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Image Experimentelle Diabetologie

Abteilung Experimentelle Diabetologie (DIAB)

Publikationen

Anzahl: 133

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Abteilung Experimentelle Diabetologie

Originalarbeiten

Rödiger, M., Werno, M. W., Wilhelmi, I., Baumeier, C., Hesse, D., Wettschureck, N., Offermanns, S., Song, K., Krauß, M., Schürmann, A.: Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes. Mol. Metab. in press (E-pub ahead of print) (Open Access) (2018).

Ambrosi, T. H., Scialdone, A., Graja, A., Gohlke, S., Jank, A.-M., Bocian, C., Woelk, L., Fan, H., Logan, D. W., Schürmann, A., Saraiva, L. R., Schulz, T. J.: Adipocyte accumulation in the bone marrow during obesity and aging impairs stem cell-based hematopoietic and bone regeneration. Cell Stem Cell 20, 771-784 (Open Access) (2017).

Baumeier, C., Saussenthaler, S., Kammel, A., Jähnert, M., Schlüter, L., Hesse, D., Canouil, M., Lobbens, S., Caiazzo, R., Raverdy, V., Pattou, F., Nilsson, E., Pihlajamäki, J., Ling, C., Froguel, P., Schürmann, A., Schwenk, R. W.: Hepatic DPP4 DNA-methylation associates with fatty liver. Diabetes 6, 25-35 (2017).

Baumeier, C., Schlüter, L., Saussenthaler, S., Laeger, T., Rödiger, M., Alaze, S. A., Fritsche, L., Häring, H.-U., Stefan, N., Fritsche, A., Schwenk, R. W., Schürmann, A.: Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease. Mol. Metab. 6, 1254–1263 (Open Access) (2017).

Laeger, T., Baumeier, C., Wilhelmi, I., Würfel, J., Kamitz, A., Schürmann, A.: FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes. Diabetologia 60, 2274–2284 (Open Access) (2017).

Speckmann, B., Schulz, S., Hiller, F., Hesse, D., Schumacher, F., Kleuser, B., Geisel, J., Obeid, R., Grune, T., Kipp, A. P.: Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice. J. Nutr. Biochem. 48, 112-119 (Open Access) (2017).

Vogel, H., Jähnert, M., Stadion, M., Matzke, D., Scherneck, S., Schürmann, A.: A vast genomic deletion in the C56BL/6 genome affects different genes within the Ifi200 cluster on chromosome 1 and mediates obesity and insulin resistance. BMC Genomics 18:172 (Open Access) (2017).

Vogel, H., Kraemer, M., Rabasa, C., Askevik, K., Adan, R. A. H., Dickson, S. L.: Genetic predisposition to obesity affects behavioural traits including food reward and anxiety-like behaviour in rats. Behav. Brain Res. 328, 95-104 (Open Access) (2017).

Kammel, A., Saussenthaler, S., Jähnert, M., Jonas, W., Stirm, L., Hoeflich, A., Staiger, H., Fritsche, A., Häring, H. U., Joost, H.-G., Schürmann, A., Schwenk, R. W.: Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice. Hum. Mol. Genet. 25, 2588-2599 (Open Access) (2016).

Laeger, T., Albarado, D. C., Burke, S. J., Trosclair, L., Hedgepeth, J. W., Berthoud, H. R., Gettys, T. W., Collier, J. J., Münzberg, H., Morrison, C. D.: Metabolic responses to dietary protein restriction require an increase in FGF21 that is delayed by the absence of GCN2. Cell Rep. 16, 707-716 (Open Access) (2016).

Vogel, H., Wolf, S., Rabasa, C., Rodriguez-Pacheco, F., Babaei, C. S., Stöber, F., Goldschmidt, J., DiMarchi, R. D., Finan, B., Tschöp, M. H., Dickson, S. L., Schürmann, A., Skibicka, K. P.: GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight. Neuropharmacology 110, 396-406 (Open Access) (2016).

Wilhelmi, I., Kanski, R., Neumann, A., Herdt, O., Hoff, F., Jacob, R., Preußner, M., Heyd, F.: Sec16 alternative splicing dynamically controls COPII transport efficiency. Nat. Commun. 7:12347 (Open Access) (2016).

Baumeier, C., Kaiser, D., Heeren, J., Scheja, L., John, C., Weise, C., Eravci, M., Lagerpusch, M., Schulze, G., Joost, H.-G., Schwenk, R. W., Schürmann, A.: Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice. Biochim. Biophys. Acta/Mol. Cell Biol. Lipids 1851, 566-576 (Open Access) (2015).

Chung, B., Stadion, M., Schulz, N., Jain, D., Scherneck, S., Joost, H.-G., Schürmann, A.: The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice. Diabetologia 58, 2403-2413 (Open Access) (2015).

Jonas, W., Lietzow, J., Wohlgemuth, F., Hoefig, C. S., Wiedmer, P., Schweizer, U., Köhrle, J., Schürmann, A.: 3,5-Diiodo-L-thyronine (3,5-T2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice. Endocrinology 156, 389-399 (Open Access) (2015).

Kanzleiter, T., Jähnert, M., Schulze, G., Selbig, J., Hallahan, N., Schwenk, R. W., Schürmann, A.: Exercise training alters DNA methylation patterns in genes related to muscle growth and differentiation in mice. Am. J. Physiol./Endocrinol. Metab. 308, E912-E920 (Open Access) (2015).

Kluth, O., Matzke, D., Kamitz, A., Jähnert, M., Vogel, H., Scherneck, S., Schulze, M., Staiger, H., Machicao, F., Häring, H. U., Joost, H.-G., Schürmann, A.: Identification of four mouse diabetes candidate genes altering β-cell proliferation. PLoS Genet. 11(9):e1005506 (Open Access) (2015).

Lubura ,M., Hesse, D., Kraemer, M., Hallahan, N., Schupp, M., von Loeffelholz, C., Kriebel, J., Rudovich, N. N., Pfeiffer, A., John, C., Scheja, L., Heeren, J., Koliaki, C., Roden, M., Schürmann, A.: Diabetes prevalence in NZO females depends on estrogen action on liver fat content. Am. J. Physiol./Endocrinol. Metab. 309, E968-E980 (Open Access) (2015).

Schwenk, R. W., Baumeier, C., Finan, B., Kluth, O., Brauer, C., Joost, H.-G., DiMarchi, R. D., Tschöp, M. H., Schürmann, A.: GLP-1-oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice. Diabetologia 58, 604-614 (Open Access) (2015).

Voigt, A., Katterle, Y., Kahle, M., Kluge, R., Schürmann, A., Joost, H. G., Klaus, S.: Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity. Genes Nutr. 10(6):57 (Open Access) (2015).

Wiedmer, P., Schwarz, F., Große, B., Schindler, N., Tuchscherer, A., Russo, V. C., Tschöp, M. H., Hoeflich, A.: Gender-specific effects on food intake but no inhibition of age-related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif. J. Cell Commun. Signal. 9, 143-150 (Open Access) (2015).

Hesse, D., Radloff, K., Jaschke, A., Lagerpusch, M., Chung, B., Tailleux, A., Staels, B., Schürmann, A.: Hepatic trans-Golgi action coordinated by the GTPase ARFRP1 is crucial for lipoprotein lipidation and assembly. J. Lipid Res. 55, 41-52 (Open Access) (2014).

Kanzleiter, T., Rath, M., Görgens, S. W., Jensen, J., Tangen, D. S., Kolnes, A. J., Kolnes, K. J., Lee, S., Eckel, J., Schürmann, A., Eckardt, K.: The myokine decorin is regulated by contraction and involved in muscle hypertrophy. Biochem. Biophys. Res. Commun. 450, 1089-1094 (2014).

Kanzleiter, T., Rath, M., Penkov, D., Puchkov, D., Schulz, N., Blasi, F., Schürmann, A.: Pknox1/Prep1 regulates mitochondrial oxidative phosphorylation components in skeletal muscle. Mol. Cell. Biol. 34, 290-298 (Open Access) (2014).

Kluth, O., Matzke, D., Schulze, G., Schwenk, R. W., Joost, H.-G., Schürmann, A.: Differential transcriptome analysis of diabetes-resistant and -sensitive mouse islets reveals significant overlap with human diabetes susceptibility genes. Diabetes 63, 4230-4238 (2014).

Schulz, N., Kluth, O., Jastroch, M., Schürmann, A.: Minor role of mitochondrial respiration for fatty-acid induced insulin secretion. Int. J. Mol. Sci. 14, 18989-18998 (2013).

Schwenk, R. W., Jonas, W., Ernst, S. B., Kammel, A., Jähnert, M., Schürmann, A.: Diet-dependent alterations of hepatic Scd1 expression are accompanied by differences in promoter methylation. Horm. Metab. Res. 45, 786-794 (2013).

Vogel, H., Mirhashemi, F., Liehl, B., Taugner, F., Kluth, O., Kluge, R., Joost, H.-G., Schürmann, A.: Estrogen deficiency aggravates insulin resistance and induces β-cell loss and diabetes in female New Zealand obese mice. Horm. Metab. Res. 45, 430-435 (2013).

Vogel, H., Montag, D., Kanzleiter, T., Jonas, W., Matzke, D., Scherneck, S., Chadt, A., Töle, J., Kluge, R., Joost, H.-G., Schürmann, A.: An interval of the obesity QTL Nob3.38 within a QTL hotspot on chromosome 1 modulates behavioral phenotypes. PLoS ONE 8(1):e53025 (2013).

Hesse, D., Jaschke, A., Kanzleiter, T., Witte, N., Augustin, R., Hommel, A., Püschel, G. P., Petzke, K.-J., Joost, H.-G., Schupp, M., Schürmann, A.: GTPase ARFRP1 is essential for normal hepatic glycogen storage and insulin-like growth factor 1 secretion. Mol. Cell. Biol. 32, 4363-4374 (2012).

Jaschke, A., Chung, B., Hesse, D., Kluge, R., Zahn, C., Moser, M., Petzke, K.-J., Brigelius-Flohé, R., Puchkov, D., Koepsell, H., Heeren, J., Joost, H.-G., Schürmann, A.: The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium. Hum. Mol. Genet. 21, 3128-3142 (2012).

Lubura, M., Hesse, D., Neumann, N., Scherneck, S., Wiedmer, P., Schürmann, A.: Non-invasive quantification of white and brown adipose tissues and liver fat content by computed tomography in mice. PLoS ONE 7(5):e37026 (2012).

Vogel, H., Scherneck, S., Kanzleiter, T., Benz, V., Kluge, R., Stadion, M., Kryvych, S., Blüher, M., Klöting, N., Joost, H.-G., Schürmann, A.: Loss of function of lfi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity. Hum. Mol. Genet. 21, 3845-3857 (2012).

Wiedmer, P., Chaudhary, N., Rath, M., Yi, C.-X., Ananthakrishnan, G., Nogueiras, R., Wirth, E. K., Kirchner, H., Schweizer, U., Jonas, W., Veyrat-Durebex, C., Rohner-Jeanrenaud, F., Schürmann, A., Joost, H.-G., Tschöp, M. H., Perez-Tilve, D.: The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism. Physiol. Behav. 105, 791-799 (2012).

Kluth, O., Mirhashemi, F., Scherneck, S., Kaiser, D., Kluge, R., Neschen, S., Joost, H.-G., Schürmann, A.: Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure. Diabetologia 54, 605-616 (Open Access) (2011).

Mirhashemi, F., Scherneck, S., Kluth, O., Kaiser D., Vogel, H., Kluge, R., Schürmann, A., Neschen, S., Joost, H.-G.: Diet dependence of diabetes in the New Zealand Obese (NZO) mouse: total fat, but not fat quality or sucrose accelerates and aggravates diabetes. Exp. Clin. Endocrinol. Diabetes 119, 167-171 (2011).

Schulz, N., Himmelbauer, H., Rath, M., van Weeghel, M., Houten, S., Kulik, W., Suhre, K., Scherneck, S., Vogel, H., Kluge, R., Wiedmer, P., Joost, H.-G., Schürmann, A.: Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis. Endocrinology 152, 4641-4651 (2011).

Wiedmer, P., Strasser, F., Horvath, T. L., Blum, D., DiMarchi, R., Lutz, T., Schürmann, A., Joost, H.-G., Tschöp, M. H., Tong, J.: Ghrelin-induced hypothermia: a physical basis but no clinical risk. Physiol. Behav. 105, 43-51 (2011).

Hesse, D., Hommel, A., Jaschke, A., Moser, M., Bernhardt, U., Zahn, C., Kluge, R., Wittschen, P., Gruber, A. D., Al-Hasani, H., Joost, H.-G., Schürmann, A.: Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1. Biochem. Biophys. Res. Commun. 394, 896-903 (2010).

Hommel, A., Hesse, D., Völker, W., Jaschke, A., Moser, M., Engel, T., Blüher, M., Zahn, C., Chadt, A., Ruschke, K., Vogel, H., Kluge, R., Robenek, H., Joost, H.-G., Schürmann, A.: The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis. Mol. Cell. Biol. 30, 1231-1242 (2010).

Kuhlow, D., Florian, S., von Figura, G., Weimer, S., Schulz, N., Petzke, K. J., Zarse, K., Pfeiffer, A. F. H., Rudolph, K. L., Ristow, M.: Telomerase deficiency impairs glucose metabolism and insulin secretion. Aging 2, 650-658 (Open Access) (2010).

Diril, M. K., Schmidt, S., Krauß, M., Gawlik, V., Joost, H.-G., Schürmann, A., Haucke, V., Augustin, R.: Lysosomal localization of GLUT8 in the testis - the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction. FEBS J. 276, 3729-3743 (Open Access) (2009).

Kirchner, H., Gutierrez, J. A., Solenberg, P. J., Pfluger, P. T., Czyzyk, T. A., Willency, J. A., Schürmann, A., Joost, H.-G., Jandacek, R. J., Hale, J. E., Heiman, M. L., Tschöp, M. H.: GOAT links dietary lipids with the endocrine control of energy balance. Nat. Med. 15, 741-745, Erratum 15, 1093 (2009).

Scherneck, S., Nestler, M., Vogel, H., Blüher, M., Block, M.-D., Diaz, M. B., Herzig, S., Schulz, N., Teichert, M., Tischer, S., Al-Hasani, H., Kluge, R., Schürmann, A., Joost, H. G.: Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. PLoS Genet. 5(7): e1000541, (Open Access) (2009).

Schmidt, S., Hommel, A., Gawlik, V., Augustin, R., Junicke, N., Florian, S., Richter, M., Walther, D. J., Montag, D., Joost, H.-G., Schürmann, A.: Essential role of glucose transporter GLUT3 for post-implantation embryonic development. J. Endocrinol. 200, 23-33 (Open Access) (2009).

Vogel, H., Nestler, M., Rüschendorf, F., Block, M.-D., Tischer, S., Kluge, R., Schürmann, A., Joost, H.-G., Scherneck, S.: Characterization of Nob3, a major quantitative trait locus for obesity and hyperglycemia on mouse chromosome 1. Physiol. Genomics 38, 226-232 (Open Access) (2009).

Schmidt, S., Gawlik, V., Hölter, S. M., Augustin, R., Scheepers, A., Behrens, M., Wurst, W., Gailus-Durner, V., Fuchs, H., de Angelis, M. H., Kluge, R., Joost, H.-G., Schürmann, A.: Deletion of glucose transporter GLUT8 in mice increases locomotor activity. Behav. Genet. 38, 396-406 (Open Access) (2008).

Chadt, A., Leicht, K., Deshmukh, A., Jiang, L. Q., Scherneck, S., Bernhardt, U., Dreja, T., Vogel, H., Schmolz, K., Kluge, R., Zierath, J. R., Hultschig, C., Hoeben, R. C., Schürmann, A., Joost, H.-G., Al-Hasani, H.: Tbc1d1 mutation in lean mouse strain confers leanless and protects from diet-induced obesity. Nat. Genet. 40, 1354-1359 (2008).

Gawlik, V., Schmidt, S., Scheepers, A., Wennemuth, G., Augustin, R., Aumüller, G., Moser, M., Al-Hasani, H., Kluge, R., Joost, H.-G., Schürmann, A.: Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa. Mol. Membr. Biol. 25, 224-235 (2008).

Mirhashemi, F., Kluth, O., Scherneck, S., Vogel, H., Kluge, R., Schürmann, A., Joost, H.-G., Neschen, S.: High-fat, carbohydrate-free diet markedly aggravates obesity but prevents β-cell loss and diabetes in the obese, diabetes-susceptible db/db strain. Obes. Facts 1, 292-297 (2008).

Neschen, S., Katterle, Y., Richter, J., Augustin, R., Scherneck, S., Mirhashemi, F., Schürmann, A., Joost, H.-G., Klaus, S.: Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover and insulin sensitivity in vivo. Physiol. Genomics 33, 333-340 (2008).

Schmidt, S., Richter, M., Montag, D., Sartorius, T., Gawlik, V., Hennige, A. M., Scherneck, S., Himmelbauer, H., Lutz, S. Z., Augustin, R., Kluge, R., Ruth, P., Joost, H.-G., Schürmann, A.: Neuronal functions, feeding behavior and energy balance in Slc2a3+/- mice. Am. J. Physiol./Endocrinol. Metab. 295, E1084-E1094 (2008).

Zahn, C., Jaschke, A., Weiske, J., Hommel, A., Hesse, D., Augustin, R., Lu, L., Hong, W., Florian, S., Scheepers, A., Joost, H.-G., Huber, O., Schürmann, A.: ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin. J. Biol. Chem. 283, 27179-27188 (2008).

Buchmann, J., Meyer, C., Neschen, S., Augustin, R., Schmolz, K., Kluge, R., Al-Hasani, H., Jürgens, H., Eulenberg, K., Wehr, R., Dohrmann, C., Joost, H.-G., Schürmann, A.: Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity. Endocrinology 148, 1561-1573 (2007).

Jürgens, H. S., Neschen, S., Ortmann, S., Scherneck, S., Schmolz, K., Schüler, G., Schmidt, S., Blüher, M., Klaus, S., Perez-Tilve, D., Tschöp, M. H., Schürmann, A., Joost, H.-G.: Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction. Diabetologia 50, 1481-1489 (2007).

Nogueiras, R., Pfluger, P., Tovar, S., Arnold, M., Mitchell, S., Morris, A., Perez-Tilve, D., Vázquez, M. J., Wiedmer, P., Castañeda, T. R., DiMarchi, R., Tschöp, M., Schurmann, A., Joost, H.-G., Williams, L. M., Langhans, W., Diéguez, C.: Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology 148, 21-26 (2007).

Nogueiras, R., Wiedmer, P., Perez-Tilve, D., Veyrat-Durebex, C., Keogh, J. M., Sutton, G. M., Pfluger, P. T., Castaneda, T. R., Neschen, S., Hofmann, S. M., Howles, P. N., Morgan, D. A., Benoit, S. C., Szanto, I., Schrott, B., Schürmann, A., Joost, H.-G., Hammond, C., Hui, D. Y., Woods, S. C., Rahmouni, K., Butler, A. A., Farooqi, I. S., O´Rahilly, S., Rohner-Jeanrenaud, F., Tschöp, M. H.: The central melanocortin system directly controls peripheral lipid metabolism. J. Clin. Invest. 117, 3475-3488 (2007).

Schmolz, K., Pyrski, M., Bufe, B., Vogel, H., Nogueiras, R., Scherneck, S., Nestler, M., Zahn, C., Rüschendorf, F., Tschöp, M., Meyerhof, W., Joost, H.-G., Schürmann, A.: Role of neuromedin-U in the central control of feeding behavior: a variant of the neuromedin-U receptor 2 contributes to hyperphagia in the New-Zealand obese mouse. Obes. Metab. 3, 28-37 (2007).

Jürgens, H. S., Schürmann, A., Kluge, R., Ortmann, S., Klaus, S., Joost, H.-G. , Tschöp, M. H.: Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice. Physiol. Genomics 25, 234-241 (2006).

Lisinski, I., Matsumoto, H., Yver, D. R., Schürmann, A., Cushman, S. W., Al-Hasani, H.: Identification and characterization of p49/STRAP as a novel GLUT4-binding protein. Biochem. Biophys. Res. Commun. 344, 1179-1185 (2006).

Schmidt, U., Briese, S., Leicht, K., Schürmann, A., Joost, H.-G., Al-Hasani, H.: Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the β2-adaptin subunit of the AP-2 adaptor complex. J. Cell Sci. 119, 2321-2331 (2006).

Zahn, C., Hommel, A., Lu, L., Hong, W., Walther, D. J., Florian, S., Joost, H.-G., Schürmann, A.: Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells. Mol. Membr. Biol. 23, 475-485 (2006).

Augustin, R., Riley, J., Moley, K. H.: GLUT8 contains a [DE]XXXL[LI] sorting motif and localizes to a late endosomal/lysosomal compartment. Traffic 6, 1196-1212 (2005).

Hauptmann, S., Grünewald, V., Molls, D., Schmitt, W. D., Köbel, M., Kriese, K., Schürmann, A.: Glucose transporter GLUT1 in colorectal adenocarcinoma cell lines is inversely correlated with tumour cell proliferation. Anticancer Res. 25, 3431-3436 (2005).

Jürgens, H., Haass, W., Castaneda, T. R., Schürmann, A., Koebnick, C., Dombrowski, F., Otto, B., Nawrocki, A. R., Scherer, P. E., Spranger, J., Ristow, M., Joost, H.-G., Havel, P. J., Tschöp, M. : Consuming fructose-sweetened beverages increases body adiposity in mice. Obes. Res. 13, 1146-1156 (2005).

Scheepers, A., Schmidt, S., Manolescu, A., Cheeseman, C. I., Bell, A., Zahn, C., Joost, H.-G., Schürmann, A.: Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. Mol. Membr. Biol. 22, 339-351 (2005).

Gaster, M., Handberg, A., Schürmann, A., Joost, H.-G., Beck-Nielsen, H., Schroder, H. D.: GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern. Pflugers Arch. 448, 105-113 (2004).

Rudlowski, C., Moser, M., Becker, A. J., Rath, W., Buttner, R., Schroder, W., Schürmann, A.: GLUT1 mRNA and protein expression in ovarian borderline tumors and cancer. Oncology 66, 404-410 (2004).

Bosch, R. R., Bazuine, M., Wake, M. M., Span, P. N., Olthaar, A. J., Schürmann, A., Maassen, J. A., Hermus, A. R., Willems, P. H., Sweep, C. G.: Inhibition of protein kinase CβII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane. Mol. Endocrinol. 17, 1230-1239 (2003).

Joost, H.-G., Bell, G. I., Best, J. D., Birnbaum, M. J., Charron, M. J., Chen, Y. T., Doege, H., James, D. E., Lodish, H. F., Moley, K. H., Moley, J. F., Mueckler, M., Rogers, S., Schürmann, A., Seino, S., Thorens, B.: Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. Am. J. Physiol./Endocrinol. Metab. 282, E974-E976 (2002).

Mueller, A. G., Joost, H.-G., Schürmann, A.: Mouse ARF-related protein 1: Genomic organization and analysis of its promoter. Biochem. Biophys. Res. Commun. 292, 113-120 (2002).

Mueller, A. G., Moser, M., Kluge, R., Leder, S., Blum, M., Büttner, R., Joost, H.-G., Schürmann, A.: Embryonic lethality caused by apoptosis during gastrulation in mice lacking the gene of the ADP-ribosylation factor-related protein 1. Mol. Cell. Biol. 22, 1488-1494 (2002).

Plum, L., Giesen, K., Kluge, R., Junger, E., Linnartz, K., Schürmann, A., Becker, W., Joost, H.-G.: Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat. Diabetologia 45, 823-830 (2002).

Schürmann, A., Axer, H., Scheepers, A., Doege, H., Joost, H.-G.: The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa. Cell Tissue Res. 307, 237-242 (2002).

Schürmann, A., Koling, S., Jacobs, S., Saftig, P., Krauß, S., Wennemuth, G., Kluge, R., Joost, H.-G.: Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor like (Arl4) gene. Mol. Cell. Biol. 22, 2761-2768 (2002).

Originalarbeiten (korrespondierender Autor nicht vom DIfE)

Rångtell, F. H., Schmidt, F., Würfel, J., Karamchedu, S., Andersson, P., Vogel, H., Benedict, C.: Morning ezymatic activity of DPP-4 is differentially altered by sleep loss in women and men. Diabetes Care. in press (E-pub ahead of print) (2018).

Henkel, J., Coleman, C. D., Schraplau, A., Jӧhrens, K., Weber, D., Castro, J. P., Hugo, M., Schulz, T. J., Krämer, S., Schürmann, A., Püschel, G. P.: Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol. Mol. Med. 23, 70-82 (Open Access) (2017).

Hill, C. M., Laeger, T., Albarado, D. C., McDougal, D. H., Berthoud, H. R., Münzberg, H., Morrison, C. D.: Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints. Sci. Rep. 7:8209 (Open Access) (2017).

Wiemerslage, L., Islam, R., van der Kamp, C., Cao, H., Olivo, G., Ence-Eriksson, F., Castillo, S., Larsen, A. L., Bandstein, M., Dahlberg, L. S., Perland, E., Gustavsson, V., Nilsson, J., Vogel, H., Schürmann, A., Larsson, E. M., Rask-Andersen, M., Benedict, C., Schiöth, H. B.: A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels. Int. J. Obes. 41, 990-994 (2017).

Benedict, C., Vogel, H., Jonas, W., Woting, A., Blaut, M., Schürmann, A., Cedernaes, J.: Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals. Mol. Metab. 5, 1175-1186 (Open Access) (2016).

Cedernaes, J., Fanelli, F., Fazzini, A., Pagotto, U., Broman, J.-E., Vogel, H., Dickson, S. L., Schiöth, H. B., Benedict, C.: Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans. Psychoneuroendocrinology 74, 258-268 (Open Access) (2016).

Chubanov, V., Ferioli, S., Wisnowsky, A., Simmons, D. G., Leitzinger, C., Einer, C., Jonas, W., Shymkiv, Y., Bartsch, H., Braun, A., Akdogan, B., Mittermeier, L., Sytik, L., Torben, F., Jurinovic, V., van der Vorst, E. P., Weber, C., Yildirim, Ö. A., Sotlar, K., Schürmann, A., Zierler, S., Zischka, H., Ryazanov, A. G., Gudermann, T.: Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. eLife 5:e20914 (Open Access) (2016).

Heise, S., Trost, J., Arends, D., Wirth, E. K., Schäfer, N., Köhrle, J., Schürmann, A., Brockmann, G. A.: High variability of insulin sensitivity in closely related obese mouse inbred strains. Exp. Clin. Endocrinol. Diabetes 124, 519-528 (2016).

Klein, C., Jonas, W., Iggena, D., Empl, L., Rivalan, M., Wiedmer, P., Spranger, J., Hellweg, R., Winter, Y., Steiner, B.: Exercise prevents high-fat diet-induced impairment of flexible memory expression in the water maze and modulates adult hippocampal neurogenesis in mice. Neurobiol. Learn Mem. 131, 26-35 (2016).

Lietzow, J., Golchert, J., Homuth, G., Völker, U., Jonas, W., Köhrle, J.: 3,5-T2 alters murine genes relevant for xenobiotic, steroid and thyroid hormone metabolism. J. Mol. Endocrinol. 56, 311-323 (2016).

Müller, A., Niederstadt, L., Jonas, W., Yi, C. X., Meyer, F., Wiedmer, P., Fischer, J., Grötzinger, C., Schürmann, A., Tschöp, M., Kleinau, G., Grüters, A., Krude, H., Biebermann, H.: Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling. Front. Endocrinol. (Lausanne) 7:109 (Open Access) (2016).

Rabasa, C., Winsa-Jörnulf, J., Vogel, H., Babaei, C. S., Askevik, K., Dickson, S. L.: Behavioral consequences of exposure to a high fat diet during the post-weaning period in rats. Horm. Behav. 85, 56-66 (Open Access) (2016).

Rask-Andersen, M., Bringeland, N., Nilsson, E. K., Bandstein, M., Olaya Búcaro, M., Vogel, H., Schürmann, A., Hogenkamp, P. S., Benedict, C., Schiöth, H. B.: Postprandial alterations in whole-blood DNA methylation are mediated by changes in white blood cell composition. Am. J. Clin. Nutr. 104, 518-525 (Open Access) (2016).

Schmidt, V., Schulz, N., Yan, X., Schürmann, A., Kempa, S., Kern, M., Blüher, M., Poy, M. N., Olivecrona, G., Willnow, T. E.: SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity. J. Clin. Invest. 126, 2706-2720 (Open Access) (2016).

Volckmar, A. L., Han, C. T., Pütter, C., Haas, S., Vogel, C. I., Knoll, N., Struve, C., Göbel, M., Haas, K., Herrfurth, N., Jarick, I., Grallert, H., Schürmann, A., Al-Hasani, H., Hebebrand, J., Sauer, S., Hinney, A.: Analysis of genes involved in body wWeight regulation by targeted re-sequencing. PLoS ONE 11(2):e0147904 (Open Access) (2016).

Wallbach, M., Duque Escobar, J., Babaeikelishomi, R., Stahnke, M.-J., Blume, R., Schröder, S., Kruegel, J., Maedler, K., Kluth, O., Kehlenbach, R. H., Miosge, N., Oetjen, E.: Distinct functions of the dual leucine zipper kinase depending on its subcellular localization. Cell. Signal. 28, 272-283 (2016).

Cedernaes, J., Osler, M. E., Voisin, S., Broman, J.-E., Vogel, H., Dickson, S. L., Zierath, J. R., Schiöth, H. B., Benedict, C.: Acute sleep loss induces tissue-specific epigenetic and transcriptional alterations to circadian clock genes in men. J. Clin. Endocrinol. Metab. 100, E1255-E1261 (2015).

Schering, L., Hoene, M., Kanzleiter, T., Jähnert, M., Wimmers, K., Klaus, S., Eckel, J., Weigert, C., Schürmann, A., Maak, S., Jonas, W., Sell, H.: Identification of novel putative adipomyokines by a cross-species annotation of secretomes and expression profiles. Arch. Physiol. Biochem. 121, 194-205 (2015).

DeBosch, B. J., Kluth, O., Fujiwara, H., Schürmann, A., Moley, K.: Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat. Commun. 5:4642 (2014).

Engel, T., Fobker, M., Buchmann, J., Kannenberg, F., Rust, S., Nofer, J. R., Schürmann, A., Seedorf, U.: 3β,5α,6β-Cholestanetriol and 25-hydroxycholesterol accumulate in ATP-binding cassette transporter G1 (ABCG1)-deficiency. Atherosclerosis 235, 122-129 (2014).

Leiss, V., Flockerzie, K., Novakovic, A., Rath, M., Schönsiegel, A., Birnbaumer, L., Schürmann, A., Harteneck, C., Nürnberg, B.: Insulin secretion stimulated by arginine and its metabolite ornithine depends on Gαi2. Am. J. Physiol./Endocrinol. Metab. 307, E800-E812 (2014).

Sartorius, T., Peter, A., Schulz, N., Drescher, A., Bergheim, I., Machann, J., Schick, F., Siegel-Axel, D., Schürmann, A., Weigert, C., Häring, H.-U., Hennige, A. M.: Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity. PLoS ONE 9(3): e92358 (2014).

Wiza, C., Chadt, A., Blumensatt, M., Kanzleiter, T., Herzfeld De Wiza, D., Horrighs, A., Mueller, H., Nascimento, E. B., Schürmann, A., Al-Hasani, H., Ouwens, D. M.: Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle. Arch. Physiol. Biochem. 120, 64-72 (2014).

Shirazi, R., Palsdottir, V., Collander, J., Anesten, F., Vogel, H., Langlet, F., Jaschke, A., Schürmann, A., Prévot, V., Shao, R., Jansson, J.-O., Skibicka, K. P.: Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6. Proc. Natl. Acad. Sci. 110, 16199-16204 (2013).

Gorboulev, V., Schürmann, A., Vallon, V., Kipp, H., Jaschke, A., Klessen, D., Friedrich, A., Scherneck, S., Rieg, T., Cunard, R., Veyhl-Wichmann, M., Srinivasan, A., Balen, D., Breljak, D., Rexhepaj, R., Parker, H. E., Gribble, F. M., Reimann, F., Lang, F., Wiese, S., Sabolic, I., Sendtner, M., Koepsell, H.: Na+-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes 61, 187-196 (2012).

Henkel, J., Frede, K., Schanze, N., Vogel, H., Schürmann, A., Spruss, A., Bergheim, I., Püschel, G. P.: Stimulation of fat accumulation in hepatocytes by PGE2-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis. Lab. Invest. 92, 1597-1606 (2012).

Weidner, C., de Groot, J. C., Prasad, A., Freiwald, A., Quedenau, C., Kliem, M., Witzke, A., Kodelja, V., Han, C.-T., Giegold, S., Baumann, M., Klebl, B., Siems, K., Müller-Kuhrt, L., Schürmann, A., Schüler, R., Pfeiffer, A. F. H., Schroeder, F. C., Büssow, K., Sauer, S.: Amorfrutins are potent antidiabetic dietary natural products. Proc. Natl. Acad. Sci. 109, 7257-7262 (2012).

Fischer-Posovszky, P., Keuper, M., Nagel, S., Hesse, D., Schürmann, A., Debatin, K.-M., Strauss, G., Wabitsch, M.: Downregulation of FLIP by cycloheximide sensitizes human fat cells to CD95-induced apoptosis. Exp. Cell Res. 317, 2200-2209 (2011).

Lutz, S. Z., Hennige, A. M., Feil, S., Peter, A., Gerling, A., Machann, J., Kröber, S. M., Rath, M., Schürmann, A., Weigert, C., Häring, H.-U., Feil, R.: Genetic ablation of cGMP-dependent protein kinase type I causes liver inflammation and fasting hyperglycemia. Diabetes 60, 1566-1576 (2011).

Scherag, A., Dina, C., Hinney, A., Vatin, V., Scherag, S., Vogel, C. I. G., Müller, T. D., Grallert, H., Wichmann, H.-E., Balkau, B., Heude, B., Jarvelin, M.-R., Hartikainen, A.-L., Levy-Marchal, C., Weill, J., Delplanque, J., Körner, A., Kiess, W., Kovacs, P., Rayner, N. W., Prokopenko, I., McCarthy, M. I., Schäfer, H., Jarick, I., Boeing, H., Fisher, E., Reinehr, T., Heinrich, J., Rzehak, P., Berdel, D., Borte, M., Biebermann, H., Krude, H., Rosskopf, D., Rimmbach, C., Rief, W., Fromme, T., Klingenspor, M., Schürmann, A., Schulz, N., Nöthen, M. M., Mühleisen, T. W., Erbel, R., Jöckel, K.-H., Moebus, S., Boes, T., Illig, T., Froguel, P., Hebebrand, J., Meyre, D.: Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups. PLoS Genet. 6(4), e1000916 (Open Access) (2010).

Lastres-Becker, I., Brodesser, S., Lütjohann, D., Azizov, M., Buchmann, J., Hintermann, E., Sandhoff, K., Schürmann, A., Nowock, J., Auburger, G.: Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice. Hum. Mol. Genet. 17, 1465-1481 (2008).

Theander-Carrillo, C., Wiedmer, P., Cettour-Rose, P., Nogueiras, R., Perez-Tilve, D., Pfluger, P., Castaneda, T. R., Muzzin, P., Schürmann, A., Szanto, I., Tschöp, M., Rohner-Jeanrenaud, F.: Ghrelin action in the brain controls adipocyte metabolism. J. Clin. Invest. 116, 1983-1993 (2006).

Übersichtsarbeiten

Joost, H.-G., Schürmann, A.: The genetic basis of obesity-associated type 2 diabetes (diabesity) in polygenic mouse models. Mamm. Genome 25, 401-412 (Open Access) (2014).

Hesse, D., Jaschke, A., Chung, B., Schürmann, A.: Trans-Golgi proteins participate in the control of lipid droplet and chylomicron formation. Biosci. Rep. 33, 1-9 (2013).

Schwenk, R. W., Vogel, H., Schürmann, A.: Genetic and epigenetic control of metabolic health. Mol. Metab. 2, 337-347 (2013).

Grallert, H., Kanzleiter, T., Schwenk, R.: Genetik und Epigenetik des Typ-2-Diabetes. Die verschiedenen Ebenen der Genregulation. Diabetes aktuell 10, 123-128 (2012).

Scherneck, S., Vogel, H., Nestler, M., Kluge, R., Schürmann, A., Joost, H.-G.: Role of zinc finger transcription factor Zfp69 in body fat storage and diabetes susceptibility of mice. In: Meyerhof, W., Beisiegel, U., Joost, H.-G. (eds.) Sensory and Metabolic Control of Energy Balance (Results and Problems in Cell Differentiation; 52), Springer, pp 57-68 (2010).

Schmidt, S., Joost, H.-G., Schürmann, A.: GLUT8, the enigmatic intracellular hexose transporter. Am. J. Physiol./Endocrinol. Metab. 296, E614-E618 (2009).

Schürmann, A.: Insight into the "odd" hexose transporters GLUT3, GLUT5, and GLUT7. Am. J. Physiol./Endocrinol. Metab. 295, E225-E226 (Editorial) (2008).

Schürmann, A.: Die Bedeutung der Genetik bei der Enstehung der Adipositas. In: Therapie der Adipositas (Fortschritt und Fortbildung in der Medizin; Bd. 31). Bundesärztekammer (Hrsg.), 2007/2008, S. 55-61 (2007).

Kahn, R. A., Cherfils, J., Elias, M., Lovering, R. C., Munro, S., Schürmann, A.: Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins. J. Biol. Chem. 172, 645-650 (2006).

Scheepers, A., Joost, H.-G., Schürmann, A.: The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN J. Parenter. Enteral Nutr. 28, 364-371 (2004).

Buchbeiträge

Kluge, R., Scherneck, S., Schürmann, A., Joost, H.-G.: Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: a model of the human metabolic syndrome. In: Joost, H.-G., Al-Hasani, H., Schürmann, A. (eds.) Animal Models in Diabetes Research (Methods in Molecular Biology; 933), Humana Press, pp. 59-73 (2012).

Schürmann, A.: Glucose transporters: their abnormalities and significance in type 2 diabetes and cancer. In: Masur, K., Thénevod, F., Zänker, K. S. (eds.) Diabetes and Cancer. Epidemiological Evidence and Molecular Links (Frontiers in Diabetes; Vol. 19), Basel, Karger, pp 71-83 (2008).

Schürmann, A., Joost, H.-G.: Glucose transporters. In: Rosenthal, W., Offermanns, S. (eds.) Encyclopedia of Molecular Pharmacology. Springer Verlag, Berlin, pp 417-421 (2003).

Schürmann, A., Joost, H.-G.: ARF-like proteins. In: Kahn, R. A. (ed.) ARF Family GTPases. Kluwer Academic Publishers, Dordrecht, pp 325-350 (2003).

Herausgeber

Joost, H.-G., Al-Hasani, H., Schürmann, A.: Animal Models in Diabetic Research. (Methods in Molecular Biology; 933) Humana Press (2012).

sonstige Arbeiten

Joost, H. G.: The role of dual leucine zipper kinase (DLK) in β-cell apoptosis: a potential target for the prevention and treatment of type 2 diabetes?: Commentary to: Börchers et al., TNF-α induced DLK activation contributes to apoptosis in the β-cell line HIT. Naunyn Schmiedebergs Arch. Pharmacol. 390, 767-768 (Editorial) (2017).

Schürmann, A.: Werner-Creutzfeldt Award 2016: Novel findings on the pathophysiology of type 2 diabetes. Diabetol. Stoffw. 11, 294-297 (2016).

Joost, H.-G., Schürmann, A.: Glucose transporter 6 (GLUT6). In: Molecular Pages of the Alliance for Cellular Signalling http://www.signaling-gateway.org (2004).

Joost, H.-G., Schürmann, A.: Glucose transporter 8 (GLUT8). In: Molecular Pages of the Alliance for Cellular Signalling http://www.signaling-gateway.org (2004).

Joost, H.-G., Schürmann, A.: Glucose transporter 11 (GLUT11). In: Molecular Pages of the Alliance for Cellular Signaling, http://www.signaling-gateway.org (2004).

Schürmann, A., Joost, H.-G.: ADP-ribosylation factor-like protein 3 (ARL3). In: Molecular Pages of the Alliance for Cellular Signaling http://www.signaling-gateway.org (2004).

Schürmann, A., Joost, H.-G.: ADP-ribosylation factor-like protein 4 (ARL4). In: Molecular Pages of the Alliance for Cellular Signaling http://www.signaling-gateway.org (2004).

Schürmann, A., Joost, H.-G.: ADP-ribosylation factor-like protein 5 (ARL5). In: Molecular Pages of the Alliance for Cellular Signaling http://www.signaling-gateway.org (2004).

Schürmann, A., Joost, H.-G.: ADP-ribosylation factor-like protein 6 (ARL6). In: Molecular Pages of the Alliance for Cellular Signaling http://www.signaling-gateway.org (2004).

Schürmann, A., Joost, H.-G.: ADP-ribosylation factor-like protein 7 (ARL7). In: Molecular Pages of the Alliance for Cellular Signaling hhtp://www.signaling-gateway.org (2004).

Schürmann, A., Joost, H.-G.: ADP-ribosylation factor related protein 1 (ARFRP1). In: Molecular Pages of the Alliance for Cellular Signaling http://www.signaling-gateway.org (2004).

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