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Status: 20.10.2018 12:16:28
Investigation of the role of nutrient-dependent factors in the pathogenesis of major diseases of industrialized countries (e.g.: obesity, fatty liver disease, diabetes mellitus, atherosclerosis and metabolic syndrome).
The fact that obesity can induce metabolic syndrome seems to be the result of genetic programming. Metabolic syndrome describes the frequent clustering of risk components which can form the basis of atherosclerosis, type 2 diabetes, and at least several types of cancer. Metabolic syndrome is characterized by disturbed glucose metabolism, central adiposity, dyslipidemia with low HDL cholesterol and high triglycerides, hypertension, microalbuminuria, and fibrinolytic disorder.
The department, together with the departments Experimental Diabetology (DIAB), Molecular Epidemiology (MEP), Adipocyte Development and Nutrition (ADE) and the Junior Research Group Central Regulation of Metabolism (CRM), is a member of the German Center for Diabetes Research (DZD). The DZD was founded in 2009 as one of six national health centers by the Federal Ministry of Education and Research. The DZD is a national research consortium in which basic researchers, clinicians and epidemiologists closely collaborate in order to clarify the causes and pathophysiology of diabetes and to develop individualized approaches to prevention and treatment.
The main focus of our studies is the prevention of metabolic syndrome through personalized nutrition based on an understanding of the molecular mechanisms governing metabolism.
In addition, Prof. Pfeiffer treats patients at the Medical Department of Endocrinology, Diabetes and Nutritional Medicine of the Charité Berlin (Campus Benjamin Franklin).