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Status: 23.01.2018 11:14:24
The mission of the department is to evaluate associations between diet, lifestyle, biochemical, and genetic markers and risk of type 2 diabetes.
Diabetes mellitus is a chronic disorder of glucose metabolism and is the single biggest cause of preventable blindness, the leading cause of non-traumatic lower extremity amputation. Furthermore, diabetes mellitus is a major cause of coronary heart disease and end-stage renal disease in European populations. Efforts to understand the aetiology of the condition and to develop preventive strategies are key public health targets. Observational and experimental studies suggest that several dietary exposures can influence diabetes risk, independently from effects on body weight.
The department (together with the departments KLE and DIAB) is a member of the German Center for Diabetes Research (DZD). The DZD was founded in 2009 as one of six national health centers by the Federal Ministry of Education and Research. The DZD is a national research consortium in which basic researchers, clinicians and epidemiologists closely collaborate in order to clarify the causes and pathophysiology of diabetes and to develop individualized to develop individualized approaches to prevention and treatment.
Aim of the Department Molecular Epidemiology is to evaluate associations between diet and lifestyle and risk of type 2 diabetes and its complications. The research concept is based on the assumption that interaction between genetic factors and lifestyle plays a central role in the development of these diseases. Current research topics include:
• the interplay between nutritional exposures and metabolic status as well as gene-environment interaction and the incidence of type 2 diabetes,
• approaches to diabetes risk prediction, and
• the role of diet in macro- and microvascular complications of diabetes.