Schriftgröße  A-  A  A+

Dife Logo

Druckversion von:
Stand: 20.10.2018 12:28:12

Image Biochemie der Mikronährstoffe

Abteilung Biochemie der Mikronährstoffe (BIM)


Anzahl: 137

Sortiert nach Jahr und alphabetisch nach Erstautor

Abteilung Biochemie der Mikronährstoffe


Lippmann, D., Lehmann, C., Florian, S., Barknowitz, G., Haack, M., Mewis, I., Wiesner, M., Schreiner, M., Glatt, H., Brigelius-Flohé, R., Kipp, A. P.: Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently. Food Funct. 5, 1073-1081 (2014).

Budnowski, J., Hanschen, F. S., Lehmann, C., Haack, M., Brigelius-Flohé, R., Kroh, L. W., Blaut, M., Rohn, S., Hanske, L.: A derivatization method for the simultaneous detection of glucosinolates and isothiocyanates in biological samples. Anal. Biochem. 441, 199-207 (2013).

Müller, M. F., Florian, S., Pommer, S., Osterhoff, M., Esworthy, R. S., Chu, F.-F., Brigelius-Flohé, R., Kipp, A. P.: Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development. PLoS ONE 8(8): e72055 (2013).

Jaschke, A., Chung, B., Hesse, D., Kluge, R., Zahn, C., Moser, M., Petzke, K.-J., Brigelius-Flohé, R., Puchkov, D., Koepsell, H., Heeren, J., Joost, H.-G., Schürmann, A.: The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium. Hum. Mol. Genet. 21, 3128-3142 (2012).

Kipp, A. P., Banning, A., van Schothorst, E. M., Méplan, C., Coort, S. L., Evelo, C. T., Keijer, J., Hesketh, J., Brigelius-Flohé, R.: Marginal selenium deficiency down-regulates inflammation-related genes in splenic leukocytes of the mouse. J. Nutr. Biochem. 23, 1170-1177 (2012).

Kipp, A. P., Müller, M. F., Göken, E. M., Deubel, S., Brigelius-Flohé, R.: The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium. Biochim. Biophys. Acta/General Subjects 1820, 1588-1596 (2012).

Krehl, S., Loewinger, M., Florian, S., Kipp, A. P., Banning, A., Wessjohann, L. A., Brauer, M. N., Iori, R., Esworthy, R. S., Chu, F.-F., Brigelius-Flohé, R.: Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply. Carcinogenesis 33, 620-628 (2012).

Florian, S., Krehl, S., Loewinger, M., Kipp, A., Banning, A., Esworthy, S., Chu, F.-F., Brigelius-Flohé, R.: Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice. Free Radic. Biol. Med. 49, 1694-1702 (2010).

Haack, M., Löwinger, M., Lippmann, D., Kipp, A., Pagnotta, E., Iori, R., Monien, B. H., Glatt, H., Brauer, M. N., Wessjohann, L. A., Brigelius-Flohé, R.: Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products. Biol. Chem. 391, 1281-1293 (2010).

Hemmerling, J., Nell, S., Kipp, A., Schumann, S., Deubel, S., Haack, M., Brigelius-Flohé, R.: α-Tocopherol enhances degranulation in RBL-2H3 mast cells. Mol. Nutr. Food Res. 54, 652-660 (2010).

Müller, M., Banning, A., Brigelius-Flohé, R., Kipp, A.: Nrf2 target genes are induced under marginal selenium-deficiency. Genes Nutr. 5, 297-307 (2010).

Hrdina, J., Banning, A., Kipp, A., Loh, G., Blaut, M., Brigelius-Flohé, R.: The gastrointestinal microbiota affects the selenium status and selenoprotein expression in mice. J. Nutr. Biochem. 20, 638-648 (2009).

Kipp, A., Banning, A., van Schothorst, E. M., Méplan, C., Schomburg, L., Evelo, C., Coort, S., Gaj, S., Keijer, J., Hesketh, J., Brigelius-Flohé, R.: Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon. Mol. Nutr. Food Res. 53, 1561-1572 (2009).

Meinl, W., Sczesny, S., Brigelius-Flohé, R., Blaut, M., Glatt, H.: Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat. Drug Metab. Dispos. 37, 1179-1186 (2009).

Banning, A., Florian, S., Deubel, S., Thalmann, S., Müller-Schmehl, K., Jacobasch, G., Brigelius-Flohé, R.: GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. Antioxid. Redox Signal. 10, 1491-1500 (2008).

Banning, A., Kipp, A., Schmitmeier, S., Löwinger, M., Florian, S., Krehl, S., Thalmann, S., Thierbach, R., Steinberg, P., Brigelius-Flohé, R.: Glutathione peroxidase 2 inhibits cyclooxygenase-2-mediated migration and invasion of HT-29 adenocarcinoma cells but supports their growth as tumors in nude mice. Cancer Res. 68, 9746-9753 (2008).

Kipp, A., Banning, A., Brigelius-Flohé, R.: Activation of the glutathione peroxidase 2 (GPx2) promoter by β-catenin. Biol. Chem. 388, 1027-1033 (2007).

Kluth, D., Banning, A., Paur, I., Blomhoff, R., Brigelius-Flohé, R.: Modulation of pregnane X receptor-and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds. Free Radic. Biol. Med. 42, 315-325 (2007).

Nell, S., Bahtz, R., Boßecker, A., Kipp, A., Landes, N., Bumke-Vogt, C., Halligan, E., Lunec, J., Brigelius-Flohé, R.: PCR-verified microarray analysis and functional in vitro studies indicate a role of α-tocopherol in vesicular transport. Free Radic. Res. 41, 930-942 (2007).

Banning, A., Brigelius-Flohé, R.: NF-κB, Nrf2 and HO-1 interplay in redox-regulated VCAM-1 expression. Antioxid. Redox Signal. 7, 889-899 (2005).

Banning, A., Deubel, S., Kluth, D., Zhou, Z., Brigelius-Flohé, R.: The GI-GPx gene is a target for Nrf2. Mol. Cell. Biol. 25, 4914-4923 (2005).

Böl, G.-F., Jurrmann, N., Brigelius-Flohé, R.: Cellular trafficking of the IL-1RI-associated kinase-1 requires intact kinase activity. Biochem. Biophys. Res. Commun. 332, 279-287 (2005).

Jurrmann, N., Brigelius-Flohé, R., Böl, G.-F.: Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells. J. Nutr. 135, 1859-1864 (2005).

Kluth, D., Landes, N., Pfluger, P., Müller-Schmehl, K., Weiss, K., Bumke-Vogt, C., Ristow, M., Brigelius-Flohé, R.: Modulation of Cyp3a11 mRNA expression by α-tocopherol but not γ-tocotrienol in mice. Free Radic. Biol. Med. 38, 507-514 (2005).

Al-Taie, O. H., Uceyler, N., Eubner, U., Jakob, F., Mörk, H., Scheurlen, M., Brigelius-Flohé, R., Schottker, K., Abel, J., Thalheimer, A., Katzenberger, T., Illert, B., Melcher, R., Köhrle, J.: Expression profiling and genetic alterations of the selenoproteins GI-GPx and SePP in colorectal carcinogenesis. Nutr. Cancer 48, 6-14 (2004).

Banning, A., Schnurr, K., Böl, G.-F., Kupper, D., Müller-Schmehl, K., Viita, H., Ylä-Herttuala, S., Brigelius-Flohé, R.: Inhibition of basal and interleukin-1-induced VCAM-1 expression by phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase in rabbit aortic smooth muscle cells. Free Radic. Biol. Med. 36, 135-144 (2004).

Brigelius-Flohé, R., Roob, J. M., Tiran, B., Wuga, S., Ribalta, J., Rock, E., Winklhofer-Roob, B. M.: The effect of age on vitamin E status, metabolism and function: metabolism as assessed by labeld tocopherols. In: Kelly, F., Meydani, M., Packer, L. (eds.) Vitamin E and Health. Ann. N. Y. Acad. Sci., Vol. 1031, pp 40-43 (2004).

Müller-Schmehl, K., Beninde, J., Finckh, B., Florian, S., Dudenhausen, J. W., Brigelius-Flohé, R., Schuelke, M.: Localization of α-tocopherol transfer protein in trophoblast, fetal capillaries´ endothelium and amnion epithelium of human term placenta. Free Radic. Res. 38, 413-420 (2004).

Rühl, R., Szech, R., Landes, N., Pfluger, P., Kluth, D., Schweigert, F. J.: Carotenoids and their metabolites are naturally occuring activators of gene expression via the pregnane X receptor. Eur. J. Nutr. 43, 336-343 (2004).

Birringer, M., EyTina, J. H., Salvatore, B. A., Neuzil, J.: Vitamin E analogues as inducers of apoptosis: structure-function relation. Br. J. Cancer 88, 1948-1955 (2003).

Böl, G.-F., Jurrmann, N., Brigelius-Flohé, R.: Recruitment of the interleukin-1 receptor (IL-1RI)-associated kinase IRAK to the IL-1RI is redox regulated. Biol. Chem. 384, 609-617 (2003).

Landes, N., Birringer, M., Brigelius-Flohé, R.: Homologous metabolites and gene activating routes for vitamins E and K. Mol. Aspects Med. 24, 337-344 (2003).

Landes, N., Pfluger, P., Kluth, D., Birringer, M., Rühl, R., Böl, G.-F., Glatt, H., Brigelius-Flohé, R.: Vitamin E activates gene expression via the pregnane X receptor. Biochem. Pharmacol. 65, 269-273 (2003).

Müller, C., Wingler, K., Brigelius-Flohé, R.: 3´UTRs of glutathione peroxidases differentially affect selenium-dependent mRNA stability and selenocysteine incorporation efficiency. Biol. Chem. 384, 11-18 (2003).

Ristow, M., Mulder, H., Pomplun, D., Schulz, T. J., Müller-Schmehl, K., Krause, A., Fex, M., Puccio, H., Müller, J., Isken, F., Spranger, J., Müller-Wieland, D., Magnuson, M. A., Möhlig, M., Koenig, M., Pfeiffer, A. F. H.: Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass. J. Clin. Invest. 112, 527-534 (2003).

Birringer, M., Pfluger, P., Kluth, D., Landes, N., Brigelius-Flohé, R.: Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells. J. Nutr. 132, 3113-3118 (2002).

Müller, C., Friedrichs, B., Wingler, K., Brigelius-Flohé, R.: Pertubation of lipid metabolism by linoleic acid hydroperoxide in CaCo-2 cells. Biol. Chem. 383, 637-648 (2002).

Schoefer, L., Mohan, R., Braune, A., Birringer, M., Blaut, M.: Anaerobic C-ring cleavage of genistein and daidzein by Eubacterium ramulus. FEMS Microbiol. Lett. 208, 197-202 (2002).

Birringer, M., Drogan, D., Brigelius-Flohé, R.: Tocopherols are metabolized in HepG2 cells by side chain omega-oxidation and consecutive beta-oxidation. Free Radic. Biol. Med. 31, 226-232 (2001).

Block, E., Birringer, M., Jiang, W., Nakahodo, T., Thompson, H. J., Toscano, P. J., Uzar, H., Zhang, X., Zhu, Z.: Allium chemistry: synthesis, natural occurrence, biological activity, and chemistry of Se-alk(en)ylselenocysteines and their gamma-glutamyl derivatives and oxidation products. J. Agric. Food Chem. 49, 458-470 (2001).

Brigelius-Flohé, R.: Vitamin E kinetics in smokers and nonsmokers. Free Radic. Biol. Med. 31, 1368-1374 (2001).

Florian, S., Wingler, K., Schmehl, K., Jacobasch, G., Kreuzer, O. J., Meyerhof, W., Brigelius-Flohé, R.: Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue. Free Radic. Res. 35, 655-663 (2001).

Lehmann, C., Wollenberger, U., Brigelius-Flohé, R., Scheller, F. W.: Modified gold electrodes for electrochemical studies of the reaction of phospholipid hydroperoxide glutathione peroxidase with glutathione and glutathione disulfide. Electroanalysis 13, 364-369 (2001).

Lisdat, F., Utepbergenov, D., Haseloff, R. F., Blasig, I. E., Stöcklein, W., Scheller, F. W., Brigelius-Flohé, R.: An optical method for the detection of oxidative stress using protein-RNA interaction. Anal. Chem. 73, 957-962 (2001).

Sztajer, H., Gamain, B., Aumann, K.-D., Slomianny, C., Becker, K., Brigelius-Flohé, R., Flohé, L.: The putative glutathione peroxidase gene of Plasmodium falciparum codes for a thioredoxin peroxidase. J. Biol. Chem. 276, 7397-7403 (2001).

Wingler, K., Müller, C., Brigelius-Flohé, R.: Stability of gastrointestinal glutathione peroxidase mRNA in selenium deficiency depends on its 3´UTR.. BioFactors 14, 43-50 (2001).

Böl, G.-F., Kreuzer, O. J., Brigelius-Flohé, R.,: Translocation of the interleukin-1 receptor-associated kinase-1 (IRAK-1) into the nucleus. FEBS Letters 477, 73-78 (2000).

Brigelius-Flohé, R., Maurer, S., Lötzer, K., Böl, G.-F., Kallionpää, H., Lehtolainen, P., Viita, H., Ylä-Herttuala, S.: Overexpression of PHGPx inhibits hydroxyperoxide-induced oxidation, NFkappaB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells. Atherosclerosis 152, 307-316 (2000).

Lodge, J. K., Traber, M. G., Elsner, A., Brigelius-Flohé, R.: A rapid method for the extraction and determination of vitamin E metabolites in human urine. J. Lipid Res. 41, 148-154 (2000).

Porkkala-Sarataho, E., Salonen, J. T., Nyyssönen, K., Kaikkonen, J., Salonen, R., Ristonmaa, U., Diczfalusy, U., Brigelius-Flohé, R., Loft, S., Poulsen, H. E.: Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydroxy-8-oxo-2´-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in non-depleted men. Arterioscler. Thromb. Vasc. Biol. 20, 2087-2093 (2000).

Schülke, M., Elsner, A., Finckh, B., Kohlschütter, A., Hübner, C., Brigelius-Flohé, R.: Urinary alpha-tocopherol metabolites in alpha-tocopherol transfer protein-deficient patients. J. Lipid Res. 41, 1543-1551 (2000).

Tolando, R., Jovanovic, A., Brigelius-Flohé, R., Ursini, F., Maiorino, M.: Reactive oxygen species and proinflammatory cytokine signaling in endothelial cells: effect of selenium supplementation. Free Radic. Biol. Med. 28, 979-986 (2000).

Wingler, K., Müller, C., Schmehl, K., Florian, S., Brigelius-Flohé, R.: Gastrointestinal glutathione peroxidase prevents transport of lipid hydroxyperoxides in CaCo-2 cells. Gastroenterology 119, 420-430 (2000).

Originalarbeiten (korrespondierender Autor nicht vom DIfE)

Förster, N., Mewis, I., Glatt, H., Haack, M., Brigelius-Flohé, R., Schreiner, M., Ulrichs, C.: Characteristic single glucosinolates from Moringa oleifera: Induction of detoxifying enzymes and lack of genotoxic activity in various model systems. Food Funct. 7, 4660-4674 (2016).

Forman, H. J., Augusto, O., Brigelius-Flohe, R., Dennery, P. A., Kalyanaraman, B., Ischiropoulos, H., Mann, G. E., Radi, R., Roberts, L. J. 2nd, Vina, J., Davies, K. J.: Even free radicals should follow some rules: A Guide to free radical research terminology and methodology. Free Radic. Biol. Med. 78, 233-235 (2015).

Emmink, B. L., Laoukili, J., Kipp, A. P., Koster, J., Govaert, K. M., Fatrai, S., Verheem, A., Steller, E. J. A., Brigelius-Flohe, R., Jimenez, C. R., Borel Rinkes, I. H. M., Kranenburg, O.: GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer. Cancer Res. 74, 6717-6730 (2014).

Blum, N. M., Mueller, K., Lippmann, D., Metges, C. C., Linn, T., Pallauf, J., Mueller, A. S.: Feeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and hepatic antioxidant and phase II enzymes in growing rats. Biol. Trace Elem. Res. 151, 384-399 (2013).

Barrera, L. N., Cassidy, A., Wang, W., Wei, T., Belshaw, N. J., Johnson, I. T., Brigelius-Flohé, R., Bao, Y.: TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death. Biochim. Biophys. Acta/Mol. Cell Res. 1823, 1914-1924 (2012).

Song, H., Bergstrasser, C., Rafat, N., Höger, S., Schmidt, M., Endres, N., Goebeler, M., Hillebrands, J. L., Brigelius-Flohé, R., Banning, A., Beck, G., Loesel, R., Yard, B. A.: The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E-selectin independently of heam oxygenase-1 expression. Br. J. Pharmacol. 157, 769-780 (2009).

Birringer, M., Kuhlow, D., Pfluger, P. T., Landes, N., Schulz, T. J., Glaubitz, M., Florian, S., Pfeiffer, A., Schuelke, M., Brigelius-Flohé, R., Ristow, M.: Improved glucose metabolism in mice lacking α-tocopherol transfer protein. Eur. J. Nutr. 46, 397-405 (2007).

González, R., Collado, J. A., Nell, S., Briceño, J., Tamayo, M. J., Fraga, E., Bernardos, A., López-Cillero, P., Pascussi, J. M., Rufián, S., Vilarem, M. J., De la Mata, M., Brigelius-Flohé, R., Maurel, P., Muntané, J.: Cytoprotective properties of α-tocopherol are related to gene regulation in cultured D-galactosamine-treated human hepatocytes. Free Radic. Biol. Med. 43, 1439-1452 (2007).

Heirman, I., Ginneberge, D., Brigelius-Flohé, R., Hendrickx, N., Agostinis, P., Brouckaert, P., Rottiers, P., Grooten, J.: Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy. Free Radic. Biol. Med. 40, 285-294 (2006).

Singh, A., Rangasamy, T., Thimmulappa, R. K., Lee, H., Osburn, W. O. Brigelius-Flohé, R., Kensler, T. W., Yamamoto, M., Biswal, S.: Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. Am. J. Respir. Cell Mol. Biol. 35, 639-650 (2006).


Brigelius-Flohé, R., Flohé, L.: Selenium and redox signaling. Arch. Biochem. Biophys. 617, 48-59 (2017).

Brigelius-Flohé, R.: Mixed results with mixed disulfides. Arch. Biochem. Biophys. 595, 81-87 (2016).

Gladyshev, V. N., Arnér, E. S., Berry, M. J., Brigelius-Flohé, R., Bruford, E. A., Burk, R. F., Carlson, B. A., Castellano, S., Chavatte, L., Conrad, M., Copeland, P. R., Diamond, A. M., Driscoll, D. M., Ferreiro, A., Flohé, L., Green, F. R., Guigó, R., Handy, D. E., Hatfield, D. L., Hesketh, J., Hoffmann, P. R., Holmgren, A., Hondal, R. J., Howard, M. T., Huang, K., Kim, H. Y., Kim, I. Y., Köhrle, J., Krol, A., Kryukov, G. V., Lee, B. J., Lee, B. C., Lei, X. G., Liu, Q., Lescure, A., Lobanov, A. V., Loscalzo, J., Maiorino, M., Mariotti, M., Prabhu, K. S., Rayman, M. P., Rozovsky, S., Salinas, G., Schmidt, E. E., Schomburg, L., Schweizer, U., Simonović, M., Sunde, R. A., Tsuji, P. A., Tweedie, S., Ursini, F., Whanger, P. D., Zhang, Y.: Selenoprotein Gene Nomenclature. J. Biol. Chem. 291, 24036-24040 (Open Access) (2016).

Brigelius-Flohé, R.: The evolving versatility of selenium in biology. Antioxid. Redox Signal. 23, 757-760 (2015).

Brigelius-Flohé, R., Kipp, A. P.: Selenium in the redox regulation of the Nrf2 and the Wnt pathway. Meth. Enzymol. 527, 65-86 (2013).

Brigelius-Flohé, R., Maiorino, M.: Glutathione peroxidases. Biochim. Biophys. Acta/General Subj. 1830, 3289-3303 (2013).

Kipp, A. P., Frombach, F., Deubel, S., Brigelius-Flohé, R.: Selenoprotein W as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis. Meth. Enzymol. 527, 87-112 (2013).

Brigelius-Flohé, R., Kipp, A. P.: Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis. Ann. N. Y. Acad. Sci. 1259, 19-25 (2012).

Brigelius-Flohé, R., Müller, M., Lippmann, D., Kipp, A. P.: The Yin and Yang of Nrf2-regulated selenoproteins in carcinogenesis. Int. J. Cell Biol. 2012, Article ID 486147 (Open Access) (2012).

Brigelius-Flohé, R., Flohé, L.: Basic principles and emerging concepts in the redox control of transcription factors. Antioxid. Redox Signal. 15, 2335-2381 Open Access (2011).

Brigelius-Flohé, R., Galli, F.: Vitamin E: A vitamin still awaiting the detection of its biological function. Mol. Nutr. Food Res. 54, 583-587 (2010).

Brigelius-Flohé, R.: Vitamin E: The shrew waiting to be tamed. Free Radic. Biol. Med. 46, 543-554 (2009).

Brigelius-Flohé, R., Kipp, A.: Glutathione peroxidases in different stages of carcinogenesis. Biochim. Biophys. Acta/General Subj. 1790, 1555-1568 (2009).

Brigelius-Flohé, R.: Selenium compounds and selenoproteins in cancer. Chem. Biodivers. 5, 389-395 (2008).

Brigelius-Flohé, R.: Adverse effects of vitamin E by induction of drug metabolism. Genes Nutr. 2, 249-256 (2007).

Brigelius-Flohé, R.: Glutathione peroxidases and redox-regulated transcription factors. Biol. Chem. 387, 1329-1335 (2006).

Brigelius-Flohé, R.: Bioactivity of vitamin E. Nutr. Res. Rev. 19, 174-186 (2006).

Brigelius-Flohé, R., Banning, A.: Part of the Series: From dietary antioxidants to regulators in cellular signaling and gene regulation sulforaphane and selenium, partners in adaptive response and prevention of cancer. Free Radic. Res. 40, 775-787 (2006).

Brigelius-Flohé, R.: Induction of drug metabolizing enzymes by vitamin E. J. Plant Physiol. 162, 797-802 (2005).

Brigelius-Flohé, R., Kluth, D., Banning, A.: Is there a future for antioxidants in atherogenesis?. Mol. Nutr. Food Res. 49, 1083-1089 (2005).

Brigelius-Flohé, R., Banning, A., Kny, M., Böl, G.-F.: Redox events in interleukin-1 signaling. Arch. Biochem. Biophys. 423, 66-73 (2004).

Pfluger, P., Kluth, D., Landes, N., Bumke-Vogt, C., Brigelius-Flohé, R.: Vitamin E: underestimated as an antioxidant. Redox Rep. 9, 249-254 (2004).

Brigelius-Flohé, R.: Vitamin E and drug metabolism. Biochem. Biophys. Res. Commun. 305, 737-740 (2003).

Brigelius-Flohé, R., Banning, A., Schnurr, K.: Selenium-dependent enzymes in endothelial cell function. Antioxid. Redox Signal. 5, 205-215 (2003).

Brigelius-Flohé, R., Flohé, L.: Is there a role of glutathione peroxidases in signaling and differentiation?. Biofactors 17, 93-102 (2003).

Birringer, M., Pilawa, S., Flohé, L.: Trends in selenium biochemistry. Nat. Prod. Rep. 19, 693-718 (2002).

Brigelius-Flohé, R., Kelly, F. J., Salonen, J. T., Neuzil, J., Zingg, J.-M., Azzi, A.: The European perspective on vitamin E: current knowledge and future research. Am. J. Clin. Nutr. 76, 703-716 (2002).

Brigelius-Flohé, R., Wingler, K., Müller, C.: Estimation of individual types of glutathione peroxidases. Meth. Enzymol. 347, 101-112 (2002).

Brigelius-Flohé, R., Müller, C., Menard, J., Florian, S., Schmehl, K., Wingler, K.: Functions of GI-GPx: Lessons from selenium-dependent expression and intracellular localization. BioFactors 14, 101-106 (2001).

Flohé, L., Andreesen, J. R., Brigelius-Flohé, R., Maiorino, M., Ursini, F.: Selenium, the element of the moon, in life on earth. IUBMB Life (International Union of Biochemistry and Molecular Biology) 49, 411-420 (2000).

Köhrle, J., Brigelius-Flohé, R., Böck, A., Gärtner, R., Meyer, O., Flohé, L.: Selenium in biology: facts and medical perspectives. Biol. Chem. 381, 849-864 (2000).


Banning, A., Kipp, A., Brigelius-Flohé, R.: Glutathione peroxidase 2 and its role in cancer. In: Hatfield, D. L., Berry, M. J., Gladyshev, V. N. (eds.) Selenium. Its Molecular Biology and Role in Human Health. 3. Auflage, Springer, 2012, pp 271-282 (2012).

Brigelius-Flohé, R., Flohé, L.: Glutathione peroxidases . In: Pantopoulos, K., Schipper, H. M. (eds.) Principles of Free Radical Biomedicine. Volume II (Biochemistry Research Trends). Nova Science, 2012 , pp 147-170 (2012).

Flohé, L., Brigelius-Flohé, R.: Selenoproteins of the Glutathione Peroxidase Family. In: Hatfield, D. L., Berry, M. J., Gladyshev, V. N. (eds.) Selenium. Its Molecular Biology and Role in Human Health. 3. Auflage, Springer, 2012 , pp 167-180 (2012).

Kipp, A., Brigelius-Flohé, R.: Selenium, selenoproteins and cancer. In: Schwerdtle, T., Ebert, F., Hartwig, A. (Hrsg.) Mikronährstoffe: Nahrungsergänzungsmittel, Analytik, Essentialität und Toxizität (Schriftenreihe der Gesellschaft für Mineralstoffe und Spurenelement e.V., Bd. 4), Utz Verlag, München,, S. 39-46 (2011).

Brigelius-Flohé, R.: Vitamine - Therapie des Vitaminmangels. In: Aktories, K., Förstermann, U., Hofmann, F., Starke, K. (Hrsg.) Allgemeine und spezielle Pharmakologie und Toxikologie. 10. Auflage, Elsevier, Urban & Fischer, München, S. 753-771 (2009).

Brigelius-Flohé, R., Banning, A.: Dietary factors in the regulation of selenoprotein biosyntheses. In: Surh, Y. J., Dong, Z., Packer, L., Cadenas, E. (eds.) Dietary modulation of cell signaling pathways. (Oxidativ Stress and Disease; 25), CRC Press, Boca Raton, Fl., pp 251-272 (2009).

Brigelius-Flohé, R., Blaut, M., Klaus, S.: Verdauung und Ernährung. In: Schartl, M., Gessler, M., von Eckardstein, A. (Hrsg.) Biochemie und Molekularbiologie des Menschen. Urban & Fischer, München, S. 862-902 (2009).

Brigelius-Flohé, R.: Vitamin E. In: Dunkelberg, H., Gebel, T., Hartwig, A. (Hrsg.) Handbuch der Lebensmitteltoxikologie, Bd. 4. Wiley-VCH, Weinheim, S. 2027-2057 (2007).

Brigelius-Flohé, R.: Selen und Krankheiten des gastrointestinalen Systems. In: Köhrle, J., Schmutzler, C. (Hrsg.) Mineralstoffe - Molekularbiologie - Medizin. (Schriftenreihe der Gesellschaft für Mineralstoffe und Spurenelemente e. V.; Bd. 2) Herbert Utz Verlag, München, S. 42-49 (2007).

Michaelis, M., Schweizer, U., Weichert, W., Denkert, C., Florian, S., Brigelius-Flohé, R., Köhrle, J., Schomburg, L.: Verstärkter Darmkrebs bei Mäusen mit reduzierter Selenoprotein P Expression. In: Köhrle, J., Schmutzler, C. (Hrsg.) Mineralstoffe - Molekularbiologie - Medizin. (Schriftenreihe der Gesellschaft für Mineralstoffe und Spurenelemente e.V.; Bd. 2), Herbert Utz Verlag, München, S. 115-121 (2007).

Polidori, M. C., Sies, H., Stahl, W., Brigelius-Flohé, R.: Vitamin E, metabolism and biological activity of metabolic products. In: Preedy, V. R., Watson, R. R. (eds.) The Encyclopedia of Vitamin E. CABI Publishing , pp 11-20 (2007).

Löffler, G. Brigelius-Flohé, R.: Vitamine. In: Löffler, G., Petrides, P. E., Heinrich, P. C. (Hrsg.) Biochemie und Pathobiochemie. Springer, Heidelberg, S. 679- 712 (2006).

Banning, A., Brigelius-Flohé, R.: Inhibition of NFκB-mediated VCAM-1 expression by PHGPx and 15-LOX. In: Puntarolo, S., Boveri, A (eds.) XII Biennial Meeting of the Society for Free Radical Research International. Medimond International Proceedinggs, Buenos Aires, 2005 (2004).

Brigelius-Flohé, R., Müller, C., Florian, S., Müller-Schmehl, K.: Selenium in cancer prevention: optimization of selenoprotein expression or specific functions of selenium compounds?. In: Scheppach, W., Scheurlen, M. (eds.) Exogenous Factors in Colonic Carcinogenesis. Falk Symposium 128, Kluwer Academic Publishers, Dordrecht,, pp 275-286 (2003).

Brigelius-Flohé, R.: Arteriosklerose. In: Biesalski, H. K., Köhrle, J., Schümann, K. (Hrsg.) Vitamine, Spurenelemente und Mineralstoffe. Prävention und Therapie mit Mikronährstoffen. Thieme Verlag, Stuttgart, New York,, S. 437-449 (2002).

Brigelius-Flohé, R., Flohé, L.: Is there a role of glutathione peroxidases in signaling and differentiation?. In: Pompella, A., Banhegyi, G., Wellman-Roesseau, M. (eds.) Thiol Metabolism and Redox Regulation of Cellular Functions. NATO ARW I/347, IOS Press, Amsterdam,, pp 96-106 (2002).

Brigelius-Flohé, R., Kluth, D., Landes, N., Pfluger, P., Birringer, M.: Mechanisms of vitamin E metabolism. In: Packer, L., Traber, M. G., Kraemer, K., Frei, B. (eds.) The antioxidant vitamins C and E. AOCS Press, Champaign/IL, USA,, pp 171-179 (2002).

Böl, G.-F., Brigelius-Flohé, R.: IL-1-induced trafficking of interleukin-1 receptor-associated proteins. In: Heilmeyer, L., Friedrich, P. (eds.) Protein Modules in Cellular signalling. NATO ASI A/318, IOS Press, Amsterdam, pp 288-297 (2001).

Brigelius-Flohé, R., Maiorino, M., Ursini, F., Flohé, L.: Selenium: An Antioxidant?. In: Cadenas, E., Packer, L. (eds.) Handbook of Antioxidants. Marcel Dekker, New York Basel, pp 633-664 (2001).

Flohé, L., Brigelius-Flohé, R.: Selenoproteins of the glutathione system. In: Hatfield, D. L. (ed.) Selenium. Its molecular biology and role in human health. Kluwer Acad. Publ., Boston, Dordrecht, London, pp 157-178 (2001).

Flohé, L., Brigelius-Flohé, R., Maiorino, M., Roveri, A., Wissing, J., Ursini, F.: Selenium and male reproduction. In: Hatfield, D. L. (ed.) Selenium. Its molecular biology and role in human health. Kluwer Acad. Publ., Boston, Dordrecht, London, pp 273-282 (2001).


Brigelius-Flohé, R.: Special issue: Widened horizon of vitamin E research. Mol. Nutr. Food Res. 54, Issue 5 (2010).

Brigelius-Flohé, R., Joost, H.-G.: Nutritional Genomics. Impact on Health and Disease. Wiley-VCH, Weinheim, (2006).

sonstige Arbeiten

Brigelius-Flohé, R.: Introduction to serial reviews on selenium and diabetes type 2—An unexpected link. Free Radic. Biol. Med. 65, 1536-1537 (2013).

Brigelius-Flohé, R.: Widened horizon of vitamin E research. Mol. Nutr. Food Res. 54, 581 (Editorial) (2010).

Brigelius-Flohé, R.: Commentary: oxidative stress reconsidered. Genes Nutr. 4, 161-163 (2009).

Brigelius-Flohé: Wie viel Vitamin E ist gesund?. Ernaehr. Umsch. 55, 296-297 (2008).

Brigelius-Flohé, R., Davies, K. J. A.: Is vitamin E an antioxidant, a regulator of signal transduction and gene expression, or a ´junk` food? Comments on the two accompanying papers: "Molecular mechanism of α-tocopherol action" by A. Azzi and "Vitamin E, antioxidant and nothing more" by M. Traber and J. Atkinson. Free Radic. Biol. Med. 43, 2-3 (Invited Editorial) (2007).

Azzi, A., Brigelius-Flohé, R., Kelly, F., Lodge, J. K., Özer, N., Packer, L., Sies, H.: On the opinion of the European Commission "Scientific Committee on Food" regarding the tolerable upper intake level of vitamin E (2003). (Letter to the Editor). Eur. J. Nutr. 44, 60-62 (2005).

Brigelius-Flohé, R.: Introductory remarks to the new series of reviews: From dietary antioxidants to regulators in cellular signalling and gene expression. Free Radic. Res. 39, 351 (2005).

Brigelius-Flohé, R., Köhrle, J.: 55th Mosbach Colloquium: How nutrients influence gene activity (editorial). Biol. Chem. 385, 569 (2004).

Böl, G.-F., Brigelius-Flohé, R.: Redoxregulation of interleukin-1 signaling. In: Galaris, D. (ed.) Free Radicals and Oxidative Stress: Chemistry, Biochemistry and Pathophysiological Implications. Proceedings of the Meeting of the Society for Free Radical Research - European Section, Medimond International Proceedings, Bologna,, pp 1-8 (2003).


Brigelius-Flohé, R., Banning, A.: PHGPx and the expression of cell adhesion molecules. Free Radic. Biol. Med. 36 (Suppl. 1), S6 (2004).

Böl, G.-F., Jurrmann, N., Brigelius-Flohé, R.: Targets for redox regulation of early interleukin-1-receptor signaling and the role of phospholipid hydroperoxide glutathione peroxidase. Signal Transduction 3-4, 147 (2003).

Brigelius-Flohé, R., Jurrmann, N., Böl, G.-F.: Redox events in IL-1 signaling. Free Radic. Res. 37 (Suppl. 1), 20 (2003).

Eder, E., Kratzin, D., Wanek, P., Zhou, Z., Köhrle, J., Brigelius-Flohé, R.: The relationship among selenium in nutrition, selenoproteins, oxidative stress, lipid peroxidation, and initiation of cancer. J. Nutr. 133 (Suppl. 1), 3866S-3866S (2003).

Eder, E., Wanek, P., Wacker, M., Zhou, Z., Jakob, F., Brigelius-Flohé, R., Köhrle, J.: Overexpression of GPxs in HepG2 cells. Formation of 4-hydroxy-2-nonenal-1,N2-propanodeoxyguanosine, a marker of lipid peroxidation induce DNA-damage. Proc. Amer. Assoc. Cancer Res. 44, 392, #1984 (2003).

Roob, J. M., Brigelius-Flohé, R., Winklhofer-Roob, B. M.: Is there a role of kidney function in vitamin E metabolism?. Clin. Nutr. 22 (S1), S37-S38 (2003).

Böl, G.-F., Brigelius-Flohé, R.: Intracellular transport of PI3-kinase and Interleukin-1-receptor associated kinase IRAK into the nucleus. Signal Transduction 1-2, 107 (2002).

Brigelius-Flohé, R., Pfluger, P., Landes, N., Kluth, D., Birringer, M.: Metabolism of vitamin E. Free Radic. Biol. Med. 33 (Suppl. 1), 485 (2002).

Landes, N., Pfluger, P., Birringer, M., Brigelius-Flohé, R.: Vitamin E acivates hPXR-mediated gene expression in HepG2 cells. Free Radic. Biol. Med. 33 (Suppl. 1), 497 (2002).

Müller, C., Buehner, S., Lochs, H., Brigelius-Flohé, R.: Effects of lipid hydroperoxides on mucosal barrier of small and large intestine of the rat. Gastroenterology 122 (Suppl. 1), T1024 (2002).

Pfluger, P., Kluth, D., Landes, N., Birringer, M., Brigelius-Flohé, R.: Metabolism of tocopherols in HepG2 cells. Free Radic. Biol. Med. 33 (Suppl. 1), 500 (2002).

© 2018 DIfE - Deutsches Institut für Ernährungsforschung. Alle Rechte vorbehalten. // Stand 26.09.2017