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Image Biochemie der Mikronährstoffe

Abteilung Biochemie der Mikronährstoffe (BIM)


Anzahl: 137

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Abteilung Biochemie der Mikronährstoffe


Lippmann, D., Lehmann, C., Florian, S., Barknowitz, G., Haack, M., Mewis, I., Wiesner, M., Schreiner, M., Glatt, H., Brigelius-Flohé, R., Kipp, A. P.: Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently. Food Funct. 5, 1073-1081 (2014).

Budnowski, J., Hanschen, F. S., Lehmann, C., Haack, M., Brigelius-Flohé, R., Kroh, L. W., Blaut, M., Rohn, S., Hanske, L.: A derivatization method for the simultaneous detection of glucosinolates and isothiocyanates in biological samples. Anal. Biochem. 441, 199-207 (2013).

Müller, M. F., Florian, S., Pommer, S., Osterhoff, M., Esworthy, R. S., Chu, F.-F., Brigelius-Flohé, R., Kipp, A. P.: Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development. PLoS ONE 8(8): e72055 (2013).

Jaschke, A., Chung, B., Hesse, D., Kluge, R., Zahn, C., Moser, M., Petzke, K.-J., Brigelius-Flohé, R., Puchkov, D., Koepsell, H., Heeren, J., Joost, H.-G., Schürmann, A.: The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium. Hum. Mol. Genet. 21, 3128-3142 (2012).

Kipp, A. P., Banning, A., van Schothorst, E. M., Méplan, C., Coort, S. L., Evelo, C. T., Keijer, J., Hesketh, J., Brigelius-Flohé, R.: Marginal selenium deficiency down-regulates inflammation-related genes in splenic leukocytes of the mouse. J. Nutr. Biochem. 23, 1170-1177 (2012).

Kipp, A. P., Müller, M. F., Göken, E. M., Deubel, S., Brigelius-Flohé, R.: The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium. Biochim. Biophys. Acta/General Subjects 1820, 1588-1596 (2012).

Krehl, S., Loewinger, M., Florian, S., Kipp, A. P., Banning, A., Wessjohann, L. A., Brauer, M. N., Iori, R., Esworthy, R. S., Chu, F.-F., Brigelius-Flohé, R.: Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply. Carcinogenesis 33, 620-628 (2012).

Florian, S., Krehl, S., Loewinger, M., Kipp, A., Banning, A., Esworthy, S., Chu, F.-F., Brigelius-Flohé, R.: Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice. Free Radic. Biol. Med. 49, 1694-1702 (2010).

Haack, M., Löwinger, M., Lippmann, D., Kipp, A., Pagnotta, E., Iori, R., Monien, B. H., Glatt, H., Brauer, M. N., Wessjohann, L. A., Brigelius-Flohé, R.: Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products. Biol. Chem. 391, 1281-1293 (2010).

Hemmerling, J., Nell, S., Kipp, A., Schumann, S., Deubel, S., Haack, M., Brigelius-Flohé, R.: α-Tocopherol enhances degranulation in RBL-2H3 mast cells. Mol. Nutr. Food Res. 54, 652-660 (2010).

Müller, M., Banning, A., Brigelius-Flohé, R., Kipp, A.: Nrf2 target genes are induced under marginal selenium-deficiency. Genes Nutr. 5, 297-307 (2010).

Hrdina, J., Banning, A., Kipp, A., Loh, G., Blaut, M., Brigelius-Flohé, R.: The gastrointestinal microbiota affects the selenium status and selenoprotein expression in mice. J. Nutr. Biochem. 20, 638-648 (2009).

Kipp, A., Banning, A., van Schothorst, E. M., Méplan, C., Schomburg, L., Evelo, C., Coort, S., Gaj, S., Keijer, J., Hesketh, J., Brigelius-Flohé, R.: Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon. Mol. Nutr. Food Res. 53, 1561-1572 (2009).

Meinl, W., Sczesny, S., Brigelius-Flohé, R., Blaut, M., Glatt, H.: Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat. Drug Metab. Dispos. 37, 1179-1186 (2009).

Banning, A., Florian, S., Deubel, S., Thalmann, S., Müller-Schmehl, K., Jacobasch, G., Brigelius-Flohé, R.: GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. Antioxid. Redox Signal. 10, 1491-1500 (2008).

Banning, A., Kipp, A., Schmitmeier, S., Löwinger, M., Florian, S., Krehl, S., Thalmann, S., Thierbach, R., Steinberg, P., Brigelius-Flohé, R.: Glutathione peroxidase 2 inhibits cyclooxygenase-2-mediated migration and invasion of HT-29 adenocarcinoma cells but supports their growth as tumors in nude mice. Cancer Res. 68, 9746-9753 (2008).

Kipp, A., Banning, A., Brigelius-Flohé, R.: Activation of the glutathione peroxidase 2 (GPx2) promoter by β-catenin. Biol. Chem. 388, 1027-1033 (2007).

Kluth, D., Banning, A., Paur, I., Blomhoff, R., Brigelius-Flohé, R.: Modulation of pregnane X receptor-and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds. Free Radic. Biol. Med. 42, 315-325 (2007).

Nell, S., Bahtz, R., Boßecker, A., Kipp, A., Landes, N., Bumke-Vogt, C., Halligan, E., Lunec, J., Brigelius-Flohé, R.: PCR-verified microarray analysis and functional in vitro studies indicate a role of α-tocopherol in vesicular transport. Free Radic. Res. 41, 930-942 (2007).

Banning, A., Brigelius-Flohé, R.: NF-κB, Nrf2 and HO-1 interplay in redox-regulated VCAM-1 expression. Antioxid. Redox Signal. 7, 889-899 (2005).

Banning, A., Deubel, S., Kluth, D., Zhou, Z., Brigelius-Flohé, R.: The GI-GPx gene is a target for Nrf2. Mol. Cell. Biol. 25, 4914-4923 (2005).

Böl, G.-F., Jurrmann, N., Brigelius-Flohé, R.: Cellular trafficking of the IL-1RI-associated kinase-1 requires intact kinase activity. Biochem. Biophys. Res. Commun. 332, 279-287 (2005).

Jurrmann, N., Brigelius-Flohé, R., Böl, G.-F.: Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells. J. Nutr. 135, 1859-1864 (2005).

Kluth, D., Landes, N., Pfluger, P., Müller-Schmehl, K., Weiss, K., Bumke-Vogt, C., Ristow, M., Brigelius-Flohé, R.: Modulation of Cyp3a11 mRNA expression by α-tocopherol but not γ-tocotrienol in mice. Free Radic. Biol. Med. 38, 507-514 (2005).

Al-Taie, O. H., Uceyler, N., Eubner, U., Jakob, F., Mörk, H., Scheurlen, M., Brigelius-Flohé, R., Schottker, K., Abel, J., Thalheimer, A., Katzenberger, T., Illert, B., Melcher, R., Köhrle, J.: Expression profiling and genetic alterations of the selenoproteins GI-GPx and SePP in colorectal carcinogenesis. Nutr. Cancer 48, 6-14 (2004).

Banning, A., Schnurr, K., Böl, G.-F., Kupper, D., Müller-Schmehl, K., Viita, H., Ylä-Herttuala, S., Brigelius-Flohé, R.: Inhibition of basal and interleukin-1-induced VCAM-1 expression by phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase in rabbit aortic smooth muscle cells. Free Radic. Biol. Med. 36, 135-144 (2004).

Brigelius-Flohé, R., Roob, J. M., Tiran, B., Wuga, S., Ribalta, J., Rock, E., Winklhofer-Roob, B. M.: The effect of age on vitamin E status, metabolism and function: metabolism as assessed by labeld tocopherols. In: Kelly, F., Meydani, M., Packer, L. (eds.) Vitamin E and Health. Ann. N. Y. Acad. Sci., Vol. 1031, pp 40-43 (2004).

Müller-Schmehl, K., Beninde, J., Finckh, B., Florian, S., Dudenhausen, J. W., Brigelius-Flohé, R., Schuelke, M.: Localization of α-tocopherol transfer protein in trophoblast, fetal capillaries´ endothelium and amnion epithelium of human term placenta. Free Radic. Res. 38, 413-420 (2004).

Rühl, R., Szech, R., Landes, N., Pfluger, P., Kluth, D., Schweigert, F. J.: Carotenoids and their metabolites are naturally occuring activators of gene expression via the pregnane X receptor. Eur. J. Nutr. 43, 336-343 (2004).

Birringer, M., EyTina, J. H., Salvatore, B. A., Neuzil, J.: Vitamin E analogues as inducers of apoptosis: structure-function relation. Br. J. Cancer 88, 1948-1955 (2003).

Böl, G.-F., Jurrmann, N., Brigelius-Flohé, R.: Recruitment of the interleukin-1 receptor (IL-1RI)-associated kinase IRAK to the IL-1RI is redox regulated. Biol. Chem. 384, 609-617 (2003).

Landes, N., Birringer, M., Brigelius-Flohé, R.: Homologous metabolites and gene activating routes for vitamins E and K. Mol. Aspects Med. 24, 337-344 (2003).

Landes, N., Pfluger, P., Kluth, D., Birringer, M., Rühl, R., Böl, G.-F., Glatt, H., Brigelius-Flohé, R.: Vitamin E activates gene expression via the pregnane X receptor. Biochem. Pharmacol. 65, 269-273 (2003).

Müller, C., Wingler, K., Brigelius-Flohé, R.: 3´UTRs of glutathione peroxidases differentially affect selenium-dependent mRNA stability and selenocysteine incorporation efficiency. Biol. Chem. 384, 11-18 (2003).

Ristow, M., Mulder, H., Pomplun, D., Schulz, T. J., Müller-Schmehl, K., Krause, A., Fex, M., Puccio, H., Müller, J., Isken, F., Spranger, J., Müller-Wieland, D., Magnuson, M. A., Möhlig, M., Koenig, M., Pfeiffer, A. F. H.: Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass. J. Clin. Invest. 112, 527-534 (2003).

Birringer, M., Pfluger, P., Kluth, D., Landes, N., Brigelius-Flohé, R.: Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells. J. Nutr. 132, 3113-3118 (2002).

Müller, C., Friedrichs, B., Wingler, K., Brigelius-Flohé, R.: Pertubation of lipid metabolism by linoleic acid hydroperoxide in CaCo-2 cells. Biol. Chem. 383, 637-648 (2002).

Schoefer, L., Mohan, R., Braune, A., Birringer, M., Blaut, M.: Anaerobic C-ring cleavage of genistein and daidzein by Eubacterium ramulus. FEMS Microbiol. Lett. 208, 197-202 (2002).

Birringer, M., Drogan, D., Brigelius-Flohé, R.: Tocopherols are metabolized in HepG2 cells by side chain omega-oxidation and consecutive beta-oxidation. Free Radic. Biol. Med. 31, 226-232 (2001).

Block, E., Birringer, M., Jiang, W., Nakahodo, T., Thompson, H. J., Toscano, P. J., Uzar, H., Zhang, X., Zhu, Z.: Allium chemistry: synthesis, natural occurrence, biological activity, and chemistry of Se-alk(en)ylselenocysteines and their gamma-glutamyl derivatives and oxidation products. J. Agric. Food Chem. 49, 458-470 (2001).

Brigelius-Flohé, R.: Vitamin E kinetics in smokers and nonsmokers. Free Radic. Biol. Med. 31, 1368-1374 (2001).

Florian, S., Wingler, K., Schmehl, K., Jacobasch, G., Kreuzer, O. J., Meyerhof, W., Brigelius-Flohé, R.: Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue. Free Radic. Res. 35, 655-663 (2001).

Lehmann, C., Wollenberger, U., Brigelius-Flohé, R., Scheller, F. W.: Modified gold electrodes for electrochemical studies of the reaction of phospholipid hydroperoxide glutathione peroxidase with glutathione and glutathione disulfide. Electroanalysis 13, 364-369 (2001).

Lisdat, F., Utepbergenov, D., Haseloff, R. F., Blasig, I. E., Stöcklein, W., Scheller, F. W., Brigelius-Flohé, R.: An optical method for the detection of oxidative stress using protein-RNA interaction. Anal. Chem. 73, 957-962 (2001).

Sztajer, H., Gamain, B., Aumann, K.-D., Slomianny, C., Becker, K., Brigelius-Flohé, R., Flohé, L.: The putative glutathione peroxidase gene of Plasmodium falciparum codes for a thioredoxin peroxidase. J. Biol. Chem. 276, 7397-7403 (2001).

Wingler, K., Müller, C., Brigelius-Flohé, R.: Stability of gastrointestinal glutathione peroxidase mRNA in selenium deficiency depends on its 3´UTR.. BioFactors 14, 43-50 (2001).

Böl, G.-F., Kreuzer, O. J., Brigelius-Flohé, R.,: Translocation of the interleukin-1 receptor-associated kinase-1 (IRAK-1) into the nucleus. FEBS Letters 477, 73-78 (2000).

Brigelius-Flohé, R., Maurer, S., Lötzer, K., Böl, G.-F., Kallionpää, H., Lehtolainen, P., Viita, H., Ylä-Herttuala, S.: Overexpression of PHGPx inhibits hydroxyperoxide-induced oxidation, NFkappaB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells. Atherosclerosis 152, 307-316 (2000).

Lodge, J. K., Traber, M. G., Elsner, A., Brigelius-Flohé, R.: A rapid method for the extraction and determination of vitamin E metabolites in human urine. J. Lipid Res. 41, 148-154 (2000).

Porkkala-Sarataho, E., Salonen, J. T., Nyyssönen, K., Kaikkonen, J., Salonen, R., Ristonmaa, U., Diczfalusy, U., Brigelius-Flohé, R., Loft, S., Poulsen, H. E.: Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydroxy-8-oxo-2´-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in non-depleted men. Arterioscler. Thromb. Vasc. Biol. 20, 2087-2093 (2000).

Schülke, M., Elsner, A., Finckh, B., Kohlschütter, A., Hübner, C., Brigelius-Flohé, R.: Urinary alpha-tocopherol metabolites in alpha-tocopherol transfer protein-deficient patients. J. Lipid Res. 41, 1543-1551 (2000).

Tolando, R., Jovanovic, A., Brigelius-Flohé, R., Ursini, F., Maiorino, M.: Reactive oxygen species and proinflammatory cytokine signaling in endothelial cells: effect of selenium supplementation. Free Radic. Biol. Med. 28, 979-986 (2000).

Wingler, K., Müller, C., Schmehl, K., Florian, S., Brigelius-Flohé, R.: Gastrointestinal glutathione peroxidase prevents transport of lipid hydroxyperoxides in CaCo-2 cells. Gastroenterology 119, 420-430 (2000).

Originalarbeiten (korrespondierender Autor nicht vom DIfE)

Förster, N., Mewis, I., Glatt, H., Haack, M., Brigelius-Flohé, R., Schreiner, M., Ulrichs, C.: Characteristic single glucosinolates from Moringa oleifera: Induction of detoxifying enzymes and lack of genotoxic activity in various model systems. Food Funct. 7, 4660-4674 (2016).

Forman, H. J., Augusto, O., Brigelius-Flohe, R., Dennery, P. A., Kalyanaraman, B., Ischiropoulos, H., Mann, G. E., Radi, R., Roberts, L. J. 2nd, Vina, J., Davies, K. J.: Even free radicals should follow some rules: A Guide to free radical research terminology and methodology. Free Radic. Biol. Med. 78, 233-235 (2015).

Emmink, B. L., Laoukili, J., Kipp, A. P., Koster, J., Govaert, K. M., Fatrai, S., Verheem, A., Steller, E. J. A., Brigelius-Flohe, R., Jimenez, C. R., Borel Rinkes, I. H. M., Kranenburg, O.: GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer. Cancer Res. 74, 6717-6730 (2014).

Blum, N. M., Mueller, K., Lippmann, D., Metges, C. C., Linn, T., Pallauf, J., Mueller, A. S.: Feeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and hepatic antioxidant and phase II enzymes in growing rats. Biol. Trace Elem. Res. 151, 384-399 (2013).

Barrera, L. N., Cassidy, A., Wang, W., Wei, T., Belshaw, N. J., Johnson, I. T., Brigelius-Flohé, R., Bao, Y.: TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death. Biochim. Biophys. Acta/Mol. Cell Res. 1823, 1914-1924 (2012).

Song, H., Bergstrasser, C., Rafat, N., Höger, S., Schmidt, M., Endres, N., Goebeler, M., Hillebrands, J. L., Brigelius-Flohé, R., Banning, A., Beck, G., Loesel, R., Yard, B. A.: The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E-selectin independently of heam oxygenase-1 expression. Br. J. Pharmacol. 157, 769-780 (2009).

Birringer, M., Kuhlow, D., Pfluger, P. T., Landes, N., Schulz, T. J., Glaubitz, M., Florian, S., Pfeiffer, A., Schuelke, M., Brigelius-Flohé, R., Ristow, M.: Improved glucose metabolism in mice lacking α-tocopherol transfer protein. Eur. J. Nutr. 46, 397-405 (2007).

González, R., Collado, J. A., Nell, S., Briceño, J., Tamayo, M. J., Fraga, E., Bernardos, A., López-Cillero, P., Pascussi, J. M., Rufián, S., Vilarem, M. J., De la Mata, M., Brigelius-Flohé, R., Maurel, P., Muntané, J.: Cytoprotective properties of α-tocopherol are related to gene regulation in cultured D-galactosamine-treated human hepatocytes. Free Radic. Biol. Med. 43, 1439-1452 (2007).

Heirman, I., Ginneberge, D., Brigelius-Flohé, R., Hendrickx, N., Agostinis, P., Brouckaert, P., Rottiers, P., Grooten, J.: Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy. Free Radic. Biol. Med. 40, 285-294 (2006).

Singh, A., Rangasamy, T., Thimmulappa, R. K., Lee, H., Osburn, W. O. Brigelius-Flohé, R., Kensler, T. W., Yamamoto, M., Biswal, S.: Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. Am. J. Respir. Cell Mol. Biol. 35, 639-650 (2006).


Brigelius-Flohé, R., Flohé, L.: Selenium and redox signaling. Arch. Biochem. Biophys. 617, 48-59 (2017).

Brigelius-Flohé, R.: Mixed results with mixed disulfides. Arch. Biochem. Biophys. 595, 81-87 (2016).

Gladyshev, V. N., Arnér, E. S., Berry, M. J., Brigelius-Flohé, R., Bruford, E. A., Burk, R. F., Carlson, B. A., Castellano, S., Chavatte, L., Conrad, M., Copeland, P. R., Diamond, A. M., Driscoll, D. M., Ferreiro, A., Flohé, L., Green, F. R., Guigó, R., Handy, D. E., Hatfield, D. L., Hesketh, J., Hoffmann, P. R., Holmgren, A., Hondal, R. J., Howard, M. T., Huang, K., Kim, H. Y., Kim, I. Y., Köhrle, J., Krol, A., Kryukov, G. V., Lee, B. J., Lee, B. C., Lei, X. G., Liu, Q., Lescure, A., Lobanov, A. V., Loscalzo, J., Maiorino, M., Mariotti, M., Prabhu, K. S., Rayman, M. P., Rozovsky, S., Salinas, G., Schmidt, E. E., Schomburg, L., Schweizer, U., Simonović, M., Sunde, R. A., Tsuji, P. A., Tweedie, S., Ursini, F., Whanger, P. D., Zhang, Y.: Selenoprotein Gene Nomenclature. J. Biol. Chem. 291, 24036-24040 (2016).

Brigelius-Flohé, R.: The evolving versatility of selenium in biology. Antioxid. Redox Signal. 23, 757-760 (2015).

Brigelius-Flohé, R., Kipp, A. P.: Selenium in the redox regulation of the Nrf2 and the Wnt pathway. Meth. Enzymol. 527, 65-86 (2013).

Brigelius-Flohé, R., Maiorino, M.: Glutathione peroxidases. Biochim. Biophys. Acta/General Subj. 1830, 3289-3303 (2013).

Kipp, A. P., Frombach, F., Deubel, S., Brigelius-Flohé, R.: Selenoprotein W as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis. Meth. Enzymol. 527, 87-112 (2013).

Brigelius-Flohé, R., Kipp, A. P.: Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis. Ann. N. Y. Acad. Sci. 1259, 19-25 (2012).

Brigelius-Flohé, R., Müller, M., Lippmann, D., Kipp, A. P.: The Yin and Yang of Nrf2-regulated selenoproteins in carcinogenesis. Int. J. Cell Biol. 2012, Article ID 486147 (Open Access) (2012).

Brigelius-Flohé, R., Flohé, L.: Basic principles and emerging concepts in the redox control of transcription factors. Antioxid. Redox Signal. 15, 2335-2381 Open Access (2011).

Brigelius-Flohé, R., Galli, F.: Vitamin E: A vitamin still awaiting the detection of its biological function. Mol. Nutr. Food Res. 54, 583-587 (2010).

Brigelius-Flohé, R.: Vitamin E: The shrew waiting to be tamed. Free Radic. Biol. Med. 46, 543-554 (2009).

Brigelius-Flohé, R., Kipp, A.: Glutathione peroxidases in different stages of carcinogenesis. Biochim. Biophys. Acta/General Subj. 1790, 1555-1568 (2009).

Brigelius-Flohé, R.: Selenium compounds and selenoproteins in cancer. Chem. Biodivers. 5, 389-395 (2008).

Brigelius-Flohé, R.: Adverse effects of vitamin E by induction of drug metabolism. Genes Nutr. 2, 249-256 (2007).

Brigelius-Flohé, R.: Glutathione peroxidases and redox-regulated transcription factors. Biol. Chem. 387, 1329-1335 (2006).

Brigelius-Flohé, R.: Bioactivity of vitamin E. Nutr. Res. Rev. 19, 174-186 (2006).

Brigelius-Flohé, R., Banning, A.: Part of the Series: From dietary antioxidants to regulators in cellular signaling and gene regulation sulforaphane and selenium, partners in adaptive response and prevention of cancer. Free Radic. Res. 40, 775-787 (2006).

Brigelius-Flohé, R.: Induction of drug metabolizing enzymes by vitamin E. J. Plant Physiol. 162, 797-802 (2005).

Brigelius-Flohé, R., Kluth, D., Banning, A.: Is there a future for antioxidants in atherogenesis?. Mol. Nutr. Food Res. 49, 1083-1089 (2005).

Brigelius-Flohé, R., Banning, A., Kny, M., Böl, G.-F.: Redox events in interleukin-1 signaling. Arch. Biochem. Biophys. 423, 66-73 (2004).

Pfluger, P., Kluth, D., Landes, N., Bumke-Vogt, C., Brigelius-Flohé, R.: Vitamin E: underestimated as an antioxidant. Redox Rep. 9, 249-254 (2004).

Brigelius-Flohé, R.: Vitamin E and drug metabolism. Biochem. Biophys. Res. Commun. 305, 737-740 (2003).

Brigelius-Flohé, R., Banning, A., Schnurr, K.: Selenium-dependent enzymes in endothelial cell function. Antioxid. Redox Signal. 5, 205-215 (2003).

Brigelius-Flohé, R., Flohé, L.: Is there a role of glutathione peroxidases in signaling and differentiation?. Biofactors 17, 93-102 (2003).

Birringer, M., Pilawa, S., Flohé, L.: Trends in selenium biochemistry. Nat. Prod. Rep. 19, 693-718 (2002).

Brigelius-Flohé, R., Kelly, F. J., Salonen, J. T., Neuzil, J., Zingg, J.-M., Azzi, A.: The European perspective on vitamin E: current knowledge and future research. Am. J. Clin. Nutr. 76, 703-716 (2002).

Brigelius-Flohé, R., Wingler, K., Müller, C.: Estimation of individual types of glutathione peroxidases. Meth. Enzymol. 347, 101-112 (2002).

Brigelius-Flohé, R., Müller, C., Menard, J., Florian, S., Schmehl, K., Wingler, K.: Functions of GI-GPx: Lessons from selenium-dependent expression and intracellular localization. BioFactors 14, 101-106 (2001).

Flohé, L., Andreesen, J. R., Brigelius-Flohé, R., Maiorino, M., Ursini, F.: Selenium, the element of the moon, in life on earth. IUBMB Life (International Union of Biochemistry and Molecular Biology) 49, 411-420 (2000).

Köhrle, J., Brigelius-Flohé, R., Böck, A., Gärtner, R., Meyer, O., Flohé, L.: Selenium in biology: facts and medical perspectives. Biol. Chem. 381, 849-864 (2000).


Banning, A., Kipp, A., Brigelius-Flohé, R.: Glutathione peroxidase 2 and its role in cancer. In: Hatfield, D. L., Berry, M. J., Gladyshev, V. N. (eds.) Selenium. Its Molecular Biology and Role in Human Health. 3. Auflage, Springer, 2012, pp 271-282 (2012).

Brigelius-Flohé, R., Flohé, L.: Glutathione peroxidases . In: Pantopoulos, K., Schipper, H. M. (eds.) Principles of Free Radical Biomedicine. Volume II (Biochemistry Research Trends). Nova Science, 2012 , pp 147-170 (2012).

Flohé, L., Brigelius-Flohé, R.: Selenoproteins of the Glutathione Peroxidase Family. In: Hatfield, D. L., Berry, M. J., Gladyshev, V. N. (eds.) Selenium. Its Molecular Biology and Role in Human Health. 3. Auflage, Springer, 2012 , pp 167-180 (2012).

Kipp, A., Brigelius-Flohé, R.: Selenium, selenoproteins and cancer. In: Schwerdtle, T., Ebert, F., Hartwig, A. (Hrsg.) Mikronährstoffe: Nahrungsergänzungsmittel, Analytik, Essentialität und Toxizität (Schriftenreihe der Gesellschaft für Mineralstoffe und Spurenelement e.V., Bd. 4), Utz Verlag, München,, S. 39-46 (2011).

Brigelius-Flohé, R.: Vitamine - Therapie des Vitaminmangels. In: Aktories, K., Förstermann, U., Hofmann, F., Starke, K. (Hrsg.) Allgemeine und spezielle Pharmakologie und Toxikologie. 10. Auflage, Elsevier, Urban & Fischer, München, S. 753-771 (2009).

Brigelius-Flohé, R., Banning, A.: Dietary factors in the regulation of selenoprotein biosyntheses. In: Surh, Y. J., Dong, Z., Packer, L., Cadenas, E. (eds.) Dietary modulation of cell signaling pathways. (Oxidativ Stress and Disease; 25), CRC Press, Boca Raton, Fl., pp 251-272 (2009).

Brigelius-Flohé, R., Blaut, M., Klaus, S.: Verdauung und Ernährung. In: Schartl, M., Gessler, M., von Eckardstein, A. (Hrsg.) Biochemie und Molekularbiologie des Menschen. Urban & Fischer, München, S. 862-902 (2009).

Brigelius-Flohé, R.: Vitamin E. In: Dunkelberg, H., Gebel, T., Hartwig, A. (Hrsg.) Handbuch der Lebensmitteltoxikologie, Bd. 4. Wiley-VCH, Weinheim, S. 2027-2057 (2007).

Brigelius-Flohé, R.: Selen und Krankheiten des gastrointestinalen Systems. In: Köhrle, J., Schmutzler, C. (Hrsg.) Mineralstoffe - Molekularbiologie - Medizin. (Schriftenreihe der Gesellschaft für Mineralstoffe und Spurenelemente e. V.; Bd. 2) Herbert Utz Verlag, München, S. 42-49 (2007).

Michaelis, M., Schweizer, U., Weichert, W., Denkert, C., Florian, S., Brigelius-Flohé, R., Köhrle, J., Schomburg, L.: Verstärkter Darmkrebs bei Mäusen mit reduzierter Selenoprotein P Expression. In: Köhrle, J., Schmutzler, C. (Hrsg.) Mineralstoffe - Molekularbiologie - Medizin. (Schriftenreihe der Gesellschaft für Mineralstoffe und Spurenelemente e.V.; Bd. 2), Herbert Utz Verlag, München, S. 115-121 (2007).

Polidori, M. C., Sies, H., Stahl, W., Brigelius-Flohé, R.: Vitamin E, metabolism and biological activity of metabolic products. In: Preedy, V. R., Watson, R. R. (eds.) The Encyclopedia of Vitamin E. CABI Publishing , pp 11-20 (2007).

Löffler, G. Brigelius-Flohé, R.: Vitamine. In: Löffler, G., Petrides, P. E., Heinrich, P. C. (Hrsg.) Biochemie und Pathobiochemie. Springer, Heidelberg, S. 679- 712 (2006).

Banning, A., Brigelius-Flohé, R.: Inhibition of NFκB-mediated VCAM-1 expression by PHGPx and 15-LOX. In: Puntarolo, S., Boveri, A (eds.) XII Biennial Meeting of the Society for Free Radical Research International. Medimond International Proceedinggs, Buenos Aires, 2005 (2004).

Brigelius-Flohé, R., Müller, C., Florian, S., Müller-Schmehl, K.: Selenium in cancer prevention: optimization of selenoprotein expression or specific functions of selenium compounds?. In: Scheppach, W., Scheurlen, M. (eds.) Exogenous Factors in Colonic Carcinogenesis. Falk Symposium 128, Kluwer Academic Publishers, Dordrecht,, pp 275-286 (2003).

Brigelius-Flohé, R.: Arteriosklerose. In: Biesalski, H. K., Köhrle, J., Schümann, K. (Hrsg.) Vitamine, Spurenelemente und Mineralstoffe. Prävention und Therapie mit Mikronährstoffen. Thieme Verlag, Stuttgart, New York,, S. 437-449 (2002).

Brigelius-Flohé, R., Flohé, L.: Is there a role of glutathione peroxidases in signaling and differentiation?. In: Pompella, A., Banhegyi, G., Wellman-Roesseau, M. (eds.) Thiol Metabolism and Redox Regulation of Cellular Functions. NATO ARW I/347, IOS Press, Amsterdam,, pp 96-106 (2002).

Brigelius-Flohé, R., Kluth, D., Landes, N., Pfluger, P., Birringer, M.: Mechanisms of vitamin E metabolism. In: Packer, L., Traber, M. G., Kraemer, K., Frei, B. (eds.) The antioxidant vitamins C and E. AOCS Press, Champaign/IL, USA,, pp 171-179 (2002).

Böl, G.-F., Brigelius-Flohé, R.: IL-1-induced trafficking of interleukin-1 receptor-associated proteins. In: Heilmeyer, L., Friedrich, P. (eds.) Protein Modules in Cellular signalling. NATO ASI A/318, IOS Press, Amsterdam, pp 288-297 (2001).

Brigelius-Flohé, R., Maiorino, M., Ursini, F., Flohé, L.: Selenium: An Antioxidant?. In: Cadenas, E., Packer, L. (eds.) Handbook of Antioxidants. Marcel Dekker, New York Basel, pp 633-664 (2001).

Flohé, L., Brigelius-Flohé, R.: Selenoproteins of the glutathione system. In: Hatfield, D. L. (ed.) Selenium. Its molecular biology and role in human health. Kluwer Acad. Publ., Boston, Dordrecht, London, pp 157-178 (2001).

Flohé, L., Brigelius-Flohé, R., Maiorino, M., Roveri, A., Wissing, J., Ursini, F.: Selenium and male reproduction. In: Hatfield, D. L. (ed.) Selenium. Its molecular biology and role in human health. Kluwer Acad. Publ., Boston, Dordrecht, London, pp 273-282 (2001).


Brigelius-Flohé, R.: Special issue: Widened horizon of vitamin E research. Mol. Nutr. Food Res. 54, Issue 5 (2010).

Brigelius-Flohé, R., Joost, H.-G.: Nutritional Genomics. Impact on Health and Disease. Wiley-VCH, Weinheim, (2006).

sonstige Arbeiten

Brigelius-Flohé, R.: Introduction to serial reviews on selenium and diabetes type 2—An unexpected link. Free Radic. Biol. Med. 65, 1536-1537 (2013).

Brigelius-Flohé, R.: Widened horizon of vitamin E research. Mol. Nutr. Food Res. 54, 581 (Editorial) (2010).

Brigelius-Flohé, R.: Commentary: oxidative stress reconsidered. Genes Nutr. 4, 161-163 (2009).

Brigelius-Flohé: Wie viel Vitamin E ist gesund?. Ernaehr. Umsch. 55, 296-297 (2008).

Brigelius-Flohé, R., Davies, K. J. A.: Is vitamin E an antioxidant, a regulator of signal transduction and gene expression, or a ´junk` food? Comments on the two accompanying papers: "Molecular mechanism of α-tocopherol action" by A. Azzi and "Vitamin E, antioxidant and nothing more" by M. Traber and J. Atkinson. Free Radic. Biol. Med. 43, 2-3 (Invited Editorial) (2007).

Azzi, A., Brigelius-Flohé, R., Kelly, F., Lodge, J. K., Özer, N., Packer, L., Sies, H.: On the opinion of the European Commission "Scientific Committee on Food" regarding the tolerable upper intake level of vitamin E (2003). (Letter to the Editor). Eur. J. Nutr. 44, 60-62 (2005).

Brigelius-Flohé, R.: Introductory remarks to the new series of reviews: From dietary antioxidants to regulators in cellular signalling and gene expression. Free Radic. Res. 39, 351 (2005).

Brigelius-Flohé, R., Köhrle, J.: 55th Mosbach Colloquium: How nutrients influence gene activity (editorial). Biol. Chem. 385, 569 (2004).

Böl, G.-F., Brigelius-Flohé, R.: Redoxregulation of interleukin-1 signaling. In: Galaris, D. (ed.) Free Radicals and Oxidative Stress: Chemistry, Biochemistry and Pathophysiological Implications. Proceedings of the Meeting of the Society for Free Radical Research - European Section, Medimond International Proceedings, Bologna,, pp 1-8 (2003).


Brigelius-Flohé, R., Banning, A.: PHGPx and the expression of cell adhesion molecules. Free Radic. Biol. Med. 36 (Suppl. 1), S6 (2004).

Böl, G.-F., Jurrmann, N., Brigelius-Flohé, R.: Targets for redox regulation of early interleukin-1-receptor signaling and the role of phospholipid hydroperoxide glutathione peroxidase. Signal Transduction 3-4, 147 (2003).

Brigelius-Flohé, R., Jurrmann, N., Böl, G.-F.: Redox events in IL-1 signaling. Free Radic. Res. 37 (Suppl. 1), 20 (2003).

Eder, E., Kratzin, D., Wanek, P., Zhou, Z., Köhrle, J., Brigelius-Flohé, R.: The relationship among selenium in nutrition, selenoproteins, oxidative stress, lipid peroxidation, and initiation of cancer. J. Nutr. 133 (Suppl. 1), 3866S-3866S (2003).

Eder, E., Wanek, P., Wacker, M., Zhou, Z., Jakob, F., Brigelius-Flohé, R., Köhrle, J.: Overexpression of GPxs in HepG2 cells. Formation of 4-hydroxy-2-nonenal-1,N2-propanodeoxyguanosine, a marker of lipid peroxidation induce DNA-damage. Proc. Amer. Assoc. Cancer Res. 44, 392, #1984 (2003).

Roob, J. M., Brigelius-Flohé, R., Winklhofer-Roob, B. M.: Is there a role of kidney function in vitamin E metabolism?. Clin. Nutr. 22 (S1), S37-S38 (2003).

Böl, G.-F., Brigelius-Flohé, R.: Intracellular transport of PI3-kinase and Interleukin-1-receptor associated kinase IRAK into the nucleus. Signal Transduction 1-2, 107 (2002).

Brigelius-Flohé, R., Pfluger, P., Landes, N., Kluth, D., Birringer, M.: Metabolism of vitamin E. Free Radic. Biol. Med. 33 (Suppl. 1), 485 (2002).

Landes, N., Pfluger, P., Birringer, M., Brigelius-Flohé, R.: Vitamin E acivates hPXR-mediated gene expression in HepG2 cells. Free Radic. Biol. Med. 33 (Suppl. 1), 497 (2002).

Müller, C., Buehner, S., Lochs, H., Brigelius-Flohé, R.: Effects of lipid hydroperoxides on mucosal barrier of small and large intestine of the rat. Gastroenterology 122 (Suppl. 1), T1024 (2002).

Pfluger, P., Kluth, D., Landes, N., Birringer, M., Brigelius-Flohé, R.: Metabolism of tocopherols in HepG2 cells. Free Radic. Biol. Med. 33 (Suppl. 1), 500 (2002).

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