Small chemical changes in the DNA building blocks, which may be influenceable by lifestyle factors, can reduce the amount of IGFBP2. A DIfE / DZD research team has now reported in the journal Diabetes that these epigenetic changes increase the risk of type 2 diabetes. Moreover, people with high blood levels of the binding protein IGFBP2 are less likely to develop this metabolic disorder. The changes in the blood are already detectable a few years prior to the onset of the disease.
The mission of the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) is to conduct experimental and clinical research in the field of nutrition and health. Scientists at the DIfE pursue these scientific goals by interdisciplinary cooperation comprising a broad spectrum of experimental, medical and epidemiological methods.
Therefore the researchers focus on three areas:
The aim is to understand the molecular basis of nutrition-dependent diseases, and to develop new strategies for prevention, treatment, and nutritional recommendations.
DIfE is an independent foundation and member of the Leibniz Association, an alliance of scientific institutions.