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Status: 22.04.2018 14:37:42
The human intestinal tract is populated by approximately 1014 microorganisms. This microbial community affects important host functions including gastrointestinal metabolism, epithelial cell growth, and colonization resistance against pathogens. However, intestinal bacteria have also been implicated in inflammatory bowel diseases, colorectal cancer and obesity. We aim to elucidate the effect of diet on the development, composition, and activity of the intestinal microbiota to define the role of intestinal bacteria in the development and prevention of diseases. In this context we have studied the bioactivation of dietary polyphenols by intestinal bacteria and how intestinal bacteria respond to nutrition and host factors.