, P. G., Zarkovic, N., Davies, S., Stocker, R., Cheng, D., Knight, A., Taylor, E. L., Oettrich, J., Ruskovska, T., Cipak Gasparovic, A., Cuadrado, A., Weber, D., Poulsen, H. E., Grune, T., Schmidt, H. H. H. W., Ghezzi, P.: Clinical relevance of biomarkers of oxidative stress. Antioxid. Redox Signal. 23, 1144-1170 (Open Access) (2015).

Grune, T.: Insulin-degrading enzyme: is it suitable for diabetes treatment?. Cell Cycle 14, 2553 (Comment) (Open Access) (2015).

Jansen, E., Beekhof, P., Cremers, J., Weinberger, B., Fiegl, S., Toussaint, O., Bernhard, J., Gonos, E., Capri, M., Franceschi, C., Sikora, E., Moreno-Villanueva, M., Breusing, N., Grune, T., Bürkle, A., Dollé, M. E. T.: Quality control data of physiological and immunological biomarkers measured in serum and plasma. Mech. Ageing Dev. 151, 54-59 (Open Access) (2015).

Kipp, A. P., Strohm, D., Brigelius-Flohé, R., Schomburg, L., Bechthold, A., Leschik-Bonnet, E., Heseker, H.: Revised reference values for selenium intake. J. Trace Elem. Med. Biol. 32, 195-199 (Open Access) (2015).

Moreno-Villanueva, M., Capri, M., Breusing, N., Siepelmeyer, A., Sevini, F., Ghezzo, A., de Craen, A. J. M., Hervonen, A., Hurme, M., Schön, C., Grune, T., Franceschi, C., Bürkle, A.: MARK-AGE standard operating procedures (SOPs): A successful effort. Mech. Ageing Dev. 151, 18-25 (Open Access) (2015).

Nowotny, K., Jung, T., Höhn, A., Weber, D., Grune, T.: Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules 5, 194-222 (Open Access) (2015).

Reeg, S., Grune, T.: Protein oxidation in aging: Does it play a role in aging progression?. Antioxid. Redox Signal. 23, 239-255 (Open Access) (2015).

Speckmann, B., Grune, T.: Epigenetic effects of selenium and their implications for health. Epigenetics 10, 179-190 (Open Access) (2015).

Weber, D., Davies, M. J., Grune, T.: Determination of protein carbonyls in plasma, cell extracts, tissue homogenates, isolated proteins: Focus on sample preparation and derivatization conditions. Redox. Biol. 5, 367-380 (Open Access) (2015).

Sadowska-Bartosz, I., Ott, C., Grune, T., Bartosz, G.: Posttranslational protein modifications by reactive nitrogen and chlorine species and strategies for their prevention and elimination. Free Radic. Res. 48, 1267-1284 (2014).

Buchbeiträge

König, J., Jung, T., Grune, T.: Protein Carbonylation in Aging and Senescence. In: Ros, J. (ed.) Protein Carbonylation: Principles, Analysis, and Biological Implications. Wiley, Hoboken, pp 272–290 (2017).

Reeg, S., Grune, T.: Protein Oxidation in Toxicology. In: Roberts, S. M., Kehrer, J. P., Klotz, L.-O. (eds.) Studies on Experimental Toxicology and Pharmacology (Oxidative Stress in Applied Basic Research and Clinical Practice). Humana Press, pp. 81-102 (2015).

Herausgeber

Bürkle, A., Grune, T.: Biomarkers of Human Ageing. (Mechanisms of Ageing and Development; Special Issue) Elsevier (2015).

sonstige Arbeiten

Kochlik, B., Grune, T., Weber, D.: Dietary concepts for the elderly. Diabetologe 13, 433-441 (2017).

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