Junior Research Group Cardiovascular Epidemiology

The junior research group Cardiovascular Epidemiology (established 01.01.2011) investigates the associations between nutritional factors, biomarkers, genetic variants and cardiovascular endpoints (i.e. myocardial infarction, stroke, and heart failure) based on data of the EPIC-Potsdam study. Besides etiologic issues, the main aim is the improvement of prediction of cardiovascular disease, including lifestyle factors - especially nutrition. Furthermore, the working group is involved in the EPIC-Heart consortium, which is carrying analyses on risk factors for myocardial infarction Europe-wide.

Biomarkers and genetics

Maria Arregui, Romina di Giuseppe

Selected new biomarkers, which might be relevant within the pathophysiology of cardiovascular diseases are of interest. Biomarkers of liver metabolism and mineral balance are the main fields of activity. For example, we are investigating the relationship between a recently discovered growth factor, the fibroblast growth factor 23, an important regulator of phosphate and vitamin D metabolism, and cardiovascular risk. Furthermore, our aim is in this context providing associations between phenotypic biomarkers, corresponding genetic variants and cardiovascular endpoints (concept of Mendelian Randomisation). Thereby, we may generate new hypotheses for causal pathways.

In addition, associations between selected functional single nucleotide polymorphisms (SNP), for example Microsomal Triglyceride Transfer Protein (MTTP) and risk of myocardial infarction and stroke, will be investigated considering metabolic pathways.

Heart failure

Janine Wirth

Heart failure has gained particular interest in the field of epidemiological research just recently. So far only a few studies have investigated associations between nutritional factors and risk of symptomatic heart failure. Therefore, the main focus is given to the investigation of the relationships between fruits, vegetables, fish, meat consumption and other important foods which contribute to risk of heart failure.

Risk prediction of cardiovascular disease

Romina di Giuseppe together with the Department of Epidemiology (Heiner Boeing)

Identification of individuals at high-risk based on epidemiological studies could be a major contribution in the field of primary prevention in cardiovascular disease. The EPIC-Potsdam study proposes a German specific risk prediction model, including lifestyle considerations- especially nutrition.