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Image Ernährungstoxikologie

Abteilung Ernährungstoxikologie (ETOX)


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Abteilung Ernährungstoxikologie


Monien, B. H., Sachse, B., Meinl, W., Abraham, K., Lampen, A., Glatt, H.: Hemoglobin adducts of furfuryl alcohol in genetically modified mouse models: Role of endogenous sulfotransferases 1a1 and 1d1 and transgenic human sulfotransferases 1A1/1A2. Toxicol. Lett. 295, 173-178 (2018).

Bendadani, C., Steinhauser, L., Albert, K., Glatt, H., Monien, B. H.: Metabolism and excretion of 1-hydroxymethylpyrene, the proximate metabolite of the carcinogen 1-methylpyrene, in rats. Toxicology 366-367, 43-52 (2016).

Glatt, H., Sabbioni, G., Monien, B. H., Meinl, W.: Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of human sulfotransferases in the bioactivation of nitro- and aminotoluenes. Environ. Mol. Mutagen. 57, 299-311 (2016).

Herrmann, K., Engst, W., Florian, S., Lampen, A., Meinl, W., Glatt, H.: The influence of the SULT1A status – wild-type, knockout or humanized – on the DNA adduct formation by methyleugenol in extrahepatic tissues of mice. Toxicol. Res. 5, 808-815 (Open Access) (2016).

Sachse, B., Meinl, W., Glatt, H., Monien, B. H.: Conversion of suspected food carcinogen 5-hydroxymethylfurfural by sulfotransferases and aldehyde dehydrogenases in postmitochondrial tissue preparations of humans, mice and rats. Toxicol. Sci. 149, 192-201 (2016).

Sachse, B., Meinl, W., Glatt, H., Monien, B. H.: Ethanol and 4-methylpyrazole increase DNA adduct formation of furfuryl alcohol in FVB/N wild-type mice and in mice expressing human sulfotransferases 1A1/1A2. Carcinogenesis 37, 314-319 (2016).

Budnowski, J., Hanske, L., Schumacher, F., Glatt, H., Platz, S., Rohn, S., Blaut, M.: Glucosinolates are mainly absorbed intact in germfree and human microbiota-associated mice. J. Agric. Food Chem. 63, 8418-8428 (2015).

Monien, B. H., Schumacher, F., Herrmann, K., Glatt, H., Turesky, R. J., Chesné, C.: Simultaneous detection of multiple DNA adducts in human lung samples by isotope-dilution UPLC-MS/MS. Anal. Chem. 87, 641-648 (2015).

Barknowitz, G., Engst, W., Schmidt, S., Bernau, M., Monien,B. H., Kramer, M., Florian, S., Glatt, H.: Identification and quantification of protein adducts formed by metabolites of 1-methoxy-3-indolylmethyl glucosinolate in vitro and in mouse models. Chem. Res. Toxicol. 27, 188–199 (2014).

Bendadani, C., Meinl, W., Monien, B. H., Dobbernack, G., Glatt, H.: The carcinogen 1-methylpyrene forms benzylic DNA adducts in mouse and rat tissues in vivo via a reactive sulphuric acid ester. Arch. Toxicol. 88, 815-821 (2014).

Bendadani, C., Meinl, W., Monien, B., Dobbernack, G., Florian, S., Engst, W., Nolden, T., Himmelbauer, H., Glatt, H.: Determination of sulfotransferase forms involved in the metabolic activation of the genotoxicant 1-Hydroxymethylpyrene using bacterially expressed enzymes and genetically modified mouse models. Chem. Res. Toxicol. 27, 1060-1069 (Open Access) (2014).

Glatt, H., Pietsch, K. E., Sturla, S. J., Meinl, W.: Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. Arch. Toxicol. 88, 161-169 (2014).

Herrmann, K., Engst, W., Meinl, W., Florian, S., Cartus, A. T., Schrenk, D., Appel, K. E., Nolden, T., Himmelbauer, H., Glatt, H.: Formation of hepatic DNA adducts by methyleugenol in mouse models: drastic decrease by Sult1a1 knockout and strong increase by transgenic human SULT1A1/2. Carcinogenesis 35, 935-941 (2014).

Lippmann, D., Lehmann, C., Florian, S., Barknowitz, G., Haack, M., Mewis, I., Wiesner, M., Schreiner, M., Glatt, H., Brigelius-Flohé, R., Kipp, A. P.: Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently. Food Funct. 5, 1073-1081 (2014).

Sachse, B., Meinl, W., Glatt, H., Monien, B. H.: The effect of knockout of sulfotransferases 1a1 and 1d1 and of transgenic human sulfotransferases 1A1/1A2 on the formation of DNA adducts from furfuryl alcohol in mouse models. Carcinogenesis 35, 2339-2345 (2014).

Schumacher, F., Florian, S., Schnapper, A., Monien, B. H., Mewis, I., Schreiner, M., Seidel, A., Engst, W., Glatt, H.: A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells. Arch. Toxicol. 88, 823-836 (2014).

Wiesner, M., Schreiner, M., Glatt, H.: High mutagenic activity of juice from pak choi (Brassica rapa ssp. chinensis) sprouts due to its content of 1-methoxy-3-indolylmethyl glucosinolate, and its enhancement by elicitation with methyl jasmonate. Food Chem. Toxicol. 67, 10-16 (2014).

Döcke, S., Lock, J. F., Birkenfeld, A. L., Hoppe, S., Lieske, S., Rieger, A., Raschzok, N., Sauer, I. M., Florian, S., Osterhoff, M. A., Heller, R., Herrmann, K., Lindenmüller, S., Horn, P., Bauer, M., Weickert, M. O., Neuhaus, P., Stockmann, M., Möhlig, M., Pfeiffer, A. F. H., von Loeffelholz, C.: Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease. Eur. J. Endocrinol. 169, 547-557 (2013).

Herrmann, K., Schumacher, F., Engst, W., Appel, K. E., Klein, K., Zanger, U. M., Glatt, H.: Abundance of DNA adducts of methyleugenol, a rodent hepatocarcinogen, in human liver samples. Carcinogenesis 34, 1025-1030 (2013).

Kollock, R., Glatt, H.: Opposing-activity or inhibitory-effects of cimetidine and daidzein on human ADH1C activity depending on substrates and solvents. Drug Metab. Lett. 6, 258-264 (2013).

Meinl, W., Tsoi, C., Swedmark, S., Tibbs, Z. E., Falany, C. N., Glatt, H.: Highly selective bioactivation of 1- and 2-hydroxy-3-methylcholanthrene to mutagens by individual human and other mammalian sulphotransferases expressed in Salmonella typhimurium. Mutagenesis 28, 609-619 (2013).

Schumacher, F., Herrmann, K., Florian, S., Engst, W., Glatt, H.: Optimized enzymatic hydrolysis of DNA for LC-MS/MS analyses of adducts of 1-methoxy-3-indolylmethyl glucosinolate and methyleugenol. Anal. Biochem. 434, 4-11 (2013).

Wiesner, M., Hanschen, F. S., Schreiner, M., Glatt, H., Zrenner, R.: Induced production of 1-methoxy-indol-3-ylmethyl glucosinolate by jasmonic acid and methyl jasmonate in sprouts and leaves of pak choi (Brassica rapa ssp. chinensis). Int. J. Mol. Sci. 14, 14996-15016 (2013).

Wiesner, M., Zrenner, R., Krumbein, A., Glatt, H., Schreiner, M.: Genotypic variation of the glucosinolate profile in pak choi (Brassica rapa ssp. chinensis). J. Agric. Food Chem. 61, 1943-1953 (2013).

Bauer-Marinovic, M., Taugner, F., Florian, S., Glatt, H.: Toxicity studies with 5-hydroxymethylfurfural and its metabolite 5-sulphooxymethylfurfural in wild-type mice and transgenic mice expressing human sulphotransferases 1A1 and 1A2. Arch. Toxicol. 86, 701-711 (2012).

Florian, S., Bauer-Marinovic, M., Taugner, F., Dobbernack, G., Monien, B. H., Meinl, W., Glatt, H.: Study of 5-hydroxymethylfurfural and its metabolite 5-sulfooxymethylfurfural on induction of colonic aberrant crypt foci in wild-type mice and transgenic mice expressing human sulfotransferases 1A1 and 1A2. Mol. Nutr. Food Res. 56, 593-600 (2012).

Glatt, H., Schneider, H., Murkovic, M., Monien, B. H., Meinl, W.: Hydroxymethyl-substituted furans: mutagenicity in Salmonella typhimurium strains engineered for expression of various human and rodent sulphotransferases. Mutagenesis 27, 41-48 (2012).

Herrmann, K., Engst, W., Appel, K. E., Monien, B. H., Glatt, H.: Identification of human and murine sulfotransferases able to activate hydroxylated metabolites of methyleugenol to mutagens in Salmonella typhimurium and detection of associated DNA adducts using UPLC-MS/MS methods. Mutagenesis 27, 453-462 (2012).

Monien, B. H., Engst, W., Barknowitz, G., Seidel, A., Glatt, H.: Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: identification and mass spectrometric quantification of DNA adducts formed. Chem. Res. Toxicol. 25, 1484-1492 (2012).

Schumacher, F., Engst, W., Monien, B. H., Florian, S., Schnapper, A., Steinhauser, L., Albert, K., Frank, H., Seidel, A., Glatt. H.: Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS. Anal. Chem. 84, 6256-6262 (2012).

Baasanjav-Gerber, C., Hollnagel, H. M., Brauchmann, J., Iori, R., Glatt, H.: Detection of genotoxicants in Brassicales using endogenous DNA as a surrogate target and adducts determined by 32P-postlabelling as an experimental end point. Mutagenesis 26, 407-413 (2011).

Baasanjav-Gerber, C., Monien, B. H., Mewis, I., Schreiner, M., Barillari, J., Iori, R., Glatt, H.: Identification of glucosinolate congeners able to form DNA adducts and to induce mutations upon activation by myrosinase. Mol. Nutr. Food Res. 55, 783-792 (2011).

Dobbernack, G., Meinl, W., Schade, N., Florian, S., Wend, K., Voigt, I., Himmelbauer, H., Gross, M., Liehr, T., Glatt, H.: Altered tissue distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adducts in mice transgenic for human sulfotransferases 1A1 and 1A2. Carcinogenesis 32, 1734-1740 (2011).

Glatt, H., Baasanjav-Gerber, C., Schumacher, F., Monien, B. H., Schreiner, M., Frank, H., Seidel, A., Engst, W.: 1-Methoxy-3-indolylmethyl glucosinolate; a potent genotoxicant in bacterial and mammalian cells: Mechanisms of bioactivation. Chem. Biol. Interact. 192, 81-86 (2011).

Kutschera, M., Engst, W., Blaut, M., Braune, A.: Isolation of catechin-converting human intestinal bacteria. J. Appl. Microbiol. 111, 165-175 (2011).

Landsiedel, R., Fabian, E., Tralau, T., Luch, A.: Chemical toxicity testing in vitro using cytochrome P450–expressing cell lines, such as human CYP1B1. Nat. Protoc. 6, 677-688 (2011).

Monien, B. H., Herrmann, K., Florian, S., Glatt, H.: Metabolic activation of furfuryl alcohol: formation of 2-methylfuranyl DNA adducts in Salmonella typhimurium strains expressing human sulfotransferase 1A1 and in FVB/mice. Carcinogenesis 32, 1533-1539 (2011).

Haack, M., Löwinger, M., Lippmann, D., Kipp, A., Pagnotta, E., Iori, R., Monien, B. H., Glatt, H., Brauer, M. N., Wessjohann, L. A., Brigelius-Flohé, R.: Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products. Biol. Chem. 391, 1281-1293 (2010).

Kuhlow, D., Florian, S., von Figura, G., Weimer, S., Schulz, N., Petzke, K. J., Zarse, K., Pfeiffer, A. F. H., Rudolph, K. L., Ristow, M.: Telomerase deficiency impairs glucose metabolism and insulin secretion. Aging 2, 650-658 (Open Access) (2010).

Liu, Y., Glatt, H.: Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis. Environ. Mol. Mutagen. 51, 23-30 (2010).

Platt, K. L., Edenharder, R., Aderhold, S., Muckel, E., Glatt, H: Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed in immortal mammalian cells. Mutat. Res./Genet. Toxicol. Environ. Mutagen. 703, 90-98 (2010).

Thierbach, R., Drewes, G., Fusser, M., Voigt, A., Kuhlow, D., Blume, U., Schulz, T. J., Reiche, C., Glatt, H., Epe, B., Steinberg, P., Ristow, M.: The Friedreich´s ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals. Biochem. J. 432, 165-172 (2010).

Bakhiya, N., Arlt, V., Bahn, A., Burckhardt, G., Phillips, D. H., Glatt, H.: Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. Toxicology 264, 74-79 (2009).

Bakhiya, N., Monien, B., Frank, H., Seidel, A., Glatt, H.: Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxymethylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxymethylfurfural. Biochem. Pharmacol. 78, 414-419 (2009).

Kollock, R., Rost, K., Batke, M., Glatt, H.: Effect of pentachlorophenol and 2,6-dichloro-4-nitrophenol on the activity of cDNA-expressed human alcohol and aldehyde dehydrogenases. Toxicol. Lett. 191, 360-364 (2009).

Meinl, W., Sczesny, S., Brigelius-Flohé, R., Blaut, M., Glatt, H.: Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat. Drug Metab. Dispos. 37, 1179-1186 (2009).

Monien, B. H., Frank, H., Seidel, A., Glatt, H.: Conversion of the common food constituent 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo. Chem. Res. Toxicol. 22, 1123-1128 (2009).

Monien, B. H., Müller, C., Bakhiya, N., Donath, C., Frank, H., Seidel, A., Glatt, H.: Probenecid, an inhibitor of transmembrane organic anion transporters, alters tissue distribution of DNA adducts in 1-hydroxymethylpyrene-treated rats. Toxicology 262, 80-85 (2009).

Schmidt, S., Hommel, A., Gawlik, V., Augustin, R., Junicke, N., Florian, S., Richter, M., Walther, D. J., Montag, D., Joost, H.-G., Schürmann, A.: Essential role of glucose transporter GLUT3 for post-implantation embryonic development. J. Endocrinol. 200, 23-33 (Open Access) (2009).

Banning, A., Florian, S., Deubel, S., Thalmann, S., Müller-Schmehl, K., Jacobasch, G., Brigelius-Flohé, R.: GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. Antioxid. Redox Signal. 10, 1491-1500 (2008).

Glatt, H., Rost, K., Frank, H., Seidel, A., Kollock, R.: Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1. Arch. Biochem. Biophys. 477, 196-205 (2008).

Kollock, R., Frank, H., Seidel, A., Meinl, W., Glatt, H.: Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology 245, 65-75 (2008).

Kollock, R., Meinl, W., Schneider, H., Batke, M., Frank, H., Seidel, A., Glatt, H.: Efficient oxidation of promutagenic hydroxymethylpyrenes by cDNA-expressed human alcohol dehydrogenase ADH2 and its inhibition by various agents. Biochem. Pharmacol. 75, 527-537 (2008).

Liu, Y., Glatt, H.: Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes. Mutat. Res./Fund. Mol. Mech. Mutagen. 643, 64-69 (2008).

Meinl, W., Donath, C., Schneider, H., Sommer, Y., Glatt, H.: SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens. Food Chem. Toxicol. 46, 1249-1256 (2008).

Meinl, W., Ebert, B., Glatt, H., Lampen, A.: Sulfotransferase forms expressed in human intestinal Caco-2 and TC7 cells at varying stages of differentiation and role in benzo[a]pyrene metabolism. Drug Metab. Dispos. 36, 276-283 (2008).

Monien, H. B., Müller, C., Engst, W., Frank, H., Seidel, A., Glatt, H.: Time course of hepatic 1-methylpyrene DNA adducts in rats determined by isotope dilution LC-MS/MS and 32P-postlabeling. Chem. Res. Toxicol. 21, 2017-2025 (2008).

Zahn, C., Jaschke, A., Weiske, J., Hommel, A., Hesse, D., Augustin, R., Lu, L., Hong, W., Florian, S., Scheepers, A., Joost, H.-G., Huber, O., Schürmann, A.: ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin. J. Biol. Chem. 283, 27179-27188 (2008).

Bakhiya, N., Batke, M., Laake, J., Monien, B. H., Frank, H., Seidel, A., Engst, W., Glatt, H.: Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic aromatic hydrocarbons. Drug Metab. Dispos. 35, 1824-1831 (2007).

Teubner, W., Meinl, W., Florian, S., Kretzschmar, M., Glatt, H.: Identification and localization of soluble sulfotransferases in the human gastrointestinal tract. Biochem. J. 404, 207-215 (2007).

Bakhiya, N., Stephani, M., Bahn, A., Ugele, B., Seidel, A., Burckhardt, G., Glatt, H.: Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters. J. Am. Soc. Nephrol. 17, 1414-1421 (2006).

Bauer-Marinovic, M., Florian, S., Müller-Schmehl, K., Glatt, H., Jacobasch, G.: Dietary resistant starch type 3 prevents tumor induction by 1,2-dimethylhydrazine and alters proliferation, apoptosis and dedifferentiation in rat colon. Carcinogenesis 27, 1849-1859 (2006).

Blaut, M., Braune, A., Wunderlich, S., Sauer, P., Schneider, H., Glatt, H.: Mutagenicity of arbutin in mammalian cells after activation by human intestinal bacteria. Food Chem. Toxicol. 44, 1940-1947 (2006).

Clavel, T., Henderson, G., Engst, W., Doré, J., Blaut, M.: Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside. FEMS Microbiol. Ecol. 55, 471-478 (2006).

Meinl, W., Pabel, U., Osterloh-Quiroz, M., Hengstler, J. G., Glatt, H.: Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue. Int. J. Cancer 118, 1090-1097 (2006).

Zahn, C., Hommel, A., Lu, L., Hong, W., Walther, D. J., Florian, S., Joost, H.-G., Schürmann, A.: Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells. Mol. Membr. Biol. 23, 475-485 (2006).

Alpert, C., Engst, W., Guehler, A., Oelschlaeger, T., Blaut, M.: Bacterial response to eukaryotic cells. Analysis of differentially expressed proteins using nano liquid chromatography-electrospray ionization tandem mass spectrometry. J. Chromatogr. A 1082, 25-32 (2005).

Braune, A., Engst, W., Blaut, M.: Degradation of neohesperidin dihydrochalcone by human intestinal bacteria. J. Agric. Food Chem. 53, 1782-1790 (2005).

Glatt, H., Schneider, H., Liu, Y.: V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals. Mutat. Res./Genet. Toxicol. Environ. Mutagen. 580, 41-52 (2005).

Moreno, V., Glatt, H., Guino, E., Fisher, E., Meinl, W., Navarro, M., Badosa, J. M., Boeing, H.: Polymorphisms in sulfotransferases SULT1A1 and SULT1A2 are not related to colorectal cancer. Int. J. Cancer 113, 683-686 (2005).

Glatt, H., Meinl, W.: Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of sulfotransferases and acetyltransferases in nitrofen mutagenicity. Carcinogenesis 25, 779-786 (2004).

Glatt, H., Pabel, U., Meinl, W., Frederiksen, H., Frandsen, H., Muckel, E.: Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) in recombinant test systems expressing human xenobiotic-metabolizing enzymes. Carcinogenesis 25, 801-807 (2004).

Majer, B. J., Kassie, F., Sasaki, Y., Pfau, W., Glatt, H., Meinl, W., Darroudi, F., Knasmüller, S.: Investigation of the genotoxic effects of 2-amino-9H-pyrido[2,3-b]indole in different organs of rodents and in human derived cells. J. Chromatogr. B 802, 167-173 (2004).

Schneider, H., Glatt, H.: Sulpho-conjugation of ethanol in humans in vivo and by individual sulphotransferase forms in vitro. Biochem. J. 383, 543-549 (2004).

Schwonbeck, S., Krause-Griep, A., Gajovic-Eichelmann, N., Ehrentreich-Förster, E., Meinl, W., Glatt, H., Bier, F. F.: Cohort analysis of a single nucleotide polymorphism on DNA chips. Biosens. Bioelectron. 20, 956-966 (2004).

Tiemersma, E. W., Bunschoten, A., Kok, F. J., Glatt, H., de Boer, S. Y., Kampman, E.: Effect of SULT1A1 and NAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas. Int. J. Cancer 108, 97-103 (2004).

Tiemersma, E. W., Voskuil, D. W., Bunschoten, A., Hogendoorn, E. A., Witteman, B. J. M., Nagengast, F. M., Glatt, H. R., Kok, F. J., Kampman, E.: Risk of colorectal adenomas in relation to meat consumption, meat preparation and genetic susceptibility in a Dutch population. Cancer Causes Control 15, 225-236 (2004).

Arlt, V. M., Glatt, H. R., Muckel, E., Pabel, U., Sorg, B. L., Seidel, A., Frank, H., Schmeiser, H. H., Phillips, D. H.: Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells. Int. J. Cancer 105, 583-592 (2003).

Bernauer, U., Glatt, H., Heinrich-Hirsch, B., Liu, Y., Muckel, E., Vieth, B., Gundert-Remy, G.: Heterologous expression of mouse cytochrome P450 2e1 in V79 cells: construction and characterisation of the cell line and comparison with V79 cell lines stably expressing rat P450 2E1 and human P450 2E1. ATLA - Altern. Lab. Anim. 31, 21-30 (2003).

Kester, M. H. A., Kaptein, E., Roest, T. J., van Dijk, C. H., Tibboel, D., Meinl, W., Glatt, H. R., Coughtrie, M. W. H., Visser, T. J.: Characterization of rat iodothyronine sulfotransferases. Am. J. Physiol./Endocrinol. Metab. 283, E592-E598 (2003).

Landes, N., Pfluger, P., Kluth, D., Birringer, M., Rühl, R., Böl, G.-F., Glatt, H., Brigelius-Flohé, R.: Vitamin E activates gene expression via the pregnane X receptor. Biochem. Pharmacol. 65, 269-273 (2003).

Schneider, H., Ma, L., Glatt, H. R.: Extractionless method for the determination of urinary caffeine metabolites using high-performance liquid chromatography coupled with tandem mass spectrometry. J. Chromatogr. B 789, 227-237 (2003).

Arlt, V. M., Glatt, H., Muckel, E., Pabel, U., Sorg, B. L., Schmeiser, H. H., Phillips, D. H.: Metabolic activation of the environmental contaminat 3-nitrobenzanthrone by human acetyltransferases and sulfotransferases. Carcinogenesis 23, 1937-1945 (2002).

Edenharder, R., Sager, J. W., Glatt, H., Muckel, E., Platt, K. L.: Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in metabolically competent V79 cells. Mutat. Res. 521, 57-72 (2002).

Engst, W., Pabel, U., Glatt, H.: Conjugation of 4-nitrophenol and 4-hydroxylonazolac in V79-derived cells expressing individual forms of human sulphotransferases. Environ. Toxicol. Pharmacol. 11, 243-250 (2002).

Glatt, H., Pabel, U., Muckel, E., Meinl, W.: Activation of polycyclic aromatic compounds by cDNA-expressed phase I and phase II enzymes. Polycyclic Aromat. Comp. 22, 955-967 (2002).

Kester, M. H. A., Bulduk, S., van Toor, H., Tibboel, D., Meinl, W., Glatt, H., Falany, C. N., Coughtrie, M. W. H., Schuur, A. G., Brouwer, A., Visser, T. J.: Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbones reveals alternative mechanism for estrogenic activity of endocrine disrupters. J. Clin. Endocrinol. Metab. 87, 1142-1150 (2002).

Luch, A., Greim, H., Buters, J. T. M., Mahadevan, B., Baird, W. M., Doehmer, J., Seidel, A., Glatt, H.: The role of cytochrome P450 1B1 in dibenzo[A,L]pyrene-induced carcinogenesis. Polycyclic Aromat. Comp. 22, 781-789 (2002).

Ma, L., Kuhlow, A., Glatt, H.: Ethanol enhances the activation of 1-Hydroxymethylpyrene to DNA adduct-forming species in the rat. Polycyclic Aromat. Comp. 22, 933-946 (2002).

Meinl, W., Meerman, J. H., Glatt, H.: Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium. Pharmacogenetics 12, 677-689 (2002).

Muckel, E., Frandsen, H., Glatt, H. R.: Heterologous expression of human N-acetyltransferases 1 and 2 and sulfotransferase 1A1 in Salmonella typhimurium for mutagenicity testing of heterocyclic amines. Food Chem. Toxicol. 40, 1063-1068 (2002).

Teubner, W., Meinl, W., Glatt, H.: Stable expression of rat sulfotransferase 1B1 in V79 cells: activation of benzylic alcohols to mutagens. Carcinogenesis 23, 1877-1884 (2002).

Braune, A., Gutschow, M., Engst, W., Blaut, M.: Degradation of quercetin and luteolin by Eubacterium ramulus. Appl. Environ. Microbiol. 67, 5558-5567 (2001).

Henschler, R., Appel, K. E., Heyworth, C. M., Glatt, H.: Proliferation and differentiation of murine haemopoietic progenitor cells in stroma-free culture in the presence of metabolites of chlorinated pesticides. Toxicol. in Vitro 15, 31-37 (2001).

Meinl, W., Glatt, H.-R.: Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene. Biochem. Biophys. Res. Commun. 288, 855-862 (2001).

Williams, J. A., Stone, E. M., Fakis, G., Johnson, N., Cordell, J. A., Meinl, W., Glatt, H., Sim, E., Phillips, D. H.: N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast. Pharmacogenetics 11, 373-388 (2001).

Blum, J., Kogan, V., Glatt, H. R.: Further studies on polycyclic arene sulfides: preparation and mutagenic activity of 9,10,10a,11a-tetrahydrotriphenylenol[1,2-b]thiirene, 1a,2,3,10b-tetrahydro-5H-thiereno[3,4]benzo[1,2-b]fluorene and 1a,2,3,11b-tetrahydroacenaphthol-[1´,2´:6,7]naphtha[1,2-b]thiirene. J. Heterocyclic Chem. 37, 1109-1112 (2000).

Davis, W., Hewer, A., Rajkowski, K. M., Meinl, W., Glatt, H. R., Phillips, D. H.: Sex differences in the activation of tamoxifen to DNA binding species in rat liver in vivo and in rat hepatocytes in vitro: role of sulfotransferase induction. Cancer Res. 60, 2887-2891 (2000).

Engelke, C. E. H., Meinl, W., Boeing, H., Glatt, H. R.: Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2. Pharmacogenetics 10, 163-169 (2000).

Kester, M. H., Bulduk, S., Tibboel, D., Meinl, W., Glatt, H. R., Falany, C. N., Coughtrie, M. W. H., Bergman, A., Safe, S. H., Kuiper, G. G., Schuur, A. G., Brouwer, A., Visser, T. J.: Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. Endocrinology 141, 1897-1900 (2000).

Kreis, P., Brandner, S., Coughtrie, M. W., Pabel, U., Meinl, W., Glatt, H., Andrae, U.: Human phenol sulfotransferases hP-PST and hM-PST activate propane 2-nitronate to a genotoxicant. Carcinogenesis 21, 295-299 (2000).

Ma, L., Landsiedel, R., Kuhlow, A., Engst, W., Seidel, A., Glatt, H.: Detection of mercapturic acids and nucleoside adducts in blood, urine and feces of rats treated with metabolites of methylpyrene. Polycyclic Aromat. Comp. 21, 135-149 (2000).

Originalarbeiten (korrespondierender Autor nicht vom DIfE)

Prantl, E.-M., Kramer, M., Schmidt, C. K., Knauer, M., Gartiser, S., Shuliakevich, A., Milas, J., Glatt, H., Meinl, W., Hollert, H.: Comparison of in vitro test systems using bacterial and mammalian cells for genotoxicity assessment within the "health-related indication value (HRIV) concept. Environ. Sci. Pollut. Res. Int. 25, 3996-4010 (Erratum: 25, 4011) (2018).

Chevereau, M., Glatt, H., Zalko, D., Cravedi, J. P., Audebert, M.: Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells. Arch. Toxicol. 91, 3175–3184 (2017).

Arlt, V. M., Meinl, W., Florian, S., Nagy, E., Barta, F., Thomann, M., Mrizova, I., Krais, A. M., Liu, M., Richards, M., Mirza, A., Kopka, K., Phillips, D. H., Glatt, H., Stiborova, M., Schmeiser, H. H.: Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone. Arch. Toxicol. 91, 1957-1975 (Open Access) (2017).

Liu, Y., Hu, K., Jia, H., Jin, G., Glatt, H., Jiang, H.: Potent mutagenicity of some non-planar tri- and tetrachlorinated biphenyls in mammalian cells, human CYP2E1 being a major activating enzyme. Arch. Toxicol. 91, 2663-2676 (2017).

Tremmel, R., Herrmann, K., Engst, W., Meinl, W., Klein, K., Glatt, H., Zanger, U. M.: Methyleugenol DNA adducts in human liver are associated with SULT1A1 copy number variations and expression levels. Arch. Toxicol. 91, 3329–3339 (2017).

Förster, N., Mewis, I., Glatt, H., Haack, M., Brigelius-Flohé, R., Schreiner, M., Ulrichs, C.: Characteristic single glucosinolates from Moringa oleifera: Induction of detoxifying enzymes and lack of genotoxic activity in various model systems. Food Funct. 7, 4660-4674 (2016).

Honda, H., Minegawa, K., Fujita, Y., Yamaguchi, N., Oguma, Y., Glatt, H., Nishiyama, N., Kasamatsu, T.: Modified Ames test using a strain expressing human sulfotransferase 1C2 to assess the mutagenicity of methyleugenol. Genes Environ. 38:1 (Open Access) (2016).

Høie, A. H., Monien, B.H., Glatt, H., Hjertholm, H., Husøy, T.: DNA adducts induced by food mutagen PhIP in a mouse model expressing human sulfotransferases 1A1 and 1A2. Toxicol. Lett. 248, 34-38 (Open Access) (2016).

Huffman, M. P., Høie, A. H., Svendsen, C., Brunborg, G., Murkovic, M., Glatt, H., Husøy, T.: An in vitro study on the genotoxic effect of substituted furans in cells transfected with human metabolizing enzymes: 2,5-dimethylfuran and furfuryl alcohol. Mutagenesis 31, 597-602 (Open Access) (2016).

Jia, H., Zhang, C., Glatt, H., Liu, Y.: Role of exposure/recovery schedule in micronuclei induction by several promutagens in V79-derived cells expressing human CYP2E1 and SULT1A1. Mutat. Res./Genet. Toxicol. Environ. Mutagen. 808, 27-37 (2016).

Rakers, C., Schumacher, F., Meinl, W., Glatt, H., Kleuser, B., Wolber, G.: In silico prediction of human sulfotransferase 1E1 activity guided by pharmacophores from molecular dynamics simulations. J. Biol. Chem. 291, 58-71 (Open Access) (2016).

Zhang, C. T., Lai, Y. M., Jin, G. F., Glatt, H., Wei, Q. Z., Liu, Y. G.: Human CYP2E1-dependent mutagenicity of mono- and dichlorobiphenyls in Chinese hamster (V79)-derived cells. Chemosphere 144, 1908-1915 (2016).

Ehlers, A., Florian, S., Schumacher, F., Meinl, W., Lenze, D., Hummel, M., Heise, T., Seidel, A., Glatt, H., Lampen, A.: The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens. Mol. Nutr. Food Res. 59, 685-697 (2015).

Høie, A. H., Monien, B. H., Sakhi, A. K., Glatt, H., Hjertholm, H., Husøy, T.: Formation of DNA adducts in wild-type and transgenic mice expressing human sulfotransferases 1A1 and 1A2 after oral exposure to furfuryl alcohol. Mutagenesis 30, 643-649 (Open Access) (2015).

Høie, A. H., Svendsen, C., Brunborg, G., Glatt, H., Alexander, J., Meinl, W., Husøy, T.: Genotoxicity of three food processing contaminants in transgenic mice expressing human sulfotransferases 1A1 and 1A2 as assessed by the in vivo alkaline single cell gel electrophoresis assay. Environ. Mol. Mutagen. 56, 709-714 (Open Access) (2015).

Cartus, A. T., Herrmann, K., Weishaupt, L. W., Merz, K.-H., Engst, W., Glatt, H., Schrenk, D.: Metabolism of methyleugenol in liver microsomes and primary hepatocytes: pattern of metabolites, cytotoxicity, and DNA-adduct formation. Toxicol. Sci. 129, 21-34 (2012).

Svendsen, C., Meinl, W., Glatt, H., Alexander, J., Knutsen, H. K., Hjertholm, H., Rasmussen, T., Husøy, T.: Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases. Mol. Carcinogen. 51, 984-992 (2012).

Menozzi-Smarrito, C., Wong, C. C., Meinl, W., Glatt, H., Fumeaux, R., Munari, C., Robert, F., Williamson, G., Barron, D.: First chemical synthesis and in vitro characterization of the potential human metabolites 5-O-feruloylquinic acid 4′-sulfate and 4′-O-glucuronide. J. Agric. Food Chem. 59, 5671-5676 (2011).

Brand, W., Boersma, M. G., Bik, H., Hoek-van den Hil, E. F., Vervoort, J., Barron, D., Meinl, W., Glatt, H., Williamson, G., van Bladeren, P. J., Rietjens, I. M. C. M.: Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. Drug Metab. Dispos. 38, 617-625 (2010).

Martin, F. L., Patel, I. I., Sozeri, O., Singh, P. B., Ragavan, N., Nicholson, C. M., Frei, E., Meinl, W., Glatt, H., Phillips, D. H., Arlt, V. M.: Constitutive expression of bioactivating enzymes in normal human prostate suggests a capability to activate pro-carcinogens to DNA-damaging metabolites. Prostate 70, 1586-1599 (2010).

Radović, B., Hussong, R., Gerhäuser, C., Meinl, W., Frank, N., Becker, H., Köhrle, J.: Xanthohumol, a prenylated chalcone from hops, modulates hepatic expression of genes involved in thyroid hormone distribution and metabolism. Mol. Nutr. Food Res. 54, S225-S235 (2010).

Stjernschantz, E., Reinen, J., Meinl, W., George, B. J., Glatt, H., Vermeulen, N. P. E., Oostenbrink, C.: Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico-implications for differences in activity, subunit dimerization and substrate inhibition. Mol. Cell. Endocrinol. 317, 127-140 (2010).

Wong, C. C., Meinl, W., Glatt, H., Barron, D., Stalmach, A., Steiling, H., Crozier, A., Williamson, G.: In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans. J. Nutr. Biochem. 21, 1060-1068 (2010).

Svendsen, C., Husøy, T., Glatt, H., Paulsen, J. E., Alexander, J.: 5-Hydroxymethyl and 5-sulfooxymethylfurfural increase adenoma and flat ACF number in the intestine of min/+ mice. Anticancer Res. 29, 1921-1926 (2009).

Wincent, E., Amini, N., Luecke, S., Glatt, H., Bergman, J., Crescenzi, C., Rannug, A., Rannung, U.: The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. J. Biol. Chem. 284, 2690-2696 (2009).

Hoelzl, C., Glatt, H., Meinl, W., Sontag, G., Haidinger, G., Kundi, M., Simic, T., Chakraborty, A., Bichler, J., Ferk, F., Angelis, K., Nersesyan, A., Knasmüller, S. : Consumption of Brussels sprouts protects peripheral human lymphocytes against 2-amino-1-methyl-6-phenylimidazol[4,5-β]pyridine (PhlP) and oxidative DNA-damage: results of a controlled human intervention trial. Mol. Nutr. Food Res. 52, 330-341 (2008).

Husøy, T., Haugen, M., Murkovic, M., Jöbstl, D., Stølen, L. H., Bjellaas, T., Rønningborg, C., Glatt, H., Alexander, J.: Dietary exposure to 5-hydroxymethylfurfural from Norwegian food and correlations with urine metabolites of short-term exposure. Food Chem. Toxicol. 46, 3697-3702 (2008).

Schweiger, W., Berthiller, F., Fischer, A., Erhart, C., Bicker, W., Shams, M., Schuhmacher, R., Krska, R., Wiesenberger, G., Mitterbauer, R., Glatt, H., Adam, G.: Formation of zearalenone-4-sulfate by yeast cells expressing sulfotransferase genes. Cereal Res. Commun. 36 Suppl. B, 385-387 (2008).

Arlt, V. M., Glatt, H., da Costa, G. G., Reynisson, J., Takamura-Enya, T., Phillips, D. H.: Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone. Toxicol. Sci. 98, 445-457 (2007).

Geyer, J., Döring, B., Meerkamp, K., Ugele, B., Bakhiya, N., Fernandes, C. F., Godoy, J. R., Glatt, H., Petzinger, E.: Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). J. Biol. Chem. 282, 19728-19741 (2007).

Al-Buheissi, S. Z., Patel, H. R., Meinl, W., Hewer, A., Bryan, R. L., Glatt, H., Miller, R. A., Phillips, D. H.: N-Acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation. Pharmacogenet. Genomics 16, 391-399 (2006).

Heine, T., Glatt, H., Epe, B.: Human cytochrome P450 reductase can act as a source of endogenous oxidative DNA damage and genetic instability. Free Radic. Biol. Med. 40, 801-807 (2006).

Reinen, J., Vriese, E., Glatt, H., Vermeulen, N. P. E.: Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase. Anal. Biochem. 357, 85-92 (2006).

Rüfer, C. E., Glatt, H., Kulling, S. E.: Structural elucidation of hydroxylated metabolites of the isoflavan equol by gas chromatography-mass spectrometry and high-performance liquid chromatography-mass spectrometry. Drug Metab. Dispos. 34, 51-60 (2006).

Sabbioni, G., Jones, C. R., Sepai, O., Hirvonen, A., Norppa, H., Järventaus, H., Glatt, H., Pomplun, D., Yan, H., Brooks, L. R., Warren, S. H., DeMarini, D. M., Liu, Y.-Y.: Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes. Cancer Epidemiol. Biomarkers Prev. 15, 559-566 (2006).

Majer, B. J., Hofer, E., Cavin, C., Lhoste, E., Uhl, M., Glatt, H. R., Meinl, W., Knasmüller, S.: Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2). Food Chem. Toxicol. 43, 433-441 (2005).


Sachse, B., Meinl, W., Sommer, Y., Glatt, H., Seidel, A., Monien, B. H.: Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a conparative study. Arch. Toxicol. 90, 137-148 (Open Access) (2016).

Glatt, H.: Sulphotransferases. In: Schwab, M. (ed.) Encyclopedia of Cancer, 2nd ed., Springer, Berlin, pp 2857-2861 (2008).

Waring, R. H., Ayers, S., Gescher, A. J., Glatt, H.-R., Meinl, W., Jarratt, P., Kirk, C. J., Pettitt, T., Rea, D., Harris, R. M.: Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruption. J. Steroid Biochem. Mol. Biol. 108, 213-220 (2008).

Kirkland, D., Pfuhler, S., Tweats, D., Aardema, M., Corvi, R., Darroudi, F., Elhajouji, A., Glatt, H., Hastwell, P., Hayashi, M., Kasper, P., Kirchner, S., Lynch, A., Marzin, D., Maurici, D., Meunier, J.-R., Müller, L., Nohynek, G., Parry, J., Parry, E., Thybaud, V., Tice, R., van Benthem, J., Vanparys, P., White, P.: How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop. Mutat. Res./Genet. Toxicol. Environ. Mutagen. 628, 31-55 (2007).

Ku, W. W., Bigger, A., Brambilla, G., Glatt, H., Gocke, E., Guzzie, P. J., Hakura, A., Honma, M., Martus, H.-J., Obach, R. S. Roberts, S.: Strategy for genotoxicity testing - Metabolic considerations. Mutat. Res./Genet. Toxicol. Environ. Mutagen. 627, 59-77 (2007).

Glatt, H., Meinl, W.: Sulfotransferases and acetyltransferases in mutagenicity testing: technical aspects. Meth. Enzymol. 400, 230-249 (2005).

Glatt, H., Meinl, W.: Pharmacogenetics of soluble sulfotransferases (SULTs). N-S Arch. Pharmacol. 369, 55-68 (2004).

Kassie, F., Mersch-Sundermann, V., Edenharder, R., Platt, K.-L., Darroudi, F., Lhoste, E., Humboldt, C., Muckel, E., Uhl, M., Kundi, M., Knasmüller, S.: Development and application of test methods for the detection of dietary constituents which protect against heterocyclic aromatic amines. Mutat. Res. 523-524, 183-192 (2003).

Glatt, H., Boeing, H., Engelke, C. E., Ma, L., Kuhlow, A., Pabel, U., Pomplun, D., Teubner, W., Meinl, W.: Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. Mutat. Res. 482, 27-40 (2001).

Glatt, H. R.: An overview of bioactivation of chemical carcinogens. Biochem. Soc. Transact. 28, 1-6 (2000).

Glatt, H. R.: Sulfotransferases in the bioactivation of xenobiotics. Chem. Biol. Interact. 126, 141-170 (2000).

Glatt, H., Engelke, C. E. H., Pabel, U., Teubner, W., Jones, A. L., Coughtrie, M. W., Andrae, U., Falany, C. N., Meinl, W.: Sulfotransferases: genetics and role in toxicology. Toxicol. Lett. 112-113, 341-348 (2000).


Baasanjav-Gerber, C., Engst, W., Florian, S., Monien, B. H., Barillari, J., Iori, R., Frank, H., Seidel, A., Krumbein, A., Schreiner, M., Glatt, H. R.: Glucosinolates: DNA adduct formation in vivo and mutagenicity in vitro. In: Eisenbrand, G. (ed.) Risk assessment of Phytochemicals in Food: Novel Approaches (Deutsche Forschungsgemeinschaft), Wiley-VCH, Weinheim, 2010, pp 325-334 (2010).

Glatt, H.: Xenobiotic metabolism: A target for nutritional chemoprevention of cancer?. In: Knasmüller, S., DeMarini, D. M., Johnson, I., Gerhäuser, C. (Eds.) Chemoprevention of Cancer and DNA Damage by Dietary Factors. Wiley-VCH, Weinheim, 2009, pp 93-108 (2009).

Glatt, H. R., Schneider, H., Seidel, A.: Polycyclische aromatische Kohlenwasserstoffe. In: Dunkelberg, H., Gebel, T., Hartwig, A. (Hrsg.) Handbuch der Lebensmitteltoxikologie, Bd. 3. Wiley-VCH, Weinheim, S. 1121-1155 (2007).

Glatt, H.: Metabolic factors affecting the mutagenicity of heterocyclic amines. In: Skog, K., Alexander, J. (eds.) Acrylamide and other hazardous compounds in heat-trested foods.Woodhead Publishing Ltd., Cambridge, pp 358-404 (2006).

Glatt, H., Sommer, Y.: Health risks of 5-hydroxymethylfurfural (HMF) and related compounds. In: Skog, K., Alexander, J. (eds.) Acrylamide and other hazardous compounds in heat-treated foods. Woodhead Publishing Ltd., Cambridge, pp 329-357 (2006).

Meinl, W., Glatt, H. R.: Sulfotransferasen 1A1 und 1A2 (Genotypisieren) [Methoden]. In: Greim, H. (Hrsg.) Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe. Band 2: Analysen in Biologischem Material, 16. Lieferung. Spezialthema: Suszeptibilitätsmarker. (Loseblattwerk), Deutsche Forschungsgemeinschaft, Wiley-VCH, Weinheim, (2006).

Glatt, H. R., Teubner, W., Meinl, W.: Sulfotransferases expressed in the human gastro-intestinal tract and their ability to activate promutagens/procarcinogens. In: Proceedings of the 15th International Symposium on Microsomes and Drug Oxidations. Medimond International Proceedings, Bologna, pp 9-15 (2005).

Glatt, H.: Activation and inactivation of carcinogens and mutagens by human sulfotransferases. In: Pacifici, G. M., Couthrie, M. W. H. (eds.) Human Cytosolic Sulfotransferases. Taylor & Francis, Boca Raton/Fl, 2005, pp 279-304 (2005).

Glatt, H. R.: Indicator assays for polycyclic aromatic-hydrocarbon-induced genotoxicity. In: Luch, A. (ed.) The Carcinogenic Effects of Polycyclic Aromatic Hydrocarbons. Imperial College Press, London, pp 283-314 (2004).

Glatt, H. R.: Genetische Polymorphismen und Suszeptibilität gegenüber der kanzerogenen Wirkung polycyclischer aromatischer Verbindungen: Grundlagen. In: Jacob, J., Greim, H. (Hrsg.) Polycyclische aromatische Kohlenwasserstoffe. Forschungsbericht der Deutschen Forschungsgemeinschaft, Wiley-VCH, Weinheim, S. 148-182 (2004).

Luch, A., Glatt, H. R.: Die Bedeutung der Entstehung von DNA-Addukten polycyclischer aromatischer Kohlenwasserstoffe für die Krebsentstehung. In: Jacob, J., Greim, H. (Hrsg.) Polycyclische aromatische Kohlenwasserstoffe. Forschungsbericht der Deutschen Forschungsgemeinschaft, Wiley-VCH, Weinheim, S. 118-124 (2004).

Meinl, W., Glatt, H. R.: Sulphotransferase 1A1 and 1A2 (genotyping) [Background]. In: Angerer, J., Müller, M., Weiss, T. (eds.) Analyses of Hazardous Substances in Biological Materials, Vol. 9: Special Issue: Marker of Susceptibility. Deutsche Forschungsgemeinschaft, Wiley-VCH, Weinheim, pp 241-246 (2004).

Meinl, W., Glatt, H. R.: Sulphofotransferase 1A1 and 1A2 (genotyping) [Methods]. In: Angerer, J., Müller, M., Weiss, T. (eds.) Analyses of Hazardous Substances in Biological Materials, Vol. 9: Special Issue: Marker of Susceptibility. Deutsche Forschungsgemeinschaft, Wiley-VCH, Weinheim, pp 247-263 (2004).

Meinl, W., Glatt, H. R.: Sulfotransferasen 1A1 und 1A2 (Genotypisieren) [Grundlagen]. In: Greim, H. (Hrsg.) Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe. Band 2: Analysen in Biologischem Material, 16. Lieferung. Spezialthema: Suszeptibilitätsmarker. (Loseblattwerk), Deutsche Forschungsgemeinschaft, Wiley-VCH, We (2004).

Hollnagel, H., Glatt, H. R.: Bioaktivierung heterozyklischer aromatischer Amine in toxikologischen Modellsystemen – Beurteilung des kanzerogenen Potentials. In: Hühn, M. (Hrsg.) Potentiell kanzerogene Inhhaltsstoffe in Lebensmitteln: 3. Workshop d. AG Lebensmittelqualität u. -sicherheit, Schriftenreihe d. Agrar- u. Ernährungswiss. Fakultät, CAU Kiel Vol. 100, 42-51 (2003).

Glatt, H.: Sulphotransferases. In: Ioannides, C. (ed.) Enzyme systems that metabolise drugs and other xenobiotics. John Wiley & Sons Ltd.,, pp 353-439 (2002).

Glatt, H.: Genetische Polymorphismen von Sulfotransferasen als Suszeptibilitätsparameter. In: Angerer, J. (ed.) Biological Monitoring. DFG, Wiley-VCH, Weinheim, pp 86-97 (2001).

sonstige Arbeiten

Glatt, H., Meinl, W., Kuhlow, A., Ma, L.: Metabolic formation, distribution, and toxicological effects of reactive sulfuric acid esters. Nova Acta Leopoldina NF 87, Nr. 329, 151-161 (2003).

Liu, Y., Muckel, E., Doehmer, J., Glatt, H.: Phenol and hydroquinone induce gene mutations in V79-derived cells expressing human xenobiotic-metabolizing enzymes. Nova Acta Leopoldina NF 87, Nr. 329, 231-237 (2003).

Ma, L., Kuhlow, A., Glatt, H.: Albumin strongly prolongs the lifespan of chemically reactive sulphuric acid esters and affects their biological activities in the rat. Nova Acta Leopoldina NF 87, Nr. 329, 265-272 (2003).

Bernauer, U., Ellrich, R., Heinrich-Hirsch, B., Teubner, W., Vieth, B., Gundert-Remy, U.,: Expression of cytochrome P450 enzymes in human colon. IARC Scientific Publications 156, 487-489 (2002).

Pfau, W., Knasmueller, S., Glatt, H. R., Frandsen, H., Alexander, J., M. Murkovic, M., Sontag, G., Galceran, T., Edenharder, R., Skog, K.: Heterocyclic amines: Human carcinogens in cooked food?. Nutr. Metab. Cardiovasc. Dis. 11 (4 Supp.), 82-86 (2001).

Landsiedel, R., Andrae, U., Kuhlow, A., Scholtyssek, M., Glatt, H. R.: Enantioselective metabolic activation of safrole. In: Eisenbrand, G., Dayan, A. D., Elias, P. S., Grunow, W., Schlatter, J. (eds.) Proceedings of the DFG-Symposium "Carcinogenic/Anticarcinogenic Factors in Food", Wiley-VCH, Weinheim, pp 474-477 (2000).


Schneider, H., Glatt, H. R.: Sulfo conjugation of ethanol in humans in vivo and by individual human sulfotransferases in vitro. N-S Arch. Pharmacol. 369, Suppl. 1, 423 (2004).

Arit, V. M., Glate, H., Muckel, E., Pabel, U., Sorg, B. L., Hewer, A., Seidel, A., Schmeiser, H. H., Phillips, D. H.: Activation of 3-nitrobenzanthrone and its metabolites in vivo in rats, and by human acetyltransferases, sulfotransferases and cytochrome P450. N-S Arch. Pharmacol. 367, Suppl. 1, 496 (2003).

Sommer, Y., Hollnagel, H., Schneider, H., Glatt, H. R.: Metabolism of 5-hydroxymethyl-2-furfural (HMF) to the mutagen 5-sulfoxymethyl-2-furfural (SMF) by individual sulfotransferases. N-S Arch. Pharmacol. 367, Suppl. 1, 650 (2003).

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